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The Choroid Plexus and Cerebrospinal Fluid
Emerging Roles in CNS Development, Maintenance, and Disease Progression
1st Edition - September 22, 2015
Editors: Josh Neman, Thomas C. Chen
Hardback ISBN:9780128017401
9 7 8 - 0 - 1 2 - 8 0 1 7 4 0 - 1
eBook ISBN:9780128018422
9 7 8 - 0 - 1 2 - 8 0 1 8 4 2 - 2
The Choroid Plexus and Cerebrospinal Fluid: Emerging Roles in CNS Development, Maintenance, and Disease Progression combines new and established work to allow for… Read more
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The Choroid Plexus and Cerebrospinal Fluid: Emerging Roles in CNS Development, Maintenance, and Disease Progression combines new and established work to allow for cross-disciplinary discussion and showcase newfound excitement surrounding the choroid plexus and cerebrospinal fluid (CSF). This book is of great utility to neuroscientists interested in biological questions about cancer, multiple sclerosis, Alzheimer’s, choroid plexus, or CSF research, and especially for researchers looking to expand their research into later stages of their disease of interest, such as metastasis. No other resource is currently available which addresses these issues in this fashion. The focus on the choroid plexus provides a practical resource on modeling clinical issues influenced by this brain region for researchers from students to principal investigators.
Presents recent progress made in the research of choroid plexus and cerebrospinal fluid across multi-disciplinary fields, including neuroscience, cancer biology, and immunology
Includes numerous illustrations of light, fluorescent, and electron micrographs
Provides data analysis boxes in each chapter to help with data interpretation and offer guidelines on how best to represent results
Includes chapters written by prominent researchers in the field
Graduate students in biological and biomedical sciences, post-doctoral students and fellows, as well as all researchers and clinicians seeking a resource on the interactions of choroid plexus, cerebrospinal fluid during normal development, maintenance of brain microenvironment and neurodegenerative diseases (Multiple Sclerosis and Alzheimer’s Disease) and brain tumors (primary and metastatic).
Dedication
List of Contributors
About the Editors
Preface
Acknowledgment
List of Abbreviations
Chapter 1: Introduction to the Ventricular System and Choroid Plexus
Abstract
Development of the ventricular system
Formation of the choroid plexus
Cerebrospinal fluid
Vascular supply of the choroid plexus
Chapter 2: Development of Brain Ventricles and Choroid Plexus
Abstract
Introduction
Neural plate and neural tube formation
Ventricular system development
Choroid plexus development
Chapter 3: Choroid Plexus: Structure and Function
Abstract
Basic anatomy
Inflammatory cells in the choroid plexus
Macrophages
Dendritic cells
T Lymphocytes
Cerebrospinal fluid
Conclusions
Acknowledgment
Chapter 4: Toward an Artificial Choroid Plexus, Concept and Clinical Implications
Abstract
Introduction
The CP is the major site for CSF formation, really?
CP as a site for secretion of biologically active compounds
Pharmacological considerations for the distribution of peptides within the CSF space
Toward an artificial choroid plexus
Conclusions
Chapter 5: Choroid Plexus Tumors
Abstract
Introduction
Primary choroid plexus tumors
Secondary choroid plexus tumors
Chapter 6: Role of Blood–Brain Barrier, Choroid Plexus, and Cerebral Spinal Fluid in Extravasation and Colonization of Brain Metastases
Abstract
Brain metastases
Blood–brain barrier versus blood–CSF barrier
Successful drug delivery through the BBB
Chapter 7: The Role of the Choroid Plexus in the Pathogenesis of Multiple Sclerosis
Abstract
The neural immune system compared with the peripheral immune system
The importance of the presence of immune cells in the neural parenchyma
The choroid plexus as a possible hot spot for immune cell infiltration
Background on multiple sclerosis
The relationship between the choroid plexus and multiple sclerosis pathogenesis
Physical changes that occur in the choroid plexus as a result of immune cell infiltration
Future directions
Conclusions
Chapter 8: The Choroid Plexus and Cerebrospinal Fluid System: Roles in Neurodegenerative Diseases
Abstract
Introduction
Part 1: Choroid plexus, cerebrospinal fluid, interstitial fluid: relationship with glymphatic system
Part 2: Choroid plexus: inflammation and neurodegenerative diseases
Part 3: CSF/ISF process in neurodegenerative diseases: pathophysiology and biomarkers
Conclusions
Acknowledgments
Chapter 9: Delivery Considerations for Targeting the Choroid Plexus–Cerebrospinal Fluid Route
Abstract
Introduction
Anatomical considerations
Pros and cons of drug delivery via the choroid plexus–CSF barrier
Novel methods for CSF delivery and choroid plexus targeting
Clinical implications of drug delivery to choroid plexus
Conclusions
Glossary
Subject Index
No. of pages: 210
Language: English
Published: September 22, 2015
Imprint: Academic Press
Hardback ISBN: 9780128017401
eBook ISBN: 9780128018422
JN
Josh Neman
Dr. Josh Neman completed his doctoral training in neurobiology at UCLA where he studied the development of oligodendrocytes from embryonic stem cells. Dr. Neman then chose to pursue his postdoctoral fellowship at City of Hope, where it would enable him to solidify the bridge between bench to bedside care for cancer patients. His current research investigates the biology of glioblastoma multiforme and breast to brain metastases. Dr. Neman’s expertise and strengths in stem cells, glial biology, neural development, synaptic plasticity, and trauma, have allowed for the development of novel approaches to study the brain and tumor microenvironment ---a vantage point that is currently lacking in the field of brain metastases. His research studies have established that the physiologic microenvironment of the brain must become a tumor-favorable microenvironment for successful metastatic colonization by circulating breast cancer cells. Dr. Neman has more than 30 peer reviewed original research articles (in PNAS, PLoS One, Spine, Neurosurgery, and Developmental Neurobiology), reviews, abstracts, and book chapters to his name. He is currently in process of co-editing the second edition of “Clinical Cases: Neuroscience” which is scheduled to be published in late 2014. Moreover, he has been recipient of research awards from NIH-NCI and California Institute for Regenerative Medicine.
Affiliations and expertise
Department of Neurological Surgery, Keck School of Medicine, USC, Los Angeles, CA, USA
TC
Thomas C. Chen
Dr. Chen is currently Professor of Neurological Surgery and Pathology at the University of Southern California. Highly experienced in the area of translational research aimed at the development of clinical trials and novel therapeutics for malignant brain tumours, he is the head of the Glioma Research Group at USC. He completed his neurological surgery residency and PhD in pathobiology at the University of Southern California, followed by fellowship training in spinal surgery from the Medical College of Wisconsin. Dr. Chen is a physician, a board certified neurosurgeon, and the Director of Surgical Neuro-oncology – recognized both for his skills as a neurosurgeon and his cutting edge research examining glioma biology.
Affiliations and expertise
Department of Neurological Surgery, Keck School of Medicine, USC, Los Angeles, CA, USA