Translational Autoimmunity, Volume 5

Challenges for Autoimmune Diseases

1st Edition - September 13, 2022
Editor: Nima Rezaei
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 3 8 9 - 7
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 3 9 0 - 3

Translational Autoimmunity: Challenges for Autoimmune Diseases, Fifth Edition addresses diagnostic approaches, therapeutic opportunities, and prognostic markers of different autoim… Read more

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Translational Autoimmunity: Challenges for Autoimmune Diseases, Fifth Edition addresses diagnostic approaches, therapeutic opportunities, and prognostic markers of different autoimmune diseases. This updated volume discusses autotoxicity, systems immunology, the prognostic significance of disease-specific autoantibodies, along with translational research to novel therapeutic policy in autoimmune diseases. From an introduction, to challenges and insights on the systems immunology of infectious and autoimmune diseases, new targets of treatments, and the role of autoantibodies in diagnosis and evolution, this book provides insights on many challenges researchers and clinicians are facing.

Cover
Title page
Table of Contents
Copyright
Dedication
Contributors
Preface
Series editor biography
Acknowledgment
Abbreviations
Chapter 1: Introduction on challenges for autoimmune diseases
Abstract
1: Introduction
2: Challenges in pathophysiology
3: Challenges in diagnosis
4: Challenges in treatment
5: Challenges in prevention
6: Conclusion
References
Chapter 2: From horror autotoxicus to autoimmunity. An historical note
Abstract
1: Introduction
2: Paul Ehrlich and the “horror autotoxicus”
3: First evidence
4: Autoimmunity in thyroid
5: Burnet and the prohibited clones
6: Further evidence
7: Influence of HLA complex
8: Vaccination and therapeutic approaches
9: Criteria of definition and classification of autoimmune diseases
10: Conclusion
References
Chapter 3: Flow cytometry in the diagnosis of autoimmune-related lymphoproliferative disorder and lymphoma in the head and neck region
Abstract
1: Introduction
2: Representative histopathology, immunohistochemistry, and flow cytometry
3: Further discussion
4: Conclusion
References
Chapter 4: Autoantigens in atopic dermatitis: The characterization of autoantigens and their diagnostic value
Abstract
1: Introduction
2: Physiology of the skin
3: Clinical characteristics of dermatitis; treatment and classification
4: Molecular mimicry in atopic dermatitis (AD)
5: Tools for the study and identification of autoantigens in atopic dermatitis
6: Particularities of type 2 immune response in atopic dermatitis
7: Conclusion
References
Chapter 5: Current paradigms of pathogenesis and challenges in vitiligo translational research
Abstract
Acknowledgments
1: Introduction
2: Understanding the pathogenesis of vitiligo
3: Histopathology of vitiligo
4: Current therapeutic modalities in vitiligo
5: Current translational research in vitiligo
6: Current challenges and future therapeutic avenues
7: Conclusion
References
Chapter 6: The role of kynurenine pathway aryl hydrocarbon receptor axis in autoimmune diseases of the skin
Abstract
1: Introduction
2: The kynurenine pathway
3: The aryl hydrocarbon receptor
4: Autoimmune diseases
5: The immune response in the skin
6: Bullous pemphigoid
7: Systemic sclerosis
8: Vitiligo
9: Cutaneous disorders orchestrated by interferons
10: Frontal fibrosing alopecia
11: Conclusion
References
Chapter 7: COVID-19 in childhood and phenotypes of pediatric inflammatory multisystem syndrome
Abstract
1: Introduction
2: COVID-19
3: Kawasaki disease
4: Kawasaki-like phenotype
5: PIMS spectrum
6: Coronary artery aneurysm
7: Future directions
8: Conclusion
References
Chapter 8: Autoimmune conditions and epigenetic challenges in periodontitis
Abstract
1: Introduction
2: Role of autoimmunity in periodontitis
3: Role of epigenetics in susceptibility to periodontitis
4: Recommendations and future directions
5: Conclusion
References
Chapter 9: Neutrophil extracellular traps in autoimmunity, renal diseases, and transplantation
Abstract
1: Introduction
2: Mechanisms and function of neutrophil extracellular traps
3: The role of NETs in autoimmunity
4: Clinical implications of neutrophil extracellular traps in renal diseases
5: NETosis from the bench to the bedside
6: Conclusion
References
Chapter 10: Membranous nephropathy: Clinical and immunological aspects
Abstract
1: Introduction
2: Epidemiology
3: Clinical aspects
4: Immunopathogenesis
5: Diagnostics
6: Treatment
7: Conclusion
References
Chapter 11: Testicular immune tolerance and viral infections
Abstract
1: Introduction
2: Testicular immune privilege: Hide-out for virus
3: Anatomical basis of testicular immune privilege
4: Molecular basis of tolerogenic microenvironment in the testis
5: Common testicular viral infections
6: Testicular antiviral defense mechanism
7: Conclusion
References
Chapter 12: Ophthalmological manifestations of systemic autoimmune diseases
Abstract
1: Introduction
2: Rheumatoid arthritis
3: Primary Sjögren’s syndrome
4: Seronegative spondyloarthropathies
5: Juvenile idiopathic arthritis
6: Systemic lupus erythematosus
7: Giant cell arteritis
8: Granulomatosis with polyangiitis
9: Multiple sclerosis, optic neuritis, and seropositive optic neuritis
10: Graves’ disease
11: Conclusion
References
Chapter 13: Challenges for diagnosis and treatment of primary biliary cholangitis
Abstract
1: Introduction
2: Epidemiology
3: Etiology
4: Diagnosis
5: Treatment
6: Management of symptoms, extrahepatic manifestations, and hepatocellular carcinoma
7: Conclusion
References
Chapter 14: Modeling primary biliary cholangitis and primary sclerosing cholangitis as infectious diseases
Abstract
Acknowledgments
1: Introduction
2: PBC
3: PSC
4: Conclusion
References
Chapter 15: Humoral epitope spreading in autoimmune bullous diseases: An update
Abstract
1: Introduction
2: Epitope spreading: Definition
3: Epitope spreading: Mechanisms
4: Epitope spreading in autoimmune bullous diseases
5: Conclusion
References
Chapter 16: Dermatologic autoimmunity associated with immune checkpoint inhibitors
Abstract
1: Introduction
2: Immune checkpoint inhibitors
3: Autoimmunity
4: Conclusion
References
Chapter 17: Insights and strategies to promote immune tolerance in allogeneic hematopoietic stem cell transplantation recipients
Abstract
1: Introduction
2: Acute GVHD
3: Chronic GVHD
4: Tolerance
5: Tissue tolerance and reparative processes
6: Conclusion
References
Chapter 18: The potential of cellular transplantation to harness autoimmunity and reverse clinical diabetes
Abstract
1: Introduction
2: Islet cell transplant
3: Islet cell regeneration and immune reset
4: Novel approaches to immunosuppression
5: Conclusion
References
Index

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