Skip to main content
Elsevier

The Neuroscience of Traumatic Brain Injury

  • 1st Edition - May 27, 2022
  • Latest edition
  • Editors: Rajkumar Rajendram, Victor R. Preedy, Colin R. Martin
  • Language: English

Diagnosis and Treatment of Traumatic Brain Injury will improve readers’ understanding of the complexities of diagnosis and management of traumatic brain injuries. Featuring… Read more

Description

Diagnosis and Treatment of Traumatic Brain Injury will improve readers’ understanding of the complexities of diagnosis and management of traumatic brain injuries. Featuring chapters on drug delivery, different treatments, and rehabilitation, this volume discusses in detail the impact early diagnosis and effective management has on the long-term prognosis of these injuries and the lives of those affected. This book will be relevant for neuroscientists, neurologists, clinicians, and anyone working to better understand these injuries.

Traumatic brain injury has complex etiology and may arise as a consequence of physical abuse, violence, war, vehicle collisions, working in the construction industry, and sports. Cellular, Molecular, Physiological, and Behavioral Aspects of Traumatic Brain Injury will improve readers’ understanding of the detailed processes arising from traumatic brain injury. Featuring chapters on neuroinflammation, metabolism, and psychology, this volume discusses the impact of these injuries on neurological and body systems to better understand underlying pathways. This book will be relevant for neuroscientists, neurologists, clinicians, and anyone working to better understand traumatic brain injury.

Key features

Diagnosis and Treatment of Traumatic Brain Injury:

  • Covers both the diagnosis and treatment of traumatic brain cord injury
  • Contains chapter abstracts, key facts, dictionary, and summary points to aid in understanding
  • Features chapters on epidemiology and pain
  • Includes MRI usage, biomarkers, and stem cell and gene therapy for management of spinal cord injury
  • Discusses pain reduction, drug delivery, and rehabilitation

Cellular, Molecular, Physiological, and Behavioral Aspects of Traumatic Brain Injury:

  • Summarizes the neuroscience of traumatic brain injury, including cellular and molecular biology
  • Contains chapter abstracts, key facts, dictionary, and summary points to aid in understanding
  • Features chapters on signaling and hormonal events
  • Includes plasticity and gene expression
  • Examines health and stress behaviors after traumatic brain injury

Readership

Designed for research and teaching purposes, it is suitable for neuroscientists, neurologists, clinicians, health scientists, public health workers, doctors, and research scientists. It is valuable as a personal reference book and also for academic libraries that covers the domains of neurology and health sciences. It is also suitable for undergraduates, postgraduate, lecturers and academic professors

Table of contents

Diagnosis and Treatment of Traumatic Brain Injury:I. Setting The Scene and Introductory Chapters1. Traumatic brain injury, and in-hospital mortality: perfusion CT and beyondSudharsana Rao Ande and Jai Jai Shiva Shankar2. Predictors of outcome in moderate and severe traumatic brain injuryRosalia Zangari, Paolo Gritti and F. Biroli3. 30 years post-injury: .Impact of traumatic brain injury on later Alzheimer's diseaseTakashi Hiraoka and Kozo Hanayama4. Drug Interventions and Stem Cells in Traumatic Brain Injury: Translation from Experimental Model to BedsideFiras H. Kobaissy and Maha Tabet5. Management of Traumatic Brain Injury from The Aspect of Emergency Department and Case StudiesBedriye Müge M. Sönmez6. Neuropsychiatric disorders after severe traumatic brain injury: an overviewDolores Villalobos, U. Bivona and Maria Paola Ciurli

