The Choroid Plexus and Cerebrospinal Fluid

Emerging Roles in CNS Development, Maintenance, and Disease Progression

1st Edition - September 22, 2015
Editors: Josh Neman, Thomas C. Chen
Language: English
Hardback ISBN:
9 7 8 - 0 - 1 2 - 8 0 1 7 4 0 - 1
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 0 1 8 4 2 - 2

The Choroid Plexus and Cerebrospinal Fluid: Emerging Roles in CNS Development, Maintenance, and Disease Progression combines new and established work to allow for cross-dis… Read more

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The Choroid Plexus and Cerebrospinal Fluid: Emerging Roles in CNS Development, Maintenance, and Disease Progression combines new and established work to allow for cross-disciplinary discussion and showcase newfound excitement surrounding the choroid plexus and cerebrospinal fluid (CSF). This book is of great utility to neuroscientists interested in biological questions about cancer, multiple sclerosis, Alzheimer’s, choroid plexus, or CSF research, and especially for researchers looking to expand their research into later stages of their disease of interest, such as metastasis. No other resource is currently available which addresses these issues in this fashion. The focus on the choroid plexus provides a practical resource on modeling clinical issues influenced by this brain region for researchers from students to principal investigators.

Dedication
List of Contributors
About the Editors
Preface
Acknowledgment
List of Abbreviations
Chapter 1: Introduction to the Ventricular System and Choroid Plexus
- Abstract
- Development of the ventricular system
- Formation of the choroid plexus
- Cerebrospinal fluid
- Vascular supply of the choroid plexus
Chapter 2: Development of Brain Ventricles and Choroid Plexus
- Abstract
- Introduction
- Neural plate and neural tube formation
- Ventricular system development
- Choroid plexus development
Chapter 3: Choroid Plexus: Structure and Function
- Abstract
- Basic anatomy
- Inflammatory cells in the choroid plexus
- Macrophages
- Dendritic cells
- T Lymphocytes
- Cerebrospinal fluid
- Conclusions
- Acknowledgment
Chapter 4: Toward an Artificial Choroid Plexus, Concept and Clinical Implications
- Abstract
- Introduction
- The CP is the major site for CSF formation, really?
- CP as a site for secretion of biologically active compounds
- Pharmacological considerations for the distribution of peptides within the CSF space
- Toward an artificial choroid plexus
- Conclusions
Chapter 5: Choroid Plexus Tumors
- Abstract
- Introduction
- Primary choroid plexus tumors
- Secondary choroid plexus tumors
Chapter 6: Role of Blood–Brain Barrier, Choroid Plexus, and Cerebral Spinal Fluid in Extravasation and Colonization of Brain Metastases
- Abstract
- Brain metastases
- Blood–brain barrier versus blood–CSF barrier
- Successful drug delivery through the BBB
Chapter 7: The Role of the Choroid Plexus in the Pathogenesis of Multiple Sclerosis
- Abstract
- The neural immune system compared with the peripheral immune system
- The importance of the presence of immune cells in the neural parenchyma
- The choroid plexus as a possible hot spot for immune cell infiltration
- Background on multiple sclerosis
- The relationship between the choroid plexus and multiple sclerosis pathogenesis
- Physical changes that occur in the choroid plexus as a result of immune cell infiltration
- Future directions
- Conclusions
Chapter 8: The Choroid Plexus and Cerebrospinal Fluid System: Roles in Neurodegenerative Diseases
- Abstract
- Introduction
- Part 1: Choroid plexus, cerebrospinal fluid, interstitial fluid: relationship with glymphatic system
- Part 2: Choroid plexus: inflammation and neurodegenerative diseases
- Part 3: CSF/ISF process in neurodegenerative diseases: pathophysiology and biomarkers
- Conclusions
- Acknowledgments
Chapter 9: Delivery Considerations for Targeting the Choroid Plexus–Cerebrospinal Fluid Route
- Abstract
- Introduction
- Anatomical considerations
- Pros and cons of drug delivery via the choroid plexus–CSF barrier
- Novel methods for CSF delivery and choroid plexus targeting
- Clinical implications of drug delivery to choroid plexus
- Conclusions
Glossary
Subject Index

Josh Neman

Dr. Josh Neman completed his doctoral training in neurobiology at UCLA where he studied the development of oligodendrocytes from embryonic stem cells. Dr. Neman then chose to pursue his postdoctoral fellowship at City of Hope, where it would enable him to solidify the bridge between bench to bedside care for cancer patients. His current research investigates the biology of glioblastoma multiforme and breast to brain metastases. Dr. Neman’s expertise and strengths in stem cells, glial biology, neural development, synaptic plasticity, and trauma, have allowed for the development of novel approaches to study the brain and tumor microenvironment ---a vantage point that is currently lacking in the field of brain metastases. His research studies have established that the physiologic microenvironment of the brain must become a tumor-favorable microenvironment for successful metastatic colonization by circulating breast cancer cells. Dr. Neman has more than 30 peer reviewed original research articles (in PNAS, PLoS One, Spine, Neurosurgery, and Developmental Neurobiology), reviews, abstracts, and book chapters to his name. He is currently in process of co-editing the second edition of “Clinical Cases: Neuroscience” which is scheduled to be published in late 2014. Moreover, he has been recipient of research awards from NIH-NCI and California Institute for Regenerative Medicine.

Affiliations and expertise

Department of Neurological Surgery, Keck School of Medicine, USC, Los Angeles, CA, USA

Thomas C. Chen

Dr. Chen is currently Professor of Neurological Surgery and Pathology at the University of Southern California. Highly experienced in the area of translational research aimed at the development of clinical trials and novel therapeutics for malignant brain tumours, he is the head of the Glioma Research Group at USC. He completed his neurological surgery residency and PhD in pathobiology at the University of Southern California, followed by fellowship training in spinal surgery from the Medical College of Wisconsin. Dr. Chen is a physician, a board certified neurosurgeon, and the Director of Surgical Neuro-oncology – recognized both for his skills as a neurosurgeon and his cutting edge research examining glioma biology.