The Biology of Ageing: From Hallmarks to Drugs
- 1st Edition, Volume 1 - October 12, 2023
- Imprint: Academic Press
- Editor: Richard Faragher
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 1 9 2 7 8 - 4
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 9 2 7 9 - 1
The Biology of Ageing: From Hallmarks to Drugs provides a series of reviews covering multiple aspects of the translational pipeline as interventions in the biology of ageing it… Read more
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Request a sales quoteThe Biology of Ageing: From Hallmarks to Drugs provides a series of reviews covering multiple aspects of the translational pipeline as interventions in the biology of ageing itself become a clinical reality. New chapters cover Cellular senescence and NAD+: what are the links?, Biomarker for ageing: potential and pitfalls, What chemists offer to ageing research, You are what you eat – or are you? Exploring dietary versus topical anti-oxidants in skin ageing, Clinical trials: A simple guide for gerontologists, Towards an ethical framework for geroscience, and more.
The book explores links between known ageing mechanisms and new interventions, agents and actions at the nutraceutical-drug divide, the challenges and opportunities provided by biomarkers and chemistry- biology interface and lastly the ethical and operational challenges of clinical trials in the age of translational geroscience.
- Covers novel mechanistic ideas
- Includes ethical and industrial input
- Focuses on problems and solutions from chemistry and biomarkers to the clinic
Postgraduate students and academics with an interest in geronscience
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- References
- Chapter One: You are what you eat—Or are you? Exploring dietary versus topical antioxidants in skin aging
- Abstract
- 1: Skin structure and function
- 2: Chronological skin aging
- 3: Photoaging
- 4: Experimental approaches for the study of antioxidants in skin aging
- 5: Discussion
- Acknowledgments
- References
- Chapter Two: Clinical trials: A simple guide for gerontologists
- Abstract
- 1: Drug development regulatory framework
- 2: Drug development process overview
- 3: Types of clinical studies
- 4: What might help during the process of product development
- 5: Clinical operations jargon
- Chapter Three: Toward an ethical framework for geroscience?
- Abstract
- 1: Demographic background
- 2: Scientific background
- 3: Ethical background
- 4: What are the goals and desires of the public?
- 5: Why do people think like this?
- 6: Future ethical frameworks
- References
- Chapter Four: Selective autophagy-driven senescence as a barrier to tumorigenesis: Arriving at the destination through an alternative path
- Abstract
- References
- Edition: 1
- Volume: 1
- Published: October 12, 2023
- Imprint: Academic Press
- No. of pages: 277
- Language: English
- Hardback ISBN: 9780443192784
- eBook ISBN: 9780443192791
RF
Richard Faragher
Richard Faragher is Professor of Biological Gerontology at the University of Brighton and is past Chair of the British Society for Research on Ageing, the International Association of Biomedical Gerontology and the American Aging Association. He read Biochemistry at Imperial College, London and undertook doctoral studies on human premature ageing at the University of Sussex. His primary research interest is the relationship between cellular senescence and organismal ageing. He has published widely on the phenotype of senescent cells and on compounds that reverse the process.
He holds the Royal Pharmaceutical Society Conference Science Medal for his work on the mechanisms of Werner’s syndrome, the Help the Aged ‘Living Legend’ award for his championship of older people, the Paul F Glenn Award for research into the mechanisms of ageing and the British Society for Research on Ageing’s highest honour, the Lord Cohen of Birkenhead Medal.
Professor Faragher is a Fellow of the American Aging Association and has served as a member of the Research Advisory Council of the Charity Research into Ageing and on strategy and funding panels for the BBSRC, the US National Institutes on Ageing and the European Union. From 2005-2008 he was Co-director of the BBSRC-EPSRC SPARC programme, a research network designed to build national capacity to conduct inter-disciplinary ageing research. He is currently a Director of the American Federation for Aging Research, serves on the Scientific Advisory Board of the Longevity Vision Fund and co-directs the BBSRC-MRC funded Building Links in Ageing Science and Translation (BLAST) research network.
Affiliations and expertise
Professor of Biological Gerontology at the University of Brighton and is past Chair of the British Society for Research on Ageing, the International Association of Biomedical Gerontology and the American Aging Association.Read The Biology of Ageing: From Hallmarks to Drugs on ScienceDirect