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Elsevier

The Exposome in Cancer Disparities

Influence of Environmental and Infectious Factors in LMICs

  • 1st Edition - June 5, 2026
  • Latest edition
  • Editor: Zodwa Dlamini
  • Language: English

The Exposome in Cancer Disparities: Influence of Environmental and Infectious Factors in LMICs examines how environmental and infectious factors drive cancer inequities in low- a… Read more

Description

The Exposome in Cancer Disparities: Influence of Environmental and Infectious Factors in LMICs examines how environmental and infectious factors drive cancer inequities in low- and middle-income countries (LMICs). The book introduces the exposome as a comprehensive framework to understand complex risk factors, such as environmental toxins, climate change, and infectious agents like HPV and HIV. The book combines scientific insights, real-world case studies, and practical strategies from international experts, highlighting region-specific contributors to cancer disparities. Structured into thematic sections, it offers a holistic view of the challenges faced by LMICs and provides actionable, evidence-based solutions tailored to resource-limited settings.

The work emphasizes the importance of multidisciplinary approaches and international collaboration to develop effective prevention and policy strategies. It will benefit researchers, policymakers, and healthcare professionals by deepening understanding of cancer risk factors, fostering global cooperation and guiding targeted interventions to reduce health inequities and improve outcomes worldwide.

Key features

  • Introduces the exposome as a transformative framework for understanding the complex interplay of environmental and infectious factors in cancer disparities
  • Integrates scientific insights, case studies, and practical strategies from international experts to provide a holistic and actionable perspective
  • Emphasizes the importance of multidisciplinary approaches and international collaboration to develop effective prevention and policy interventions in resource-limited settings

Readership

Cancer researchers, epidemiologists, public health professionals, and healthcare practitioners focused on oncology and environmental health

Table of contents

I: Foundations of exposomics and cancer disparities

  1. Introduction: The exposome framework and its relevance to cancer disparities
    Zodwa Dlamini, Rodney Hull, Tebogo Marutha, Thulo Molefi, Richard Khanyile, Ahmed Adam, and Roel Vermeulen

  2. Environmental exposures and cancer risk: An exposomics perspective in low- and middle-income countries
    Thabiso Victor Miya, Paolo Vineis, Clayton Yates, and Zodwa Dlamini

  3. Infectious agents, HIV, and carcinogenic risks of cancer in low- and middle-income countries
    Benny Mosoane, Shobana Sampath, and Zodwa Dlamini

  4. Socioeconomic inequities and the exposome: A double burden in low- and middle-income countries
    Mohammed Alaouna, Jenny Edge, Jose Fanjul Fuente, Shakti Ramkissoon, Laura Vidal, Kamal S. Saini, and Zodwa Dlamini

II: Mechanisms and intersections of the exposome

  1. Neglected tropical diseases, coinfections, and the exposome: The overlapping burden in low- and middle-income countries
    Zilungile L. Mkhize-Kwitshana, Pragalathan Naidoo, Stylianos Makrogkikas, Georgios Lolas, and Zodwa Dlamini

  2. Climate change, the exposome, and cancer disparities in low- and middle-income countries
    Zukile Mbita, Talent Chipiti, Nonkululeloko Mthembu, Rui Manuel Reis, and Zodwa Dlamini

  3. Culture, society, and the exposome: Understanding cancer risk in low- and middle-income countries
    Rahaba Marima, Egnesious Sambo, Olalekan Fadebi, Babatunde Alabi, Aadilah Omar, Vivash Naidoo, Elisa V. Bandera, Gugu Mazibuko, and Zodwa Dlamini

  4. Gene–environment interactions: The exposome and cancer susceptibility
    Meshack Bida, Catherine Cingo, Nisange Janda, Benny Mosoane, Kamal S. Saini, and Zodwa Dlamini

  5. The microbiome and the exposome: Implications for cancer risk
    Langanani Mbodi, Lloyd Mabonga, Rob Knight, and Zodwa Dlamini

III: Exposome-informed strategies for cancer prevention and equity

  1. Cancer prevention in low- and middle-income countries: Targeting environmental and infectious exposures
    Tebogo Marutha, Demetra Mavri-Damelin, Ravi Mehrotra, and Zodwa Dlamini

  2. Strengthening healthcare systems through exposomics
    Pragalathan Naidoo, Zilungile L. Mkhize-Kwitshana, Nontobeko Eunice Mvubu, Refilwe Phemelo Molatlhegi, Sheeba Irshad, and Zodwa Dlamini

  3. Policy reform and environmental justice: Bridging gaps in cancer prevention
    Nkhensani Chauke-Malinga, Demetra Demetriou, Charles Maimela, Rhulani Thobakgale, Thoriso Molefi, Godfrey Grechand, and Zodwa Dlamini

IV: Innovations and global collaboration in exposomics

  1. Emerging technologies in exposomics: Advancing cancer diagnosis and treatment
    Rodney Hull, Fieke Froeling, Moshawa Khaba, Andreas M. Kaufmann, and Zodwa Dlamini

  2. Artificial intelligence, big data, and the exposome: Transforming cancer risk assessment
    Sikhumbuzo Z. Mbatha, Debra Rivera, and Zodwa Dlamini

  3. Global collaboration in exposomics: A multistakeholder approach to reducing cancer disparities
    Botle Precious Damane, Thanyani Victor Mulaudzi, Tania Maphoso, Dakalo Ramali, June Serem, Nigel Mongan, and Zodwa Dlamini

  4. The future of exposomics: Pathways to address cancer disparities in low- and middle-income countries
    Zodwa Dlamini, Thulo Molefi, Marco Durini, Ashokkumar Deenabandu, Niti Raizada, Kamal S. Saini, and Richard Khanyile

Product details

  • Edition: 1
  • Latest edition
  • Published: June 9, 2026
  • Language: English

About the editor

ZD

Zodwa Dlamini

Zodwa Dlamini is a Professor of Molecular Oncology and the founding Director and the Executive Head of the Pan African Cancer Research Institute (PACRI) in South Africa. She is the Director of South African Medical Research Council (SAMRC) Precision Oncology Research Unit (PORU). She is the DSI/NRF SARChI Chair in Precision Oncology and Cancer Prevention (POCP). She is a member of the American Association for Cancer Research (AACR) Advisory Group on Sub-Saharan Africa. She is a member of the AACR Pathology Resources in Africa Advisory Group. Professor Dlamini is a member of the African Organisation for Research and Training in Cancer (AORTIC) Research Committee Scientific Advisory Board. She is an elected member of the Academy of Science of South Africa. Professor Dlamini is an overseas Fellow of the Royal Society of Medicine (London). She is the Associate Editor for Frontiers in Oncology: Cancer Genetics Section
Affiliations and expertise
University of Pretoria, South Africa