Skip to main content
Elsevier

The Neuroscience of Depression

  • 1st Edition - March 22, 2021
  • Latest edition
  • Editors: Colin R. Martin, Lan-Anh Hunter, Vinood B. Patel, Victor R. Preedy, Rajkumar Rajendram
  • Language: English

The Neuroscience of Depression: Genetics, Cell Biology, Neurology, Behaviour and Diet is a comprehensive reference to the aspects, features and effects of depression. This book p… Read more

Description

The Neuroscience of Depression: Genetics, Cell Biology, Neurology, Behaviour and Diet is a comprehensive reference to the aspects, features and effects of depression. This book provides readers with the behavior and psychopathological effects of depression, linking anxiety, anger and PSTD to depression. Readers are provided with a detailed outline of the genetic aspects of depression including synaptic genes and the genome-wide association studies (GWAS) of depression, followed by a thorough analysis of the neurological and imaging techniques used to study depression. This book also includes three full sections on the various effects of depression, including diet, nutrition and molecular and cellular effects. The Neuroscience of Depression: Genetics, Cell Biology, Neurology, Behaviour and Diet is the only resource for researchers and practitioners studying depression.

Key features

The Neuroscience of Depression: Features, Diagnosis and Treatment

  • Covers a pharmacological and behavioral treatment options
  • Features sections on diagnosis and biomarkers of depression
  • Discusses depression in children, teens and adults
  • Contains information on comorbidity of physical and mental conditions
  • Includes more than 250 illustrations and tables

The Neuroscience of Depression: Genetics, Cell Biology, Neurology, Behaviour and Diet

  • Features a section on neurological and imaging, including SPECT Neuroimaging
  • Analyzes how diet and nutrition effect depression
  • Examines the molecular and cellular effects of depression
  • Covers genetics of depression
  • Includes more than 250 illustrations and tables

Readership

Researchers, graduate students, and clinicians in behavioral neuroscience, cognitive neuroscience, neurobiology, translational neuroscience, and neuropsychology

Table of contents

The Neuroscience of Depression: Features, Diagnosis and Treatment

I. Depression: Introductory Chapters

1. Clinical staging in depression2. Neurodevelopmental theory of depression3. Depression after pregnancy 4. Modeling maternal depression during pregnancy: rodent models of Major Depressive Disorder with Peripartum Onset5. Depression in mothers and mental health in children:Impact, risk factors and interventions6. Depression in college students7. Depression in disasters and traumatic events8. Depression and associated Alzheimer s disease9. Comorbidities of depression and Parkinson's disease10. Understanding the relationship between depression and alcohol among students11. Depression in obesity12. Depression and heart rate variability13. Neuroinflammation and depression14. Interlinking antidepressants and the immune system

II. Biomarkers and Diagnosis

 15. Assessment scoring tools of depression16. The Beck Depression Inventory: uses and applications17. The Hamilton Depression Rating scale: uses and applications18. The Patient Health Questionnaire (PHQ)19. Screening for Antenatal Depression (AND) using self-report questionnaires: conceptual issues and measurement limitations20. Edinburgh Postnatal Depression Scale: description and applicationsJacqueline 21. The Death Depression Scale: description and applications 22. Depression Anxiety Stress Scales: Features and Applications 23. Arabic version of the two-question Quick Inventory of Depression: description and applications (QID-2-Ar) 24. Depressive Symptoms and Biomarkers of Cardiovascular Disease25. Thioredoxin as an antioxidant protein as a marker in depression26. Methods of neuroimaging in depression: applications to resting-state functional connectivity 27. Neural markers of depression in MRI

III. Pharmacological Treatments for Depression

28. Angiotensin receptor 1 blockade as an antidepression strategy29. Cannabinoid CB1 receptors and antidepressant effects30. Agomelatine: profiles and applications to depression31. Bumetanide and use in depressive states 32. Linking citalopram, serotonin reuptake inhibitors and depressed pregnant women 33. Citalopram and usage in sleep-deprivation-induced depression34. Monoaminergic System and Antidepressants35. Duloxetine usage in depression36. Escitalopram and blonanserin as antidepressant agents linking in neurotrophic mechanisms37. Ketamine and the role of (2R,6R)-Hydroxynorketamine in depression38. Linking 5-Hydroxytryptamine, antidepressant actions of (R)-Ketamine and social stress model 39. Mirtazapine: multi-target strategies for treating substance use disorder and depression

