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The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents
1st Edition - December 14, 2011
Editors: Mark A. Suckow, Karla A. Stevens, Ronald P. Wilson
Hardback ISBN:
9 7 8 - 0 - 1 2 - 3 8 0 9 2 0 - 9
eBook ISBN:
9 7 8 - 0 - 1 2 - 3 8 0 9 2 1 - 6
The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents is a single volume, comprehensive book sanctioned by the American College of Laboratory Animal Medicine (ACLAM),… Read more
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The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents is a single volume, comprehensive book sanctioned by the American College of Laboratory Animal Medicine (ACLAM), covering the rabbit, guinea pig, hamster, gerbil and other rodents often used in research. This well-illustrated reference won a 2012 PROSE Award for Best Single Volume Reference in Science from the Association of American Publishers. The book includes basic biology, anatomy, physiology, behavior, infectious and noninfectious diseases, husbandry and breeding, common experimental methods, and use of the species as a research model. With many expert contributors, this will be an extremely valuable publication for biomedical researchers, laboratory animal veterinarians and other professionals engaged in laboratory animal science.
- 2012 PROSE Award winner for Best Single Volume Reference in Science from the Association of American Publishers
- One-stop resource for advancements in the humane and responsible care of: rabbit, guinea pig, hamster, gerbil, chinchilla, deer mouse, kangaroo rat, cotton rat, sand rat, and degu
- Includes up-to-date, common experimental methods
- Organized by species for easy access during bench research
Preface
List of Contributors
List of Reviewers
PART I. General
Chapter 1. Ethical Considerations and Regulatory Issues
Introduction
Ethical Concepts
Ethical Challenges
Institutional Animal Welfare Oversight
Regulations and Non-regulatory Considerations
Conclusion
REFERENCES
Chapter 2. Anesthesia and Analgesia
Pre-anesthetic Preparation
Controlled Substances
Pharmacology
Anesthesia Circuits
Anesthesia Monitoring and Support
Surgical Anesthesia
Post-operative Monitoring and Pain Assessment
REFERENCES
Chapter 3. Clinical Biochemistry and Hematology
Introduction
Clinical Biochemistry
Rabbit
Guinea Pig
Hamster
Other Rodents
Hematology
Rabbit
Guinea Pig
Hamster
Other Rodents
REFERENCES
Chapter 4. Euthanasia and Necropsy
Introduction
Euthanasia
Necropsy
Pathology Considerations
Acknowledgments
REFERENCES
Chapter 5. Zoonoses and Occupational Health
Introduction
Viral Diseases
Rickettsial Diseases
Chlamydial Diseases
Bacterial Diseases
Fungal Diseases
Cestode Infections
Arthropod Infections
Allergies
Prevention of Allergy and Zoonotic Disease
REFERENCES
PART II. Rabbits
Chapter 6. The Domestic Rabbit,
Introduction and Background
Phylogeny and Taxonomy
Geographic Origins and Diversity
Domestication and Breed Development
Ecology and Conservation
REFERENCES
Chapter 7. Rabbit Genetics and Transgenic Models
Rabbit Genetics
Transgenic Rabbits
Conclusions
REFERENCES
Chapter 8. Anatomy, Physiology, and Behavior
Introduction
External Features
Osteology
Oral Cavity
Abdominal Viscera
Urogenital System
Thoracic Viscera
Brain and Spinal Cord
Metabolism
Behavior
Acknowledgments
REFERENCES
Chapter 9. Rabbit Colony Management and Related Health Concerns
Introduction
Laboratory Management
Breeding
Nutrition
