Textbook of Pediatric Rheumatology
- 8th Edition - December 3, 2020
- Imprint: Elsevier
- Authors: Ross E. Petty, Ronald M. Laxer, Carol B Lindsley, Lucy Wedderburn, Robert C Fuhlbrigge, Elizabeth D. Mellins
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 6 3 6 5 2 - 0
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 3 5 2 0 6 - 5
Offering up-to-date, comprehensive coverage of disease progression, diagnosis, management, and prognosis, Textbook of Pediatric Rheumatology is the definitive reference in the fi… Read more
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Request a sales quoteOffering up-to-date, comprehensive coverage of disease progression, diagnosis, management, and prognosis, Textbook of Pediatric Rheumatology is the definitive reference in the field. For physicians caring for children with rheumatic diseases, this revised 8th Edition is an unparalleled resource for the full spectrum of rheumatologic diseases and non-rheumatologic musculoskeletal disorders in children and adolescents. Global leaders in the field provide reliable, evidence-based guidance, highlighted by superb full-color illustrations that facilitate a thorough understanding of the science that underlies rheumatic disease.
Offers expanded coverage of autoinflammatory diseases, plus new chapters on Takayasu Arteritis and Other Vasculitides, Mechanistic Investigation of Pediatric Rheumatic Diseases, Genetics and Pediatric Rheumatic Diseases, and Global Issues in Pediatric Rheumatology.
Reflects the changes in diagnosis, monitoring, and management that recent advances have made possible.
Covers the latest information on small molecule treatment, biologics, biomarkers, epigenetics, biosimilars, and cell-based therapies, helping you choose treatment protocols based on the best scientific evidence available today.
Features exhaustive reviews of the complex symptoms, signs, and lab abnormalities that characterize these clinical disorders.
Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Rheumatologists (pediatric and adult)
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Preface
- Contributors
- Section I. Basic Concepts
- 1. Structure and Function
- The skeleton
- Tendons
- Ligaments and fascia
- Entheses
- Bursae
- Skeletal muscle
- 2. Genetics and Pediatric Rheumatic Diseases
- Introduction
- Genes, Variation, and the Human Genome Sequence in Biomedical Research
- Techniques for Genetic and Genomic Investigation
- Approaches for Investigating Monogenic Pediatric Rheumatic Disease
- Approaches for Investigating Polygenic Pediatric Rheumatic Disease
- Candidate Gene Studies in Pediatric Rheumatology
- Transmission Disequilibrium Testing
- Genome-Wide Association Studies
- Genome Editing
- 3. Mechanistic Investigation of Pediatric Rheumatic Diseases
- Introduction
- The Essence of a Test
- Genetic and Epigenetic Investigations
- Cellular Characterization and Enumeration
- Protein Quantitation and Proteomics
- Quantitating RNA
- Assessment of Microbial Populations
- Summary
- 4. Inflammation and Its Mediators
- Cells of Innate Immunity
- The Inflammatory Response
- When Defective Regulation of Innate Immunity Leads to Rheumatic Disease
- 5. Adaptive Immunity and Autoimmunity
- Introduction to Adaptive Immunity
- T Cells
- B Cells
- Antigen Presentation
- Conclusions
- 6. Understanding Clinical Investigations
- Truth, Levels of Evidence, and Evidence-Based Medicine
- Types of Clinical Investigations
- Basic Concepts
- Study Design
- Describing Data
- Paradigms of Inference
- Concepts and Terminology for Communicating Study Results
- Basic Tests of Association
- Advanced Data Analyses
- Assessing and Interpreting Results
- Assessing the Quality of Clinical Investigations
- 7. Clinical Outcome Measures in Pediatric Rheumatic Diseases
- Introduction
- Juvenile Idiopathic Arthritis
- Systemic Lupus Erythematosus
- Juvenile Dermatomyositis
- Scleroderma
- Systemic Vasculitis
- Parent- and Child-Reported Outcomes
- Conclusions
- 8. Pain and Its Assessment
- Introduction
- Biopsychosocial Model of Pain
- Assessment of Pain
- Treatment of Pain
- Future Directions
- 9. Imaging in Pediatric Rheumatic Diseases
- Introduction
- Imaging Modalities: Technical Aspects
- Physiological Findings, Normal Variants, and Reference Standards
- Inflammatory Arthritis
- Enthesitis-Related Arthritis/Spondylarthopathies
- Psoriatic Arthritis
- Imaging Findings In Juvenile Dermatomyositis
- 10. Laboratory Investigations
- Introduction
- Laboratory Methods
- Tests
- Other Laboratory Investigations
- The Future
- 11. Principles in the Management of Patients with Rheumatic Disease
- Introduction
- General Approach to Management
- Other Important Topics
- Future Endeavors
- Summary
- Resources for Further Information on Rheumatic Diseases for Patients and Parents
- 12. Global Issues in Pediatric Rheumatology
- Epidemiology
- Challenges in Diagnosis and Management
- Strategies to Improve Outcomes
- 13. Therapeutics: Nonbiologics
- Concepts in Pharmacology
- Antirheumatic Drugs
