LIMITED OFFER
Save 50% on book bundles
Immediately download your ebook while waiting for your print delivery. No promo code needed.
Therapeutic Targets for Diabetic Retinopathy
A Translational Approach
- 1st Edition - January 11, 2023
- Authors: Weiye Li, Jingfa Zhang
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 3 0 6 4 - 2
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 3 0 6 5 - 9
Therapeutic Targets For Diabetic Retinopathy: A Translational Approach offers a consolidated view of this complex disorder by summarizing the latest evidence-based studies and… Read more
Purchase options
Institutional subscription on ScienceDirect
Request a sales quoteTherapeutic Targets For Diabetic Retinopathy: A Translational Approach offers a consolidated view of this complex disorder by summarizing the latest evidence-based studies and translating their findings into practical, actionable knowledge. This concise resource covers the fundamentals of diabetic retinopathy and diabetic macular edema with an emphasis on basic science and therapeutic targets on the horizon. Ophthalmologists, optometrists, and researchers will find the translational approach to this common eye disorder to be useful in both research and clinical practice settings.
-
Takes a concise yet comprehensive approach to diabetic eye disorders, covering basic science as well as therapeutic agents with both current and future clinical applications.
-
Covers current diagnostic and management guidelines as well developments on the horizon that are likely to improve patient outcomes.
-
Explains the pathophysiological mechanisms of diabetic retinopathy and diabetic macular edema from both a basic and clinical perspective, helping readers seek promising new therapeutic targets.
-
Consolidates today's available information on this timely topic into a single, convenient resource.
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedications
- About the authors
- Preface
- Acknowledgments
- Chapter 1. Introduction of Diabetic retinopathy and principles of treatment
- Epidemiology of diabetes mellitus and diabetic retinopathy
- Classification, staging, and severity of DR
- Current management and its limitations for DR, DME, and PDR
- Chapter 2. Diabetes-induced metabolic disorders of diabetic retinopathy
- Hyperglycemia-induced metabolic pathways and therapeutic targets for diabetic retinopathy
- Other metabolic alterations in DR
- Metabolic memory effect on the progression of DR
- Chapter 3. Diabetic retinopathy, a neurovascular unit disease
- Embryonic origins of neurosensory retina and RPE
- Inner and outer blood–retinal barrier
- Neurovascular coupling in inner and outer retina
- Altered neurovascular coupling of inner retina in DR
- Altered neurovascular coupling of outer retina in DR
- Compromised intercellular communication and BRB breakdown in DR
- Chapter 4. The pathogenic role of apoptosis in the development of diabetic retinopathy
- Cell death in the neurovascular unit of the early diabetic retina
- Apoptosis of retinal vascular pericytes and endothelial cells
- Apoptosis of retinal neurons and dysfunction of glia cells
- Protecting the NVU as therapeutic strategy for DRN
- Antiapoptotic protein BcL-xL to restore vasoregression and attenuate pathological angiogenesis in diabetic retina
- Chapter 5. Diabetic retinopathy, a disease with low-grade inflammation
- Leukocyte adhesion and leukostasis
- Activation of microglia
- Inflammatory cytokines and chemokines in diabetic eyes
- Inflammatory impact on BRB breakdown
- Anti-inflammation as a therapeutic strategy
- Innate and adaptive immunity in DR
- Chapter 6. Neurodegeneration and microangiopathy in diabetic retina and choroid
- Distinct pathophysiologic mechanisms in diabetic retinal neurons, glial cells, and vascular cells
- Diabetic retinal neuronopathy
- Diabetic retinal microangiopathy
- Diabetic choroidopathy
- Potential therapeutic targets in diabetic retina and choroid
- Chapter 7. Proliferative diabetic retinopathy, a disease of pathologic angiogenesis and vasculogenesis
- Angiogenesis and vasculogenesis in physiological and diabetic retina
- Pathological angiogenesis in PDR
- Translational approach for anti-angiogenesis in PDR
- Chapter 8. Pathogenesis of diabetic macular edema
- Overview of diabetic macular edema
- New DME classification based on anatomic features of fovea
- Intracellular/cytotoxic edema
- Extracellular/vasogenic edema
- Inflammation and vasogenic DME
- Therapeutic strategy for DME
- Chapter 9. Treatments for diabetic retinopathy and diabetic macular edema in pipeline
- Impact of the protocols by DRCR.net on treatment of diabetic retinopathy and diabetic macular edema
- Targeting VEGF family
- Targeting HIF-1α
- Targeting VEGFRs
- Targeting VEGF coreceptor or auxiliary proteins
- Targeting Ang-2/tyrosine kinase with immunoglobulin-like and EGF-like domains 2 (Tie2) system
- Other targets
- Targeting inflammation
- Neuroprotection
- Drug delivery and durability
- Subthreshold micropulse laser for DME
- Improvement of pars plana vitrectomy for PDR
- Chapter 10. Future perspectives for diabetic retinopathy management
- Multidisciplinary collaboration for DR care
- Oxidative stress as a unifying mechanism and key therapeutic target for DR
- Regulation of apoptotic pathways as therapeutic strategy
- VEGF and non-VEGF signaling pathways as therapeutic targets
- Genetics of DR
- Application of artificial intelligence in DR
- Index
- No. of pages: 325
- Language: English
- Edition: 1
- Published: January 11, 2023
- Imprint: Elsevier
- Paperback ISBN: 9780323930642
- eBook ISBN: 9780323930659
WL
Weiye Li
Dr. Weiye Li, Professor Emeritus, Retina Surgeon, and Researcher of Drexel University, College of Medicine, an internationally renowned expert in the study of diabetic retinopathy and age-related macular degeneration, shares his practice, experience, and insight in this book.
Affiliations and expertise
Professor emeritus of Ophthalmology, Drexel University College of Medicine, Philadelphia, PennsylvaniaJZ
Jingfa Zhang
Dr. Jingfa Zhang, Senior Scientist and Attending Physician at the Department of Ophthalmology, Shanghai General Hospital (Shanghai First People’s Hospital), Shanghai Jiao Tong University, Shanghai, P.R. China, is a physician-scientist focusing on diabetic retinopathy and age-related macular degeneration.
Affiliations and expertise
Associate Chief Physician, Associate Professor, Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), ShanghaiRead Therapeutic Targets for Diabetic Retinopathy on ScienceDirect