Nutritionally Related Diseases
REFERENCES
Chapter 10. Basic Experimental Methods in the Rabbit
Introduction
Handling and Restraint
Sampling Techniques
Compound Administration
Specialized Research Techniques
REFERENCES
Chapter 11. Polyclonal Antibody Production
Introduction
The Immunogen
Immunogen Dose
Route of Immunization
Immunization Schedule
Adjuvants
Summary
REFERENCES
Chapter 12. Toxicity and Safety Testing
Introduction
Toxicity Testing
Safety Testing
Metabolism and Toxicokinetics
Acknowledgments
REFERENCES
Chapter 13. Bacterial Diseases
Introduction
Pasteurellosis
Enterotoxemia
Tyzzer’s Disease
Colibacillosis
Salmonellosis
Staphylococcosis
Treponematosis
Necrobacillosis
Listeriosis
Tuberculosis
Tularemia
Proliferative Enteropathy
Miscellaneous Bacterial Diseases
REFERENCES
Chapter 14. Viral Diseases
Introduction
DNA Virus Infections
RNA Virus infections
REFERENCES
Chapter 15. Parasitic Diseases
Introduction
Protozoa
Arthropods
Helminths
REFERENCES
Chapter 16. Rabbit Neoplasia
Introduction
Neoplasms of Oryctolagus cuniculus
Neoplasms of Sylvilagus
Neoplasms of Lepus
REFERENCES
Chapter 17. Mycoses and Non-Infectious Diseases
Introduction
Mycotic Diseases
Non-Infectious Diseases
REFERENCES
Chapter 18. The Rabbit as an Experimental Model
Introduction
Cardiovascular Diseases
Ophthalmic Diseases
Central Nervous System Diseases
Respiratory Diseases
Urogenital Diseases
Gastrointestinal Diseases
Musculoskeletal Diseases
Multisystemic Diseases
Acknowledgments
REFERENCES
PART III. Guinea Pigs
Chapter 19. Taxonomy and History
Introduction
Taxonomy and Geographical Distribution
Origin and Domestication
Genetics
REFERENCES
Chapter 20. Anatomy, Physiology, and Behavior
Introduction
External Anatomy
Musculoskeletal System
Digestive System
Cardiovascular System
Pulmonary System
Genitourinary System
Nervous System
Special Senses
Behavior
REFERENCES
Chapter 21. Management, Husbandry, and Colony Health
Introduction
Handling
Housing
Reproduction and Breeding
Nutrition
Colony Health
Record Keeping
REFERENCES
Chapter 22. Basic Experimental Methods
Introduction
Handling and Restraint
Sampling Techniques
Compound Administration
Specialized Research Techniques
REFERENCES
Chapter 23. Infectious Diseases
Introduction
Viral infections
Bacterial infections
Fungal infections
Protozoa infections
Parasitic infections
REFERENCES
Chapter 24. Non-Infectious Diseases
Introduction
Cardiovascular System
Respiratory System
Gastrointestinal System
Urinary System
Endocrine System
Reproductive System
Musculoskeletal System
Integumentary System
Special Senses
Hematolymphatic System
Multisystemic Conditions
REFERENCES
Chapter 25. Guinea Pigs as Experimental Models
Introduction
Models of Disease
REFERENCES
PART IV. Hamsters
Chapter 26. Taxonomy and History
Taxonomy
Geographical Distribution
Origin and Domestication
Genetics
Acknowledgments
REFERENCES
Chapter 27. Anatomy, Physiology, and Behavior
Introduction
External Features
Musculoskeletal System
Digestive System
Circulatory System
Pulmonary System
Genitourinary System
Nervous System
Special Senses
Behavior
REFERENCES
Chapter 28. Management, Husbandry, and Colony Health
Introduction
Housing
Environmental Conditions
Nutrition
Breeding
Colony Health
Record Keeping
REFERENCES
Chapter 29. Biomedical Research Techniques
Introduction
General Non-Surgical Procedures
Injections and Intubations
Biological Specimen Collections
Other Surgical Procedures
REFERENCES
Chapter 30. Bacterial and Fungal Diseases
Introduction
