Toxoplasma Gondii
The Model Apicomplexan - Perspectives and Methods
- 3rd Edition - February 28, 2020
- Editors: Louis M. Weiss, Kami Kim
- Language: English
Toxoplasma gondii: The Model Apicomplexan - Perspectives and Methods, Third Edition, reflects significant advances in the field in the last five years, including new informati… Read more
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Description
Description
Toxoplasma gondii: The Model Apicomplexan - Perspectives and Methods, Third Edition, reflects significant advances in the field in the last five years, including new information on the genomics, epigenomics and proteomics of T. gondii, along with a new understanding of the population biology and genetic diversity of this organism. This edition expands information on the effects of T. gondii on human psychiatric disease and new molecular techniques, such as CAS9/CSPR. T gondii remains the best model system for studying the entire Apicomplexa group of protozoans, which includes Malaria, making this new edition essential for a broad group of researchers and scientists.
Key features
Key features
- Presents a complete review of molecular and cellar biology and immunology of Toxoplasma gondii combined with methods and resources for working with this pathogen
- Provides a single source reference for a wide range of scientists and physicians working with this pathogen, including parasitologists, cell and molecular biologists, veterinarians, neuroscientists, physicians and food scientists
- Covers recent advances in the genomics, related bioinformatics analysis, epigenomics, gene regulation, genetic manipulation and proteomics of T. gondii
- Details advances in the molecular and cellular biology and immunology of Toxoplasma, and in the epidemiology, diagnosis, treatment and prevention of toxoplasmosis
Readership
Readership
Parasitologists, Cell and molecular biologists, Immunologists, research Clinicians, neuroscientists, food scientists
Table of contents
Table of contents
1. The History and Life Cycle of Toxoplasma gondii
2. The Ultrastructure of Toxoplasma gondii
3. Molecular Epidemiology and Population Structure of Toxoplasma gondii
4. Human Toxoplasma Infection
5. Ocular Disease due to Toxoplasma gondii
6. Toxoplasmosis in Wild and Domestic Animals
7. Toxoplasma Animal Models and Therapeutics
8. Biochemistry and Metabolism of Toxoplasma gondii: Lipids and Nutrient Acquisition
9. Biochemistry and Metabolism of Toxoplasma gondii: Nucleotide and Amino Acid Metabolism
10. Biochemistry and Metabolism of Toxoplasma gondii: Carbohydrates and Metabolomics
11. The Apicoplast and Mitochondrion of Toxoplasma gondii
12. Calcium Storage and Homeostasis in Toxoplasma gondii
13. Signaling Networks in Toxoplasma gondii
14. Toxoplasma Secretory Proteins (Micronemes, Rhoptries, Dense Granules)
15. Toxoplasma Secretory Pathway, Intracellular Trafficking, and Autophagy
16. The Toxoplasma Cytoskeleton: Structures, Proteins and Processes (Need to include actin)
17. Toxoplasma Host Effectors in Cell Interactions
18. Bradyzoite and Sexual Stage Development
19. Development and Application of Classical Genetics in Toxoplasma gondii
20. Genetic Manipulation of Toxoplasma gondii
21. Epigenetic and Genetic Factors that Regulate Gene Expression in Toxoplasma gondii
22. Proteomics and Post Translational Protein Modifications in Toxoplasma gondii
23. ToxoDB: An Integrated Functional Genomic Resource for Toxoplasma and Other Sarcocystidae
24. Cerebral Toxoplasmosis: Pathogenesis, Host Resistance and Behavioral Consequences
25. Innate Immunity to Toxoplasma gondii
26. Adaptive Immunity and Genetics of the Host Immune Response
2. The Ultrastructure of Toxoplasma gondii
3. Molecular Epidemiology and Population Structure of Toxoplasma gondii
4. Human Toxoplasma Infection
5. Ocular Disease due to Toxoplasma gondii
6. Toxoplasmosis in Wild and Domestic Animals
7. Toxoplasma Animal Models and Therapeutics
