Translational Autoimmunity, Volume 4

Autoimmune Diseases in Different Organs

1st Edition - May 1, 2022
Editor: Nima Rezaei
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 2 4 4 6 6 - 1
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 5 9 7 6 - 9

As the autoimmune diseases could affect different organs, Translational Autoimmunity: Autoimmune Diseases in Different Organs addresses the spectrum of autoimmune diseases. The fo… Read more

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As the autoimmune diseases could affect different organs, Translational Autoimmunity: Autoimmune Diseases in Different Organs addresses the spectrum of autoimmune diseases. The fourth volume of Translational Immunology Series focuses on clinical and laboratory details of autoimmune diseases which are broadly categorized into two types of organ-specific autoimmune diseases and non-organ specific autoimmune diseases (also known as systemic autoimmune diseases). Autoimmune rheumatic diseases such as systemic lupus erythematosus and rheumatoid arthritis, autoimmune rheumatic diseases such as diabetes mellitus and thyroid diseases, autoimmune neurologic diseases such as multiple sclerosis, as well as autoimmune hepatobiliary diseases, autoimmune renal diseases and autoimmune cutaneous diseases as the subject of discussion in Translational Autoimmunity: Autoimmune Diseases in Different Organs.

Cover image
Title page
Table of Contents
Copyright
Dedication
Contributors
Preface
Series editor biography
Acknowledgment
Abbreviations
Chapter 1: Autoimmune diseases in different organs
Abstract
1: Introduction
2: Autoimmune complications of the cardiovascular system
3: Autoimmune complications of the respiratory system
4: Autoimmune complications of the endocrine system
5: Autoimmune complications of the gastrointestinal system
6: Autoimmune complications of the hematological system
7: Autoimmune complications of the musculoskeletal system
8: Autoimmune complications of the nervous system
9: Autoimmune complications of the integumentary system
10: Conclusion
References
Chapter 2: Autoimmune polyendocrinopathies in pediatric age
Abstract
1: Introduction
2: Autoimmune polyendocrine syndrome type 1 (APS-1)
3: Autoimmune polyendocrine syndrome type 2 (APS-2)
4: Autoimmune polyendocrine syndrome type 3 (APS-3)
5: IPEX syndrome
6: Conclusion
References
Chapter 3: Autoimmune thyroid diseases: Peculiarities in pediatric age
Abstract
1: Introduction
2: Epidemiology
3: Pathogenesis
4: Thyroid function patterns at presentation
5: Clinical manifestations
6: Diagnosis
7: Thyroid function patterns of evolution over time
8: Therapy and management
9: Newborn of mother with autoimmune thyroid disease
10: Autoimmune thyroid diseases in genetic syndromes
11: Conclusion
References
Chapter 4: TSH receptor autoantibodies in Graves’ disease
Abstract
1: Introduction
2: Basedow-Graves’ disease: Clinical aspects
3: Graves’ orbitopathy and myxedema
4: Immunopathogenesis of Graves’ disease
5: Autoantibodies to the TSH receptor
6: Detection and measurement of autoantibodies to TSHR
7: Standardization of TRAb measurement
8: Use of TRAb in the management of Graves’ disease
9: Therapy of Graves’ disease
10: Conclusion
References
Chapter 5: The heterogeneity of type 1 diabetes: From immunopathology to immune intervention
Abstract
1: Introduction
2: Heterogeneity of type 1 diabetes
3: The novel concept of T1D endotypes
4: Heterogeneity of autoimmune responses and pancreas histopathology in T1D
5: The multifaceted pathophysiology of T1D: Beyond insulin, beta cells, and endocrine pancreas
6: The heterogeneous response to immunotherapies in T1D
7: Conclusion
References
Chapter 6: Pathophysiology of autoimmune orbital diseases and target therapy for orbital inflammatory and neoplastic diseases
Abstract
1: Introduction
2: Thyroid eye disease
3: Idiopathic orbital inflammatory disease (IOIS)
4: Oculofacial malignancies
5: Conclusion
References