IV. Counselling, Psychotherapy and Behavioural Treatments For Depression

40. Mindfulness-based cognitive therapy and depression 41. Online (web based) programs for depression42. Clay art therapy on emotion regulation: Research, theoretical underpinnings, & treatment mechanisms 43. Solution-focused counselling: and use in postpartum depression44. Transcranial direct current stimulation (tDCS) combined with cognitive emotional training (CET) as a novel treatment for depression

V. Other Aspects of Treatment: Specific Groups, Monitoring and Novel Regimens

45. Putative effects of cannabidiol in depression and synaptic plasticity46. Tanscutaneous vagus nerve stimulation in depression47. Exercise for depression as a primary and comorbid with obesity disorder: a narrative48. Acupressure and depression: a scientific narrative49. Potential beneficial effects of Bifidobacterium breve A1 on cognitive impairment and psychiatric disorders 50. Coenzyme Q and use in depression 51. Gene expression in Major Depressive Disorder: peripheral and brain based studies 52. Electroconvulsive therapy for depression: effectiveness, cognitive side-effects and mechanisms of action 53. Depression and offspring DNA methylation 54. Other Aspects of Treatment: Specific Groups, Monitoring and Novel Regimens: Treating depression with Theta burst stimulation (TBS)

The Neuroscience of Depression: Genetics, Cell Biology, Neurology, Behaviour and Diet

I. Genetic Aspects Of Depression

 1. Epigenetics in depressionMonika Talarowska2. Genes, depression and nuclear DNA Xenia Gonda3. Molecular aspects of postpartum depression Anna Landsman4. Genetics and epigenetics of the SLC6A4 gene in depressionÁlvaro F.L. Rios5. Tryptophan related genes and depression Tomasz Sliwinski6. Metalloproteinases genes and depressionMonika Talarowska7. Linking gene regions jointly with environment and depressionErin B. Ware

II. Molecular and Cellular Effects Of Depression

 8. Linking depression, mRNA translation and serotonin Jean-Claude Lacaille9. Changes in cortical gene expression in major depression: More evidence implicating inflammatory-related pathways in disease aetiologyBrian Dean10. FKBP5 gene expression and depressionMarcus Ising11. Cytokines related to depression Patricia Broderick12. Linking Interleukin-6 and Depression Manivel Rengasamy13. The role of inflammatory signaling in comorbid depression and epilepsyJana D. Tchekalarova Sr.14. Brain inflammasomes in depression C. Beyer15. Inflammatory factors and depression in substance use disorderFrancisco Javier Pavon16. Linking Huntington disease, brain-derived neurotrophic factor and depressive-like behaviorsPatricia Brocardo17. Depression and the NMDA receptor/NO/cGMP pathwayAna Cristina Oliveira Monteiro-Moreira18. Translocator protein (18 kDa TSPO) binding in depression Szabolcs Keri19. Axonal transport proteins: what they are and how they relate to depressive behaviours Arezo Nahavandi20. Molecular features of adenylyl cyclase isoforms and cAMP signaling: a link between adenylyl cyclase 7 and depression Tarsis F. Brust21. Neurobiology of depression: the role of glycogen synthase kinase 3Minal Sonawane, Giuseppe Aceto, Jessica Di Re, Marcello D'Ascenzo, Thomas Green and Fernanda Laezza22. Sortilin/NTSR3 in depressionJean Mazella23. Wnt/beta-catenin signaling pathway and antidepressant roleShubha Shukla24. The prefrontal cortex in depression: use of proteomicsGábor Juhász

III. Neurological and Imaging Features

25. SPECT Neuroimaging and depressionDaniel G. Amen26. Resting-state functional magnetic resonance imaging (MRI), bipolar depression and unipolar depression K.K. Ellard27. Linking amygdala blood oxygenation-level-dependent (BOLD) activity and frontal EEG in depressionVadim Zotev28. The rostromedial tegmental nucleus: features and links with alcohol and depressionJiang-Hong Ye29. Serotonergic neurons, selective serotonin reuptake inhibitor (SSRI) resistance and major depressive disorderFred H. Gage and Krishna C. Vadodaria30. Role of nesfatin-1 in major depressionEce Türkyılmaz Uyar31. Impact of NGF signaling in neuroplasticity during depression: Insights in neuroplasticity dependent therapeutic approachesAmal Chandra Mondal32. Depression and germ cells memoryM.A. Alsaleh and Amani A. Ahmed