8. Biochemistry and Metabolism of Toxoplasma gondii: Lipids and Nutrient Acquisition
9. Biochemistry and Metabolism of Toxoplasma gondii: Nucleotide and Amino Acid Metabolism
10. Biochemistry and Metabolism of Toxoplasma gondii: Carbohydrates and Metabolomics
11. The Apicoplast and Mitochondrion of Toxoplasma gondii
12. Calcium Storage and Homeostasis in Toxoplasma gondii
13. Signaling Networks in Toxoplasma gondii
14. Toxoplasma Secretory Proteins (Micronemes, Rhoptries, Dense Granules)
15. Toxoplasma Secretory Pathway, Intracellular Trafficking, and Autophagy
16. The Toxoplasma Cytoskeleton: Structures, Proteins and Processes (Need to include actin)
17. Toxoplasma Host Effectors in Cell Interactions
18. Bradyzoite and Sexual Stage Development
19. Development and Application of Classical Genetics in Toxoplasma gondii
20. Genetic Manipulation of Toxoplasma gondii
21. Epigenetic and Genetic Factors that Regulate Gene Expression in Toxoplasma gondii
22. Proteomics and Post Translational Protein Modifications in Toxoplasma gondii
23. ToxoDB: An Integrated Functional Genomic Resource for Toxoplasma and Other Sarcocystidae
24. Cerebral Toxoplasmosis: Pathogenesis, Host Resistance and Behavioral Consequences
25. Innate Immunity to Toxoplasma gondii
26. Adaptive Immunity and Genetics of the Host Immune Response
Product details
Product details
- Edition: 3
- Published: July 7, 2020
- Language: English
About the editors
About the editors
LW
Louis M. Weiss
Louis M. Weiss, MD, MPH is Professor of Medicine (Division of Infectious Diseases) and Professor of Pathology (Division of Parasitology and Tropical Medicine) of the Albert Einstein College of Medicine, Bronx, New York. Dr. Weiss received his M.D. and M.P.H degrees from the Johns Hopkins University in 1982. He then completed a residency in Internal Medicine at the University of Chicago and a fellowship in Infectious Diseases at the Albert Einstein College of Medicine. Following this fellowship, he joined the faculty at Einstein where he is currently a Professor of Pathology and Medicine. His laboratory group has an active research program on parasitic diseases with a research focus on Toxoplasma gondii, the Microsporidia and Trypanosoma cruzi. Dr. Weiss is the author of over 200 publications and the editor of 3 books on parasitology. He is a fellow of the American College of Physicians, Infectious Disease Society of America and the American Academy of Microbiology. Dr. Weiss is the Co-Director of the Einstein Global Health Center.
Affiliations and expertise
Professor of Medicine and Pathology, Albert Einstein College of Medicine of Yeshiva University, NY, USAKK
Kami Kim
Dr. Kami Kim is a physician-scientist who joined the USF faculty in 2017 as a Professor of Internal Medicine (Infectious Diseases and International Medicine) and Professor of Global Health. Her laboratory focuses upon understanding the pathogenesis of toxoplasmosis and malaria, parasitic diseases of global significance. The Toxoplasma projects use a multidisciplinary systems biology approach to understand how the parasite senses and responds to changes in its host. Using a combination of epigenomics, genetics and proteomics, her group is studying how the parasite transitions from the pathogenic tachyzoite form to the persistent bradyzoite form. She is investigating the epigenetic and genetic factors that govern the host response to parasites. Dr. Kim is a fellow of the American Academy of Microbiology and the Infectious Disease Society of America as well as an elected member of the Association for American Physicians and the American Society for Clinical Investigation.
Affiliations and expertise
Professor of Internal Medicine (Infectious Diseases and International Medicine) and Professor of Global Health, University of South Florida, USF Medicine International, Tampa, Florida. USAView book on ScienceDirect
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