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Elsevier

The Neuroscience of Aging

  • 1st Edition - June 25, 2021
  • Latest edition
  • Editors: Colin R. Martin, Victor R. Preedy, Rajkumar Rajendram
  • Language: English

Assessments, Treatments and Modeling in Aging and Neurological Disease: The Neuroscience of Aging is a comprehensive reference on the diagnosis and management of neurol… Read more

Description

Assessments, Treatments and Modeling in Aging and Neurological Disease: The Neuroscience of Aging is a comprehensive reference on the diagnosis and management of neurological aging and associated disorders. This book discusses the mechanisms underlying neurological aging and provides readers with a detailed introduction to the aging of neural connections and complexities in biological circuitries, as well as the interactions between genetics, epigenetics and other micro-environmental processes. It also examines pharmacological and non-pharmacological interventions of age-related conditions that affect the brain including Alzheimer’s, stroke, and multiple sclerosis.

Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, and Diet is a comprehensive reference on the genetic and behavioral features associated with neurological aging and associated disorders. This book discusses the mechanisms underlying neurological aging and provides readers with a detailed introduction to the aging of neural connections and complexities in biological circuitries, as well as the physiological, behavioral, molecular, and cellular features of neurological aging. It also examines the use of animal modelling of aging and neurological disease.

Key features

Assessments, Treatments and Modeling in Aging and Neurological Disease: The Neuroscience of Aging:

  • Provides the most comprehensive coverage of the broad range of topics related to the neuroscience of aging
  • Features sections on diagnosis and biomarkers of neurological aging, Alzheimer’s, and stroke
  • Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding
  • Focuses on neurological diseases and conditions linked to aging, environmental factors, and clinical recommendations
  • Includes more than 500 illustrations and tables

Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, and Diet:

  • Provides the most comprehensive coverage of the broad range of topics related to the neuroscience of aging
  • Features sections on the genetics influencing aging and diseases of aging
  • Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding
  • Focuses on neurological diseases and conditions linked to aging, environmental factors, and clinical recommendations
  • Includes more than 500 illustrations and tables

Readership

Neuroscientists, geriatricians, neurobiologists, experimental biologists, clinicians, graduate students, and post-doctoral fellows

Table of contents

Assessments, Treatments and Modeling in Aging and Neurological Disease: The Neuroscience of Aging

I. Introductory chapters: Setting the scene for the neuroscience of aging 1. The concept of productive agingPremchand Dommaraju2. Quality of life in the over 80sTimo Strandberg3. Successful aging and dietD. Panagiotakos and Ekavi Georgousopoulou4. The impact of positive social relations on the quality of life of older people. An alternative to medicalization from an integral perspectiveL. Rondon Garcia5. The brain in life span: use of phase fMagnetic Resonance Imaging (MRI)Zikuan Chen6. Neuronal structure in aging: Cytoskeleton in health and diseaseDaniele Cartelli7. Sporadic Alzheimer’s Triad: Age, Sex, and ApoEL. Zhao8. How polymorphisms impact: BDNF polymorphism, inhibitory performance and the elderlyMichel Francis Audiffren9. Menopause as an aging process and alcohol misuseJelena Milic10. Brain banking and aging Glenda Halliday and Claire Elaine Shepherd

II. Impairments and Diseases11. Dementia or no dementia in the very elderly. Why?Lewis H. Kuller12. Neuropsychology, Social Cognition and Loss of Insight in Frontotemporal DementiaFiadhnait O'Keeffe13. Neuroinflammation in the elderlyJ. Malva14. Cortical microinfarcts and the aging brainE. Kovari15. Vascular brain injury and neurodegeneration in elderly racial and ethnic minority populationsA. Suchy-Dicey16. Hearing loss amongst the elderlyGary Jek Chong Lee17. Aging Auditory Cortex: The Impact of Reduced Inhibition on FunctionBjörn Herrmann18. Aging and vestibular disordersAugusto Pietro Casani19. Brain aging in HIV and antiretrovirals Jasmina Boban20. Antioxidants, Methylmercury, and AgingAndrew Shen and Christopher Newland21. Aging and the effects of ethanol on the brain: Comparing the effects of different agingDoug Matthews