IV. Behaviour And Psychopathological Effects

33. Cognitive function and neurocognitive deficits in depressionM. Semkovska34. Cognitive and interpersonal contributors to relationship distress and depressionDavid J. A. Dozois35. Adolescence life stage and cognitive vulnerability to depressionR.T. Liu36. Determining the cognitive performance in first episode of depression Maria J. Portella37. Body image and depressionPäivi Maria Pylvanainen38. Sleep, anxiety and depressionKelly Sullivan39. Depression, anxiety and quality of lifeKeming Gao40. Reward Processing and Depression: Current Findings and Future DirectionsDaniel M. Mackin41. Sexual functioning in depressive disordersS. Grover

V. Diet, Nutrition and Botanicals

 42. Linking dietary glycemic index and depressionSima Jafarirad43. Gut microbiota and DepressionKurosh Djafarian44. Linking dietary methyl donors, maternal separation and depressionMaría J. Ramirez45. Convolvulus pluricaulis usage and depression Girdhari Lal Gupta46. Antidepressant effects of Crocus sativus (saffron) and its constituents Hossein Hosseinzadeh47. Mechanisms of action of herbal antidepressantsHossein Hosseinzadeh48. Depression, antidepressant-like effects and mechanisms of the herbal formula xiaochaihutangChun fu Wu

VI. Resources

49. Resources in depressionRajkumar Rajendram

Product details

  • Edition: 1
  • Latest edition
  • Published: March 22, 2021
  • Language: English

About the editors

Colin R. Martin

Editor
Colin R. Martin RN, BSc, MSc, PhD, MBA, YCAP, FHEA, C.Psychol, AFBPsS, C.Sci is Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director of the Institute of Health and Wellbeing at the University of Suffolk, UK. He is a Chartered Health Psychologist and a Chartered Scientist. He also trained in analytical biochemistry, this aspect reflecting the psychobiological focus of much of his research within mental health. He has published or has in press well over 300 research papers and book chapters. He is a keen book author and editor having written and/or edited more than 50 books. These outputs include the prophetic insight into the treatment of neurological disease, Handbook of Behavior, Food and Nutrition (2011), Nanomedicine and the Nervous System (2012), Oxidative Stress and Dietary Antioxidants in Neurological Disease (2020), Zika Virus Impact, Diagnosis, Control and Models (2021), Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior and Diet (2021), Diagnosis and Treatment of Spinal Cord Injury (2022), The Neurobiology, Physiology, and Psychology of Pain (2022) and The Handbook of Lifespan Cognitive Behavioral Therapy: Childhood, Adolescence, Pregnancy, Adulthood, and Aging (2023). Professor Martin is particularly interested in all aspects of the relationship between underlying physiological substrates and behavior, particularly in how these relationships manifest in both acute and chronic psychiatric disorder. He has published original research germane to significant mental health disorders including the areas of schizophrenia, anxiety, depression, self-esteem, alcohol and drug dependency, high secure forensic mental health and personality disorder. He has a keen interest in the impact of postviral illness and is actively involved in clinical research post-Covid pandemic and in particular, the impact of Long Covid on psychological, neurological, physiological and social functioning. He is involved in collaborative International research with many European and Non-European countries.
Affiliations and expertise
Visiting Professor of Perinatal Wellbeing, Institute for Health and Wellbeing, University of Suffolk, Ipswich, UK

Lan-Anh Hunter

Editor
Dr Lan-Anh Hunter BSc MBBS DFFP DRCOG MRCGP qualified from Guys, King’s & St. Thomas’ Medical School, London in 2001, where she developed an early interest in psychological medicine. She went on to study culture bound syndromes, whilst reading Medical Anthropology Honours degree at University College London, focusing on the cultural aspects of anorexia nervosa in her thesis. She subsequently worked in Australia and explored the psychological aspects of diabetes and its many complications on the aboriginal population. Prior to becoming a GP Principal, she lectured at Charing Cross Hospital teaching doctors in training, continuing this passion, as a GP trainer in her current role. Much has been written about depression in primary care and hence her call to this area. She specialises in psychological medicine, with training in coaching, narrative based medicine, cognitive behaviour therapy and she continues to see, support, treat and manage clinical depression on an everyday basis as a family GP in her Maidenhead practice.
Affiliations and expertise
Rosemead Surgery, Maidenhead, Berkshire, UK

