The Ovary
- 4th Edition - June 1, 2027
- Latest edition
- Editors: Peter C.K. Leung, Jie Qiao, Eli Y. Adashi
- Language: English
A go-to resource for mastering both fundamental concepts and cutting-edge advances ovarian biology and reproductive medicineThe Ovary, Fourth Edition offers readers an authori… Read more
Description
Description
A go-to resource for mastering both fundamental concepts and cutting-edge advances ovarian biology and reproductive medicine
The Ovary, Fourth Edition offers readers an authoritative, comprehensive resource on the latest advances in ovarian research, spanning molecular, cellular, and clinical perspectives. Edited by leading experts, this volume consolidates cutting-edge discoveries made over the past six years, including breakthroughs in genomics, artificial intelligence, and ethical considerations in reproductive medicine. It benefits scientists and researchers by providing an unparalleled compilation of foundational knowledge, novel experimental models, and state-of-the-art methodologies, enabling them to deepen their understanding and stay current in this rapidly evolving field. Clinicians will also find it invaluable for updating their knowledge on ovarian physiology, female infertility treatments, assisted reproductive technologies, and ovarian cancer. With 40+ chapters and extensive visual content, the book serves as a
definitive reference that bridges basic science and clinical application, supporting research innovation and improved patient care in reproductive medicine.
Key Features
•Integrates hot topics and controversial issues to keep readers abreast of current debates
•Includes cutting-edge research methodologies such as genomics and artificial intelligence
•Presents comprehensive coverage of ovarian biology, development, and pathophysiology spanning from molecular mechanisms to clinical applications
•Offers detailed exploration of ovarian disorders, fertility preservation, and ovarian cancer with practical clinical relevance
The Ovary, Fourth Edition offers readers an authoritative, comprehensive resource on the latest advances in ovarian research, spanning molecular, cellular, and clinical perspectives. Edited by leading experts, this volume consolidates cutting-edge discoveries made over the past six years, including breakthroughs in genomics, artificial intelligence, and ethical considerations in reproductive medicine. It benefits scientists and researchers by providing an unparalleled compilation of foundational knowledge, novel experimental models, and state-of-the-art methodologies, enabling them to deepen their understanding and stay current in this rapidly evolving field. Clinicians will also find it invaluable for updating their knowledge on ovarian physiology, female infertility treatments, assisted reproductive technologies, and ovarian cancer. With 40+ chapters and extensive visual content, the book serves as a
definitive reference that bridges basic science and clinical application, supporting research innovation and improved patient care in reproductive medicine.
Key Features
•Integrates hot topics and controversial issues to keep readers abreast of current debates
•Includes cutting-edge research methodologies such as genomics and artificial intelligence
•Presents comprehensive coverage of ovarian biology, development, and pathophysiology spanning from molecular mechanisms to clinical applications
•Offers detailed exploration of ovarian disorders, fertility preservation, and ovarian cancer with practical clinical relevance
Key features
Key features
- Integrates hot topics and controversial issues to keep readers abreast of current debates
- Includes cutting-edge research methodologies such as genomics and artificial intelligence
- Presents comprehensive coverage of ovarian biology, development, and pathophysiology spanning from molecular mechanisms to clinical applications
- Offers detailed exploration of ovarian disorders, fertility preservation, and ovarian cancer with practical clinical relevance
Readership
Readership
Basic scientists and clinicians in reproductive medicine
Table of contents
Table of contents
Part I
1. Cellular Atlas of the Human Ovary
2. Differentiation Trajectory of Theca/Stroma Cells
3. Germline-soma Interactions in Oocyte Growth
4. Organization of Ovarian Steroidogenic Cells and Cholesterol Metabolism
5. Follicle Selection in Mammalian Ovaries
6. Regulation of Follicle Formation and Development by Ovarian Signaling Pathways
7. Development of the Mammalian Ovary and Follicles
8. Activin, Inhibin, and Follistatin in Ovarian Physiology
9. Cell-cell Interactions in the Ovarian Follicle