II. Clinical Features of Traumatic Brain Injury 7. Cerebral hemorrhages in traumatic brain injuryAndrei Irimia8. Linking fibrinogen, coagulopathy prophylaxis and traumatic brain injury Ryuta Nakae and Shoji Yokobori9. Linking traumatc brain injury and osocomial infectionsAntoine Roquilly10. Late-life neurodegenerative disorders due to traumatic brain injury: Epidemiology, clinical symptoms and in vivo quantification of neuropathology Keisuke Takahata, Kenji Tagai, Makoto Higuchi and Masaru Mimura11. Evaluating the integrity of white matter after traumatic brain injury and the clinical utility of diffusion tensor imaging Eunkyung Kim, Min-Gu Kang and Byung-Mo Oh12. Cerebral activation of attention and working memory in traumatic brain injuryAthena Stein, Kartik K. Iyer and Karen Barlow13. Traumatic brain injury: Linking intracranial pressure, arterial pressure and the pressure reactivity indexAlwyn Titus Gomez, Carleen Batson, Logan Froese and Frederick A. Zeiler14. Cerebral perfusion pressure parameters and traumatic brain injuryAlwyn Titus Gomez, Carleen Batson, Logan Froese and Frederick A. Zeiler15. Brain swelling in traumatic brain injurySilvia De Rosa16. Severe traumatic brain Injury and post-coma syndromeRita Formisano

III. Diagnosis and Evaluation 17. Features of the World Health Organization Disability Assessment Schedule 2.0 and its applications for traumatic brain injury assessmentT.-H. Liou18. Biomarkers in pediatric traumatic injury: the brain and beyondGeorge Alexiou, Dimitrios Metaxas, Olga Ygropoulou, Dimitrios Rizos and Spyridon Voulgaris19. Brain injury biomarkers: Proteins and autoantibodies InterplayFiras H. Kobaissy and Samar Abdelhady20. Chitinase-3-Like Protein 1: features and applications as a biomarker in traumatic brain injury C. S. Carabias and A. Lagares21. Micro-RNA: features and bio markers in traumatic brain injury: a new narrativeSteven Hicks22. Pediatric minor head injury imagingGeorge Alexiou, Spyridon Voulgaris and Anastasios Nasios23. Traumatic brain injury: Use of transcranial doppler and injury severityAlexey O. Trofimov24. Computed tomography assessment of brain swellingMatheus Fernandes de Oliveira25. Machine learning and prediction of traumatic brain injury mortalityW. S. Paiva and João Gustavo Rocha Peixoto dos Santos Sr.26. Pituitary dysfunction after traumatic brain injury: a focus on screening, diagnosis and treatment Fahrettin Kelestimur, Zuleyha Karaca and Aysa Hacioglu

IV. Treatments: Experimental and Clinical 27. European aspects of Guidelines used in traumatic brain injury Alvaro Cordoba28. Anesthesia in traumatic brain injury Girija Prasad Rath29. Treatment of raised intracranial pressure in traumatic head injuryAlvaro Cordoba30. Seizures after traumatic brain injury and their treatment L.F.F. Royes31. Neurosurgical treatment of critical brain damageAlexey O. Trofimov32. Hypertonic saline usage in traumatic brain Injury: a focus on pediatricsAndrew G. Wu, Tina Slusher and Andrew Kiragu33. Treatment of vascular lesions in traumatic head injuryAlvaro Cordoba34. Airway Pressure Release Ventilation (APRV) in traumatic brain injury E. Eriksson and Chris Thomas35. Linking death, the paranasal sinuses and traumatic head trauma Treatments: Experimental and Clinical A. Kanat36. Oral cannabidiol in modulation of mild traumatic brain injurySabatino Maione37. Valproic acid: features and effects in traumatic brain injury: a new narrativeMichael T. Kemp38. Dietary supplementation for traumatic brain injuryMohan Raja, Agilandeswari Devarajan and Vipin V. Dhote

V. Rehabilitation in traumatic brain injury 39. Virtual reality and cognitive rehabilitation after traumatic brain injury Rocco S. Calabrò and Maria Grazia Maggio40. How the elderly and young compare in response to traumatic brain injury rehabilitationSung-Bom Pyun and Doo-Young Kim41. Rehabilitation of social cognition in traumatic brain injuryPhilippe Allain42. Psycho-educational Intevention on caregivers within the rehabilitation process: from the post-acute to the homecoming phases U. Bivona

