The Epidemiology of Plasmodium vivax: History, Hiatus and Hubris, Part B

Series Editors

Contributors

Preface

Chapter One. Plasmodium vivax

1. Introduction

2. The General Life Cycle of Plasmodium vivax and Other Primate Malaria Parasite Species

3. In Vitro and Ex Vivo Models for Examining P. vivax Biology

4. Neotropical Non-Human Primate Models (New World Monkeys) for Investigating the Varied Biology of vivax Malaria

5. The Relapsing Malaria Parasites of Southern Asian Macaque Monkeys as Models for P. vivax Biology

6. From Genomics to Systems Biology: The Bigger Picture Puzzles

7. Conclusions

8. Acknowledgements

References

Chapter Two. Red Blood Cell Polymorphism and Susceptibility to Plasmodium vivax

1. Introduction

2. The Era of Great Biological Discovery

3. Resistance to P. vivax and Insights On Malaria Red Cell Invasion

4. Evolving Perspectives on Resistance to P. vivax

5. Conclusions and Future Directions

6. Acknowledgements

References

Chapter Three. Natural Acquisition of Immunity to Plasmodium vivax

1. Overview of Naturally Acquired Immunity to Malaria

2. Differential Acquisition of Immunity to P. vivax and P. falciparum Under Natural Exposure

3. Acquisition of Immunity in Experimental Infections – Lessons from Malaria Therapy Patients and Irradiated Sporozoites

4. Unique Biological Characteristics of P. vivax that Contribute to NAI

5. Effector Mechanisms for Blood-Stage Immunity

6. Targets of Blood-Stage Immunity

7. Immune Responses to Malaria Pre-Erythrocytic Stages

8. Sexual Stage Parasites and Transmission-Blocking Immunity

9. Conclusions

10. Future Directions

References

Chapter Four. G6PD Deficiency

1. Introduction

2. Historical Overview

3. Glucose-6-Phosphate Dehydrogenase Deficiency: The Enzyme and Its Gene

4. Diagnosing G6PD Deficiency

5. Mapping the Spatial Distribution of G6PD Deficiency

6. Spatial Co-occurrence of G6PD Deficiency with P. vivax Endemicity

7. Evolutionary Drivers of the Distribution of G6PD Deficiency

8. Primaquine, P. vivax and G6PD Deficiency

9. Towards a Risk Framework for P. vivax Relapse Treatment

10. Conclusions

11. Acknowledgements

References

Chapter Five. Genomics, Population Genetics and Evolutionary History of Plasmodium vivax

1. The Importance of Studying Plasmodium Diversity

2. The Evolutionary History of P. vivax

3. The P. vivax Genome and Comparative Genomics

4. P. vivax Global Genetic Diversity and Population Structure

5. P. vivax Population Genetics in India

6. Conclusion

7. Acknowledgements

References

Chapter Six. Malariotherapy – Insanity at the Service of Malariology

1. Introduction

2. The Era of Malariotherapy

3. The Practice of Malariotherapy

4. Malariotherapy and Malariology

5. Malariotherapy’s Major Contributions to Malariology

6. Lessons from Malariotherapy: Caveats and Current Relevance

7. Conclusions

References

Index