Chapter 7: Autoimmune uveitis in childhood
Abstract
1: Introduction
2: Juvenile idiopathic arthritis-associated uveitis
3: Diagnosis
4: Complications
5: Treatment
6: Conclusion
References
Chapter 8: Etiology and pathogenesis of auditory and vestibular dysfunction in patients with autoimmune disorders
Abstract
1: Introduction
2: Etiopathogenesis
3: Auditory and vestibular symptoms
4: Ear symptoms and systemic autoimmune disorders
5: Temporal bone aspects (inner and middle ear)
6: Conclusion
References
Chapter 9: Autoimmune heart disease
Abstract
1: Introduction
2: Background
3: Organ-specific autoimmunity
4: Secondary antibody-mediated autoimmune heart disease
5: Conclusion
References
Chapter 10: Autoimmunity and its correlation to inflammatory vascular diseases
Abstract
1: Introduction
2: Vasculitis
3: Conclusion
References
Chapter 11: Cryoglobulinemic vasculitis
Abstract
1: Introduction
2: Historical background
3: Etiology and epidemiology
4: Pathogenesis
5: Clinical presentations
6: Risk of malignancy
7: VII: The differential diagnosis
8: Diagnosis
9: Classification criteria
10: Treatment
11: Conclusion
References
Chapter 12: Immunopathogenesis of acute disseminated encephalomyelitis
Abstract
1: Introduction
2: Definition and diagnosis
3: Origins and etiologies
4: Immunopathogenesis
5: Clinical features
6: Neurodiagnostic features
7: Treatment and prognosis
8: ADEM as a herald for relapsing neuroinflammatory disorders
9: Conclusion
References
Chapter 13: Pulmonary manifestations of autoimmune diseases
Abstract
1: Introduction
2: Endocrine
3: Systemic inflammatory diseases
4: Connective tissue/musculoskeletal/integumentary
5: Vascular
6: Nervous system
7: Gastrointestinal
8: Other diseases
9: Conclusion
References
Chapter 14: Inflammatory bowel diseases: Sex differences and beyond
Abstract
1: Introduction
2: Sexual dimorphism in IBDs: Not as “nuanced” as it seems
3: Gut microbiome in IBD: Where do we stand?
4: Sexual dimorphism in the gut microbiome
5: Impact of the gut microbiome on sexual dimorphism in IBDs: Future perspectives and applications, from bench to bedside
6: Conclusion
References
Chapter 15: Autoimmunity of the liver
Abstract
1: Introduction
2: Pathogenesis
3: Pathophysiology
4: Diagnosis
5: Therapy
6: Conclusion
References
Chapter 16: Advances in autoimmune cutaneous diseases
Abstract
1: Introduction
2: Morphea or localized scleroderma
3: Dermatomyositis
4: Cutaneous lupus erythematosus
5: Conclusion
References
Chapter 17: Pathogenesis-based treatments in bullous pemphigoid
Abstract
1: Introduction
2: Epidemiology
3: Pathogenesis
4: Clinical manifestations
5: Diagnosis
6: Differential diagnosis
7: Treatment
8: Conclusion
References
Chapter 18: Autoinflammatory disorders
Abstract
1: Introduction
2: Familial Mediterranean fever (FMF)
3: Mevalonate kinase deficiency (hyper IgD syndrome)
4: Cryopyrin-associated periodic syndrome (CAPS)
5: NLRP1-associated autoinflammatory diseases
6: TNF receptor-associated periodic syndrome (TRAPS)
7: Pyogenic sterile arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome, hyperzincemia, and hypercalprotectinemia
8: Chronic recurrent multifocal osteomyelitis and congenital dyserythropoietic anemia (Majeed syndrome)
9: Deficiency of the interleukin 1 receptor antagonist (DIRA)
10: Cherubism
11: Blau syndrome
12: CARD14-mediated psoriasis (CAMPS)
13: Deficiency of the IL-36 receptor antagonist (DITRA)
14: ADAM17 deficiency
15: SLC29A3 mutation
16: COPA defect
17: Otulipenia/ORAS
18: AP1S3 deficiency
19: A20 deficiency
20: ADA2 deficiency
21: Aicardi-Goutières syndrome (AGS)
22: Spondyloenchondrodysplasia with immune dysregulation (SPENCD)
23: STING-associated vasculopathy with onset in infancy (SAVI)
24: X-linked reticulate pigmentary disorder
25: USP18 deficiency
26: Chronic atypical neutrophilic dermatitis with lipodystrophy (CANDLE)
27: Singleton-Merten syndrome
28: Conclusion
References
Index

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Nima Rezaei