Skip to main content
Elsevier

The Intestine

  • 1st Edition - June 15, 2021
  • Latest edition
  • Editors: Ahmed El-Hashash, Eiman Abdel Meguid
  • Language: English

The intestine is among the leading organs, in which several cutting edge in vitro and in vivo research tools and approaches have recently been developed and used to investigate st… Read more

Data Mining & ML

Unlock the cutting edge

Up to 20% on trusted resources. Build expertise with data mining, ML methods.

Explore now

Description

The intestine is among the leading organs, in which several cutting edge in vitro and in vivo research tools and approaches have recently been developed and used to investigate stem cell biology/function, and the potential applications of stem cells in the treatment of intestinal diseases. These cutting-edge research tools and approaches involve human and murine organoid cultures, genetic editing in vitro and in vivo, human induced pluripotent cell (iPS cell) models of disease, haploid cells for genetic as well as compound screening paradigms, genetically engineered mice, and stem cell transplantation to cure diseases.

Stem Cell Innovation in Health and Disease: Volume 1: The Intestine contains two major sections describing cutting edge research for understanding stem cell functions in the intestine, and for developing methods to bring stem cells from bench to bedside; respectively. Each section includes insights ranging from using mouse and human organoid cultures, genetic editing in vitro and in vivo, and human induced pluripotent cells (iPSCs) to study stem cell functions and model intestinal diseases, through the cutting-edge research, including the potential application of iPSCs, ESCs and blood stem cells (stem cell transplants) in the treatment of intestinal diseases/disorders. This volume, therefore, discusses the fact-based promise of stem cells and regenerative medicine in the intestine in the real world.

Key features

  • Provides intensive scientific background and most recent information on cutting edge research to understand intestinal stem cell functions and develop methods to bring stem cells from bench to bedside for different intestinal diseases
  • Analyzes the current state, opportunities, and challenges of innovative technologies and stem cells from bench to bed, including organoids and the CRISPR gene editing system in the intestine
  • Contains two major sections describing cutting-edge research for understanding stem cell functions and for developing methods specific to the intestine

Readership

Researchers and practitioners in the following fields: Life Science: Stem Cell Biology Research and Biotechnology; Medicine: Stem Cell Research, Regenerative Medicine; Healthcare: Disease, Medical Education, Stem Cells, Regenerative Medicine; Engineering: Biomedical Engineering; Graduate and undergraduate students in these fields

Table of contents

Section 1: Cutting edge research on the intestinal stem cell functions

1. Intestinal organoid cell culture as a new modality to intestinal function, cellular processes and stem cell functions

2. Intestinal organoids in gastrointestinal pathology

Section 2: Cutting edge research on stem cell application in the intestinal diseases (from bench to bed)

3. Intestinal organoid culture as a new test-bed for intestinal therapeutic research and development

4. Engineered stem cells combine stem cell and gene therapy approaches to move intestine therapy from bench to bed

5. Application of CRISPR/Cas9 and other gene editing/ engineering technology in intestine diseases

6. New approaches for intestine and colon repair via stem cell-based tissue engineering

7. iPSCs and intestine diseases from bench to bed

8. The potential of embryonic stem cells for treating intestinal diseases from bench to bed

9. Stem-cell therapy with bone marrow (hematopoietic) stem cells for intestinal diseases

10. Mesenchymal and other stem cell-therapy of intestinal diseases

Product details

  • Edition: 1
  • Latest edition
  • Published: June 15, 2021
  • Language: English

About the editors

AE

Ahmed El-Hashash

Dr. Ahmed Hashash is currently Endowed Chair and Distinguished Professor at Elizabeth City State University, campus of the University of North Carolina (UNC). He received his PhD from Manchester University, UK. Dr. Hashash was a fellow of the California Institute of Regenerative Medicine (CIRM) and New York University Medical School (MSSM), USA. He was Assistant Professor and Principal Investigator of Stem Cell & Regenerative Medicine at School of Medicine University of California, USA. Dr Hashash was Associate Professor of Biomedicine at the University of Edinburgh (UK) Zhejiang Intl. campus and Texas A &M University, USA from 2017 to 2025. He has published more than 40 papers in reputed international journals, 10 books with Elsevier and Springer and over 20 book chapters, and is serving as an editorial board member of repute.
Affiliations and expertise
Endowed Chair, Distinguished Professor, University of North Carolina, USA

EM

Eiman Abdel Meguid

She completed her PhD thesis at Eberhard-Karls Universität Tübingen, Germany. Dr Abdel Meguid is an innovative educator and researcher and has published multiple scientific works in leading journals and is a reviewer and a member of the editorial board of a number of journals. Dr Abdel Meguid taught gross anatomy to medical, dental, human biology students and students enrolled in MSc in clinical anatomy. Her research interests are in the areas of stem cells, lung development, anatomical pedagogy, teaching strategies, and the integration of novel technologies to enhance learning.
Affiliations and expertise
Senior Lecturer, Centre for Biomedical Sciences Education, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, UK

View book on ScienceDirect

Read The Intestine on ScienceDirect