The Enzymes
- 1st Edition, Volume 54 - November 7, 2023
- Imprint: Academic Press
- Editors: Laurie S. Kaguni, Fuyuhiko Tamanoi
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 1 3 6 9 1 - 7
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 3 6 9 2 - 4
The Enzymes, Volume 54 highlights new advances in enzymes, with new chapters on a variety of topics, including the History of The Enzymes, Impact of The Enzymes in chronicli… Read more
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Request a sales quoteThe Enzymes, Volume 54 highlights new advances in enzymes, with new chapters on a variety of topics, including the History of The Enzymes, Impact of The Enzymes in chronicling biochemical processes and pathways, Metabolism and Catalysis, Mitochondrial ATP synthase, The respiratory chain, A century of mitochondrial research, Five decades of metalloenzymology, Mechanisms of catalysis, Mitochondrial fatty acid synthesis and associated processes, Signaling, MAPK cascades: Origins, mechanisms and current status, Sphingolipids: From structural components to signaling hubs, Protein Homeostasis and Hydrolysis, Mitochondrial AAA+ proteases, Hsp70 and JDP proteins: structure-function perspective on molecular chaperone activity.
Other sections cover DNA Replication and Repair, Structure-function studies of DNA replication proteins, and Helicases required for nucleotide excision repair.
- Provides the authority and expertise of leading contributors from an international board of authors
- Updated release includes the latest information on enzymes
Life science researchers, biochemists, medical scientists
- Cover image
- Title page
- Table of Contents
- Series Page
- Copyright
- Contributors
- Preface: History of The Enzymes, Current Topics and Future Perspectives
- Section 1 Introduction
- Chapter One: History of The Enzymes: 1950–2023
- Abstract
- 1 History of The Enzymes
- 2 Topics covered
- 3 Series editors
- 4 PubMed citation
- 5 2023 volumes
- References
- Section 2 Metabolism and catalysis
- Chapter Two: The mitochondrial respiratory chain
- Abstract
- 1 Introduction
- 2 Electron transfer and proton translocation
- 3 Complex I
- 4 Complex III
- 5 Complex IV
- 6 Supercomplexes and respirasomes
- 7 Proton circuits and the nature of the protonmotive force
- 8 Physiological aspects
- Acknowledgements
- References
- Chapter Three: A century of mitochondrial research, 1922–2022
- Abstract
- 1 Foreword
- 2 Endosymbiosis
- 3 The era of mitochondrial biochemistry
- 4 The era of mitochondrial genetics
- 5 The era of mitochondrial pathology
- 6 The era of mitochondrial cell biology
- 7 The future of mitochondrial enzymology
- References
- Chapter Four: Five decades of metalloenzymology
- Abstract
- 1 Introduction
- 2 Urease and nickel-containing enzymes
- 3 Oxygenases that require iron- and 2-oxoglutarate
- 4 Enzymes containing non-canonical iron-sulfur clusters
- 5 Conclusions
- Acknowledgments
- References
- Chapter Five: History of advances in enzyme kinetic methods: From minutes to milliseconds
- Abstract
- Abbreviations
- 1 A brief history of enzyme kinetic analysis
- 2 Principles of mechanism-based data fitting methods
- 3 Recent history of transient state kinetic analysis of enzymes
- 4 Advances in global data fitting in the detection of enzyme intermediates
- 5 The role of conformational changes in enzyme specificity
- 6 Single molecule kinetic analysis
- 7 Summary
- References
- Section 3 Signaling
- Chapter Six: Mitogen-activated protein kinase (MAPK) cascades—A yeast perspective
- Abstract
- 1 Discovery of MAPKs
- 2 Prospectus
- Acknowledgments
- References
- Chapter Seven: Sphingolipids: From structural components to signaling hubs
- Abstract
- Abbreviations
- 1 Introduction
- 2 Enzymes of sphingolipid metabolism
- 3 Functional pleiotropy of sphingolipids
- 4 Conclusion and future directions
- 5 In memoriam
- References
- Section 4 Protein homeostasis and hydrolysis
- Chapter Eight: Mitochondrial AAA+ proteases
- Abstract
- Abbreviations
- 1 Introduction
- 2 i-AAA
- 3 m-AAA
- 4 Lon
- 5 ClpXP
- 6 Conclusions
- Acknowledgment
- References
- Chapter Nine: The Hsp70 and JDP proteins: Structure-function perspective on molecular chaperone activity
- Abstract
- Abbreviations
- 1 Introduction
- 2 Protein folding, misfolding and aggregation
- 3 Molecular chaperones in the proteostasis network
- 4 JDP/Hsp70 chaperone systems
- 5 Perspective
- Acknowledgments
- References
- Section 5 DNA replication and repair
- Chapter Ten: DNA replication machineries: Structural insights from crystallography and electron microscopy
- Abstract
- 1 Introduction
- 2 Replicative DNA polymerases
- 3 Processivity factors: clamps and clamp loaders
- 4 Replicative DNA helicases
- 5 Single-stranded DNA binding proteins
- 6 The replisome
- References
- Chapter Eleven: Helicases required for nucleotide excision repair: structure, function and mechanism
- Abstract
- 1 Introduction
- 2 UvrB
- 3 UvrD
- 4 XPB
- 5 XPD
- 6 Summary
- References
- Edition: 1
- Volume: 54
- Published: November 7, 2023
- Imprint: Academic Press
- No. of pages: 306
- Language: English
- Hardback ISBN: 9780443136917
- eBook ISBN: 9780443136924
LK
Laurie S. Kaguni
Laurie S. Kaguni is at Michigan State University, MI, USA
Affiliations and expertise
Michigan State University, MI, USAFT
Fuyuhiko Tamanoi
Fuyu Tamanoi is a biochemist who has served on the UCLA School of Medicine and UCLA College faculty since he joined the Department of Microbiology, Immunology & Molecular Genetics in 1993. He became a full professor in 1997.
Affiliations and expertise
Biochemist, Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, USARead The Enzymes on ScienceDirect