Textbook of Pediatric Rheumatology
- 9th Edition - May 25, 2026
- Latest edition
- Editors: Ross E. Petty, Ronald M. Laxer, Lucy Wedderburn, Elizabeth D. Mellins, Robert C. Fuhlbrigge, Jonathan Akikusa, Hermine Brunner
- Language: English
This core textbook discusses the presentation and pathophysiology, differential diagnosis, management, and prognosis for a comprehensive range of pediatric rheumatic condit… Read more
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This core textbook discusses the presentation and pathophysiology, differential diagnosis, management, and prognosis for a comprehensive range of pediatric rheumatic conditions. Global leaders in the field provide evidence-based guidance highlighted by superb full-color illustrations that facilitate a thorough understanding of the science that underlies the investigation, recognition, and management of rheumatic diseases in childhood and adolescence.
- Addresses the full spectrum of rheumatic diseases, from typical juvenile idiopathic arthritis to rare and newly recognized syndromes, providing practical guidance on diagnosis, outcome measurement, and management—including both pharmacologic and multidisciplinary strategies
- Covers state-of-the-art advances in pediatric rheumatology, including genomic and multi-omics approaches, the latest targeted therapies, modern imaging, and evolving concepts in autoinflammation and immune deficiency
- Reflects the changes in diagnosis, monitoring, and management that recent advances have made possible, and provides updates of laboratory investigations, imaging techniques, physical and occupational therapy, approach to chronic musculoskeletal pain syndromes, and much more
- Features reviews of the complex symptoms, signs, and laboratory abnormalities that characterize these disorders
- Shares the knowledge and expertise of two new editors, Drs. Jonathan Akikusa and Hermine Brunner, and 38 new contributing authors who are international leaders in the field of pediatric rheumatology
- An eBook version is included with purchase. The eBook allows you to access all of the text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud
Pediatric and General Rheumatologists
Section 1. Introduction
1. Evolution of Pediatric Rheumatology
Section 2: Basic Concepts
2. Structure and Function
3. Innate Immunity
4. Adaptive Immunity
5. Multi-omics Approaches to Rheumatic Disease
6. Genetics and Pediatric Rheumatic Diseases
Section 3: Clinical Research in Pediatric Rheumatology
7. Understanding Clinical Investigations
8. Clinical Outcome Measures in Pediatric Rheumatic Diseases
Section 4: Clinical Investigations in Pediatric Rheumatology
9. Laboratory Investigations
10. Imaging in Pediatric Rheumatic Diseases
Section 5: Management of Rheumatic Diseases in Children
11. Principles in the Management of Patients with Rheumatic Diseases
12. Therapeutics: Nonbiologics
13. Therapeutics: Biologics and Targeted Small Molecules
14. Physical and Occupational Therapy
15. The Assessment and Management of Osteoporosis in Childhood
Section 6: Juvenile Idiopathic Arthritis and Related Conditions
16. Juvenile Idiopathic Arthritis: Classification and Basic Concepts
17. Systemic Juvenile Idiopathic Arthritis
18. Polyarticular Juvenile Idiopathic Arthritis
19. Oligoarticular Juvenile Idiopathic Arthritis
20. Enthesitis-Related Juvenile Idiopathic Arthritis
21. Psoriatic Juvenile Idiopathic Arthritis
22. Uveitis in Juvenile Idiopathic Arthritis
Section 7 Arthritis Related to Infection
23. Acute Rheumatic Fever and Post-Streptococcal Arthritis
24. Reactive Arthritis
25. Lyme Disease
26. Infectious Arthritis and Osteomyelitis
Section 8: Autoimmune and Inflammatory Connective Tissue Disorders and Related Syndromes
27. Systemic Lupus Erythematosus, Mixed Connective Tissue Disease, and Undifferentiated Connective Tissue Disease
28. Neonatal Lupus Erythematosus