III. Biomarkers And Diagnosis 22. Aging brain: Radiological biomarkersBanu Alicioglu Jr.23. Plasma ADAM10 as a biomarker of mental impairment in the elderlyMariana Luciano de Almeida24. Circulating microRNAs as biomarkers of healthy elderlyJonas Mengel-From Sr.25. DHEA as a biomarker of aging in humans and nonhuman primates: Synthesis, neuroprotection and cognitivefunctionH. Urbanski26. Evaluation of subjective memory abilities in elderly peopleLuigi Trojano27. The Functional Activities Questionnaire: applications to agingOndrej Bezdicek Sr.28. Autobiographical memory as a diagnostic tool in agingJuan C. Melendez29. Assessment tools for subjective memory abilities in elderly peopleLuigi Trojano30. Knowledge of Memory AgingKatie E. Cherry

IV. Management and Treatments 31. Pharmacological use of transient receptor potential (TRP) ion channel antagonists in neurological disease: effects on swallowing and implications for nutrition P. Clave and Noemí Tomsen32. Aripiprazole: features and use in the agedUnax Lertxundi33. Cognition-Enhancing Drugs and Applications to AgingJelena Milic34. Creatine supplementation and impact on the aging brainB. Gualano35. Photobiomodulation as a brain-boosting strategy in agingSaeed Sadigh-Eteghad36. Innovation in deep brain stimulation in aging: a focus on Parkinson DiseasePaolo Amami37. Exergames: what they are and how they can be used to improve cognition in agingRenato Sobral Monteiro-Junior, Ana Rodrigues, Laís Felício, Luiz Figueiredo and Túlio Rocha38. Linking cognitive decline and ballroom dance as a therapeutic intervention in the elderlyJacqueline C. Dominguez39. Active experiencing training in the elderlyMaria Requena40. Psychiatric self-management, smartphone apps and older adultsKaren Fortuna41. Psychosocial Interventions for Suicide Prevention in the Elderly: Advances and Future DirectionsD. Kiosses

V. Models And Modelling42. D-galactose-induced aging and brain mitochondriaFereshteh Farajdokht43. Drosophila as a model organism in ageing researchMaximo Ibo Galindo44. The Zebrafish (Danio rerio) and its uses for understanding the neuroscience of aging: applications and observationMichelle M. Adams45. Murine models of primary Tauopathy as a model of agingDavid Westaway46. Modelling nutrition and brain aging in rodentsDevin Wahl47. Modelling primates and neurological aging: a focus on Alzheimer's diseaseMelissa K. Edler48. Linking aging and animal models to neurodegeneration: the Striatum, Substantia Nigra and Parkinson's DiseaseRodrigo Portes Ureshino49. Behavioral evaluation of agingAna Perez-Villalba

VI. Resources50. Research and recommended resources in the neuroscience of agingRajkumar RajendramFactors Affecting Neurological Aging: Genetics, Neurology, Behavior, And Diet

I. Genetics, Molecular and Cellular Biology1. Genetics of frontotemporal dementiaEbru Erzurumluoglu Gokalp, Demet Adapinar and Sevilhan Artan2. Aging, brain-derived neurotrophic factor (BDNF) and its polymorphismTing Shen3. Aging, demented patients, and polymorphisms in cytokine genes Karina Braga Borges4. RNA fragments and brain agingAndrey Grigoriev5. Centrosome functions and remodeling during neuronal development and centrosome abnormalities in neuronal disorders, disease, and in agingH. Schatten6. Brain aging and microarray analysisMichelino Di Rosa7. Human nuclear tau and agingSalvatore Saccone8. Lipoxidation: features, neurological tissues and aging Reinald Pamplona Sr.9. Aging and brain amino acidsM. Furuse10. How 3’,5’-cyclic nucleotide phosphodiesterases change in the brain with normal aging and dementiaMichy Kelly11. The prohibitin complex in aging and neurodegenerationEnrique Santamaría12. Synaptic ATPase and energy metabolism in the nervous system: roles and changes in the aging process Roberto Villa and Federica Ferrari

