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Therapy Resistance in Prostate Cancer

Mechanisms and Insights

  • 1st Edition, Volume 20 - October 24, 2023
  • Latest edition
  • Editor: Hisham Bahmad
  • Language: English

Therapy Resistance in Prostate Cancer: Mechanisms and Insights, Volume 20 highlights the main mechanisms that are responsible for therapy resistance in PCa allowing researche… Read more

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Description

Therapy Resistance in Prostate Cancer: Mechanisms and Insights, Volume 20 highlights the main mechanisms that are responsible for therapy resistance in PCa allowing researchers and clinicians to have a synopsis of current options and therapies that can be proposed to overcome resistance. Understanding the mechanisms responsible for chemotherapy resistance helps researchers all over the world delve deeper into the pathways behind this resistance and potentially discover new therapeutic targets for PCa. Prostate cancer (PCa) is among the most diagnosed cancers in men worldwide, as well as one of the most common causes of cancer-related deaths.

Despite the advances in treatment, the disease remains associated with poor survival and resistance to cytotoxic and targeted therapies.

Key features

  • Tackles the topic of resistance from a broader perspective, including, but not limited to, the role of the extracellular matrix and cancer stem cells in therapy resistance
  • Creates understanding on how to develop novel therapies that specifically target CSCs to eliminate the regenerating capacity of the tumor and overcome therapy resistance
  • Helps in identifying novel molecular biomarkers and potential therapeutic targets pertaining to the tumor microenvironment to overcome therapy resistance
  • Provides a general view of the main pathways involved in PCa progression that will aid in understanding the mechanisms responsible for chemotherapy resistance

Readership

Researchers and healthcare personnel in the field of prostate cancer, Urologists, Hemato-oncologists, genitourinary pathologists.Medical students and resident physicians and fellows interested in genitourinary medicine, and patients with prostate cancer

Table of contents

1. Prostate Gland Anatomy and Hormonal Factors Contributing to Cancer Development

2. Pathophysiology and Molecular Aberrations of Castration Resistant Prostate Cancer

3. Role of Tumor Microenvironment in Prostate Cancer Therapy Resistance

4. Androgen Receptor-Dependent Mechanisms Mediating Therapy Resistance in Prostate Cancer

5. Epigenetic Changes Driving Therapy Resistance in Prostate Cancer

6. Role of Cancer Stem Cells in Prostate Cancer Therapy Resistance

7. Resistance to Taxane Chemotherapies in Prostate Cancer

8. Resistance of Prostate Cancer to Topoisomerase Inhibitors

9. Resistance of Prostate Cancer to Kinase Inhibitors

10. Radioresistance Mechanisms in Prostate Cancer

11. Immunotherapeutic Strategies and Immunotherapy Resistance in Prostate Cancer

12. Overcoming Resistance in Prostate Cancer with Targeted and Small Molecule-Based Therapies

13. Novel Treatment Strategies to Overcome Resistance in Prostate Cancer

Product details

  • Edition: 1
  • Latest edition
  • Volume: 20
  • Published: October 24, 2023
  • Language: English

About the editor

HB

Hisham Bahmad

Dr. Bahmad is a physician scientist with more than 8 years of experience in basic, clinical, and translational research (2014-Present), mainly focusing on prostate, bladder, and brain tumors. His research work concentrates on understanding cancer progression and isolating and therapeutically targeting cancer stem cells in solid tumors (such as prostate cancer among others) which are believed to be responsible for therapy resistance and tumor recurrence. He has so far published more than 100 peer-reviewed papers and book chapters in well-reputable journals mainly related to cancer stem cells and overcoming therapy resistance in various tumors. Dr. Bahmad has an MBA degree in Healthcare Management from West Texas A&M University and is currently pursuing his Pathology Residency at Mount Sinai Medical Center of Florida.
Affiliations and expertise
Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL, USA

View book on ScienceDirect

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