The Plasma Proteins V5

Contributors

Preface

Contents of Other Volumes


1 DNA Sequencing and Chromosomal Locations of Human Plasma Protein Genes

I. Introduction

II. Plasma Proteins Mapped on Human Chromosomes

III. Gene Organization Revealed by DNA Sequences Encoding Human Plasma Proteins

IV. Conclusions

References


2 Immunoglobulins: Structure, Function, and Genes

I. Introduction

II. Principles of Immunoglobulin Structure

III. The Variable Region

IV. Primary Structure of the Constant Regions of Immunoglobulin Polypeptide Chains

V. Structure and Function of Oligosaccharides

VI. Three-Dimensional Structure and Binding Sites

VII. Cytotropic Functions of the Fc Region

VIII. Structure and Evolution of the Immunoglobulin Supergene Family

References


3 Plasma Apolipoproteins: Gene Structure, Function, and Variants

I. Introduction

II. ApoA-I

III. ApoA-II

IV. ApoA-IV

V. ApoB

VI. Lp(a)

VII. ApoC-I

VIII. ApoC-II

IX. ApoC-III

X. ApoE

XI. Phylogenetic Relationships among Plasma Apolipoproteins

XII. Apolipoprotein Variants Associated with Pathological States

XIII. Concluding Remarks

References


4 α2-Macroglobulin and Related Thiol Ester Plasma Proteins

I. Introduction

II. Brief Historical Perspective

III. The Family of α2M-Related Proteins

IV. α2M, PZP, C3, C4, and C5 as a Class of Homologous Proteins

V. Chromosome Assignment, Genetic Variation, and Sites of Synthesis

VI. Shape of the Macroglobulins, C3, C4, and C5

VII. The β-Cysteinyl-γ-glutamyl Thiol Ester Structure in α2M, C3, and C4

VIII. Conformational Change and the Nascent State

IX. Formation and Properties of α2M-Proteinase Complexes

X. Cell Recognition, Receptor-Mediated Endocytosis, and Cellular Effects

XI. Conclusions and Perspectives

References


5 Synthesis, Processing, and Secretion of Plasma Proteins by the Liver and Other Organs and Their Regulation

I. Introduction: Coordinate Regulation of Plasma Protein Synthesis and Mechanism of Synthesis and Secretion

II. Response of the Plasma Protein Synthesizing System in the Liver to Trauma and Inflammation

III. Perinatal Development of the Plasma Protein Synthesizing System

IV. Molecular Mechanisms of the Regulation of Plasma Protein Synthesis in the Liver

V. Plasma Protein Synthesis in the Choroid Plexus

VI. Human Acute-Phase Proteins and Their Physiopathological Role and Clinical Significance. Modulation of the Acute-Phase Response

VII. Concluding Remarks

References

Appendix: Sequences of Plasma Proteins

I. Introductory Remarks

II. Amino Acid Sequences

Index