Bacterial Diseases
Fungal Diseases
REFERENCES
Chapter 31. Viral Diseases
Introduction
DNA Viruses
RNA Viruses
Miscellaneous Viruses
REFERENCES
Chapter 32. Parasitic Diseases
Introduction
Protozoa
Nematodes
Arthropods
REFERENCES
Chapter 33. Non-Infectious Diseases
Introduction
Diseases Associated with Aging
Nutritional Disorders
Genetic, Traumatic, Environmental and Other Non-Infectious Diseases
Neoplasms
REFERENCES
Chapter 34. The Experimental Use of Syrian Hamsters
Introduction
Cancer Research
Metabolic Diseases
Non-Cancerous Respiratory Diseases
Cardiovascular
Infectious Disease Research
Other Models
REFERENCES
Chapter 35. The Chinese or Striped-Back Hamster
Introduction
Biology
Care and Husbandry
Cytogenetics and Fetal Development
Diseases
Research Uses
Summary
REFERENCES
Chapter 36. The European Hamster
Taxonomy
History
Biology
Behavior
Diseases
Management, Husbandry, and Colony Health
Experimental Methodology
Use in Biomedical Research
REFERENCES
Chapter 37. Other Hamsters
Introduction
Phodopus sungorus (Djungarian Hamster)
Mesocricetus brandti (Turkish Hamster)
Cricetulus migratorius (Armenian Hamster)
Mesocricetus newtoni (Romanian Hamster)
REFERENCES
PART V. Chinchillas
Chapter 38. Taxonomy and History
Introduction
Taxonomy
History
REFERENCES
Chapter 39. Anatomy, Physiology, and Behavior
Introduction
External Features
Unique Biological Characteristics
Behavior
REFERENCES
Chapter 40. Management, Husbandry, and Colony Health
Introduction
Housing Systems
Environmental Conditions
Nutrition
Breeding
Colony Health
Record Keeping
REFERENCES
Chapter 41. Basic Experimental Methods
Introduction
Handling and Restraint
Mechanical Methods
Sampling Techniques
Compound Administration
Specialized Research Techniques
REFERENCES
Chapter 42. Diseases and Veterinary Care
Introduction
Gastrointestinal and Metabolic Diseases
Traumatic Lesions
Management-Related Disorders
Neoplastic Diseases
Miscellaneous Conditions
REFERENCES
Chapter 43. Chinchillas as Experimental Models
Introduction
Models Related to Aural Disease
Models Related to Hearing Loss
Future of Chinchilla Models
REFERENCES
PART VI. Other Rodents
Chapter 44. Degu
Introduction
History and Taxonomy
Anatomy, Physiology, and Behavior
Management, Husbandry, and Colony Health
Handling and Restraint
Sampling Techniques
Compound Administration
Anesthesia and Analgesia
Euthanasia and Necropsy
Diseases
The Degu as an Experimental Model
REFERENCES
Chapter 45. Naked Mole Rat
History
Taxonomy
General Description
Natural Habitat
Behavior
Reproductive Behavior
General Physiology
Anatomy and Physiology of Organ Systems
Aging
Husbandry
Colony Health
Use in Research
REFERENCES
Chapter 46. Deer Mice, White-Footed Mice, and their Relatives
Introduction
Biology
Husbandry
Captive Breeding
Diseases
Anesthesia/Analgesia
REFERENCES
Chapter 47. Dormouse
Introduction
Taxonomy and History (Table 47.1)
Anatomic Characteristics
Husbandry
Nutrition
Housing
Environmental Conditions
Handling
Breeding
Diseases and Zoonoses
Colony Health Monitoring
Experimental Applications
Biomethodology
REFERENCES
Chapter 48. Kangaroo Rat
Introduction
Biology
Diseases
Use in Research
Laboratory Care
REFERENCES
Chapter 49. Cotton Rat
Introduction
Biology
Husbandry
Diseases
Experimental Methods
Use in Research
Acknowledgments
REFERENCES
Chapter 50. Pocket Gopher
Introduction
Biology
Diseases
REFERENCES
Chapter 51. White-Tailed Rat
Introduction
Taxonomy, History, and Genetics
Anatomy, Physiology, and Behavior