VI. Resources43. ResourcesRajkumar Rajendram

Cellular, Molecular, Physiological, and Behavioral Aspects of Traumatic Brain Injury:I. Setting The Scene and Introductory Chapters1. Fall-related traumatic brain injuries: The role of the neck Jacob Sosnoff and Tobia Zanotto2. The implications of sex and gender in traumatic brain injuryTatyana Mollayeva3. Concussion and sports injuries the role of repetitive head injury exposureBrian D. Stemper4. Traumatic brain injury and molecular biology: a new narrativeAsma Akbar Ladak, Sarosh Irfan Madhani, Fatima Gauhar, Kiran Aftab, Fatima Mubarak and Syed Ather Enam5. Features of Decompressive Craniectomy in Traumatic Brain Injury: History, Effects, Management and New TrendsZefferino Rossini6. Management of Traumatic Brain Injury in Accordance With Contemporary Guidelines: Treatment, Monitorization and Thresholds Gregory W.J. Hawryluk and Buse Sarigul

II. Cellular and Molecular Aspects of Traumatic Brain Injury7. Neuroinflammatory responses in traumatic brain injuryJ Narayanan, T. Tamilanban, V. Chitra and M.K Kathiravan8. Seizures in traumatic brain injury: a focus on cellular aspectsThara Tunthanathip9. Linking traumatic brain injury, neural stem and progenitor cells Li Cai10. The microglia in traumatic brain injuryRamesh Raghupathi, Dana Lengel and JIMMY HUH11. Dendritic spine plasticity and traumatic brain injury Ye Xiong, Asim Mahmood and Michael Chopp12. Immune response and traumatic brain injurySandy Shultz and Mujun Sun13. The adaptive immune system in traumatic brain injury: a focus on T and B lymphocytesMaria Daglas, Robert Medcalf and Maithili Sashindranath14. Regulatory T cells and traumatic brain injury Michael K.E. Schäfer15. The role of prokineticin 2 in traumatic brain injuryMarimelia A. Porcionatto16. Na+/K+- ATPase activity and traumatic brain injuryL.F.F. Royes17. Pyruvate dehydrogenase complex enzymes, metabolic enzymes and energy derangement in traumatic brain injury Giacomo Lazzarino, Patrick O’Halloran, Valentina Di Pietro, Renata Mangione, Barbara Tavazzi, Angela Maria Amorini, giuseppe lazzarino and Stefano Signoretti18. Angiopoietin-1/Tie-2 and traumatic brain injury Yutaka Koyama and Shotaro Michinaga19. Brain microdialysis and applications to drug therapy in severe traumatic brain injury N. Ketharanathan, U. Rohlwink, A. Figaji, Enno Wildschut, D. Tibboel and Elizabeth Cunera maria de Lange20. Comparing radiation and traumatic brain injuries: new narrativeSteve Kornguth21. Electrolytes and traumatic brain injury: a focus on sodiumYvonne Lui and Hemal Grover22. WNT genes and their role in traumatic brain injury Linyi Chen, Min-Zong Liang and Chu-Yuan Chang

