The Cancer Stem Cell Niche
- 1st Edition, Volume 5 - January 23, 2021
- Imprint: Academic Press
- Editor: Susie Nilsson
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 8 5 3 2 5 - 5
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 8 5 3 2 6 - 2
The Cancer Stem Cell Niche, Volume Five in the Advances in Stem Cells and their Niches series, highlights new advances in the field, with this new volume presenting intere… Read more
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Request a sales quoteThe Cancer Stem Cell Niche, Volume Five in the Advances in Stem Cells and their Niches series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Acute lymphoblastic leukemia and the bone marrow microenvironment, Stem cell niches in bone and their roles in cancer metastasis, The role of vasculature in cancer stem cell niches, The lung cancer stem cell niche, The prostate cancer stem cell niche: Genetic drivers and therapeutic approaches, Impact of prostate cancer stem cell niches on prostate cancer tumorigenesis and progression, The testicular cancer stem cell niche.
- Provides the authority and expertise of leading contributors from an international board of authors
- Presents the latest release in the Advances in Stem Cells and their Niches series
- Includes the latest information on the Cancer Stem Cell Niche
Academic Researchers, Research scientists and graduate students in universities, industry and government
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Chapter One: Acute lymphoblastic leukemia and the bone marrow microenvironment
- Abstract
- 1: Introduction
- 2: Cellular components of the ALL niche
- 3: Extracellular components of the ALL niche
- 4: Summary
- Chapter Two: Stem cell niches in bone and their roles in cancer metastasis
- Abstract
- 1: Introduction
- 2: Niches within the bone marrow
- 3: Niche constituents originating from mesenchymal stem cells
- 4: Niche constituents originating from hematopoietic stem cells
- 5: Other niche constituent cell types
- 6: Future perspectives
- Chapter Three: The role of vasculature in cancer stem cell niches
- Abstract
- 1: Introduction
- 2: Niche functions of vasculature
- 3: Links between vasculature and cancer cell stemness
- 4: Angiocrine crosstalk in the tumor microenvironment
- 5: Maladaptation of vasculature in the tumor microenvironment
- 6: Vascular microenvironments supporting the cancer stem cell quiescence
- 7: Vascular niches for disseminated tumor cells and CSCs in the bone marrow
- 8: Conclusions
- Chapter Four: The lung cancer stem cell niche
- Abstract
- 1: Introduction
- 2: Epithelial stem cell compartments in the adult lung
- 3: Lung cancer stem cells
- 4: Deconstructing the lung cancer stem cell niche
- 5: Organotropism and the metastatic niche
- 6: Conclusion
- Chapter Five: The prostate cancer stem cell niche: Genetic drivers and therapeutic approaches
- Abstract
- 1: Introduction
- 2: The prostate gland: Structure and general overview
- 3: Prostate cancer and prostate cancer stem cells
- 4: Genetic drivers of stemness in prostate cancer
- 5: The PCSC NICHE environment
- 6: Therapeutic targeting of PCSCs
- 7: Conclusions
- Acknowledgments
- Chapter Six: Impact of prostate cancer stem cell niches on prostate cancer tumorigenesis and progression
- Abstract
- 1: Introduction
- 2: Prostate cancer stem cells
- 3: Niche involvement in PCSC-mediated tumor initiation
- 4: Utilization of HSC niches by PCSC for bone metastasis
- 5: Conclusions and perspectives
- Chapter Seven: The testicular cancer stem cell niche
- Abstract
- 1: Introduction
- 2: Establishment of the Spermatogonial stem cell (SSC) niche
- 3: Anatomical and histological organization of the SSC niche
- 4: Developmental origin of germ cell tumors
- 5: Tools to study the SSC niche
- 6: Vascular system and oxygenation
- 7: Immune system
- 8: Concluding remarks
- Edition: 1
- Volume: 5
- Published: January 23, 2021
- No. of pages (Paperback): 246
- No. of pages (eBook): 246
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780323853255
- eBook ISBN: 9780323853262
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Susie Nilsson
Dr Nilsson is currently involved in multiple research projects, all aimed to conduct extensive cellular, molecular and functional analyses of blood stem cells, their progeny and their bone marrow microenvironment.
Affiliations and expertise
Biomedical Manufacturing, CSIRO; Monash University, AustraliaRead The Cancer Stem Cell Niche on ScienceDirect