10. Mutations and Polymorphisms, and Their Functional Consequences, in Gonadotropin and Gonadotropin Receptor Genes
11. Environmentally Induced Epigenetic Transgenerational Inheritance of Ovarian Disease
Part II
12. Mammalian Oogenesis: The Fragile Foundation of the Next Generation
13. Regulation of Mammalian Oocyte Maturation
14. Oocyte Meiotic Maturation
15. Gene Expression During Oogenesis and Oocyte Development
16. Ovulation: The Coordination of Intrafollicular Networks to Ensure Oocyte Release
Part III
17. Molecular Regulation of Progesterone Production in Corpus Luteum
18. Corpus Luteum Formation
19. Luteolysis and The Corpus Luteum of Pregnancy
Part IV
20. In Vitro Gametogenesis
21. Ovary-on-a-Chip Models
22. Transgenic Models to Study Ovarian Function
23. Genome-Wide Association Studies of Ovarian Function Disorders
24. Mitochondria Research in Human Reproduction
25. The Role of Mitochondria in Reproductive Function and Assisted Reproduction
26. Oocyte-mediated Intergenerational Transmission of Chronic Diseases
28. Human Ovarian Aging: Insights from Single-nuclei Multi-omics Analyses
29. Application of Artificial Intelligence in Assisted Reproductive Technologies
Part V
30. Ovarian Hyperstimulation Syndrome
31. The Role of GnRH Agonist Trigger in GnRH Antagonist-Based Ovarian Hyperstimulation Protocols 32. The Ovarian Factor in Assisted Reproductive Technology
33. The Role of Anti-Müllerian Hormone in Assisted Reproduction
34. Polycystic Ovary Syndrome
35. Genetic and Environmental Factors in the Etiology of Polycystic Ovary Syndrome
36. Germ Cell Failure and Ovarian Resistance: Human Genes and Disorders
37. Environmental Contaminants and Ovarian Toxicity
38. Autologous Transplantation of Human Ovarian Tissue
39. Fertility Preservation
40. Oncofertility: Preservation of Ovarian Function After a Cancer Diagnosis
41. Implications of Recent Breakthroughs and Innovations on the Future of In Vitro Fertilization
Part VI
42. Cellular Origins of Ovarian Cancer
43. Phenotypic Plasticity and the Origins and Progression of Ovarian Cancer
44. Novel Therapeutic Approaches and Targets for Ovarian Cancer
45. Chemoresistance in Ovarian Cancer: Integrating Single-Cell Transcriptomics with Targeted Proteomics
46. Artificial Intelligence Liquid Biopsy Approaches for Early Detection and Monitoring of Cancer Patients
47. Artificial Intelligence in Reproductive Medicine: Legal and Ethical Implications
1. Cellular Atlas of the Human Ovary
2. Differentiation Trajectory of Theca/Stroma Cells
3. Germline-soma Interactions in Oocyte Growth
4. Organization of Ovarian Steroidogenic Cells and Cholesterol Metabolism
5. Follicle Selection in Mammalian Ovaries
6. Regulation of Follicle Formation and Development by Ovarian Signaling Pathways
7. Development of the Mammalian Ovary and Follicles
8. Activin, Inhibin, and Follistatin in Ovarian Physiology
9. Cell-cell Interactions in the Ovarian Follicle
10. Mutations and Polymorphisms, and Their Functional Consequences, in Gonadotropin and Gonadotropin Receptor Genes
11. Environmentally Induced Epigenetic Transgenerational Inheritance of Ovarian Disease
Part II
12. Mammalian Oogenesis: The Fragile Foundation of the Next Generation
13. Regulation of Mammalian Oocyte Maturation
14. Oocyte Meiotic Maturation
15. Gene Expression During Oogenesis and Oocyte Development
16. Ovulation: The Coordination of Intrafollicular Networks to Ensure Oocyte Release
Part III
17. Molecular Regulation of Progesterone Production in Corpus Luteum
18. Corpus Luteum Formation
19. Luteolysis and The Corpus Luteum of Pregnancy
Part IV
20. In Vitro Gametogenesis
21. Ovary-on-a-Chip Models
22. Transgenic Models to Study Ovarian Function
23. Genome-Wide Association Studies of Ovarian Function Disorders
24. Mitochondria Research in Human Reproduction
25. The Role of Mitochondria in Reproductive Function and Assisted Reproduction
26. Oocyte-mediated Intergenerational Transmission of Chronic Diseases
28. Human Ovarian Aging: Insights from Single-nuclei Multi-omics Analyses
29. Application of Artificial Intelligence in Assisted Reproductive Technologies
Part V
30. Ovarian Hyperstimulation Syndrome
31. The Role of GnRH Agonist Trigger in GnRH Antagonist-Based Ovarian Hyperstimulation Protocols 32. The Ovarian Factor in Assisted Reproductive Technology
33. The Role of Anti-Müllerian Hormone in Assisted Reproduction
34. Polycystic Ovary Syndrome
35. Genetic and Environmental Factors in the Etiology of Polycystic Ovary Syndrome
36. Germ Cell Failure and Ovarian Resistance: Human Genes and Disorders
37. Environmental Contaminants and Ovarian Toxicity
38. Autologous Transplantation of Human Ovarian Tissue