29. Antiphospholipid Syndrome
30. Juvenile Dermatomyositis and Other Inflammatory Muscle Diseases
31. Juvenile Systemic Sclerosis
32. Localized Scleroderma and Eosinophilic Fasciitis
33. Sjögren Disease and Immunoglobulin-G4 Related Disease
34. Raynaud Phenomena and Vasomotor Syndromes
35. Inflammatory Central Nervous System Disorders
Section 9: Vasculitis
36. Vasculitis and Its Classification
37. Takayasu Arteritis
38. Polyarteritis Nodosa
39. Kawasaki Disease
40. Antineutrophil Cytoplasmic Antibody Associated Vasculitis
41. Immune Complex Small-Vessel Vasculitis: IgA Vasculitis and Hypersensitivity Vasculitis
42. Behcet Syndrome and its Mimics
43. Central Nervous System Vasculitis
44. Other Vasculitides
Section 10:Immune System Dysfunction, Autoinflammation and Immune Deficiency
45. Periodic Fever Syndromes and Other Inherited Autoinflammatory Diseases
46. Autoinflammatory Bone Diseases
47. Blau Syndrome, Sarcoidosis and Related Systemic Granulomatous Diseases
48. Macrophage Activation Syndrome
49. Inborn Errors of Immunity and Rheumatic Diseases
Section 11. Musculoskeletal Manifestations of Systemic Disorders
50. Malignancies and Non-malignant Musculoskeletal Conditions That May Mimic Rheumatic Disease
51. Musculoskeletal Manifestations of Inflammatory Bowel Disease
52. Musculoskeletal Manifestations of Systemic Disease
Section 12. Non-Inflammatory Musculoskeletal Conditions and Pain Syndromes
53. Primary Disorders of Connective Tissue
54. Localized Musculoskeletal Pain
55. Primary and Secondary Chronic Musculoskeletal Pain Syndromes
1. Evolution of Pediatric Rheumatology
Section 2: Basic Concepts
2. Structure and Function
3. Innate Immunity
4. Adaptive Immunity
5. Multi-omics Approaches to Rheumatic Disease
6. Genetics and Pediatric Rheumatic Diseases
Section 3: Clinical Research in Pediatric Rheumatology
7. Understanding Clinical Investigations
8. Clinical Outcome Measures in Pediatric Rheumatic Diseases
Section 4: Clinical Investigations in Pediatric Rheumatology
9. Laboratory Investigations
10. Imaging in Pediatric Rheumatic Diseases
Section 5: Management of Rheumatic Diseases in Children
11. Principles in the Management of Patients with Rheumatic Diseases
12. Therapeutics: Nonbiologics
13. Therapeutics: Biologics and Targeted Small Molecules
14. Physical and Occupational Therapy
15. The Assessment and Management of Osteoporosis in Childhood
Section 6: Juvenile Idiopathic Arthritis and Related Conditions
16. Juvenile Idiopathic Arthritis: Classification and Basic Concepts
17. Systemic Juvenile Idiopathic Arthritis
18. Polyarticular Juvenile Idiopathic Arthritis
19. Oligoarticular Juvenile Idiopathic Arthritis
20. Enthesitis-Related Juvenile Idiopathic Arthritis
21. Psoriatic Juvenile Idiopathic Arthritis
22. Uveitis in Juvenile Idiopathic Arthritis
Section 7 Arthritis Related to Infection
23. Acute Rheumatic Fever and Post-Streptococcal Arthritis
24. Reactive Arthritis
25. Lyme Disease
26. Infectious Arthritis and Osteomyelitis
Section 8: Autoimmune and Inflammatory Connective Tissue Disorders and Related Syndromes
27. Systemic Lupus Erythematosus, Mixed Connective Tissue Disease, and Undifferentiated Connective Tissue Disease
28. Neonatal Lupus Erythematosus
29. Antiphospholipid Syndrome
30. Juvenile Dermatomyositis and Other Inflammatory Muscle Diseases
31. Juvenile Systemic Sclerosis
32. Localized Scleroderma and Eosinophilic Fasciitis
33. Sjögren Disease and Immunoglobulin-G4 Related Disease
34. Raynaud Phenomena and Vasomotor Syndromes
35. Inflammatory Central Nervous System Disorders
Section 9: Vasculitis
36. Vasculitis and Its Classification
37. Takayasu Arteritis
38. Polyarteritis Nodosa
39. Kawasaki Disease
40. Antineutrophil Cytoplasmic Antibody Associated Vasculitis
41. Immune Complex Small-Vessel Vasculitis: IgA Vasculitis and Hypersensitivity Vasculitis
42. Behcet Syndrome and its Mimics
