Translational Autoimmunity, Volume 5
Challenges for Autoimmune Diseases
- 1st Edition - September 13, 2022
- Editor: Nima Rezaei
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 8 5 3 8 9 - 7
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 8 5 3 9 0 - 3
Translational Autoimmunity: Challenges for Autoimmune Diseases, Fifth Edition addresses diagnostic approaches, therapeutic opportunities, and prognostic markers of different autoim… Read more
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Request a sales quoteTranslational Autoimmunity: Challenges for Autoimmune Diseases, Fifth Edition addresses diagnostic approaches, therapeutic opportunities, and prognostic markers of different autoimmune diseases. This updated volume discusses autotoxicity, systems immunology, the prognostic significance of disease-specific autoantibodies, along with translational research to novel therapeutic policy in autoimmune diseases. From an introduction, to challenges and insights on the systems immunology of infectious and autoimmune diseases, new targets of treatments, and the role of autoantibodies in diagnosis and evolution, this book provides insights on many challenges researchers and clinicians are facing.
- Describes challenges in the diagnosis, management and treatment of autoimmune diseases
- Highlights major difficulties in the diagnosis and management of autoimmune diseases
- Reflects important remediable deficiencies in current management
- Meets the needs of basic scientists, clinicians and translational scientists and industry partners
Immunologists, Clinical immunologists, Endocrinologists, Microbiologists, Neurologists, Oncologists, Rheumatologists, Clinicians, research scientists, and industry partners
- Cover
- Title page
- Table of Contents
- Copyright
- Dedication
- Contributors
- Preface
- Series editor biography
- Acknowledgment
- Abbreviations
- Chapter 1: Introduction on challenges for autoimmune diseases
- Abstract
- 1: Introduction
- 2: Challenges in pathophysiology
- 3: Challenges in diagnosis
- 4: Challenges in treatment
- 5: Challenges in prevention
- 6: Conclusion
- References
- Chapter 2: From horror autotoxicus to autoimmunity. An historical note
- Abstract
- 1: Introduction
- 2: Paul Ehrlich and the “horror autotoxicus”
- 3: First evidence
- 4: Autoimmunity in thyroid
- 5: Burnet and the prohibited clones
- 6: Further evidence
- 7: Influence of HLA complex
- 8: Vaccination and therapeutic approaches
- 9: Criteria of definition and classification of autoimmune diseases
- 10: Conclusion
- References
- Chapter 3: Flow cytometry in the diagnosis of autoimmune-related lymphoproliferative disorder and lymphoma in the head and neck region
- Abstract
- 1: Introduction
- 2: Representative histopathology, immunohistochemistry, and flow cytometry
- 3: Further discussion
- 4: Conclusion
- References
- Chapter 4: Autoantigens in atopic dermatitis: The characterization of autoantigens and their diagnostic value
- Abstract
- 1: Introduction
- 2: Physiology of the skin
- 3: Clinical characteristics of dermatitis; treatment and classification
- 4: Molecular mimicry in atopic dermatitis (AD)
- 5: Tools for the study and identification of autoantigens in atopic dermatitis
- 6: Particularities of type 2 immune response in atopic dermatitis
- 7: Conclusion
- References
- Chapter 5: Current paradigms of pathogenesis and challenges in vitiligo translational research
- Abstract
- Acknowledgments
- 1: Introduction
- 2: Understanding the pathogenesis of vitiligo
- 3: Histopathology of vitiligo
- 4: Current therapeutic modalities in vitiligo
- 5: Current translational research in vitiligo
- 6: Current challenges and future therapeutic avenues
- 7: Conclusion
- References
- Chapter 6: The role of kynurenine pathway aryl hydrocarbon receptor axis in autoimmune diseases of the skin
- Abstract
- 1: Introduction
- 2: The kynurenine pathway
- 3: The aryl hydrocarbon receptor
- 4: Autoimmune diseases
- 5: The immune response in the skin
- 6: Bullous pemphigoid
- 7: Systemic sclerosis
- 8: Vitiligo
- 9: Cutaneous disorders orchestrated by interferons
- 10: Frontal fibrosing alopecia
- 11: Conclusion
- References
- Chapter 7: COVID-19 in childhood and phenotypes of pediatric inflammatory multisystem syndrome
- Abstract
- 1: Introduction
- 2: COVID-19
- 3: Kawasaki disease
- 4: Kawasaki-like phenotype
- 5: PIMS spectrum
- 6: Coronary artery aneurysm
- 7: Future directions
- 8: Conclusion
- References
- Chapter 8: Autoimmune conditions and epigenetic challenges in periodontitis
- Abstract
- 1: Introduction
- 2: Role of autoimmunity in periodontitis
- 3: Role of epigenetics in susceptibility to periodontitis
- 4: Recommendations and future directions
