Theranostics Nanomaterials in Drug Delivery

1st Edition - October 10, 2024
Editors: Prashant Kesharwani, N.K Jain
Language: English
Paperback ISBN:
9 7 8 - 0 - 4 4 3 - 2 2 0 4 4 - 9
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 2 2 0 4 5 - 6

Theranostics Nanomaterials in Drug Delivery presents the most recent advances in the development of theranostic nanomaterials for drug delivery. This book compiles reports a… Read more

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Theranostics Nanomaterials in Drug Delivery presents the most recent advances in the development of theranostic nanomaterials for drug delivery. This book compiles reports and studies on the latest changes and improvements of theranostic nanocarriers such as nanoemulsions, liposomes, exosomes, polymeric micelles, PLGA nanoparticles, chitosan nanoparticles, dendrimer, quantum dots, silica nanoparticles, gold nanoparticles, silver nanoparticles, magnetic nanoparticles, and many more, all of which can help in the sensitive diagnosis, precise targeting, and efficient and controlled delivery of nanomaterials to control various diseases at different clinical stages.

Theranostics nanomaterials in drug delivery will serve as a solid foundation and reference for pharmaceutical scientists, undergraduate and postgraduate students, researchers, and experts in the medical field involved in the development of advanced drug delivery systems.

Title of Book
Cover image
Title page
Table of Contents
Copyright
Dedication
List of contributors
About the editors
Preface
Acknowledgment
Chapter 1. An overview of theranostic nanomedicine
Abstract
1.1 Introduction
1.2 Imaging techniques in theranostic medicine
1.3 Theranostic nanomedicines
1.4 Inorganic nanoparticles
References
Chapter 2. Nano–bio interactions: understanding their dynamic connections
Abstract
2.1 Introduction
2.2 Redox reactions at the nano–bio interface
2.3 The driving forces: how nano–bio interaction shapes nanomedicines’ biological features
2.4 Nano–bio interactions’ role in cancer
2.5 Herbal nano–bio interactions
2.6 Designing nanomedicine by controlling the nano–bio interaction
2.7 Forecasting nano–bio interaction by artificial intelligence
2.8 Various mechanisms of nanomedicine delivery into the cell
2.9 Application of nano–bio interaction
2.10 Conclusion and future aspects
Acknowledgments
References
Chapter 3. Multifunctional theranostic nanomaterials as magnetic resonance imaging contrasting agents and imaging
Abstract
3.1 Introduction
3.2 Cancer
3.3 Renal carcinoma
3.4 CNS / Neurological disease
3.5 Thrombosis
3.6 Regulatory aspects of theranostic
3.7 Future perspectives
3.8 Conclusion
References
Chapter 4. Theranostic liposome-mediated drug delivery for anticancer applications
Abstract
4.1 Introduction
4.2 Liposomes as efficient carriers in drug delivery
4.3 Liposomes as carriers for therapeutic applications in cancer therapy
4.4 Liposomes as carriers for diagnostic applications in cancer therapy
4.5 Advancements in cancer diagnostics and therapy using liposomes
4.6 Challenges in the development of liposomal formulations for cancer therapy
4.7 Pros and cons in commercial pharmaceutical liposome applications
4.8 Conclusion and future perspectives
References
Chapter 5. Theranostics exosomes mediated drug delivery
Abstract
5.1 Biogenesis, content, functions and applications of exosomes
5.2 Exosomes as the delivery system
5.3 Production, isolation and characterization of exosomes
5.4 Cargoes loading strategies into exosomes
5.5 Administration routes and biodistribution of exosomes
5.6 Experimental, preclinical and clinical studies of exosomes as delivery system
5.7 Conclusion
References
Chapter 6. Theranostic polymeric micelles mediated drug delivery
Abstract
6.1 Introduction
6.2 Structure and properties of polymeric micelles
6.3 Synthesis of polymeric micelles
6.4 Encapsulation and release mechanism in micellar drug delivery
6.5 Types of polymeric micelles
6.6 Targeted drug delivery strategies using polymeric micelles
6.7 Advantages of polymer micelles over other drug delivery
6.8 Theranostic applications of polymeric micelles
6.9 Adverse effects of polymeric micelles
6.10 Challenges and future perspectives in theranostic drug delivery
6.11 Conclusion
References
Chapter 7. Nanoengineering multifunctional organized systems highlighting hybrid micelles, vesicles and lipidic aggregates towards higher sized structures for theranostics perspectives
Abstract
7.1 Introduction
7.2 Focus on the design of lipidic nanoplatforms as versatile functional organized systems
7.3 Design of optical active organized systems for smart responses and early diagnoses
7.4 Development of drug delivery and multifunctional platforms for targeted treatments
7.5 Concluding remarks and design of future perspectives
Acknowledgments
References
Chapter 8. Theranostics polylactic-co-glycolic acid nanoparticles mediated drug delivery
Abstract
8.1 Introduction
8.2 Polylactic-co-glycolic acid and its formulations
8.3 Polylactic-co-glycolic acid-lipids hybrid nanocarriers
8.4 Preparation techniques
8.5 Engineered and surface-modified polylactic-co-glycolic acid nanoparticles
8.6 Imaging modality
