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Elsevier

The Transcription Factor NRF2

Biology, Disease and Translational Opportunities

  • 1st Edition - March 1, 2027
  • Latest edition
  • Editors: Narendra Kumar Sharma, Yasmin Ahmad
  • Language: English

The Transcription Factor NRF2: Biology, Disease and Translational Opportunities offers a detailed and authoritative reference on NRF2, a key regulator of cellular defence agains… Read more

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Description

The Transcription Factor NRF2: Biology, Disease and Translational Opportunities offers a detailed and authoritative reference on NRF2, a key regulator of cellular defence against oxidative stress. This book thoroughly examines the latest research, from molecular mechanisms to clinical applications, highlighting NRF2’s essential function in cell protection, disease prevention, and its promise as a therapeutic target. The book opens with an introduction to NRF2 and its role in cellular homeostasis before exploring its molecular structure, regulation and signalling mechanisms. Its antioxidant response is then discussed, followed by its impact on inflammation, autophagy, and resistance to environmental and chemical stresses. Later chapters cover NRF2’s role in cancer, neurodegenerative, cardiovascular, autoimmune, and metabolic diseases. Cutting-edge techniques are also provided, including AI-based and systems biology tools. Case studies emphasize translational potential and therapeutic development.

The Transcription Factor NRF2: Biology, Disease and Translational Opportunities equips researchers, clinicians, and advanced students with critical knowledge to understand NRF2’s multifaceted functions and therapeutic potential. It serves as an essential guide for advancing research and strategies targeting NRF2 in a diverse array of medical conditions, and is an ideal reference for those working across cell biology, molecular biology, biomedicine and related fields.

Key features

  • Explores NRF2 as a therapeutic target across a diverse range of diseases
  • Considers the dual nature of NRF2 as both detrimental and beneficial in various disease states
  • Highlights clinical applications and drug development strategies
  • Investigates the latest experimental techniques and AI-based tools for studying NRF2

Readership

Biomedical researchers and clinicians in oxidative stress and cellular signaling, including cell biologists, molecular biologists, biochemistry, pharmacology and related areas

Table of contents

1. Introduction to cellular homeostasis and NRF2

2. Molecular structure and regulation of NRF2 and NRF2-KEAP1-PGAM5 ternary complex at the outer mitochondrial membrane

3. NRF2 targets and antioxidant response

4. NRF2 in cellular defense mechanisms, pharmacological activators and inhibitors and their relevance in disease

5. NRF2 in metabolic regulation and its crosstalk with other signalling pathways

6. Recent advances in experimental techniques and methodologies for studying NRF2 and AI-based/systems biology tools

7. NRF2 in disease states: cancer—dual roles in tumorigenesis and chemoresistance

8. NRF2 in disease states: chronic inflammatory and autoimmune diseases

9. NRF2 in disease states: neurodegenerative disorders—Alzheimer’s and Parkinson’s Disease

10. NRF2 in disease states: cardiovascular diseases

11. NRF2 in disease states: diabetes, metabolic syndrome, MASH and MASLD

12. Therapeutic implications and drug development

Product details

  • Edition: 1
  • Latest edition
  • Published: March 1, 2027
  • Language: English

About the editors

NS

Narendra Kumar Sharma

Dr. Narendra Kumar Sharma is currently an Assistant Professor in the Department of Biosciences and Biotechnology at Banasthali Vidyapith, Rajasthan, India. He has a PhD from the Defence Institute of Physiology and Allied Sciences (DRDO) and completed his post-doctoral training at the Guangzhou Institutes of Biomedicine and Health (GIBH) in China and at the Federal University of Sao Paulo (UNIFESP) in Brazil. He has more than eight years of teaching and research experience. He has published more than 30 research articles in peer-reviewed international journals, has authored and edited books, and has presented his research at various international conferences in India, Brazil, China, USA, and Germany. He has also been awarded. He has been awarded several prestigious awards such as the Dr. T S Vasundhara Memorial Best Paper Award and the Young Scientist and Best Innovator Award by Microbiologist Society of India.

Affiliations and expertise
Assistant Professor, Banasthali Vidyapith (Deemed University), Department of Bioscience and Biotechnology, Rajasthan, India

YA

Yasmin Ahmad

Dr. Yasmin Ahmad is currently a Senior Scientist at the Peptide and Proteomics Division of DIPAS, India. She earned her Ph.D. in Analytical Chemistry from Aligarh Muslim University (AMU), where she also completed a prestigious Senior Research Fellowship under CSIR.

Dr. Ahmad has published over 45 original research articles in prestigious peer reviewed journals. Her impactful research has garnered recognition in the form of numerous awards, such as the Surg. Rear Admiral M.S. Malhotra Research Prize (2013), the Dr. T.S. Vasundhara Memorial Best Paper Award (2015), and the VIRA Outstanding Scientist Award in Analytical Chemistry (2017), Smt. Kusum Sharma Award for a Young Woman Scientist, IABS (2017), Laboratory Scientist of the year (2021), Marie Curie Excellence Award (2022). In addition to her research, Dr. Ahmad serves on the editorial boards of several leading journals, including the “Journal of Translational Proteomics Research” and “World Journal of Pharmacy and Pharmaceutical Sciences”.

Affiliations and expertise
Senior Scientist, Peptide and Proteomics Division, Defence Institute of Physiology and Allied Sciences, DRDO, Delhi, India