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The New Era of Precision Medicine
What it Means for Patients and the Future of Healthcare
- 1st Edition - December 1, 2023
- Editor: Mohamad Bydon
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 3 9 6 3 - 5
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 3 9 6 4 - 2
The New Era of Precision Medicine: What it Means for Patients and the Future of Healthcare highlights the aspects of precision medicine in different specialties and offers an… Read more
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Request a sales quoteThe New Era of Precision Medicine: What it Means for Patients and the Future of Healthcare highlights the aspects of precision medicine in different specialties and offers an understanding of how a biological background integrates into clinical guidelines, the therapeutic efficacy of interventions, and disease prevention. The book explains how precision healthcare differs among countries, as well as how there is a collaboration among many laboratories to share resources and knowledge to advance the field across the globe. The book also discusses the cultural differences and cultural sensitivity that may be involved in the precision medicine approach. Finally, with regard to safety and quality outcomes, the book presents a range of current and possible future concerns related to those outcomes. Precision medicine is the new standard of quality healthcare delivery. It aims to optimize patient safety and clinical outcomes, enhance the efficacy of therapeutic interventions, and facilitate disease prevention, offering a way to customize patient care, decision-making, and clinical practice.
- Highlights the characteristics of precision medicine in different areas
- Offers an understanding of how a biological background integrates into clinical guidelines, the therapeutic efficacy of interventions, and disease prevention
- Emphasizes how medicine has transformed from a “one-size-fits-all” approach to personalized medicine influenced by individual characteristics
- Introduces complex topics delivered in terms that target a broad range of audiences
Clinicians and Researchers working in Precision Medicine – Developing Research and Data Sharing infrastructure
Nurse practitioners
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Preface
- Acknowledgment
- Introduction
- Chapter 1. On the modern evolution of personalized medicine
- Abstract
- Origins of the concept of individualized treatment on the basis of human genetic differences
- Advances in novel therapeutic systems of gene therapy: the future is now
- The expanding number of diagnostics using genomic technologies
- Consumer genomic testing
- Global public R&D investments in personalized medicine continues
- Key roles of the U.S. Food and Drug Administration in advancing personalized medicine
- Regulation of laboratory-developed genomic tests
- Other regulatory advances to accelerate personalized approaches to therapy
- Other regulatory advances to accelerate personalized approaches to therapy
- Healthcare payment system reforms impact on the clinical advancement of personalized medicine
- Public–private partnerships and their role in personalized medicine
- The role advocacy in development and adoption of personalized medicine
- Conclusion
- References
- Chapter 2. Precision approach in the medical and surgical management of newly diagnosed and refractory epilepsy
- Abstract
- Introduction
- What is precision medicine?
- What is a seizure?
- Stratification of patient characteristics
- The bottom-to-top approach in epilepsy
- Precision techniques in epilepsy
- Treatment of refractory epilepsy
- Thinking beyond the temporal lobe
- Converting “nonlesional” epilepsy to “lesional” epilepsy
- Advances in imaging methods
- Precision surgery in epilepsy
- Future implications and conclusion
- References
- Chapter 3. In vitro diagnostics in oncology in precision medicine
- Abstract
- Regulation of in vitro diagnostics
- Quality system regulation/good manufacturing practices
- Reporting of Corections and Removals
- Investigational diagnostics in precision medicine
- Diagnostics in personalized medicine
- Review of personalized medicine diagnostics
- Unique initiatives
- Interacting with FDA
- Final considerations
- Acknowledgment
- References
- Chapter 4. Precision medicine: success stories and challenges from science to implementation
- Abstract
- Introduction
- Why we need precision medicine now?
- The paradox of precision medicine
- What are the challenges and solutions with precision medicine?
- From the Cancer Genome Atlas project to targeted therapy
- Targeted cancer therapy
- Challenges involving targeted therapies
- Biomarkers in clinical practice
- Early and late examples of precision medicine
- Conclusions and future perspectives
- Acknowledgments
- Abbreviations
- References
- Chapter 5. Big Data and Health Analytics explained
- Abstract
- Introduction
- Big Data in research
- Precision medicine and personalized medicine
- Big Data for disease detection and pharmacovigilance
- Artificial intelligence, clinical imaging, and multiomics
- Limitations of Big Data
- Conclusion
- References
- Chapter 6. Artificial intelligence and personalized medicine: transforming patient care
- Abstract
- Introduction
- Foundations of artificial intelligence in personalized medicine
- Artificial intelligence for personalized drug therapy
- Artificial intelligence in disease prediction and prevention
- Artificial intelligence and patient-centered care
- Ethical and legal considerations in artificial intelligence and personalized medicine
- Future directions and challenges
- Conclusion
- References
- Chapter 7. Ethical considerations in precision medicine
- Abstract
- Introduction
- The diagnostic odyssey and quest for treatment of rare conditions: economics and policy lessons for precision medicine
- Precision oncology: considerations of informed consent, incidental findings, and the “Duty to Warn”
- Polygenic risk assessment and complex conditions: health disparities, disparate benefits of risk assessment, and the risks of discrimination, stigmatization, and blame
- Pharmacogenomics
- Conclusion
- References
- Chapter 8. Precision of diagnostic approaches and individualized therapy toward improving patient outcomes
- Abstract
- Background
- Precision medicine in hematology
- Liquid biomarkers – circulating tumor cells, cfDNA, and c-miRNA
- Radiomics
- Spatial omics
- Precision medicine in autoimmunity
- Precision medicine in infectious diseases
- Precision medicine in gastroenterology
- References
- Chapter 9. “Multiomics in precision medicine”
- Abstract
- Introduction
- Different types of “omic” data
- “Multiomics” applications in precision medicine
- Challenges
- Conclusions
- References
- Chapter 10. Global impact and application of Precision Healthcare
- Abstract
- Introduction: “In the beginning was the Word”
- “Nth-generation” sequencing approaches: a deep dive into Precision Healthcare
- The emerging value of “N-of-1” studies
- Precision Healthcare: is “translating” from “Bench” to “Bedside” enough to achieve global applications?
- Precision Healthcare and equity: the challenge from “Bench to the Agora”
- Narrative and traditional medicine: “Neglected” forms of Precision Healthcare?
- Toward implementing Precision Healthcare: the challenge of reproducibility
- Conclusion
- Acknowledgments
- Conflicts of interest
- References
- Chapter 11. The financial burden of precision medicine
- Abstract
- Introduction
- The rising cost of precision medicine
- Costs associated with research and development, clinical trials, and regulatory approval
- Strategies for addressing the financial burden of precision medicine
- Implications for the future of healthcare
- References
- Index
- No. of pages: 300
- Language: English
- Edition: 1
- Published: December 1, 2023
- Imprint: Academic Press
- Paperback ISBN: 9780443139635
- eBook ISBN: 9780443139642
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Mohamad Bydon
Dr. Mohamad Bydon is the Charles B. and Ann L. Johnson Professor of Neurosurgery and Professor of Orthopedics and Health Services Research, specializing in complex spinal surgery and spinal oncology. He utilizes techniques of minimally invasive spine (MIS) surgery for a variety of spinal conditions. As a neurosurgeon clinician-scientist, Dr. Bydon is the principal investigator of the Mayo Clinic Neuro-Informatics Laboratory. The laboratory is focused on data analytics, patient safety, surgical outcomes, and novel therapeutic treatments for spine disease. He is also the medical director of the Mayo Clinic Neurosurgical Registry, a database focused on improving outcomes and safety for patients.