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The Development Of Dictyostelium Discoideum
1st Edition - January 28, 1982
Editor: William Loomis
9 7 8 - 0 - 3 2 3 - 1 4 5 6 6 - 4
The Development of Dictyostelium discoideum consists of 11 chapters representing the 11 major aspects at which continuous progress are made in the study of Dictyostelium… Read more
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The Development of Dictyostelium discoideum consists of 11 chapters representing the 11 major aspects at which continuous progress are made in the study of Dictyostelium discoideum. This book begins with the discovery, classification, ecology, and development of Dictyostelium discoideum. It then outlines the advances in genetic manipulation and mutant isolation of the organism. Much of the advances in cell biology have been related to a better understanding of the composition and function of the cell membrane. Hence, analyses of Dictyostelium plasma membranes are collated. This reference material also describes the role of chemoattractants in organizing cell movements and the intracellular events triggered by occupancy of chemoreceptors. It also explains the understanding of the macromolecular components of the chemosensory system of Dictyostelium discoideum. It further discusses the cell motility, cell adhesion, morphogenetic signaling, cytodifferentiation, and gene expression in the species. Finally, the phenomenon of cell-type specification and regulation in this organism is addressed. This book will be valuable for those already familiar with the general outlines of Dictyostelium biology.
ContributorsPreface1. Comparative Biology of Cellular Slime Molds I. Historical II. The Life History III. Classification IV. Ecology V. Development References2. Genetics I. Introduction II. Chromosomes III. Genetic Analysis Using the Parasexual Cycle IV. The Macrocyst Cycle References3. Membranes I. Introduction II. Membrane Function III. Membrane Ultrastructure IV. Isolation of Membranes V. Composition of Membranes VI. Extracellular Material VII. Concluding Remarks References4. Chemotaxis I. Introduction II. Analysis of Early Aggregation III. Chemosensory Transduction IV. Molecular Components of the Chemosensory SystemV. Role of the Chemotactic Signal in Early Development VI. Working Model of Early Aggregation References5. Cell Motility I. Introduction and Perspectives II. Directed Cell Movement Involves Selective Pseudopod Formation III. Actin and Myosin Are Primary Components of a Filamentous Matrix That Underlies the Cell Membrane IV. Actin and Myosin Are Involved in Ca2+-Dependent Contractions and Gelation — Solation Phenomena V. Dictyostelium Actin VI. Dictyostelium Myosin VII. The Interaction of Actin and Myosin May Be Controlled by Ca2+ VIII. Concluding Remarks References6. Cell Adhesion I. Introduction II. Descriptive Studies Consistent with Selective Cell — Cell Adhesion III. Quantitative Assay of Cell — Cell Adhesion IV. The Immunological Approach to the Identification of Cell Adhesion Molecules V. Lectins in Cell Adhesion VI. Summary References7. The Organization and Expression of the Dictyostelium Genome I. Introduction II. General Properties of Genome Structure III. General Patterns of mRNA Transcription and Maturation IV. Genes Encoding Abundant Stable RNAs V. Patterns of Developmental Gene Expression VI. Actin Multigene Family VII. Discoidin I Multigene Family VIII. Transcription of Short, Interspersed Repeat Sequences IX. Sequences Common to the 5'-Ends of Dictyostelium Genes X. RNA Polymerases and Transcription in Isolated Nuclei XI. DNA-Mediated Transformation XII. Conclusions and Perspectives References8. Control of Gene Expression I. Developmental Changes in Gene Expression II. The Number of Developmentally Regulated Genes III. Appearance of Aggregation-Stage mRNAs Is under Transcriptional Control IV. Stability of mRNAs during Differentiation V. Requirement for Induction of Aggregation-Dependent mRNAs VI. Gene Expression Is Dependent on Continued Cell — Cell Interactions VII. cAMP and Gene Expression during Differentiation VIII. Conclusion References9. Morphogenetic Signaling, Cytodifferentiation, and Gene Expression I. Introduction II. Cell Contact-Mediated Signaling III. Positional Signaling IV. Holistic Signaling V. A Unified Theory of Morphogenesis and Cytodifferentiation References10. Polysphondylium and Dependent Sequences I. Introduction II. Morphogenesis III. Pallidin IV. Microcysts V. Dependent Pathways VI. Commitment VII. Prospects References11. Cell Proportioning and Pattern Formation I. Introduction II. The Spatial Pattern III. The Role of the Slug Pattern in Terminal Differentiation IV. Cell Sorting V. Diffusible Substances That May Control Differentiation VI. Theories of Cell Proportioning and Pattern Formation VII. Summary ReferencesBibliography on DictyosteliumIndex