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The neurobiology of Alcohol Use Disorder
Neuronal mechanisms, current treatments and novel developments
- 1st Edition, Volume 175 - March 28, 2024
- Editors: Andrea de Bejczy, Bo Söderpalm
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 1 4 1 6 4 - 5
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 4 1 6 5 - 2
The Mechanisms Behind Developing Dependence, Sub-groups, and Novel Approaches to Treatment, Volume 174 in the Neurobiology of Alcohol Abuse series, highlights new advances in t… Read more
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Request a sales quoteThe Mechanisms Behind Developing Dependence, Sub-groups, and Novel Approaches to Treatment, Volume 174 in the Neurobiology of Alcohol Abuse series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Substitution therapy in alcohol treatment, with a focus on mechanisms and possibilities, Designing and analyzing studies on treatments for alcohol dependence, The harm reduction approach for treatment of alcohol dependence, Current treatments for alcohol dependence, with a suggested focus on mechanisms and possibilities, Metabolomics in relation to alcohol dependence with focus on possibilities for precision medicine, and Repurposing drugs for treatment of alcohol dependence.
- Provides the authority and expertise of leading contributors from an international board of authors
- Presents the latest release in International Review of Neurobiology series
- Updated release includes the latest information on The Neurobiology of Alcohol Abuse
Undergraduates, graduates, academics, and researchers in the field of neurobiology of alcohol abuse
- Cover image
- Title page
- Table of Contents
- Series Page
- Copyright
- Contributors
- Preface
- Chapter One: AUD in perspective
- Abstract
- 1 A global public health burden
- 2 Alcohol dependence and alcohol use disorder
- 3 Treatment goals
- 4 An undertreated disorder
- 5 Etiology and pathophysiology
- 6 Co-occurring disorders
- 7 Further on the role of stigma
- 8 Personalized medicine
- References
- Chapter Two: Alcohol and the dopamine system
- Abstract
- Abbreviations
- 1 Brain dopamine systems
- 2 Ethanol and brain dopamine systems
- 3 Ethanol, acetaldehyde and the mesolimbic dopamine system
- 4 Ethanol and cystein-loop ligand-gated ion channels
- 5 Ethanol, nAChR and the mesolimbic dopamine system
- 6 Ethanol, GlyR and the mesolimbic dopamine system
- 7 Ethanol, 5-HT3 receptors the mesolimbic dopamine system
- 8 Ethanol, GABAA receptors and the mesolimbic dopamine system
- 9 Ethanol, glutamate receptors and the mesolimbic dopamine system
- 10 Ethanol, opioid receptors and the mesolimbic dopamine system
- 11 Ethanol, gastric peptides and the mesolimbic dopamine system
- 12 Glucagon-like peptide-1 (GLP-1)
- 13 Alcohol relapse preventing drugs and the mesolimbic dopamine system
- 14 Summary and implications
- References
- Chapter Three: GABAergic mechanisms in alcohol dependence
- Abstract
- Abbreviations
- 1 Introduction
- 2 GABA-linked genes and alcoholism
- 3 Alcohol actions on main components of the GABA system
- 4 Adaptations of GABA receptor mechanisms by acute and prolonged alcohol exposures
- 5 Actions of drugs selective for GABAA or GABAB receptors on alcohol-related behaviors
- 6 Closing remarks
- Acknowledgements
- References
- Chapter Four: Current treatments of alcohol use disorder
- Abstract
- 1 Behavioral and psychological therapies
- 2 Medication-assisted therapies
- 3 Clinical implication
- 4 Conclusions
- References
- Chapter Five: Repurposing drugs for treatment of alcohol use disorder
- Abstract
- 1 Basic principles of the treatment of alcohol use disorder
- 2 Challenge for the development of new drugs
- 3 Repurposing drugs for the treatment of alcohol dependence
- 4 Approved drugs
- 5 Off-label drugs
- 6 Conclusion
- Conflicts of interest
- References
- Chapter Six: Substitution therapy for patients with alcohol dependence: Mechanisms of action and efficacy
- Abstract
- 1 Introduction
- 2 Substitution therapy for AD—definition
- 3 Ethanol sensitive sites on ionotropic receptors and ion channels are the molecular rational for alcohol subsitution
- 4 Alcohol discrimination studies can reveal substituting effects of potential substitution drugs
- 5 Examples of potential substitution drugs for alcohol
- 6 Clinical evidence for potential substitutes
- 7 Summary
- References
- Chapter Seven: Reducing the harms of alcohol: nutritional interventions and functional alcohol alternatives
- Abstract
- 1 Introduction
- 2 Summary
- References
- Further reading
- Chapter Eight: Designing and testing treatments for alcohol use disorder
- Abstract
- 1 Introduction
- 2 Regulatory guidance
- 3 Trial registration
- 4 Eligibility criteria
- 5 Recruitment
- 6 Randomization
- 7 Retention
- 8 Measurement selection
- 9 Measuring behavior change across time
- 10 Statistical methods
- 11 Implementation science
- 12 Conclusions
- References
- Chapter Nine: Phosphatidylethanol (B-PEth) and other direct and indirect biomarkers of alcohol consumption
- Abstract
- 1 Introduction
- 2 Definition of alcohol units and risk consumption
- 3 Subjective alcohol reporting
- 4 Definition of a biomarker
- 5 Indirect markers
- 6 Carbohydrate-deficient transferrin
- 7 Gamma-glutamyl transferase
- 8 Mean corpuscular volume
- 9 Aminotransferase and alanine aminotransferase
- 10 Further shortcomings
- 11 Direct markers
- 12 The molecule of ethanol
- 13 Ethanol in blood
- 14 Ethyl glucoronide
- 15 Ethyl sulfate
- 16 Fatty acid ethyl esters
- 17 Transdermal alcohol sensors
- 18 Biomarkers of food intake
- 19 Phosphatidylethanol
- 20 Conclusion
- References
- No. of pages: 358
- Language: English
- Edition: 1
- Volume: 175
- Published: March 28, 2024
- Imprint: Academic Press
- Hardback ISBN: 9780443141645
- eBook ISBN: 9780443141652
AB
Andrea de Bejczy
Andrea de Bejczy, M.D, Ph.D, is a senior researcher and head of the Clinical Trial Section of the Addiction Biology Unit at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry at the Sahlgrenska Academy, University of Gothenburg and has a leading role in alcohol studies as at the Department of Addiction and Dependency, Sahlgrenska University Hospital. Andrea de Bejczy’s main research area is randomized controlled trials on new pharmacotherapies for alcohol dependence, with focus on drugs targeting the dopamine system. A parallel focus for de Bejczy’s research is bio-markers in alcohol dependence.
Affiliations and expertise
Department of Psychiatry and Neurochemistry, University of Gothenburg, SwedenBS
Bo Söderpalm
Affiliations and expertise
Department of Psychiatry and Neurochemistry, University of Gothenburg, SwedenRead The neurobiology of Alcohol Use Disorder on ScienceDirect