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The Orthopoxviruses
- 1st Edition - December 2, 2012
- Author: Frank Fenner
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 4 3 1 2 2 4 - 1
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 1 5 0 2 2 - 4
The Orthopoxviruses presents knowledge and comprehensive and integrated picture of orthopoxviruses. The book looks into the molecular biology of this genusof viruses, partic… Read more
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Request a sales quoteThe Orthopoxviruses presents knowledge and comprehensive and integrated picture of orthopoxviruses. The book looks into the molecular biology of this genusof viruses, particularly, the structure and chemical composition of the virion, replication, morphogenesis, pathogenesis, pathology, and immunology of this virus’ infections. It also elucidates the global spread, control, and eradication of smallpox. Additionally, the book describes a potentially important use of vaccinia virus, namely, its use as a vector for genes from other viruses, bacteria, or protozoa that specify antigens important in stimulating the production of a protective immune response. Such comprehensive account of all aspects of the biology of all known species of orthopoxviruses will be valuable to molecular biologists, virologists, immunologists, pathologists, and researchers in the veterinary sciences.
Preface
1. Historical Introduction and Overview
Variolation and Vaccination
Classification of the Orthopoxviruses
Species within the Genus Orthopoxvirus
Species of Orthopoxvirus: An Overview
Physical Properties of the Orthopoxvirus Virion
Chemical Composition of the Orthopoxvirus Virion
The Use of Laboratory Animals for Poxvirus Research
Growth of Orthopoxviruses in Cultured Cells
Assay of Viral Infectivity
The Replication Cycle of Vaccinia Virus
Genetic Studies of Orthopoxviruses
Pathology, Pathogenesis, and Immunology
Experimental Epidemiology
The Global Eradication of Smallpox
Vaccinia Virus as a Vector for Vaccine Antigens
Summary of Historical Events in Orthopoxvirus Research
2. Structure and Chemical Composition of the Virion
Structure of the Virion
Chemical Composition of Virions of Vaccinia Virus
Structure of the Genome
Polypeptides of Orthopoxviruses
Lipids of Virions of Vaccinia Virus
3. Replication and Morphogenesis of Vaccinia Virus
The Replication Cycle
Initiation of Infection
Early Transcription
Late Transcription
Regulation of Early and Late Gene Expression
Replication of the Genome
Role of the Host Cell Nucleus in the Replication of Poxviruses
Morphogenesis
4. The Pathogenesis, Pathology, and Immunology of Orthopoxvirus Infections
Portals of Entry in Orthopoxvirus Infections
The Spread of Infection through the Body
The Consequences of Systemic Infection
Pathological Changes in Orthopoxvirus Infections
Viral Persistence and Reactivation
The Immune Response in Orthopoxvirus Infections
Methods of Immunization against Orthopoxvirus Infections
Nonspecific Mechanisms Involved in Host Defense
5. Vaccinia Virus: The Tool for Smallpox Eradication
Vaccinia Virus as a Separate Species
History of Smallpox Vaccine
Variants of Vaccinia Virus
Sources of Vaccinia Virus Strains Used for Smallpox Vaccine
The Origin of Vaccinia Virus
Vaccinia Virus as a Vector for Other Antigens
6. Cowpox Virus
Properties of Cowpox Virus
Naturally Occurring Infections with Cowpox Virus
7. Variola Virus
Variola Virus in Its Human Host
The Properties of Variola Virus
Comparison of Variola Virus with Other Orthopoxviruses
Differences between Strains of Variola Virus
Unusual Strains of Variola Virus
Use of Individual Markers as Epidemiological Tracers
Variola-like Viruses from Animals—the "Whitepox" Viruses
Laboratory Aids to the Diagnosis of Smallpox
8. Monkey pox Virus
Monkeypox in Captive Primates
The Properties of Monkeypox Virus
Human Monkeypox
The Ecology of Monkeypox Virus
Summary
9. Ectromelia Virus
Properties of Ectromelia Virus
Mousepox in Laboratory Mice
Laboratory Diagnosis
Prophylaxis and Control
10. Other Orthopoxviruses
Camelpox Virus
Raccoon Poxvirus
Tatera Poxvirus
Uasin Gishu Disease Virus
Vole Poxvirus
11. The Global Spread, Control, and Eradication of Smallpox
Clinical Features of Smallpox
Epidemiology of Smallpox
Smallpox in the Ancient World up to 1000 AD
The Spread of Smallpox by European Colonists
Methods of Control
The Spread of Variola Minor
Control and Eradication of Smallpox
12. Vaccinia Virus as a Vector for Vaccine Antigens
Insertion of Foreign Genes into Vaccinia Virus DNA
Analysis of Viral Gene Function
Vaccination of Experimental Animals
Potential for Human Vaccines
Potential for Veterinary Vaccines
Bibliography
Index
- No. of pages: 442
- Language: English
- Edition: 1
- Published: December 2, 2012
- Imprint: Academic Press
- Paperback ISBN: 9780124312241
- eBook ISBN: 9780323150224
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