III. Physiological and Metabolic Effects23. Circuit Reorganization After Diffuse Axonal Injury: Utility of the Whisker Barrel CircuitTheresa Currier Thomas and Gokul Krishna24. Neuroendocrine Abnormalities Following Traumatic Brain InjuryJehane Dagher and Benjamin Green25. Thyroid hormone actions in the setting of traumatic brain injuryAdomas Bunevicius26. Testosterone: features and role in treating traumatic brain injuryL. Portela27. The rate of empty sella (ES) in traumatic brain injury: links with endocrine profilesFausto Fama, Alessandro Sindoni, Ulla Feldt-Rasmussen, Salvatore Benvenga and Marianne Klose28. Traumatic brain injury. Interrelationship with sleep Rachel Rowe29. Pubety and traumatic brain injury Rachel Rowe30. Role of endocannabinoids in the escalation of alcohol use following traumatic brain injuryPatricia E. Molina, Zachary Stielper, Scott Edwards and Nicholas Gilpin31. Imaging connectivity and functional brain networks in mild traumatic brain injuryMaria M. D'Souza, Mukesh Kumar, Jeanne D'Souza, Prabhjot Kaur and Pawan Kumar32. Multi-shell diffusion MR imaging and brain microstructure after mild traumatic brain injury: A focus on working memorySohae Chung, Els Fieremans, Joseph Rath and Yvonne Lui33. Monitoring real-time changes in physiology: impact of pediatric traumatic brain injuryBrian Appavu34. Blood gasses, arterial and end-tidal carbon dioxide in traumatic brain injuryJen-Ting Yang, Chun-Yu Wu, and David R. Wright35. Disturbances of cerebral microcirculation in traumatic brain injury: the role of changes in microcirculatory biomarkersAlexey O. Trofimov

IV. Behavioural and Psychological Effects36. Social cognition in traumatic brain injuryPhilippe Allain37. Physical exercise: effects on cognitive function after traumatic brain injuryMargalida Coll, Laura Amorós-Aguilar, David Costa-Miserachs, Isabel Portell-Cortés and Meritxell Torras-Garcia38. Linking cognitive function, diffuse traumatic brain injury and dementiaLyndsey Collins-Praino39. Neuropsychological Functioning of Children and Youth after Traumatic Brain Injury Paula Karina Perez-Delgadillo, Daniela Ramos-Usuga, Nini Lucia Muñoz-Perez and Juan Arango Arango-Lasprilla40. Behavioral effects of traumatic brain injury: use of guanosineFelix Alexandre Antunes Soares and Fernando Dobrachinski41. Recognizing emotions and effects of traumatic brain injuryAlessia Celeghin, Ylenia Camassa Nahi, Blanca Tasso and Olga Dal Monte42. Cognitive Communication Connections and Higher-Level Language with Traumatic Brain Injured PopulationJ. Koebli43. Self-awareness after severe traumatic brain injury: from impairment of Self-awareness to psychological adjustmentU. Bivona, Susanna Lucatello and Alberto Costa44. Disentangling antecedents from consequences of traumatic brain injury: The need for prospective longitudinal studiesSheilagh Hodgins and G. Guberman45. Linking sleeping patterns and quality of life in childhood traumatic brain injuryEdith Botchway

Product details

  • Edition: 1
  • Latest edition
  • Published: May 27, 2022
  • Language: English

About the editors

Rajkumar Rajendram

Editor

Dr Rajkumar Rajendram is a clinician-scientist with expertise in internal medicine, anaesthesia, intensive care and peri-operative medicine. He graduated with distinctions from Guy’s, King’s and St Thomas’ Medical School, King’s College London, in 2001, where he received several prizes, merits and distinctions in pre-clinical and clinical subjects.

Dr Rajendram completed specialist training in acute and general medicine in Oxford and subsequently held a Consultant appointment in Acute General Medicine at the John Radcliffe Hospital, Oxford. He also trained in anaesthesia and intensive care in London, including advanced training in regional anaesthesia and intensive care, and subsequently held a Consultant appointment in Intensive Care, Anaesthesia and Peri-operative Medicine at the Royal Free London Hospitals.

His postgraduate training has spanned internal medicine, anaesthesia, intensive care and point-of-care ultrasound (POCUS). He was awarded Fellowship of the Royal College of Anaesthetists in 2009, Fellowship of the Faculty of Intensive Care Medicine in 2013, and the European Diploma in Intensive Care Medicine in 2014. He is a Fellow of both the Royal College of Physicians of Edinburgh and the Royal College of Physicians of London.

Dr Rajendram is currently a Consultant at King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia, and holds a joint appointment as Associate Professor in the Research Unit, Department of Medical Education, at King Saud bin Abdulaziz University for Health Sciences.