- 5: Conclusion
- References
- Chapter 9: Neutrophil extracellular traps in autoimmunity, renal diseases, and transplantation
- Abstract
- 1: Introduction
- 2: Mechanisms and function of neutrophil extracellular traps
- 3: The role of NETs in autoimmunity
- 4: Clinical implications of neutrophil extracellular traps in renal diseases
- 5: NETosis from the bench to the bedside
- 6: Conclusion
- References
- Chapter 10: Membranous nephropathy: Clinical and immunological aspects
- Abstract
- 1: Introduction
- 2: Epidemiology
- 3: Clinical aspects
- 4: Immunopathogenesis
- 5: Diagnostics
- 6: Treatment
- 7: Conclusion
- References
- Chapter 11: Testicular immune tolerance and viral infections
- Abstract
- 1: Introduction
- 2: Testicular immune privilege: Hide-out for virus
- 3: Anatomical basis of testicular immune privilege
- 4: Molecular basis of tolerogenic microenvironment in the testis
- 5: Common testicular viral infections
- 6: Testicular antiviral defense mechanism
- 7: Conclusion
- References
- Chapter 12: Ophthalmological manifestations of systemic autoimmune diseases
- Abstract
- 1: Introduction
- 2: Rheumatoid arthritis
- 3: Primary Sjögren’s syndrome
- 4: Seronegative spondyloarthropathies
- 5: Juvenile idiopathic arthritis
- 6: Systemic lupus erythematosus
- 7: Giant cell arteritis
- 8: Granulomatosis with polyangiitis
- 9: Multiple sclerosis, optic neuritis, and seropositive optic neuritis
- 10: Graves’ disease
- 11: Conclusion
- References
- Chapter 13: Challenges for diagnosis and treatment of primary biliary cholangitis
- Abstract
- 1: Introduction
- 2: Epidemiology
- 3: Etiology
- 4: Diagnosis
- 5: Treatment
- 6: Management of symptoms, extrahepatic manifestations, and hepatocellular carcinoma
- 7: Conclusion
- References
- Chapter 14: Modeling primary biliary cholangitis and primary sclerosing cholangitis as infectious diseases
- Abstract
- Acknowledgments
- 1: Introduction
- 2: PBC
- 3: PSC
- 4: Conclusion
- References
- Chapter 15: Humoral epitope spreading in autoimmune bullous diseases: An update
- Abstract
- 1: Introduction
- 2: Epitope spreading: Definition
- 3: Epitope spreading: Mechanisms
- 4: Epitope spreading in autoimmune bullous diseases
- 5: Conclusion
- References
- Chapter 16: Dermatologic autoimmunity associated with immune checkpoint inhibitors
- Abstract
- 1: Introduction
- 2: Immune checkpoint inhibitors
- 3: Autoimmunity
- 4: Conclusion
- References
- Chapter 17: Insights and strategies to promote immune tolerance in allogeneic hematopoietic stem cell transplantation recipients
- Abstract
- 1: Introduction
- 2: Acute GVHD
- 3: Chronic GVHD
- 4: Tolerance
- 5: Tissue tolerance and reparative processes
- 6: Conclusion
- References
- Chapter 18: The potential of cellular transplantation to harness autoimmunity and reverse clinical diabetes
- Abstract
- 1: Introduction
- 2: Islet cell transplant
- 3: Islet cell regeneration and immune reset
- 4: Novel approaches to immunosuppression
- 5: Conclusion
- References
- Index
- No. of pages: 418
- Language: English
- Edition: 1
- Published: September 13, 2022
- Imprint: Academic Press
- Paperback ISBN: 9780323853897
- eBook ISBN: 9780323853903
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Nima Rezaei
Professor Nima Rezaei gained his medical degree (MD) from Tehran University of Medical Sciences and subsequently obtained an MSc in Molecular and Genetic Medicine and a PhD in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also spent a short-term fellowship of Pediatric Clinical Immunology and Bone Marrow Transplantation in the Newcastle General Hospital. Professor Rezaei is now the Full Professor of Immunology and Vice Dean of Research, School of Medicine, Tehran University of Medical Sciences, and the co-founder and Head of the Research Center for Immunodeficiencies. He is also the founding President of the Universal Scientific Education and Research Network (USERN). Professor Rezaei has already been the Director of more than 55 research projects and has designed and participated in several international collaborative projects. Professor Rezaei is an editorial assistant or board member for more than 30 international journals. He has edited more than 35 international books, has presented more than 500 lectures/posters in congresses/meetings, and has published more than 1,000 scientific papers in the international journals.
Affiliations and expertise
Professor, Department of Immunology, School of Medicine; Head, Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences; Founding President, Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA),Universal Scientific Education and Research Network (USERN),Tehran, IranRead Translational Autoimmunity, Volume 5 on ScienceDirect