Theragnostics, An Issue of PET Clinics

1st Edition, Volume 19-3 - June 4, 2024
Editors: Andrei Iagaru, Heather A. Jacene
Language: English
Hardback ISBN:
9 7 8 - 0 - 4 4 3 - 1 2 9 2 1 - 6
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 2 9 2 2 - 3

Contains 12 relevant, practice-oriented topics including theragnostics trials; neuroendocrine tumors: diagnostics; prostate-specific membrane antigen: diagnostics; theragnostics:… Read more

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Contains 12 relevant, practice-oriented topics including theragnostics trials; neuroendocrine tumors: diagnostics; prostate-specific membrane antigen: diagnostics; theragnostics: post-therapy imaging; fibroblast-activation-protein inhibitors (FAPI) theragnostics; and more.

Provides in-depth clinical reviews on theragnostics, offering actionable insights for clinical practice.

Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
CME Accreditation Page
Preface
Alpha and Beta Radiation for Theragnostics
Key points
Introduction
Summary
Clinics care points
Neuroendocrine Tumors: Diagnostics
Key points
Introduction
Conventional imaging
Somatostatin receptor scintigraphy: overview
18F-fluoro-d-glucose-PET/computerized tomography imaging
PET/CT somatostatin receptor scintigraphy in initial evaluation
PET/CT somatostatin receptor scintigraphy in follow-up evaluation
Potential pitfalls in interpretation of PET/CT somatostatin receptor scintigraphy
Somatostatin Receptor PET/MR imaging
New PET/CT radiotracers for imaging of neuroendocrine neoplasms
Summary
Clinics care points
Alpha-emitter Peptide Receptor Radionuclide Therapy in Neuroendocrine Tumors
Key points
Introduction
Preclinical studies
Clinical trials and current experience
Future directions
Summary
Clinics care points
Prostate-specific Membrane Antigen: Diagnostics
Introduction
Recurrent disease
Primary tumor staging
Comment and future directions
Prostate-specific Membrane Antigen: Interpretation Criteria, Standardized Reporting, and the Use of Machine Learning
Key points
Background
Standardized reporting of prostate-specific membrane antigen targeting positron emission tomography findings
Technical aspects of machine learning-based tools for prostate-specific membrane antigen targeting positron emission tomography reporting
Dedicated software solutions for prostate cancer molecular imaging standardized reporting and prostate-specific membrane antigen reporting and data system
Summary
Clinics care points
Prostate-specific Membrane Antigen: Alpha-labeled Radiopharmaceuticals
Key points
Introduction
Prostate-specific membrane antigen
Alpha-emitting radionuclides for prostate-specific membrane antigen: physics and radiobiology
Clinical experience with targeted alpha therapy for prostate cancer
Current evidence for the efficacy of [225Ac]Ac-prostate-specific membrane antigen therapy in metastatic castrate-resistant prostate cancer
Efficacy of [225Ac]Ac-prostate-specific membrane antigen in the post−[177Lu]Lu-prostate-specific membrane antigen therapy setting
[225Ac]Ac-prostate-specific membrane antigen: in the prechemotherapy and/or postandrogen deprivation therapy settings
[225Ac]Ac-prostate-specific membrane antigen: application in the hormone-sensitive setting
Rechallenge options
Summary
Clinics care points
Prostate Cancer Radioligand Therapy: Beta-labeled Radiopharmaceuticals
Introduction
PSMA-based theranostics
Summary
Gastrin Releasing Peptide Receptors-targeted PET Diagnostics and Radionuclide Therapy for Prostate Cancer Management: Preclinical and Clinical Developments of the Past 5 Years
Key points
Introduction
The gastrin releasing peptide receptor
Gastrin releasing peptide receptor-targeting radiopharmaceuticals
Preclinical reports on gastrin releasing peptide receptor-targeting radiopharmaceuticals for PET imaging and/or radionuclide therapy
Gastrin releasing peptide receptor-targeting radiopharmaceuticals for prostate cancer targeting in clinical studies
Future perspectives
Summary
Clinics care points
Treatment Response Imaging in Prostate Cancer
Key points
Introduction
Current Standard of Care (Prostate Cancer Working Group 3 Criteria)
Role of Advanced Molecular/Metabolic Imaging in Treatment Response
Response criteria on molecular/metabolic imaging
Summary
Clinics care points
Hepatic Radioembolization: A Multistep Theragnostic Procedure
Key points
Introduction
Microspheres
Radioembolization
The evidence for hepatic radioembolization
Future perspectives
Summary
Clinics care points

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Andrei Iagaru

Heather A. Jacene