His multidisciplinary clinical background has informed his research interests in nutrition, fluid management and fluid balance in health and disease, particularly in acutely and critically ill patients. His research has also addressed POCUS, COVID-19 phenotypes and nutritional support in illness. Dr Rajendram has contributed extensively to medical research and education and has authored more than 400 textbook chapters, review articles, peer-reviewed papers and conference abstracts.

Affiliations and expertise
Consultant, Medical Protocol Department, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia & Joint Appointment Associate Professor, Research Unit, Department of Medical Education, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia

Victor R. Preedy

Editor

Victor R. Preedy, BSc, PhD, DSc, FRSB, FRSPH, FRCPath, FRSC, FRSM, is Professor of Clinical Biochemistry (Hon) at King’s College Hospital and Emeritus Professor of Nutritional Biochemistry at King’s College London. He also holds an Honorary Professorship at the University of Suffolk and served as the long‑term Director of the Genomics Centre at King’s College London from 2006 to 2020. Professor Preedy graduated with an Honours Degree in Biology and Physiology with Pharmacology and later obtained his PhD from the University of London. He subsequently received Membership of the Royal College of Pathologists and later earned his second doctorate (DSc) in recognition of his contributions to protein metabolism. He is a Fellow of the Royal Society of Medicine, the Royal Society of Biology, the Royal College of Pathologists, the Royal Society for the Promotion of Health, the Royal Institute of Public Health and Hygiene, the Royal Society for Public Health, and the Royal Society of Chemistry. Professor Preedy has conducted research while affiliated with Imperial College London, the School of Pharmacy (now part of University College London), and the MRC Centre at Northwick Park Hospital. He has collaborated widely with international research groups in Finland, Japan, Australia, the USA, and Germany. His longstanding academic interests include health and well‑being. He has published more than 750 works, including peer‑reviewed research articles, abstracts, symposium presentations, reviews, and edited books.

Affiliations and expertise
Professor, Department of Clinical Biochemistry, King’s College Hospital, London, UK; Emeritus Professor, Faculty of Life Sciences and Medicine, King’s College London, UK; Visiting Professor, University of Hull, UK

Colin R. Martin

Editor
Colin R. Martin RN, BSc, MSc, PhD, MBA, YCAP, FHEA, C.Psychol, AFBPsS, C.Sci is Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director of the Institute of Health and Wellbeing at the University of Suffolk, UK. He is a Chartered Health Psychologist and a Chartered Scientist. He also trained in analytical biochemistry, this aspect reflecting the psychobiological focus of much of his research within mental health. He has published or has in press well over 300 research papers and book chapters. He is a keen book author and editor having written and/or edited more than 50 books. These outputs include the prophetic insight into the treatment of neurological disease, Handbook of Behavior, Food and Nutrition (2011), Nanomedicine and the Nervous System (2012), Oxidative Stress and Dietary Antioxidants in Neurological Disease (2020), Zika Virus Impact, Diagnosis, Control and Models (2021), Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior and Diet (2021), Diagnosis and Treatment of Spinal Cord Injury (2022), The Neurobiology, Physiology, and Psychology of Pain (2022) and The Handbook of Lifespan Cognitive Behavioral Therapy: Childhood, Adolescence, Pregnancy, Adulthood, and Aging (2023). Professor Martin is particularly interested in all aspects of the relationship between underlying physiological substrates and behavior, particularly in how these relationships manifest in both acute and chronic psychiatric disorder. He has published original research germane to significant mental health disorders including the areas of schizophrenia, anxiety, depression, self-esteem, alcohol and drug dependency, high secure forensic mental health and personality disorder. He has a keen interest in the impact of postviral illness and is actively involved in clinical research post-Covid pandemic and in particular, the impact of Long Covid on psychological, neurological, physiological and social functioning. He is involved in collaborative International research with many European and Non-European countries.
Affiliations and expertise
Visiting Professor of Perinatal Wellbeing, Institute for Health and Wellbeing, University of Suffolk, Ipswich, UK