8.7 Theranostics polylactic-co-glycolic acid nanoparticles mediated drug delivery
8.8 Toxicity and challenges
8.9 Conclusion and future prospects
References
Chapter 9. Alginate-based nanoparticles for drug delivery
Abstract
9.1 Alginates as drug delivery excipients
9.2 Drug delivery applications
9.3 Gelling agents
9.4 Oral drug delivery of alginates
9.5 Uses in oral particulates (microparticles/bead) for drug delivery
9.6 Uses in nanoparticles for drug delivery
9.7 Uses in gastro-retentive drug delivery systems
9.8 Uses in protein delivery
9.9 Preparation of alginate-based hydrogels
9.10 Physical hydrogels
9.11 Chemical hydrogels
9.12 Drug delivery applications of alginate-based hydrogels
9.13 Using grafted alginates in drug delivery systems
9.14 Sustained release drug delivery
9.15 Limitations of using alginate in pharmaceutical nanotechnology
9.16 Conclusion
References
Chapter 10. Theranostics quantum dots mediated drug delivery
Abstract
10.1 Introduction
10.2 A brief of synthesis methods of quantum dots
10.3 An overview of quantum dots properties
10.4 Quantum dots mediated drug delivery: diagnostics and therapy
10.5 Conclusion
References
Chapter 11. Theranostic silica nanoparticles mediated drug delivery
Abstract
11.1 Introduction
11.2 Silica nanoparticles: types, synthesis, and characterization
11.3 Silica nanoparticles in medicine
11.4 State of the art: clinical trials
11.5 Conclusions
Acknowledgments
References
Chapter 12. Theranostic gold nanoparticles mediated drug delivery
Abstract
12.1 Introduction
12.2 The major types of Au nanostructures for drug delivery systems
12.3 Synthetic strategies of Au nanoparticles
12.4 Superiority and restriction of chemical synthesis of Au nanoparticles
12.5 Characteristics of Au nanostructures
12.6 Various applications of gold nanostructures in drug delivery
12.7 Conclusion
References
Chapter 13. Theranostics: silver nanoparticles mediated drug delivery
Abstract
13.1 Introduction
13.2 Synthesis, characterization, and functionalization of silver nanoparticles
13.3 Silver nanoparticles for drug delivery
13.4 Silver nanoparticles for imaging and diagnosis
13.5 Theranostic applications of silver nanoparticles
13.6 Biocompatibility and toxicity of silver nanoparticles
13.7 Challenges and future directions
13.8 Conclusion
Author contributions
References
Chapter 14. Theranostic magnetic nanoparticles mediated drug delivery
Abstract
14.1 Introduction
14.2 Magnetic nanoparticles
14.3 Magnetic materials for drug release
14.4 Magnetic materials for diagnostic
14.5 Magnetic nanoparticles for theranostic
14.6 Conclusion
References
Chapter 15. Application of theranostic polymersomes for magnetic resonance imaging
Abstract
15.1 Introduction
15.2 Conventional magnetopolymersomes
15.3 Targeted magnetopolymersomes
15.4 Smart release magnetopolymerosmes
15.5 Conclusion and future perspective
References
Chapter 16. Theranostics inorganic nanohybrids: an expanding horizon
Abstract
16.1 Introduction
16.2 Recent progress and perspectives of smart inorganic nanomaterials-based theranostics
16.3 Carbon-conjugated polymers
16.4 Synthesis of nanoinorganic hybrids
16.5 Surface modification of hybrid nanostructures
16.6 Hybrid nanostructures for biomedical diagnosis in theranostics
16.7 Nanoengineered photoactive inorganic theranostic agents
16.8 Toxicity aspect and other challenges
16.9 Strategies to overcome challenges
16.10 Conclusion
16.11 Future prospect
References
Chapter 17. Bile saltbased vesicles—a nanotheranostics perspective
Abstract
17.1 Why bilosomes—the motivation
17.2 Importance of bile salts in drug delivery
17.3 Commonly employed strategies for the preparation of Bilosomes
17.4 Characterization of bilosomes
17.5 Spectroscopic probing of bilosomes
17.6 Applications of bilosomes
17.7 Conclusions and future perspectives
Acknowledgments
References
Chapter 18. Multifunctional theranostic nanomedicine for infectious diseases
Abstract
18.1 Introduction
18.2 Synthesis and modification methods
18.3 Multifunctional theranostic nanomedicine
18.4 Clinical trials and challenges
18.5 Future perspectives
18.6 Summary
References
Chapter 19. Nanotechnology-based theranostic approaches in brain diseases
Abstract
19.1 Introduction
19.2 The blood–brain barrier
19.3 Bioimaging, biosensor, and diagnostic methods
19.4 Nanotheranostics in various CNS diseases
19.5 Conclusion and future perspective
References
Chapter 20. Theranostic nanomaterials for intervention of the blood–brain barrier
Abstract
20.1 Introduction
20.2 Blood–brain barrier
20.3 Theranostic nanomaterials
20.4 External stimuli-responsible theranostic nanomaterials
20.5 Conclusions and perspectives
Disclosure statement
References
Chapter 21. Advances in theranostic nanocarriers for cancer immunotherapy
Abstract
21.1 Introduction
21.2 Fundamentals of theranostic nanocarriers
21.3 Constituents of the immune system
21.4 Nanocarriers with a role in cancer immunotherapy
21.5 Combinatorial therapy
21.6 Bacterial extracellular vesicle-based delivery
21.7 Imaging modalities integrated with nanocarriers
21.8 Morphology-dependent immunotherapy
21.9 Challenges and Considerations
21.10 Clinical application
21.11 Conclusion
References
Index