43. Central Nervous System Vasculitis
44. Other Vasculitides
Section 10:Immune System Dysfunction, Autoinflammation and Immune Deficiency
45. Periodic Fever Syndromes and Other Inherited Autoinflammatory Diseases
46. Autoinflammatory Bone Diseases
47. Blau Syndrome, Sarcoidosis and Related Systemic Granulomatous Diseases
48. Macrophage Activation Syndrome
49. Inborn Errors of Immunity and Rheumatic Diseases
Section 11. Musculoskeletal Manifestations of Systemic Disorders
50. Malignancies and Non-malignant Musculoskeletal Conditions That May Mimic Rheumatic Disease
51. Musculoskeletal Manifestations of Inflammatory Bowel Disease
52. Musculoskeletal Manifestations of Systemic Disease
Section 12. Non-Inflammatory Musculoskeletal Conditions and Pain Syndromes
53. Primary Disorders of Connective Tissue
54. Localized Musculoskeletal Pain
55. Primary and Secondary Chronic Musculoskeletal Pain Syndromes
- Edition: 9
- Latest edition
- Published: May 25, 2026
- Language: English
RP
Ross E. Petty
Ross E. Petty is a Canadian pediatric rheumatologist. He is a professor emeritus in the Department of Pediatrics at the University of British Columbia and a pediatric rheumatologist at BC Children’s Hospital in Vancouver, Canada. He established Canada’s first formal pediatric rheumatology program at the University of Manitoba in 1976, and three years later, he founded a similar program at the University of British Columbia.
In 2006, he was appointed a member of the Order of Canada for his contribution within Canada and around the world to improving the lives of children and youth with rheumatic diseases. In 2012, he was awarded a Queen Elizabeth II Diamond Jubilee medal. Petty has contributed more than 225 original research papers and book chapters in medical and scientific journals.
Affiliations and expertise
Professor Emeritus, Pediatric Rheumatology, Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, CanadaRL
Ronald M. Laxer
Dr. Ronald Laxer is an active staff physician in the Division of Rheumatology, and was an inaugural Division Head at the Hospital for Sick Children in Toronto. He is internationally recognized in the field of autoinflammatory disease and has been a part of genetic discoveries of several new autoinflammatory diseases. In addition to co-editing the Textbook of Pediatric Rheumatology, he is a co-editor of the Textbook of Autoinflammation. His recent achievements include receiving the American College of Rheumatology Master Designation Award from the American College of Rheumatology and the CRA Master Award from the Canadian Rheumatology Association. In 2020, he was appointed to the Covid-19 Government of Canada Task Force addressing gaps related to care for children.
Affiliations and expertise
Professor, Departments of Pediatrics and Medicine, University of Toronto; Division of Rheumatology, The Hospital for Sick Children, Toronto, Ontario, CanadaLW
Lucy Wedderburn
Lucy Wedderburn is Professor in Paediatric Rheumatology at UCL (Institute of Child Health), Director of Arthritis Research UK Centre for Adolescent Rheumatology at UCL, and UCL Hospitals/GOSH consultant. Her research interests are T cell immunology, immune regulation and muscle biology, with a major focus upon human T cell responses and immune regulation. In particular, the autoimmune conditions of childhood, including Juvenile Idiopathic Arthritis (JIA) and Juvenile Dermatomyositis (JDM); the mechanisms which allow survival and expansion of inflammatory T cells within the joint, the control of their production of cytokines and chemokines, and their contribution to disease. She trained in Cambridge and then London in Immunology and Rheumatology and then spent time training in science at the University of Stanford, USA, before returning to the University College London and Great Ormond Street Hospital on a Wellcome Trust Fellowship.
