Textbook of SARS-CoV-2 and COVID-19
Epidemiology, Etiopathogenesis, Immunology, Clinical Manifestations, Treatment, Complications, and Preventive Measures
- 1st Edition - September 21, 2022
- Imprint: Elsevier
- Authors: Subramani Mani, Jorn-Hendrik Weitkamp
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 8 7 5 3 9 - 4
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 8 7 5 4 0 - 0
Written by physicians and scientists with expertise in this evolving area, Textbook of SARS-CoV-2 and COVID-19 provides a coherent, readable, and clinically relevant review of the… Read more
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Request a sales quoteWritten by physicians and scientists with expertise in this evolving area, Textbook of SARS-CoV-2 and COVID-19 provides a coherent, readable, and clinically relevant review of the biology, epidemiology, pathophysiology, immunology, clinical features, current treatment, and prevention strategies for the SARS-CoV-2 virus. Using both a systemic and topic-based approach, it summarizes and clarifies the extensive literature published on SARS-CoV-2 and COVID-19, includes a comprehensive bibliography, and provides answers to clinical questions at the point of care from multiple specialty perspectives.
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Includes dedicated chapters for pulmonary, cardiac, neurological, and oral manifestations of COVID-19.
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Covers therapeutics and novel therapeutic targets of SARS-CoV-2 and COVID-19.
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Addresses the diagnostic and management challenges of COVID-19 in the emergency department.
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Discusses COVID-19 in special populations, including the effect of SARS-CoV-2 infection in pregnant mothers and to the fetus and newborn.
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Provides a systematic overview and comparison of vaccines that are approved and in development.
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Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Internal medicine residents (7500 in the US each year) and practitioners (115,000 in the US), Infectious Diseases practitioners (9000+ in the US in 2018, up from 6000 in 2008).
- Cover Image
- Title Page
- Copyright
- Dedication
- Contributors
- Acknowledgments
- Preface
- Table of Contents
- Part I The Basics: Epidemiology, Biology, Pathogenesis, Immunology, and Natural History
- Chapter 1 Epidemiology of SARS-CoV-2 and COVID-19
- Outline
- Asia
- Europe
- Americas
- Africa
- Oceania
- Risk Factors for COVID-19
- Conclusion
- References
- Chapter 2 SARS-CoV-2: Structure, Pathogenesis, and Diagnosis
- Outline
- SARS-CoV-2 and Coronaviruses
- Structural Proteins
- Accessory Proteins
- Nonstructural Proteins
- Mechanisms of SARS-CoV-2 Pathogenesis
- Testing for Present and Past Infection
- Conclusion
- Acknowledgments
- References
- Chapter 3 Immunology of COVID-19
- Outline
- Innate Immune Responses
- Adaptive Immune Responses
- Immune Dysregulation and Immunopathology
- The Global Pandemic and Questions for Future Research
- Conclusion
- Acknowledgments
- References
- Chapter 4 COVID-19: Natural History and Spectrum of Disease
- Outline
- Short Comparison of SARS-CoV-2 With SARS-CoV-1 and MERS-CoV
- Natural History
- Spectrum of COVID-19
- Pathogenesis
- Clinical Characteristics
- Impact of Comorbidities
- Radiology and Laboratory Features
- Treatment, Clinical Course, and Outcomes
- Drug Pipeline
- Vaccines
- Children and COVID-19
- Post Recovery Symptoms and the Long-Hauler Syndrome
- Racial Disparities in Susceptibility to SARS-CoV-2
- Conclusion
- References
- Part II The Clinical: Manifestations in Systems and Domains of the Body
- Chapter 5 Pulmonary Manifestations of COVID-19
- OUTLINE
- COVID-19 Manifestations in the Respiratory System
- Treatment and Management of Salient Pulmonary Manifestations and Complications of COVID-19
- Management of Respiratory Failure
- Current Guidelines and Medications Available for Management of COVID-19
- General Principles of Management of Long-Term Pulmonary Sequelae
- Case Reports Highlighting the Varied Pulmonary Manifestations of COVID-19
- CONCLUSION
- References
- Chapter 6 COVID-19 and the Cardiovascular System
- OUTLINE
- Epidemiology of Cardiac Injury From COVID-19
- History of Cardiovascular Effects From SARS-CoV-1 and MERS-CoV
- Pathophysiology and Potential Mechanisms of Cardiovascular Injury From COVID-19
- Clinical Manifestations and Complications
- Cardiovascular Comorbidities and COVID-19
- Management of COVID-19–Related Cardiac Complications
- Case Reports
- COVID-19–Induced Cardiac Complications and Long-Term Sequelae
- Conclusion
- References
- Chapter 7 Neurological Manifestations of COVID-19
- Outline
- Epidemiology of Neurological Manifestations of COVID-19
- Historical Background of Neurological Effects of the Coronavirus Family
- Pathophysiology, Pathogenesis, and Proposed Mechanisms of the SARS-CoV-2 Virus and the Nervous System
- COVID-19 and the Peripheral Nervous System
- COVID-19 and the Central Nervous System
- Long COVID and Neurological Postacute Sequelae of SARS-CoV-2 Infection
- COVID 19 and Challenges
- Summary
- References
- Chapter 8 Oral Cavity and COVID-19: Clinical Manifestations, Pathology, and Dental Profession
- Outline
- The Oral Cavity and Viral Infections
- SARS-CoV-2 and the Oral Cavity
- Mechanisms of Oral Manifestations of SARS-CoV-2
- The Oral Microbiome and COVID-19
- Salivary Diagnostics, Transmission, and Biomarkers for COVID-19
- SARS-CoV-2 and the Dental Office
- Conclusion
- References
- Chapter 9 Gastrointestinal Manifestations of COVID-19
- Outline
- Prevalence of Gastrointestinal Symptoms
- Implications of Gastrointestinal Symptoms in COVID-19
- Mechanism on How SARS-CoV-2 Affects Gut Health
- Impact of Gastric Acid Reduction on COVID-19 Outcomes
- Impact of COVID-19 in Inflammatory Bowel Disease
- Impact of COVID-19 on Liver
- Impact of COVID-19 on Pancreatic Disorders
- Association Between Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker Use and Gastrointestinal Symptoms in COVID-19
- Postinfectious Gastrointestinal Symptoms
- Conclusion
- References
- Chapter 10 Kidney Manifestations of COVID-19
- Outline
- Acute Kidney Injury Incidence and Mortality Associated With SARS-CoV-2 Infection
- Could Viral Tropism in Kidney Parenchyma Be Responsible for Acute Kidney Injury?