II. Neurological and Imaging Features13. Microstructural Imaging of the Human Brain with Normal and "Abnormal" Aging using Diffusion Magnetic Resonance ImagingYu-Chien Wu14. Imaging the brain and its vascular in aging: applications of optical coherence tomography angiographyRuikang Wang15. Potential involvement of perineuronal nets in brain aging: an anatomical point of view Shozo Jinno16. Grey-matter networks in agingMarisa Koini17. Brain synapse-related proteins what they do and how they change in aging Yoshimi Takai18. Macro- and chaperone-mediated autophagy in agingBen Loos19. Neuronal L-type calcium channels in aging Tuck Wah Soong20. D-serine-regulated glutamatergic transmission and microglia: impact of agingJaime L. Eugenin21. Voltage-gated potassium channels and the aging brainFederico Sesti22. Dendritic spine remodeling and agingJeremy Herskowitz23. High-density lipoprotein-cholesterol and neuroaging: memory, gyrification of the insular and frontal opercular cortexRyuta Kinno24. Astrocyte and microglial aging: morphology and modelling A. MacLean25. Neural scaffolding: features, profiles and the aging cerebellumPavel Filip26. BACE1 RNAi, memory and aging P. Cardona-Gomez27. Aging, myelination and the optic nerveH. Attia and Ahmed Abdellatif28. Linking proteostasis, brain aging, and ischemiaWei Yang29. Luteinizing hormone and the aging nervous systemG. Casadesus30. Insights into aging using transcranial magnetic stimulationD. Blumberger31. Alpha rhythms: What they are and how they alter with agingMaria Knyazeva32. Nicotine and its derivatives in healthy brain aging Saeed Sadigh-Eteghad

III. Physiological Aspects 33. Environmental enrichment and physiological agingAlla Salmina34. Treadmill exercise and neuroinflammation: links with agingCaroline Real35. Impact of aerobic exercise on brain structure in models of aging: hippocampus and beyondLars S. Stiernman, Chelsea Stillman and Kirk Erickson36. The physiology of fitness and the brain in agingMonica Fabiani37. Aging, Babble Noise and the processing of speech perceptionA. N. Yusoff38. The blood-brain barrier in agingF. Erdo

IV. Behavior And Psychopathological Aspects 39. Linking aging, anticholinergic drug use, and cognitive impairmentVirginia Boccardi40. Cognitive Frailty: Definition, components and impact on disability, and mortalityFrancesco Panza41. The physiology of the "Brain-muscle loop" in agingF. Lauretani42. Disentangling the effects of aging and ovarian hormone loss on sleep: Implications for health and diseaseNicole Gervais43. Role of DNA methylation in aging-related cognitive functioning'Anna Starnawska44. Depression in the elderly and psychobioticsElnaz Vaghef-Mehrabany

V. Diet And Nutrition45. Aging, dietary patterns and cognitionAngela Marie Abbatecola46. Geriatric nutritional risk index: Application, and limitationsElnaz Vaghef-Mehrabany47. Diet, inflammatory biomarkers, and brain agingYian Gu48. DASH diet and brain agingStephanie Ruth Rainey-Smith49. The ketogenic diet and healthy brain aging Georgia Anne Francis Rogerson50. Autophagy and aging: diet, exercise, and the link with the target of rapamycin complex 1 (TORC)Kurt Anthony Escobar51. Dietary Flavonoids and Brain Health in Ageing: food for ThoughtJustin S. Rhodes and Catarina Rendeiro52. Antioxidant effects of curcumin and neuroagingShameemah Abrahams53. Lipoic acid and vitamin D3 and their use in preventing brain agingFrancesca Uberti54. Aging and working memory: impact of the leucine metabolite beta hydroxy-beta-methyl butyrateJoshua M. Gulley and Roberto Galvez55. Hydration, the brain and aging Agata Białecka-Dębek

Product details

  • Edition: 1
  • Latest edition
  • Published: June 25, 2021
  • Language: English

About the editors

CM

Colin R. Martin

Colin R. Martin RN, BSc, MSc, PhD, MBA, YCAP, FHEA, C.Psychol, AFBPsS, C.Sci is Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director of the Institute of Health and Wellbeing at the University of Suffolk, UK. He is a Chartered Health Psychologist and a Chartered Scientist. He also trained in analytical biochemistry, this aspect reflecting the psychobiological focus of much of his research within mental health. He has published or has in press well over 300 research papers and book chapters. He is a keen book author and editor having written and/or edited more than 50 books. These outputs include the prophetic insight into the treatment of neurological disease, Handbook of Behavior, Food and Nutrition (2011), Nanomedicine and the Nervous System (2012), Oxidative Stress and Dietary Antioxidants in Neurological Disease (2020), Zika Virus Impact, Diagnosis, Control and Models (2021), Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior and Diet (2021), Diagnosis and Treatment of Spinal Cord Injury (2022), The Neurobiology, Physiology, and Psychology of Pain (2022) and The Handbook of Lifespan Cognitive Behavioral Therapy: Childhood, Adolescence, Pregnancy, Adulthood, and Aging (2023). Professor Martin is particularly interested in all aspects of the relationship between underlying physiological substrates and behavior, particularly in how these relationships manifest in both acute and chronic psychiatric disorder. He has published original research germane to significant mental health disorders including the areas of schizophrenia, anxiety, depression, self-esteem, alcohol and drug dependency, high secure forensic mental health and personality disorder. He has a keen interest in the impact of postviral illness and is actively involved in clinical research post-Covid pandemic and in particular, the impact of Long Covid on psychological, neurological, physiological and social functioning. He is involved in collaborative International research with many European and Non-European countries.
Affiliations and expertise
Visiting Professor of Perinatal Wellbeing, Institute for Health and Wellbeing, University of Suffolk, Ipswich, UK

