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Elsevier

Thalassemia, An Issue of Hematology/Oncology Clinics of North America

  • 1st Edition, Volume 37-2 - March 16, 2023
  • Latest edition
  • Editors: Edward J. BenzJr, Vijay G. Sankaran
  • Language: English

In this issue of Hematology/Oncology Clinics, guest editors Drs. Edward J. Benz, Jr. and Vijay G. Sankaran bring their considerable expertise to the topic of Thalassemia. Top… Read more

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Description

In this issue of Hematology/Oncology Clinics, guest editors Drs. Edward J. Benz, Jr. and Vijay G. Sankaran bring their considerable expertise to the topic of Thalassemia. Top experts in the field provide an overview of the history, epidemiology, pathogenic mechanisms, and clinical management of the thalassemia syndromes.

Key features

  • Contains 16 practice-oriented topics including molecular basis and genetic modifiers of thalassemia; fetal hemoglobin in thalassemia; clinical complications and their management; iron chelation in thalassemia; fertility and pregnancy in women with transfusion-dependent thalassemia; gene therapy and genome editing in thalassemia; emerging medical therapies for thalassemia; and more.

  • Provides in-depth clinical reviews on thalassemia, offering actionable insights for clinical practice.

  • Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Readership

Hematology

Table of contents

Introduction to the Thalassemia Syndromes: Molecular Medicine’s Index Case
The Need for Translational Epidemiology in Beta Thalassemia Syndromes:A Thalassemia International Federation Perspective
Molecular Basis and Genetic Modifiers of Thalassemia
Fetal Hemoglobin Regulation in Beta-Thalassemia
Clinical Classification, Screening, and Diagnosis in Beta-Thalassemia and Hemoglobin E/Beta-Thalassemia
The Clinical Phenotypes of Alpha Thalassemia
Pathogenic Mechanisms in Thalassemia I: Ineffective Erythropoiesis and Hypercoagulability
Pathogenic Mechanisms in Thalassemia II: Iron Overload
Clinical Complications and Their Management
Clinical Challenges with Iron Chelation in Beta Thalassemia
Fertility and Pregnancy in Women with Transfusion-Dependent Thalassemia
Hematopoietic Stem Cell Transplantation in Thalassemia
Gene Therapy and Gene Editing for b-Thalassemia
Emerging Therapies in b-Thalassemia

Product details

  • Edition: 1
  • Latest edition
  • Volume: 37-2
  • Published: March 16, 2023
  • Language: English

About the editors

EB

Edward J. BenzJr

Affiliations and expertise
Professor, Pediatrics, Richard and Susan Smith Professor, Medicine, Professor, Genetics,Harvard Medical School ,President and CEO, Emeritus, Office of the President, Dana-Farber Cancer Institute

VS

Vijay G. Sankaran

Affiliations and expertise
Jan Ellen Paradise, M.D. Associate Professor of Pediatrics, Harvard Medical School Lodish Family Chair, Division of Hematology/Oncology, Boston Children's Hospital Robertson Investigator, New York Stem Cell , Foundation, Principal Faculty, Harvard Stem Cell Institute, Attending Physician, Dana Farber/Boston Children's Cancer and Blood Disorders Center, Associate Member, Broad Institute of MIT and Harvard