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The Ovary

  • 3rd Edition - September 10, 2018
  • Latest edition
  • Editors: Peter C.K. Leung, Eli Y. Adashi
  • Language: English

The Ovary, Third Edition, includes more than 60% new material that highlights the clinical aspects of human ovarian functions. It covers advances in the areas of genomics,… Read more

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Description

The Ovary, Third Edition, includes more than 60% new material that highlights the clinical aspects of human ovarian functions. It covers advances in the areas of genomics, assisted reproductive technology, and cancer diagnosis and treatment. This updated edition synthesizes new information at the molecular, cellular and organismal levels, while also presenting modern ovarian physiology in a more understandable and comparative context. The book looks at ovarian function from a detailed molecular and cellular level that examines all phases of the ovarian lifecycle that places special emphasis on the pathophysiology of the human ovary, including ovarian carcinogenesis.

Key features

  • Represents an unparalleled compilation of chapters that are relevant to contemporary ovarian physiology
  • Provides basic and clinical research on ovarian function, abnormalities, assisted reproductive technology, and cancer
  • Highlights contemporary strategies and treatment paradigms in female factor infertility

Readership

Reproductive endocrinologists, physiologists, cell and molecular biologists, fertility/infertility specialists, as well as OB/GYNs

Table of contents

Part I. The Ovarian Follicular Apparatus: Operational Characteristics

1. Follicle Selection in Mammalian Ovaries

2. Regulation of follicle formation and development by ovarian signaling pathway

3. Human Folliculogenesis Revisited: The Menstrual Cycle Visualized by Ultrasonography

4. Development of the Mammalian Ovary and Follicles

5. Organization of Ovarian Steroidogenic Cells and Cholesterol Metabolism

6. Inhibin, Activin and Follistatin in Ovarian Physiology

7. Cell-cell Interactions in the Ovarian Follicles: Role of TGF-beta Superfamily Members

8. Mutations and Polymorphisms, and their Functional Consequences, in Gonadotropin and Gonadotropin Receptor Genes

9. Environmentally Induced Epigenetic Transgenerational Inheritance of Ovarian Disease

Part II. Oocyte Maturation and Ovulation

10. Mammalian Oogenesis – the fragile foundation of the next generation

11. Regulation of Mammalian Oocyte Maturation

12. Oocyte Meiotic Maturation

13. Gene Expression During Oogenesis and Oocyte Development

Part III. The Corpus Luteum

15. Molecular Regulation of Progesterone Production in Corpus Luteum

16. Corpus Luteum Formation

17. Luteolysis and The Corpus Luteum of Pregnancy

Part IV. Novel Experimental Models

18. Transgenic Mouse Models in the Study of Ovarian Function

19. Genome-Wide Association Studies of Ovarian Function Disorders

20. Mitchondria Research in Human Reproduction

21. The Role of Mitochondria in Reproductive Function and Assisted Reproduction

Part V. Human Ovarian Pathophysiology: Select Aspects

22. Ovarian Hyperstimulation Syndrome

23. The Role of GnRH Agonist Triggering in GnRH Antagonist-Based Ovarian Stimulation Protocols

24. The Ovarian Factor in Assisted Reproductive Technology

25. The Role of Antimullerian Hormone in Assisted Reproductionr

26. Polycystic Ovary Syndrome

27. Genetic and Environmental Factors in the Aetiology of Polycystic Ovary Syndrome

28. Germ Cell Failure and Ovarian Resistance: Human Genes and Disorders

29. Environmental Contaminants and Ovarian Toxicity

30. Autologous Transplantation of Human Ovarian Tissue

31. Oncofertility: Preservation of ovarian function after a cancer diagnosis

Part VI. Human Ovarian Cancer

32. Ovarian cancers: their varied origins and pathologically implicated microenvironment

33. Phenotypic Plasticity and the Origins and Progression of Ovarian Cancer

34. Novel Therapeutic Approaches and Targets for Ovarian Cancer

35. Molecular and Cellular Basis of Chemoresistance in Ovarian Cancer

Product details

  • Edition: 3
  • Latest edition
  • Published: October 19, 2018
  • Language: English

About the editors

PL

Peter C.K. Leung

Dr. Leung is a Professor at the University of British Columbia’s Department of Obstetrics & Gynecology and former Associate Dean in the Faculty of Medicine at UBC. Dr. Leung received his PhD from Western University. After post-doctoral training at the University of California at Los Angeles and the Laval University, he joined the University of British Columbia in 1982 as a faculty member. Dr. Leung has received a number of prestigious awards, including a Scholar Award and a Scientist Award from the Medical Research Council of Canada, a Distinguished Scholar Award from the Michael Smith Foundation for Health Research and a Senior Scientist Award from the BC Children Hospital Research Institute. Dr. Leung has served on many national and international organizations, including as President of the Canadian Fertility and Andrology Society, Director of the Society for the Study of Reproduction, Director of the Ovarian Workshops in the USA, temporary advisor to the World Health Organization, Fellow of the Canadian Academy for Health Sciences, and Fellow of the Royal Society of Canada. Dr. Leung’s research focuses on hormonal determinants of women’s reproductive health. His publication record to date includes 400 papers, 350 abstracts, 22 book chapters and 7 monographs. Since his appointment at UBC, Dr. Leung has served as the research supervisor for more than 100 graduate students, postdoctoral fellows and visiting scientists.
Affiliations and expertise
Professor, Department of Obstetrics and Gynecology, University of British Columbia, Canada

EA

Eli Y. Adashi

Dr. Alan B. Adashi is a prominent academic physician-executive and former Dean of Medicine and Biological Sciences at Brown University during its 2007 renaming. He earned his medical degree from the Sackler School of Medicine in 1973, completed residency in Obstetrics and Gynecology at Tufts University, and fellowship training in Reproductive Endocrinology and reproductive biology at Johns Hopkins and UC San Diego. He holds an MS in Health Care Management from Harvard T.H. Chan School of Public Health. Dr. Adashi served on faculty at the University of Maryland, University of Utah—where he chaired Obstetrics and Gynecology and founded the Ovarian Cancer Program—and Brown University. He is a former president of the Society for Reproductive Endocrinologists, Society for Gynecologic Investigation, and American Gynecological and Obstetrical Society. With nearly 400 publications and over 50 mentored postdoctoral trainees, his work has been widely recognized and featured in major media outlets.
Affiliations and expertise
Emeritus Professor of Medical Science, Former Dean of Medicine and Biological Sciences, Center for Prisoner Health and Human Rights, The Warren Alpert Medical School, Division of Biology and Medicine, Brown University, Providence, RI, USA

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