Transition Metal Toxicity

Contributors

Preface

Iron Toxicosis

I. Introduction: History and Prevalence of Iron Toxicosis

II. Chemistry of Iron Toxicity

III. Pathophysiology of Iron Overload

IV. Treatment of Iron Overload

References

Host Defenses against Copper Toxicity

I. Essentiality of Copper in Normal Metabolism

II. Balance between Essential Copper Levels and Toxicosis

III. Regulation of Copper Balance: Control of Homeostasis in Animals

IV. Copper Homeostasis in Nonanimal Cells

V. Conclusions

References

Chromium Toxicity and Carcinogenesis

I. Introduction

II. Uptake-Reduction Model of Chromium(VI) in the Cell

III. Chromium(VI)-Induced DNA Damage

IV. Conclusion

References

The Chemistry of Dioxygen Species (O2, O2-, HOO·, and HOOH) and Their Activation by Transition Metals

I. Introduction

II. Redox Chemistry of O2, O2-, and HOOH

III. Reactivity of O2- and HOO·

IV. Iron-Induced Activation of HOOH

V. Iron-Induced Activation of Dioxygen

References

Transition Metal Ions and Oxygen Radicals

I. Introduction

II. The Chemistry of Oxygen Species

III. The Biochemistry and Biology of Oxygen Species

IV. Mechanism of the Toxicity of Oxygen Radicals

V. The Dual Effect of Transition Metal Ions

VI. Defenses against Oxygen Species Derived Damage

References

The Cytopathology of Metal Overload

I. Introduction

II. Iron

III. Copper

References

Index