Transition Metal Toxicity
- 1st Edition - November 14, 2013
- Latest edition
- Editors: G. W. Richter, Kim Solez
- Language: English
- Paperback ISBN:9 7 8 - 1 - 4 8 3 2 - 0 4 9 7 - 0
- eBook ISBN:9 7 8 - 1 - 4 8 3 2 - 1 8 4 0 - 3
International Review of Experimental Pathology, Volume 31: Transition Metal Toxicity merges discussions of normal and deranged metabolism of transition metals; redox cycling of… Read more
International Review of Experimental Pathology, Volume 31: Transition Metal Toxicity merges discussions of normal and deranged metabolism of transition metals; redox cycling of metal ions in biological systems; oxidative stress during the metabolic interactions of metal ions; and the actions of oxygen-derived free radicals in the pathogenesis of metal ion toxicity. The book also describes the roles played by chromium and other metals in carcinogenesis; the morphologic pathology of metal toxicosis; and metal ion overload due to inborn metabolic defects, as well as to excessive environmental exposure. Research findings at the molecular, cellular, and organ levels are reviewed. Physiologists, biochemists, pathologists, and biophysicists will find the book invaluable.
Contributors
Preface
Iron Toxicosis
I. Introduction: History and Prevalence of Iron Toxicosis
II. Chemistry of Iron Toxicity
III. Pathophysiology of Iron Overload
IV. Treatment of Iron Overload
References
Host Defenses against Copper Toxicity
I. Essentiality of Copper in Normal Metabolism
II. Balance between Essential Copper Levels and Toxicosis
III. Regulation of Copper Balance: Control of Homeostasis in Animals
IV. Copper Homeostasis in Nonanimal Cells
V. Conclusions
References
Chromium Toxicity and Carcinogenesis
I. Introduction
II. Uptake-Reduction Model of Chromium(VI) in the Cell
III. Chromium(VI)-Induced DNA Damage
IV. Conclusion
References
The Chemistry of Dioxygen Species (O2, O2-, HOO·, and HOOH) and Their Activation by Transition Metals
I. Introduction
II. Redox Chemistry of O2, O2-, and HOOH
III. Reactivity of O2- and HOO·
IV. Iron-Induced Activation of HOOH
V. Iron-Induced Activation of Dioxygen
References
Transition Metal Ions and Oxygen Radicals
I. Introduction
II. The Chemistry of Oxygen Species
III. The Biochemistry and Biology of Oxygen Species
IV. Mechanism of the Toxicity of Oxygen Radicals
V. The Dual Effect of Transition Metal Ions
VI. Defenses against Oxygen Species Derived Damage
References
The Cytopathology of Metal Overload
I. Introduction
II. Iron
III. Copper
References
Index
- Edition: 1
- Latest edition
- Published: November 14, 2013
- Language: English
KS
Kim Solez
Affiliations and expertise
Department of Laboratory Medicine and Pathology, University of Alberta, EdmontonRead Transition Metal Toxicity on ScienceDirect