VP

Victor R. Preedy

Victor R. Preedy, BSc, PhD, DSc, FRSB, FRSPH, FRCPath, FRSC, FRSM, is Professor of Clinical Biochemistry (Hon) at King’s College Hospital and Emeritus Professor of Nutritional Biochemistry at King’s College London. He also holds an Honorary Professorship at the University of Suffolk and served as the long‑term Director of the Genomics Centre at King’s College London from 2006 to 2020. Professor Preedy graduated with an Honours Degree in Biology and Physiology with Pharmacology and later obtained his PhD from the University of London. He subsequently received Membership of the Royal College of Pathologists and later earned his second doctorate (DSc) in recognition of his contributions to protein metabolism. He is a Fellow of the Royal Society of Medicine, the Royal Society of Biology, the Royal College of Pathologists, the Royal Society for the Promotion of Health, the Royal Institute of Public Health and Hygiene, the Royal Society for Public Health, and the Royal Society of Chemistry. Professor Preedy has conducted research while affiliated with Imperial College London, the School of Pharmacy (now part of University College London), and the MRC Centre at Northwick Park Hospital. He has collaborated widely with international research groups in Finland, Japan, Australia, the USA, and Germany. His longstanding academic interests include health and well‑being. He has published more than 750 works, including peer‑reviewed research articles, abstracts, symposium presentations, reviews, and edited books.

Affiliations and expertise
Professor, Department of Clinical Biochemistry, King’s College Hospital, London, UK; Emeritus Professor, Faculty of Life Sciences and Medicine, King’s College London, UK; Visiting Professor, University of Hull, UK

RR

Rajkumar Rajendram

Dr Rajkumar Rajendram is a clinician-scientist with expertise in internal medicine, anaesthesia, intensive care and peri-operative medicine. He graduated with distinctions from Guy’s, King’s and St Thomas’ Medical School, King’s College London, in 2001, where he received several prizes, merits and distinctions in pre-clinical and clinical subjects.

Dr Rajendram completed specialist training in acute and general medicine in Oxford and subsequently held a Consultant appointment in Acute General Medicine at the John Radcliffe Hospital, Oxford. He also trained in anaesthesia and intensive care in London, including advanced training in regional anaesthesia and intensive care, and subsequently held a Consultant appointment in Intensive Care, Anaesthesia and Peri-operative Medicine at the Royal Free London Hospitals.

His postgraduate training has spanned internal medicine, anaesthesia, intensive care and point-of-care ultrasound (POCUS). He was awarded Fellowship of the Royal College of Anaesthetists in 2009, Fellowship of the Faculty of Intensive Care Medicine in 2013, and the European Diploma in Intensive Care Medicine in 2014. He is a Fellow of both the Royal College of Physicians of Edinburgh and the Royal College of Physicians of London.

Dr Rajendram is currently a Consultant at King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia, and holds a joint appointment as Associate Professor in the Research Unit, Department of Medical Education, at King Saud bin Abdulaziz University for Health Sciences.

His multidisciplinary clinical background has informed his research interests in nutrition, fluid management and fluid balance in health and disease, particularly in acutely and critically ill patients. His research has also addressed POCUS, COVID-19 phenotypes and nutritional support in illness. Dr Rajendram has contributed extensively to medical research and education and has authored more than 400 textbook chapters, review articles, peer-reviewed papers and conference abstracts.

Affiliations and expertise
Consultant, Medical Protocol Department, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia & Joint Appointment Associate Professor, Research Unit, Department of Medical Education, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia