The Design and Development of Novel Drugs and Vaccines
Principles and Protocols
- 1st Edition - January 22, 2021
- Latest edition
- Editors: Tarun Kumar Bhatt, Surendra Nimesh
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 1 4 7 1 - 8
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 1 4 7 5 - 6
The Design and Development of Novel Drugs and Vaccines: Principles and Protocols presents both in silico methods and experimental protocols for vaccine and drug design and develo… Read more
The Design and Development of Novel Drugs and Vaccines: Principles and Protocols presents both in silico methods and experimental protocols for vaccine and drug design and development, critically reviewing the most current research and emphasizing approaches and technologies that accelerate and lower the cost of product development. Sections review the technologies and approaches used to identify, characterize and establish a protein as a new drug and vaccine target, cover several molecular methods for in vitro studies of the desired target, and present various physiological parameters for in vivo studies. The book includes preclinical trials and research, along with information on FDA approval.
- Covers both in silico methods and experimental protocols for vaccine and drug development in a single, accessible volume
- Offers a holistic accounting of how developments in bioinformatics and large experimental datasets can be used in the development of vaccines and drugs
- Shows researchers the entire gamut of current therapies, ranging from computational inputs to animal studies
- Reviews the most current, cutting-edge research available on vaccine and drug design and development
Researchers and advanced students in life sciences, pharmacology, chemistry, biochemistry, toxicology and pharmaceutical science
1. Introduction of structural bioinformatics with respect to drug discovery
2. Target identification and validation
3. Retrieval of compounds
4. Lead identification and optimization
5. Molecular dynamics simulations
6. An overview of vaccine design
7. Key steps in the selection of vaccine targets
8. Epitope prediction and selection of linkers and adjuvant
9. Design of vaccine constructs
10. In-silico validation through protein-protein docking
11. Molecular cloning
12. Protein expression
13. Protein purification and desalting
14. Biological assay
15. Biophysical methods
16. Outline of animal study for lead/ vaccine testing
17. Evaluation of immunogenicity of vaccine candidate
18. In-vitro evaluation of lead molecule
19. Medical physiological parameter for lead/vaccine testing
20. Brief introduction of clinical research and trials
21. An overview of IND, NDA, approval agencies and FDA post-marketing surveillance
22. Introduction of Intellectual property rights
- Edition: 1
- Latest edition
- Published: January 22, 2021
- Language: English
TB
Tarun Kumar Bhatt
Tarun Kumar Bhatt is an Assistant Professor in the Department of Biotechnology, at the Central University of Rajasthan, India. He received his PhD from the International Centre for Genetic Engineering and Biotechnology, New Delhi and gained post-doctoral experience at the Scripps Research Institute in San Diego, California. He has published over 25 articles and has extensive experience researching drug and vaccine development.
Affiliations and expertise
Assistant Professor, Department of Biotechnology, Central University of Rajasthan, IndiaSN
Surendra Nimesh
Surendra Nimesh, UGC Assistant Professor at Central University of Rajasthan, Rajasthan, India. Surendra received his M.S. in Biomedical Science from the Dr. B.R. Ambedkar Center for Biomedical Research (ACBR), University of Delhi. He completed his PhD. In Nanotechnology at the Institute of Genomics and Integrative Biology (CSIR), Delhi. After completing his postdoctoral studies at the Ecole Polyetchnique of Montreal, Surendra joined the Clinical Research Institute of Montreal (IRCM), Canada as Postdoctoral Fellow. After completing his commitment at IRCM, he joined McGill University for short time. He also worked as NSERC visiting fellow at Health Canada, Canada. His research interests include nanoparticles-mediated gene, siRNA and drug delivery.
Affiliations and expertise
UGC Assistant Professor, Central University of Rajasthan, Rajasthan, IndiaRead The Design and Development of Novel Drugs and Vaccines on ScienceDirect