39. Fertility Preservation
40. Oncofertility: Preservation of Ovarian Function After a Cancer Diagnosis
41. Implications of Recent Breakthroughs and Innovations on the Future of In Vitro Fertilization
Part VI
42. Cellular Origins of Ovarian Cancer
43. Phenotypic Plasticity and the Origins and Progression of Ovarian Cancer
44. Novel Therapeutic Approaches and Targets for Ovarian Cancer
45. Chemoresistance in Ovarian Cancer: Integrating Single-Cell Transcriptomics with Targeted Proteomics
46. Artificial Intelligence Liquid Biopsy Approaches for Early Detection and Monitoring of Cancer Patients
47. Artificial Intelligence in Reproductive Medicine: Legal and Ethical Implications
Product details
Product details
- Edition: 4
- Latest edition
- Published: June 1, 2027
- Language: English
About the editors
About the editors
Peter C.K. Leung
Editor
Dr. Leung is a Professor at the University of British Columbia’s Department of Obstetrics & Gynecology and former Associate Dean in the Faculty of Medicine at UBC. Dr. Leung received his PhD from Western University. After post-doctoral training at the University of California at Los Angeles and the Laval University, he joined the University of British Columbia in 1982 as a faculty member. Dr. Leung has received a number of prestigious awards, including a Scholar Award and a Scientist Award from the Medical Research Council of Canada, a Distinguished Scholar Award from the Michael Smith Foundation for Health Research and a Senior Scientist Award from the BC Children Hospital Research Institute. Dr. Leung has served on many national and international organizations, including as President of the Canadian Fertility and Andrology Society, Director of the Society for the Study of Reproduction, Director of the Ovarian Workshops in the USA, temporary advisor to the World Health Organization, Fellow of the Canadian Academy for Health Sciences, and Fellow of the Royal Society of Canada. Dr. Leung’s research focuses on hormonal determinants of women’s reproductive health. His publication record to date includes 400 papers, 350 abstracts, 22 book chapters and 7 monographs. Since his appointment at UBC, Dr. Leung has served as the research supervisor for more than 100 graduate students, postdoctoral fellows and visiting scientists.
Affiliations and expertise
Professor, Department of Obstetrics and Gynecology, University of British Columbia, CanadaJie Qiao
Editor
Dr. Jie Qiao, Professor and Director of Peking University Health Science Center, President of Peking University Third Hospital, Academician of Chinese Academy of Engineering, Beijing, China. She has been engaged in reproductive health-related clinical and basic research throughout her career, including as a visiting scholar at the University of Hong Kong and as a post-doctoral researcher at Stanford University. Her research has focused on gametes fertilization, infertility and embryo implantation mechanisms, and polycystic ovary syndrome pathogenesis among other topics. Dr. Jie Qiao has published more than 250 paper publications in peer reviewed journals on topics related to reproductive health.
Affiliations and expertise
Jie Qiao, Professor and Director of Peking University Health Science Center, President of Peking University Third Hospital, Academician of Chinese Academy of Engineering, Beijing, ChinaEli Y. Adashi
Editor
Dr. Alan B. Adashi is a prominent academic physician-executive and former Dean of Medicine and Biological Sciences at Brown University during its 2007 renaming. He earned his medical degree from the Sackler School of Medicine in 1973, completed residency in Obstetrics and Gynecology at Tufts University, and fellowship training in Reproductive Endocrinology and reproductive biology at Johns Hopkins and UC San Diego. He holds an MS in Health Care Management from Harvard T.H. Chan School of Public Health. Dr. Adashi served on faculty at the University of Maryland, University of Utah—where he chaired Obstetrics and Gynecology and founded the Ovarian Cancer Program—and Brown University. He is a former president of the Society for Reproductive Endocrinologists, Society for Gynecologic Investigation, and American Gynecological and Obstetrical Society. With nearly 400 publications and over 50 mentored postdoctoral trainees, his work has been widely recognized and featured in major media outlets.
Affiliations and expertise
Emeritus Professor of Medical Science and Former Dean of Medicine and Biological Sciences, Center for Prisoner Health and Human Rights, Warren Alpert Medical School, Division of Biology and Medicine, Brown University, Providence, USA