- Tubular Injury in COVID-19
- Glomerular Disease and COVID-19
- COVID-19–Associated Nephropathy
- Reports of Other Glomerulonephritis
- Thrombotic Microangiopathy
- Proposed Mechanisms
- Management of COVID-19 Acute Kidney Injury
- Medication Treatment
- Renal Replacement Therapy
- Unique Kidney Populations and COVID-19
- End-Stage Kidney Disease and COVID-19
- Transplant and COVID-19
- Mortality of COVID-19 Infection in Kidney Transplant
- Impact on Kidney Transplantation and Medication Management
- Conclusion
- References
- Chapter 11 Ophthalmic Manifestations of COVID-19
- Outline
- Introduction and Historical Perspectives
- Role of the Eye in Transmission and Prevention
- Ocular Manifestations
- Conclusion
- References
- Chapter 12 Psychiatric Manifestations of COVID-19
- Outline
- Introduction
- Delirium
- Impact of Preexisting Psychiatric Disorders on COVID-19 Outcomes
- Anxiety, Depression, Mania, and Suicide Risk
- Posttraumatic Stress Disorder and Trauma-Related Symptoms
- Psychosis and Catatonia
- Psychiatric Symptoms Directly Linked to Viral Infection
- Conclusion
- References
- Part III Fetus, Newborn, Infants, Children
- Chapter 13 Impact of Maternal SARS-CoV-2 Infection on the Fetus and Newborn
- Outline
- History of Perinatal Coronavirus Infections
- Impacts of SARS-CoV-2 Infection on the Pregnant Mother
- Impact of SARS-CoV-2 Infections on the Fetus and Newborn
- Conclusion
- References
- Chapter 14 COVID-19 in Children and Adolescents
- Outline
- Coronavirus Infections in Children and Adolescents
- Epidemiology of SARS-CoV-2 Infection in Children and Adolescents
- Clinical Manifestations of SARS-CoV-2 Infection in Infants and Children
- Treatment of Acute COVID-19 in Children
- Prevention of SARS-CoV-2 Infection
- COVID-19 Impact on Well-Being of Children
- Conclusion
- References
- Part IV Special Topics: Emergency Medicine, Therapeutics, Novel Targets, Vaccines
- Chapter 15 COVID-19: Emergency Medicine Perspectives
- Outline
- Introduction
- Clinical Manifestations
- Diagnostic Workup and Investigation
- Management
- Disposition
- Special Considerations
- Conclusion
- References
- Chapter 16 Therapeutics for COVID-19
- Outline
- Evolution of Therapeutic Approaches
- Treatments Authorized for Emergency Use
- Repurposed Drugs and New Molecular Entities in Clinical Development
- Therapeutic Management: Current Guidelines and Unmet Needs
- Conclusion
- References
- Chapter 17 Novel Therapeutic Targets for SARS-CoV-2 and COVID-19
- Outline
- Factors That Affect Therapy for Treatment of COVID-19
- Emerging Therapeutic Treatments of the Disease
- Brief Description of Structure and Parts of SARS-CoV-2
- Therapeutic Targets for the Treatment of COVID-19
- Overview of Therapies Based on Repurpose Drugs and Corresponding Targets
- Viral Mutations and Selection of Drug Targets
- Conclusion
- References
- Chapter 18 Vaccine Basics and the Development and Rollout of COVID-19 Vaccines
- Outline
- Historical Introduction to Vaccines
- Vaccines and Vaccinology
- COVID-19 Vaccine Development
- COVID-19 Vaccine Rollout
- Conclusion
- References
- Glossary
- Acronyms
- Index
- Edition: 1
- Published: September 21, 2022
- Imprint: Elsevier
- No. of pages: 400
- Language: English
- Hardback ISBN: 9780323875394
- eBook ISBN: 9780323875400
SM
Subramani Mani
Dr. Mani is a physician scientist with a strong background and training in internal medicine, a research fellowship in cardiology, a doctorate in biomedical informatics, and an extensive research track record and experience teaching medical and graduate students.
Affiliations and expertise
Independent research consultant; Former Associate Professor, Department of Medicine, University of New Mexico School of Medicine; Former Assistant Professor, Department of Biomedical Informatics, Vanderbilt University, Franklin, TennesseeJW
Jorn-Hendrik Weitkamp
Dr. Weitkamp is an Associate Professor of Pediatrics and research scientist at Vanderbilt University, specializing in pediatric infectious diseases and neonatal-perinatal medicine. Dr Weitkamp has conducted a large number of clinical and translational research studies in the neonatal intensive care unit (NICU), including industry, foundation, and NIH-supported trials.
Affiliations and expertise
Associate Professor of Pediatrics, Monroe Carrell Jr. Children’s Hospital, Vanderbilt University Medical Center, Nashville, TennesseeRead Textbook of SARS-CoV-2 and COVID-19 on ScienceDirect