Management, Husbandry, and Colony Health
Basic Experimental Methods
Diseases and Veterinary Care
Experimental Models
REFERENCES
Chapter 52. Gerbils
Introduction
Taxonomy and History
Anatomy, Physiology, and Behavior
Management, Husbandry, and Colony Health
Basic Experimental Methods
Veterinary Care and Diseases
Gerbils as Experimental Models
REFERENCES
Chapter 53. Egyptian Fat-Tailed Jird
Introduction
Anatomy, Physiology, and Behavior
Management, Husbandry, and Colony Health
Diseases
Anesthesia/Analgesia, Euthanasia, and Necropsy
Use in Research
Basic Experimental Methods
REFERENCES
Chapter 54. Sand Rat
Introduction
Selection of Reliable Diets and Psammomys Lines for Diabetes Research
Metabolic Efficiency
Morphology, Physiology, Breeding Performance, and Husbandry
The Basis of Diabetes in Psammomys
The Relevance of Psammomys to Diabetes Research
The Genetic Basis of Psammomys Diabetes
Worldwide Research Using Psammomys
Complications of Diabetes in Psammomys
Concluding Remarks
REFERENCES
PART VII. Formulary and Normative Values
Chapter 55. Formulary
Introduction
Rabbit (Oryctolagus cuniculus)
Guinea Pig (Cavia porcellus)
Hamster (Mesocricetus auratus)
Degu (Octodon degus)
Other Species
REFERENCES
Chapter 56. Normative Values
Rabbits (Oryctolagus cuniculus)
Guinea pigs (Cavia porcellus)
Hamsters
Gerbils (Meriones unguiculatus)
Chinchillas (Chinchilla laniger)
Other rodents
REFERENCES
Index
- No. of pages: 1288
- Language: English
- Published: December 14, 2011
- Imprint: Academic Press
- Hardback ISBN: 9780123809209
- eBook ISBN: 9780123809216
MS
Mark A. Suckow
Mark Suckow received his DVM from the University of Wisconsin in 1987 and subsequently completed a post-doctoral residency in laboratory animal medicine at the University of Michigan in 1990. He spent 8 years as a clinical laboratory animal veterinarian at Purdue University and then 17 years at the University of Notre Dame where he served as Director of the Freimann Life Science Center and later as Associate Vice President for Research Compliance. Prior to coming to the University of Kentucky, he was Professor of Veterinary Population Medicine and Director, Research Animal Resources at the University of Minnesota. With an interest in cancer models, biomaterials models, and vaccines, Dr. Suckow has functioned as an independent and collaborative investigator and has published in refereed journals and has seven issued patents related to vaccine adjuvants and cancer vaccines. He has written or edited over 20 books on topics related to research and laboratory animal medicine. Further, he served as the 2006 President of the American Association for Laboratory Animal Science and the 2011 President of the American Society of Laboratory Animal Practitioners; and currently he serves on the AVMA Council on Research and is a member of the Council on Accreditation of AAALAC, International.
Affiliations and expertise
Associate Vice President for Research, Attending Veterinarian, University of Kentucky, USA.KS
Karla A. Stevens
Affiliations and expertise
Ethicon Endo-Surgery, Inc., Sommerville, NJ, U.S.A.RW
Ronald P. Wilson
Ronald P. Wilson, VMA, MS, DACLAM, is the Professor and Chair of Comparative Medicine at Pennsylvania State University. Research interests are related to experimental surgery, pain, analgesia and anesthesia of laboratory animals.
Affiliations and expertise
Professor and Chair, Department of Comparative Medicine, Penn State University College of Medicine, Hershey, PA, USA