Vinood B. Patel

Editor

Vinood B. Patel, BSc, PhD, FRSC, is Professor in Clinical Biochemistry at the University of Westminster. In 2014 Dr Patel was elected as a Fellow to The Royal Society of Chemistry. Dr Patel graduated from the University of Portsmouth with a degree in Pharmacology and completed his PhD in protein metabolism from King’s College London in 1997. His postdoctoral work was carried out at Wake Forest University Baptist Medical School, NC, USA studying structural-functional alterations to mitochondrial ribosomes, where he developed novel techniques to characterize their biophysical properties. Research is being undertaken to study the role of nutrients, antioxidants, phytochemicals, iron, alcohol and fatty acids in the pathophysiology of disease. Other areas of interest are identifying new biomarkers that can be used for the diagnosis and prognosis of disease and understanding mitochondrial oxidative stress. Dr Patel is a nationally and internationally recognized researcher and has several edited biomedical books related to health and well being These books include Ancient and traditional foods, plants and herbs and spices in human health; coffee in health and disease prevention, Nuts and seeds in health and disease prevention Handbook of Substance Misuse and Addictions: From Biology to Public Health, tea in health and disease prevention.

Affiliations and expertise
Professor, Clinical Biochemistry, School of Life Sciences University of Westminster, London, UK

Victor R. Preedy

Editor

Victor R. Preedy, BSc, PhD, DSc, FRSB, FRSPH, FRCPath, FRSC, FRSM, is Professor of Clinical Biochemistry (Hon) at King’s College Hospital and Emeritus Professor of Nutritional Biochemistry at King’s College London. He also holds an Honorary Professorship at the University of Suffolk and served as the long‑term Director of the Genomics Centre at King’s College London from 2006 to 2020. Professor Preedy graduated with an Honours Degree in Biology and Physiology with Pharmacology and later obtained his PhD from the University of London. He subsequently received Membership of the Royal College of Pathologists and later earned his second doctorate (DSc) in recognition of his contributions to protein metabolism. He is a Fellow of the Royal Society of Medicine, the Royal Society of Biology, the Royal College of Pathologists, the Royal Society for the Promotion of Health, the Royal Institute of Public Health and Hygiene, the Royal Society for Public Health, and the Royal Society of Chemistry. Professor Preedy has conducted research while affiliated with Imperial College London, the School of Pharmacy (now part of University College London), and the MRC Centre at Northwick Park Hospital. He has collaborated widely with international research groups in Finland, Japan, Australia, the USA, and Germany. His longstanding academic interests include health and well‑being. He has published more than 750 works, including peer‑reviewed research articles, abstracts, symposium presentations, reviews, and edited books.

Affiliations and expertise
Professor, Department of Clinical Biochemistry, King’s College Hospital, London, UK; Emeritus Professor, Faculty of Life Sciences and Medicine, King’s College London, UK; Visiting Professor, University of Hull, UK

Rajkumar Rajendram

Editor

Dr Rajkumar Rajendram is a clinician-scientist with expertise in internal medicine, anaesthesia, intensive care and peri-operative medicine. He graduated with distinctions from Guy’s, King’s and St Thomas’ Medical School, King’s College London, in 2001, where he received several prizes, merits and distinctions in pre-clinical and clinical subjects.

Dr Rajendram completed specialist training in acute and general medicine in Oxford and subsequently held a Consultant appointment in Acute General Medicine at the John Radcliffe Hospital, Oxford. He also trained in anaesthesia and intensive care in London, including advanced training in regional anaesthesia and intensive care, and subsequently held a Consultant appointment in Intensive Care, Anaesthesia and Peri-operative Medicine at the Royal Free London Hospitals.

His postgraduate training has spanned internal medicine, anaesthesia, intensive care and point-of-care ultrasound (POCUS). He was awarded Fellowship of the Royal College of Anaesthetists in 2009, Fellowship of the Faculty of Intensive Care Medicine in 2013, and the European Diploma in Intensive Care Medicine in 2014. He is a Fellow of both the Royal College of Physicians of Edinburgh and the Royal College of Physicians of London.

Dr Rajendram is currently a Consultant at King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia, and holds a joint appointment as Associate Professor in the Research Unit, Department of Medical Education, at King Saud bin Abdulaziz University for Health Sciences.

His multidisciplinary clinical background has informed his research interests in nutrition, fluid management and fluid balance in health and disease, particularly in acutely and critically ill patients. His research has also addressed POCUS, COVID-19 phenotypes and nutritional support in illness. Dr Rajendram has contributed extensively to medical research and education and has authored more than 400 textbook chapters, review articles, peer-reviewed papers and conference abstracts.

Affiliations and expertise
Consultant, Medical Protocol Department, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia & Joint Appointment Associate Professor, Research Unit, Department of Medical Education, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia