The Proteins Pt 3

List of Contributors

Preface

Contents of Volume I

Chapter 1. The Chemical Modification of Proteins by Group-Specific and Site-Specific Reagents

I. Introduction

II. lonization Behavior and Reactivity of Functional Groups in Native Proteins

III. "Exposed" and "Buried" Groups

IV. Motility of Protein Structure

V. Modification of Protein Side Chains

VI. Unusually Reactive Groups

VII. Affinity Labeling

VIII. Photochemical Labeling

IX. Sensitized Photooxidation

X. Bifunctional Reagents

XI. Concluding Remarks

References

Chapter 2. The Synthesis of Peptides by Solution Methods with Emphasis on Peptide Hormones

I. Introduction

II. General Methods of Synthesis

III. Protecting Groups

IV. Racemization

V. Methods of Purification and Criteria of Homogeneity

VI. Biologically Active Peptides and Proteins

VII. Outlook

References

Chapter 3. Solid-Phase Peptide Synthesis

I. Introduction

II. Synthetic Strategies

III. Solid Supports

IV. Attachment to the Solid Support

V. Protection and Deprotection

VI. Neutralization

VII. Activation and Coupling

VIII. Cleavage from the Solid Support

IX. Purification and Characterization

X. Side Reactions

XI. Automation

XII. Peptides and Proteins Synthesized by the Solid-Phase Method

XIII. Other Oligomers Synthesized by the Solid-Phase Method

XIV. Applications of the Solid-Phase Method

XV. Prospects for the Future

References

Author Index

Subject Index