The Biochemistry of Poliomyelitis Viruses
A Synopsis of Poliomyelitis Infection and Research
- 1st Edition - January 1, 1964
- Imprint: Pergamon
- Author: Ernest Kovács
- Editors: P. Alexander, Z. M. Bacq
- Language: English
- Paperback ISBN:9 7 8 - 1 - 4 8 3 1 - 1 7 9 1 - 1
- eBook ISBN:9 7 8 - 1 - 4 8 3 1 - 5 0 3 3 - 8
The Biochemistry of Poliomyelitis Viruses deals with the interrelationships and differences of positions in the field of poliomyelitis research. This volume presents a general… Read more
Purchase options
Institutional subscription on ScienceDirect
Request a sales quoteThe Biochemistry of Poliomyelitis Viruses deals with the interrelationships and differences of positions in the field of poliomyelitis research. This volume presents a general introduction to viruses as to their descriptions and biological, biochemical, and epidemiological aspects. Clinical poliomyelitis, test measurements in the cerebrospinal fluid, and the actions of the poliomyelitis virus are explained. The isolation of the poliomyelitis virus and some aspects of its immunology and serology through refinements of serologic tools and special techniques, plus the state of poliovirus purification, are noted. This book also gives assumptions about the virus' synthetic activities in vivo based on experiments conducted in other viral diseases other than the polio virus. This text also notes that important discoveries such as those made by Gierer and Schramm or Fraenkel-Conrat provide updated poliomyelitis research. Other research studies are taken into consideration and emphasis is given to the biochemical concept of the polio infection and the related features induced during infection such as the presence of tumors. The most promising trend in research is in the study of enzymes of infected cells leading to an understanding of the biochemistry of viral diseases. The use of inference microscopy and X-ray analysis of cell mass is recommended. This book will prove invaluable for microbiologists, disease investigators, clinical workers, and research scientists.
Foreword
Acknowledgments
Chapter 1. The Viruses (A General Introduction)
A. Virus in Older Definitions
B. Virus as it Looks Now
References to Chapter 1
Chapter 2. The Biological, Biochemical and Epidemiological Aspects of Poliomyelitis of Man and Animals
The Human Disease
1. General Notions
2. Clinical Poliomyelitis
3 . Biochemical Aspects
References to Chapter 2
Chapter 3. Experimental Poliomyelitis
1. The Disease in Animals
2. Isolation of the Poliomyelitis Virus and Its Bioassay
Virus Identification and Titration on Experimental Animal
The Use of Cells in Culture for Identification of the Poliomyelitis Viruses
Some Aspects of the Immunology and Aerology of Poliovirus
References to Chapter 3
Chapter 4. Biochemical Data on Poliovirus
Purification, Crystallization, Biochemical and Biophysical Characterization of Poliomyelitis Viruses
Preparation of Crystalline and Radioactive Poliovirus
Physical and Chemical Parameters of Purified Poliovirus
Additional Biological, Biochemical and Biophysical Characteristics of Poliovirus
Effect of Electronic and/or Ionizing Radiation
Specific Infectivity and the Infectious Unit
Virus Nucleic Acid and Infectivity
Resistance of Poliovirus to Cytolytic Agents and Enzymes
Resistance of Poliovirus to some Physical Factors
Effect of Chemical Agents and Disinfectants
References to Chapter 4
Chapter 5. Biochemistry of Animal-Adapted Poliomyelitis Infection, In Vivo
Introduction
Respiration and Glycolysis
Phosphate Metabolism and Change in the Activity of Oxidative Enzymes
Biochemical Data of Chromatolytic Neurons and Virus Infected Tissues
Further Intracellular Localization of Virus Growth
The Role of Nutrition and Co-factors
The Application of Enzyme Inhibitors
Environmental Conditions and Conditional Factors
Effect of Hormones
Data on the Effect of X-Ray Radiation, Physical and Chemical Agents
References to Chapter 5
Chapter 6. Further Considerations of the General Biology, Biochemistry and Pathology of Experimental Poliomyelitis Infection in Animals
1. Nucleic Acid of the Host and the Virus during Experimental Poliomyelitis, In Vivo
2. Complementary Data on the Biology of Animal Infection
References to Chapter 6
Chapter 7. The Host Cells in General
1. General Properties of the Cells in Culture In Vitro
2. Light Microscopic Cytopathic Changes due to the Poliovirus Infection
3. Some Facts on the Cellular Organization as Revealed by Utrastructural Research
References to Chapter 7
Chapter 8. Some Cytological and Biological Effects of Poliomyelitis Virus on Cells in Culture
1. General Notions
2. Changes in Cell Morphology
3. General Biological Observations and Use of Special Techniques
References to Chapter 8
Chapter 9. Biochemistry of Poliovirus Infection in Cells in Culture
General Notions, Respiration and Glycolysis
Effect of Nutrition and Environmental Temperature
Work with Radioactive Tracers
Quantitative Nucleic Acid Changes
Recent Findings Regarding the Biosynthesis of the Protein and Nucleic Acid of Poliovirus
Some Biochemical Data of Latent Infection
References to Chapter 9
Chapter 10. Change in the Physiology of Cells during Poliovirus Infection, In Vitro
1. Further Data on Biochemical and Especially Enzyme Changes in the Host Cells
2. Early Irreversible Enzyme Alterations Leading to the Destruction of the Host
3 . The Influence of Hormones and Other Biological Agents Administered In Vitro
References to Chapter 10
Chapter 11. The Role of Heredity
1. Genetic Aspects of Clinical and Experimental Poliomyelitis
2. Virus Genetics
3 . Hypotheses on the Biochemical Mechanism of Heredity
References to Chapter 11
Chapter 12. Further Considerations on the Epidemiology and Immunology of Poliomyelitis Infection
1. General Notions
2. The Question of Immunity against Poliomyelitis
3. Defense Against Poliomyelitis and the Efforts for the Prevention of the Disease
References to Chapter 12
Chapter 13. Facts and Speculations on the Biosynthesis of the Poliovirus, a Working Hypothesis of the Author
References to Chapter 13
Chapter 14. Chemical, Physical and Biological Foundation of Virus Research
1. Essential Notions of Nucleic Acid and Protein Biochemistry
Physical and Chemical Properties and Structure of Polynucleotides
Structure, Enzymic Degradation and Synthesis of RNA and DNA
2. Chemical Structure and Biochemistry of Proteins
Proteolytic Enzymes
3. Biosynthesis of the Proteins and Nucleic Acids
Uptake of the Aminoacids into the Cells
Synthesis of Proteins in Subcellular Components
The pH-5 Enzyme and Aminoacid Activation
Essential Aspects of the Biosynthesis of Nucleic Acids
Enzymatic Synthesis of Polynucleotides
4. Nucleic Acid Synthesis in Animal Systems
References to Chapter 14
Chapter 15. The Biochemical Concept of Poliomyelitis Virus Infection
References to Chapter 15
Chapter 16. Biochemical Aspects of Some Other Features of the Virus Problem
Virology and Tumors
References to Chapter 16
Chapter 17. Recent Developments in Poliomyelitis Research
References to Chapter 17
Chapter 18. Discussion and Conclusions
Author Index
Subject Index
Other Titles in this Series
- Edition: 1
- Published: January 1, 1964
- No. of pages (eBook): 284
- Imprint: Pergamon
- Language: English
- Paperback ISBN: 9781483117911
- eBook ISBN: 9781483150338
Read The Biochemistry of Poliomyelitis Viruses on ScienceDirect