The Role of Chromosomes in Development
- 1st Edition - December 2, 2012
- Editor: Michael Locke
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 4 3 3 3 7 3 - 4
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 1 5 6 8 5 - 1
The Role of Chromosomes in Development is a collection of papers presented at the 23rd Symposium of the Society for the Study of Development and Growth, held at Amherst,… Read more
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Request a sales quoteThe Role of Chromosomes in Development is a collection of papers presented at the 23rd Symposium of the Society for the Study of Development and Growth, held at Amherst, Massachusetts in June 1964. Contributors explore the role of chromosomes in development, highlighting important processes such as the diversification and specialization of cells; the regulation of gene function by the physical state of the chromosome; the functional organization of chromosomes; DNA replication and synthesis; and macronuclear differentiation and subnuclear assortment. This volume is organized into 11 chapters and begins with an overview of chromosome structure and function and the mechanisms underlying the role of the chromosome in embryonic development. This book then discusses the chromosomal DNA replication, the mechanisms of gene modulation, the binding of actinomycin to DNA, and the cytological aspects of DNA replication in higher animals. The next chapters explain localized DNA synthesis in polytene chromosomes; chromosomal RNA and other nuclear RNA fractions; and experimental work probing both genetic and functional mosaicism in the mouse, as well as genetic repression of the R locus in maize. The book also considers how developmental pathways are controlled by genetic mechanisms, and then concludes with a chapter on nuclear differentiation in ciliates and on the phenomenon of subnuclear assortment. This book will be of interest to developmental biologists and embryologists.
Contributors and Presiding Chairmen
Dedication
The Role of Chromosomes in Development
Text
References
Structural Patterns and the Functional Organization of Chromosomes
Replication
Repository Function
Variation
Discussion and Summary
References
Chromosomal Proteins
Proteins and Chromosome Structure
The Acidic Nuclear Proteins
The Acidic Proteins and Gene Modulation
The Histones and Gene Modulation
Structure of the N-Proline Histone
Mechanisms of Gene Modulation
Functional State of the Genome
Summary
References
Binding of Actinomycin as a Model for the Complex-Forming Capacity of DNA
Text
References
DNA Replication Sequences in Higher Animals
Introduction
Materials and Methods
The Relationship between Heteropyknosis, Gene Inactivation, and DNA Replication
The Terminal Stages of DNA Replication
Late Replication and Metaphase Chromosome Morphology
The Commencement of DNA Replication
Quantitative Autoradiography of Chromosomes
Discussion
References
Localized DNA Synthesis in Polytene Chromosomes and Its Implications
Text
References
Chromosomal RNA and Other Nuclear RNA Fractions
Chromosomal RNA
Nucleolar RNA
Nuclear Sap RNA
Summary
References
Genetic and Functional Mosaicism in the Mouse
Genetic Mosaicism
Functional Mosaicism
Summary
References
Genetic Repression of R Action in Maize
Experimental Materials and Methods
Paramutation of Rr in RrRst and Rrrr Heterozygotes
Partial Reversion of Paramutant R
Changes in Action of Rr and R9 Alleles from Stock Cultures in Heterozygotes with Each Other
Acquisition of Paramutagenicity by Rr in Stippled Hétérozygotes
Association of the R Locus with Paramutation
Continuous Variation in Paramutation
Compound Nature of the Stippled Allele
Progressive Paramutation in Successive Generations
Occurrence of Paramutation in Somatic Cells
Manifestation of Paramutation in Sporophytic Tissues
The Origin and Geographic Distribution of Paramutable and Nonparamutable R Alleles
R Action in Structurally Altered Chromosome 10
Paramutability of Rr When Carried by Chromosome K10
Level of R Action in Relation to Mode of Sexual Transmission
Effects on Rr and Rst of High Energy Irradiation
Is a Gene-Dependent Cytoplasmic Particle Associated with R Paramutation?
Paramutation in Other Organisms
Summary and Discussion
References
Genetic Control and Regulation of Developmental Pathways
Introduction
Genetic Methods for the Analysis of Development
The Bithorax Pseudoallelic Series
Developmental Effects of the Bithorax Mutants
Gene Dosage Studies
Somatic Mosaics
Cis-Trans Effects
The Trans-Vection Effect
Discussion
Summary
References
Macronuclear Differentiation and Subnuclear Assortment in Ciliates
Morphological Nuclear Differentiation
Caryonidal Distribution: Mating Type Differentiation in Syngen 1, Paramecium aurelia
Subnuclear Assortment: Mating Type Differentiation in Syngen 1, Tetrahymena pyriformis
Subnuclear Assortment: Allelic Repression or Hétérozygote Resolution?
Conclusion
References
Author Index
Subject Index
- No. of pages: 302
- Language: English
- Edition: 1
- Published: December 2, 2012
- Imprint: Academic Press
- Paperback ISBN: 9780124333734
- eBook ISBN: 9780323156851
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