Prashant Kesharwani

Dr. Prashant Kesharwani is an assistant professor of pharmaceutics at School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India. He has more than 12 years of teaching, research, and industrial experience at international levels from various countries, including the United States, Malaysia, and India. An overarching goal of his current research is the development of nanoengineered drug delivery systems for various diseases. He has more than 300 international publications in well-reputed journals and more than 25 international books (Elsevier). He is a recipient of many research grants from various funding bodies. He is also the recipient of several internationally acclaimed awards, such as “USERN Laureate award”, most prestigious “Ramanujan Fellowship Award”. He actively participates in outreach and scientific dissemination for the service of the wider community.

Affiliations and expertise

Assistant Professor, Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India

N.K Jain

Prof. N.K. Jain is an internationally renowned academician and researcher and a senior professor in India who superannuated in June 2014 after rendering more than 40 years of dedicated and distinguished service as a teacher and 25 years as full professor. Prof. Jain is the author of two dozen celebrated books in pharmaceutical sciences in India and has contributed several chapters in national and international books. He has to his credit over 480 publications in reputed pharmaceutical Journals and has supervised 55 PhD and 141 M. Pharm. candidates. He has been a reviewer for several international and national research journals. Professor Jain’s current research interests include various aspects of controlled, novel and targeted drug delivery; nanotechnology and nanomedicine and he is globally known for his excellent research in the field of hydrotropic solubilization, resealed erythrocytes-based drug delivery and dendrimer drug delivery. Currently he is exploring the pharmaceutical potential of Carbon Nanotubes and Quantum Dots.

Affiliations and expertise

Professor of Pharmaceutics (Ex), Department of Pharmaceutical Sciences, Dr. H. S. Gour University, Sagar 470 002, India

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Theranostics Nanomaterials in Drug Delivery

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Prashant Kesharwani

N.K Jain