Thyroid Hormones

1st Edition - January 1, 1978
Editor: Choh Hao Li
Language: English
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 1 6 2 9 8 - 2

Hormonal Proteins and Peptides, Volume VI: Thyroid Hormones is a compilation of papers that details the various aspects, chemical properties, effects, and history of thyroid… Read more

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Hormonal Proteins and Peptides, Volume VI: Thyroid Hormones is a compilation of papers that details the various aspects, chemical properties, effects, and history of thyroid hormones. The book covers a wide range of topics related to the study of thyroid hormones. Six chapters are devoted to the various aspects of thyroid hormones. Chapter 1 deals with the chemistry of human thyrotropin. Chapters 2 and 3 survey the chemistry of thyroid hormones and analogs, focusing on synthesis and structure-activity relationships. Chapter 4 presents thyroxin action and the possible direct participation of thyroxin in catecholamine pathways in the nervous system. Chapter 5 discusses the thyroid hormone action during amphibian metamorphosis at the cellular and molecular levels. An account of the evolution of the thyroid function is given in Chapter 6. The final chapter delves on the historical aspect of thyroid hormones. Biochemists, physicians, pharmacologists, researchers, and students in the medical field will benefit from this book.

List of Contributors

Preface

Contents of Previous Volumes

1. Chemistry of Human Pituitary Thyrotropin

I. Introduction

II. Isolation Procedures

III. Chemical and Physical Characteristics

IV. Chemical Composition

V. Preparation and Properties of the Subunits

VI. Biological Properties of Thyrotropin

VII. Primary Structure of the Subunits

VIII. Chemical Similarities among Human Glycoprotein Hormones

IX. Immunological Characteristics of Thyrotropin

X. Relationship between Pituitary Thyrotropin and Human Chorionic Thyrotropin

XI. Concluding Remarks

References

2. Thyroid Hormones and Analogs. I. Synthesis, Physical Properties and Theoretical Calculations

I. Introduction

II. Methods of Synthesis

III. Physical Properties

IV. Theoretical Calculations

References

3. Thyroid Hormones and Analogs. II. Structure-Activity Relationships

I. Introduction

II. Biological Test Systems

III. Structure-Activity Relationships

IV. General Summary and Comments

References

4. The Mechanism of Thyroxine Action

I. Overview

II. Role of Iodocompounds

III. General Aspects of Iodothyronine Action

IV. Requirements of a Comprehensive Hypothesis of Thyroid Hormone Action

V. Mechanisms of Thyroid Hormone Action: Current Hypotheses

VI. Concluding Statement

References

5. Cellular and Molecular Aspects of Thyroid Hormone Action during Amphibian Metamorphosis

I. Introduction

II. Thyroid Hormones

III. Amphibian Metamorphosis

IV. Metabolic Regulation and Calorigenesis

V. Primary Events and Mechanism of Thyroxine Action

VI. Summary

VII. Addendum

References

6. Evolution of Thyroid Function

I. Introduction

II. Iodoproteins in Invertebrates

III. Prevertebrates and Primitive Vertebrates

IV. Thyroid Gland Secretions

References

7. The Thyroid Hormones: Historical Aspects

I. Introduction

II. The Colloid of the Thyroid

III. Thyroxine: E.C. Kendall

IV. Thyroxine: C.R. Harington

V. Configurative Relationship between Throxine and Tyrosine

VI. Glaxo Synthesis of L-Thyroxine

VII. Isolation of Diiodotyrosine from the Thyroid Gland

VIII. The Circulating Thyroid Hormone

IX. Thyroxine and Total Thyroidal Activity

X. Radioactive Iodine in Thyroid Research

XI. Triiodothyronine

XII. Other Iodothyronines

References

Author Index

Subject Index