Affiliations and expertise
Professor in Paediatric Rheumatology, Institute of Child Health, University College London; Consultant in Paediatric Rheumatology, Department of RheumatologyGreat Ormond Street Hospital National Health Service Trust, London, UKEM
Elizabeth D. Mellins
Dr. Elizabeth Mellins graduated from Cornell University with a degree in political science, did a post-bachelor year at MIT and received her MD from Harvard Medical School. She trained in Pediatrics at the University of Colorado and in Pediatric Rheumatology at the University of Washington. She began to focus on research in immunology and immunogenetics during her postdoctoral work at the University of Washington with Dr. Donald Pious. She had her first independent laboratory at the University of Pennsylvania and then moved to Stanford, where she is now a professor of Pediatrics and a member of the Interdisciplinary Program in Immunology. She was a member of the Cellular and Molecular Immunology NIH study section for 9 years (2 terms) and is a Distinguished Fellow of the American Association of Immunologists. She was also a founder and first chairperson of the Childhood Arthritis and Rheumatology Research Alliance.
Affiliations and expertise
Professor of Pediatrics, Department of Pediatrics – Human Gene Therapy, Stanford University, Stanford, California, USARF
Robert C. Fuhlbrigge
Robert Fuhlbrigge is currently Professor and Section head for the division of Pediatric Rheumatology at the Children’s Hospital Colorado Anschutz Medical Campus. He earned his medical degree from Washington University in St. Louis School of Medicine in 1989, completed his residency at Washington University/Barnes-Jewish Hospital/St. Louis Children’s Hospital, and his fellowship in pediatric rheumatology at Children’s Hospital (Boston). He is a member of the Childhood Arthritis and Rheumatology Research Alliance (Vice President) and the American College of Rheumatology. Most recently, he was given the Pediatric Rheumatology Visiting Professor Award, American College of Rheumatology Research and Education Foundation/Amgen, which is a teaching award in clinical pediatric rheumatology.
Affiliations and expertise
Professor and Section Head – Pediatric Rheumatology, University of Colorado; Children’s Hospital Colorado, Aurora, Colorado, USAJA
Jonathan Akikusa
Jonathan Akikusa is head of the Pediatric Rheumatology unit at the Royal Children’s Hospital in Melbourne, Australia. His top areas of expertise are Juvenile Idiopathic Arthritis JIA, Psoriatic Arthritis, Arthritis, and Adult Still's Disease. He has co-authored approximately 40 peer-reviewed articles.
Affiliations and expertise
Pediatric Rheumatology and Head of Unit, The Royal Children’s Hospital Melbourne, Melbourne, AustraliaHB
Hermine Brunner
At.Cincinnati Children’s, Dr. Brunner leads the Division of Rheumatology, where she and her team integrate clinical and translational research into daily care. Her research at Cincinnati Children’s is focused on the development of clinical trial endpoints, surrogate measures and biomarkers as they pertain to pediatric rheumatic diseases, particularly lupus. She conducts clinical trials in pediatric rheumatic disease, drug development, and biomarker discovery for lupus nephritis and lupus that affects the brain. As part of her investigator-initiated research, she has successfully conducted several large multinational studies to develop flare, improvement, remission and inactive disease criteria for children with lupus. Dr. Brunner serves as the scientific director of the Pediatric Rheumatology Collaborative Study Group, where she works alongside researchers at more than 80 academic centers across the U.S. and Canada. Her personal affiliations include the Childhood Arthritis and Rheumatology and Research Alliance and the American College of Rheumatology. She has received the Castle Connolly Regional Top Doctor and Exceptional Women in Medicine awards (2017, 2018 and 2019), the Halsted R. Holman Award for Excellence in Clinical Research (2018), and the Above & Beyond Doctor of the Year award from the Aubrey Rose Foundation (2018).
Affiliations and expertise
Director, Division of Rheumatology; Professor, UC Department of Pediatrics, Cincinnati Children's Hospital, USA