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Elsevier

The Resistance of Cervical Cancer to Chemotherapy and its Reversal

  • 1st Edition, Volume 9 - March 20, 2026
  • Latest edition
  • Editor: S. Muthusami
  • Language: English

The Resistance of Cervical Cancer to Chemotherapy and its Reversal provides a holistic understanding of cervical cancer development, immune-evading mechanisms of HPV, immunothe… Read more

Description

The Resistance of Cervical Cancer to Chemotherapy and its Reversal provides a holistic understanding of cervical cancer development, immune-evading mechanisms of HPV, immunotherapies available, methods to study cervical cancer and the development of newer drugs. Content shows the involvement of signaling pathways during chemoresistance in cervical cancer, the involvement of genes in drug resistance, and introduces long noncoding RNAs as novel biomarkers.

In 10 chapters, this book first provides an introduction and history of cervical cancer; next, it discusses the influence of viruses on cervical cancer and finally, it describes therapies to overcome chemotherapy resistance in cervical cancer. This is the perfect reference to provide the fundamental base of knowledge needed for oncologists, pharmacologists, translational investigators, immunotherapists, scientists, and clinicians interested in building a comprehensive understanding of the field.

Key features

  • Focuses on the aspects of cervical cancer resistance towards therapies such as chemoresistance and radioresistance
  • Discusses the sensitizing agents that are being developed for the improvement of current therapies and better management of cervical cancer
  • Identifies the molecular mechanism of HPV integration and cervical cancer development

Readership

cancer researchers, medical oncologists, clinicians, pharmacologists, translational investigators, immunologists, immunotherapists, scientists and clinicals interested in allogeneic adoptive cell therapy, medical students, translational research students, academic institution libraries

Table of contents

  1. Role of Wnt/β‑catenin signaling pathway in cervical cancer: Strategies to overcome therapeutic resistance
    Gautham Chengizkhan, Akash Guruswamy, Balaji Sadhasivam, Rayvathy Balasubramanian, Sridhar Muthusami, Satish Ramalingam, Lurdes Queimado, R. Ileng Kumaran, Ilangovan Ramachandran
  2. Targeting epigenetic regulatory machinery to overcome cervical cancer chemoresistance
    Soundharya Ravindran, Sivaramakrishnan Venkatabalasubramanian, Aruljothi Nagarajan, Satish Ramalingam
  3. The role of immune checkpoint proteins PD1 and PD‑L1 during cancer resistance
    Vidya Balasubramanian, Sivasankaran Munusamy Ponnan, Sridhar Muthusami, Vijayakumar Velu
  4. Advancements in radiotherapy: transforming cervical cancer treatment
    Shamyugta Chandrasekaran, Selvaraj Jayaraman, Ponnulakshmi Rajagopal, Anupriya Eswaran, Woo Yoon Park
  5. Pathogenesis of human papillomavirus induced carcinogenesis: insights on in vivo models and prophylactic strategies
    Atchuthan Purushothaman, Ramachandran Srinivasan, Dhashnamoorthy S. Prabakaran, Esaki M. Shankar
  6. Subcellular transport of epidermal growth factor receptor: diverse approaches in targeting epidermal growth factor receptor‑driven cervical carcinoma
    Sneha Krishnamoorthy, Loganayaki Periyasamy, Sridhar Muthusami
  7. Structural insights into Human papillomavirus E6 and E7 oncoproteins: implications for drug design and therapeutic targeting
    Tamilselvi Yuvaraj, Lekhavani Ramesh, Suguna Krishnamoorthy, Ramalakshmi Subbarayalu, Rajesh Pandiyan
  8. Critical insights to understand the underlying mechanisms in cervical cancer metastasis
    Anirban Goutam Mukherjee, Arpita Pani, Abilash Valsala Gopalakrishnan, Raunak Kumar Das, Dhashnamoorthy S. Prabakaran, Sabina Evan Prince, Rahul Vashishth
  9. Advancements of cytology in cervical cancer
    Jayapradha Gnanagurusamy, Rajalakshmi Sabanayagam, Giulia Guerriero, Sridhar Muthusami
  10. Insights on molecular mechanisms of chemoresistance in cervical cancer
    Monica Elangovan, Samatha M. Jain, Shabana Thabassum Mohammed Rafi, Nandita Thakkar, Ilangovan Ramachandran, Surajit Pathak, Antara Banerjee
  11. Computational techniques to study the cervical cancer
    Kaviyaprabha Rangaraj, Miji Thandaserry Vasudevan, Apsara Unni, Chaiyavat Chaiyasut, Bharathi Muruganantham
  12. Advances in nanotechnology‑based drug development and delivery for cervical cancer therapeutic strategies
    Thimma Mohan Viswanathan, Sridhar Muthusami, Anitha Devadoss, Sudhagar Pitchaimuthu

Product details

  • Edition: 1
  • Latest edition
  • Volume: 9
  • Published: March 20, 2026
  • Language: English

About the editor

SM

S. Muthusami

Dr. Sridhar Muthusami completed his Ph.D in endocrinology in the year 2011 from the University of Madras, India. His doctoral study was aimed at delineating the molecular mechanism underlying the anabolic actions of Cissus quadrangularis, an indigenous herb believed to exert anabolic effects on bone cells through IGFR. After completing his Ph.D, he has joined for his Postdoctoral work in the department of Radiation Oncology, Chungbuk National University, South Korea. He has worked on the role of Epidermal growth factor/receptor (EGF/EGFR) signaling and its regulation of oncoprotein Fused Toes Homolog (FTS) in cervical cancer cells from 2011 to 2014. He is also involved in the identifying the role of T0070907/EGCG/cordycepin on cervical cancer cells. Since 2015, he moved to the department of biochemistry, Karpagam Academy of Higher Education (Deemed to be University) and serving as Associate Professor and Head at Cancer Research Centre working in the area of development of EGFR TKIs for the treatment/management of cervical cancer/pancreatic cancer.
Affiliations and expertise
Associate Professor and Head, Cancer Research Centre, Karpagam Academy of Higher Education, Coimbatore, India

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