The Glycoconjugates V4

List of Contributors

Preface

Contents of Previous Volumes


1 Uptake of Glycoconjugates

Section 1 The Uptake and Transport of Lysosomal Enzymes

I. Introduction

II. Evidence for Mannose 6-Phosphate in the "Common Recognition Marker"

III. Structural Features Important for Enzyme Recognition

IV. Secretion-Recapture Pathway to Lysosomes

V. Intracellular Pathway for Receptor-Mediated Segregation of Lysosomal Enzymes

VI. Recycling of Cell Surface Receptors after Enzyme Delivery

VII. Role of Lysosomotropic Amines

VIII. Limitation by Mannose 6-Phosphate of Processing of Oligosaccharide Chains

IX. Mannose 6-Phosphate Receptor-Mediated Transport Pathway: Generality and Relationship to the "Secretory Pathway" for Glycoproteins

X. Alternate Routes for Acid Hydrolases in Mammalian Cells

XI. Physiological Role of Cell Surface Receptors for Lysosomal Enzymes

References

Section 2 The Hepatic Receptor for Asialoglycoproteins

I. Introduction

II. The Fate of Injected Asialoglycoproteins

III. The Influence of Ligand Structure on Interaction with Receptor

IV. Properties of Mammalian Receptors for Asialoglycoproteins

V. Morphological Examination of Asialoglycoprotein Catabolism

VI. Subcellular Distribution and Reutilization of Receptor

VII. Asialoglycorprotein Catabolism in Isolated Cells

VIII. Serum Glycoprotein Clearance in Nonmammalian Species

IX. Summary and Perspectives

References

Section 3 Neoglycoproteins as Probes for Binding and Cellular Uptake of Glycoconjugates

I. Introduction

II. Preparation of Neoglycoproteins

III. Properties of Neoglycoproteins

IV. Neoglycoproteins for in Vitro Clearance Studies

V. Neoglycoproteins as Probes for in Vitro Studies

VI. Neoglycoproteins as Cytochemical Markers

VII. Conclusion

References

Section 4 Transfer of Glycoconjugates from Living to Fixed Cells

I. Introduction

II. Transfer of Substances from Overlying Living Cells to Fixed Cells

III. Character of Glycoconjugates Transferred to Fixed Cells

IV. Transfer of Glycoconjugates from Conditioned Medium to Fixed Cells

V. Comparison between Glycoconjugates Transferred from Living Cells and from Conditioned Medium

VI. Production of Glycoconjugates Transferable to Fixed Cells: Change during Cell Growth

VII. Change in Acceptance of Glycoconjugates during Cell Growth: Comparison between Transformed and Nontransformed Cells

VIII. Concluding Remarks

References


2 Turnover and Shedding of Cell Surface Glycoconjugates

Section 1 Turnover of Plasma Membrane Glycoproteins and Glycolipids (Hepatoma as a Model)

I. Introduction

II. Labeling of Membrane Glycoproteins and Glycolipids for Turnover Studies

III. Turnover of Plasma Membrane Glycoproteins and Glycolipids

IV. Influence of Environment on the Turnover of Plasma Membrane Glycoconjugates

References

Section 2 Cell Surface Shedding

I. Introduction

II. Structural and Biochemical Aspects of the Cell Surface

III. Surface Membrane Biosynthesis and Turnover

IV. Direct Experimental Evidence for the Shedding of Cell Surface Components to the Extracellular Environment

V. Surface Components and Antigens in Serum and Other Body Fluids

VI. Shedding versus Secretion

VII. Phenomena that may be Similar to Shedding

VIII. Questions about the Mechanism of the Shedding Process

IX. Possible Role of Shed Surface Components

References


3 Virus Glycoproteins and Glycolipids

Virus Glycoproteins and Glycolipids: Structure, Biosynthesis, Biological Function, and Interaction with Host

I. Introduction

II. Structure of Virus Membranes

III. Structure of Virus Glycoproteins

IV. Biosynthesis of Virus Glycoproteins

V. Function of Virus Glycoproteins

VI. Glycoproteins

References


4 Glycosyltransferases and Glycoconjugates: Applications to Chemotherapy, Aging, and Disease

Section 1 Development of Membrane Sugar and Nucleotide Sugar Analogs as Potential Inhibitors or Modifiers of Cellular Glycoconjugates

I. Introduction

II. Development of Hexosamine Analogs

III. Development of Modified Neutral Sugars

IV. Development of Sialic Acid Analogs

V. Development of Sialyltransferase Inhibitors

VI. Concluding Remarks

References

Section 2 Glycosaminoglycans in Atherosclerosis

I. Introduction

II. Overview of Atherogenesis

III. Arterial Wall Connective Tissue and Atherosclerosis

IV. Glycosaminoglycans of the Arterial Wall

V. Proteoglycans of the Arterial Wall

VI. Glycosaminoglycans (Proteoglycans) and Lipoprotein Interactions

VII. Glycosaminoglycan Changes in Atherosclerosis

VIII. Inhibition of Atherosclerotic Lesions by Glycosaminoglycans

References

Section 3 Glycosyltransferases in Cancer

I. Introduction

II. Glycoslytransferases as Shed or Secreted Glycoproteins

III. Glycosyltransferases as Tumor Markers

IV. Summary and Conclusions

References

Section 4 Articular Cartilage Proteoglycans in Aging and Osteoarthritis

I. Structure and Metabolism of Cartilage Proteoglycans

II. Articular Cartilage in Aging

III. Articular Cartilage in Osteoarthritis

IV. Concluding Remarks

References

Index