- Therapeutics for Amplified Pain
- 14. Therapeutics: Biologics and Small Molecules
- General Considerations
- Intravenous Immunoglobulin
- Inhibition Of T Cell Costimulation
- B-Cell Targeted biological Dmards
- Interference With Cytokines
- Targeted Synthetic Therapies/Small Molecules
- Kinase Inhibitors
- Biosimilars Versus Biocopies Versus Me-Too DrugS
- Stem-Cell And Mesenchymal Stem-Cell Transplantation
- 15. Nonmedical Therapies in Pediatric Rheumatic Diseases
- Joint and Muscle Health
- Epidemiology of Joint and Muscle Health in Pediatric Rheumatic Conditions
- Improving Joint and Muscle Health
- Motor Development and Motor Performance
- Physical Activity Level and Exercise Tolerance
- Psychosocial and Occupational Health
- Additional Aspects of Health
- Summary
- Section II. Inflammatory Joint Disease and Related Conditions
- 16. Juvenile Idiopathic Arthritis: Classification and Basic Concepts
- Historical Aspects
- Classifications of Chronic Childhood Arthritis
- Epidemiology
- Genetic Associations
- Clinical Manifestations of JIA
- Pathology
- Imaging
- Burden of Disease
- 17. Systemic Juvenile Idiopathic Arthritis
- Epidemiology
- Etiology and Pathogenesis
- Clinical Manifestations
- Diagnosis and Differential Diagnosis
- Pathology
- Laboratory Examination
- Radiological Examination
- Treatment
- Course of the Disease and Prognosis
- 18. Polyarticular Juvenile Idiopathic Arthritis
- Definitions
- RF-Negative Polyarticular JIA
- Rheumatoid Factor Positive Polyarthritis
- 19. Oligoarticular Juvenile Idiopathic Arthritis
- Definition
- Epidemiology
- Genetics
- Etiology and Pathogenesis
- Clinical Manifestations
- Laboratory Evaluation
- Radiographic Evaluation
- Pathology
- Diagnosis
- Treatment
- Disease Course and Prognosis
- Perspective
- 20. Enthesitis-Related Arthritis
- Definition and Classification
- Epidemiology
- Etiology
- Pathogenic Mechanisms
- Clinical Manifestations
- Pathology
- Differential Diagnosis
- Laboratory Examination
- Radiological Examination
- Whole-Body MRI
- Treatment
- Course of the Disease and Prognosis
- 21. Psoriatic Juvenile Idiopathic Arthritis
- Definition and Classification
- Epidemiology
- Etiology, Pathology, and Pathogenesis
- Pathology
- Pathogenesis
- Clinical Manifestations
- Laboratory Examination
- Radiologic Examination
- Treatment
- Course and Prognosis
- 22. Uveitis in Juvenile Idiopathic Arthritis
- Classification of Uveitis
- Uveitis in Juvenile Idiopathic Arthritis
- Laboratory Examination
- Management
- Disease Course and Prognosis
- Section III. Inflammatory Connective Tissue Disease
- 23. Systemic Lupus Erythematosus, Mixed Connective Tissue Disease, and Undifferentiated Connective Tissue Disease
- Systemic Lupus Erythematosus
- Epidemiology
- Etiology and Pathogenesis
- Clinical Disease Presentation
- Outcomes and Prognosis in Lupus Nephritis
- Other Renal Manifestation of SLE
- Skin Pathology
- Treatment of Skin Disease
- Treatment of Neuropsychiatric–Systemic Lupus Erythematosus
- Other Cardiac Manifestations of Sle
- Hematological Involvement
- Vasculitis
- Approach to the Child With SLE
- General Laboratory Evaluation
- Treatment
- Morbidity and Mortality
- Summary
- Mixed Connective Tissue Disease and Undifferentiated Connective Tissue Disease
- Mixed Connective Tissue Disease: Definition and Classification
- Undifferentiated Connective Tissue Disease and Overlap Syndromes
- 24. Antiphospholipid Syndrome
- Definition and Classification
- Epidemiology
- Etiology and Pathogenesis
- Genetic Background
- Clinical Manifestations
- Pathology
- Diagnosis and Differential Diagnosis
- Laboratory Examination
- Radiologic Examination
- Treatment
- Course of the Disease and Prognosis
- 25. Neonatal Lupus Erythematosus
- Etiology and Pathogenesis
- Clinical Features
- Long-Term Risk of Autoimmune Disease
- 26. Juvenile Dermatomyositis and Other Inflammatory Muscle Diseases
- Epidemiology
- Causes and Pathogenesis
- Clinical Manifestations
- Classification and Diagnostic Criteria
- Laboratory Examination/Investigations
- Differential Diagnosis
- Treatment
- Clinical Assessment
- Course of the Disease and Prognosis
- Complications
- 27. Juvenile Systemic Sclerosis
- Introduction
- Demographics and Epidemiology
- Etiology and Pathogenesis
- Diagnosis and Classification of Juvenile Systemic Sclerosis
- Clinical Features
- Patient Reported Outcomes
- Systemic Sclerosis Treatment
- Raynaud Phenomenon
- Digital Ulcers
- The Future of Treatment in Pediatric Systemic Sclerosis
- Prognosis
- 28. Localized Scleroderma and Eosinophilic Fasciitis
- Historical Review
- Definition and Classification
- Epidemiology
- Etiology and Pathogenesis
- Pathology
- Differential Diagnosis
- Laboratory Examination
- Treatment of Localized Scleroderma
- Course of the Disease and Prognosis
- 29. Sjögren Syndrome and Immunoglobulin-G4 Disease
- SjÖgren Syndrome
- Definition and Epidemiology
- Classification
- Clinical Manifestations
- Pathology
- Pathogenesis
- Laboratory Examination
- Imaging Studies
- Management
- Outcome Measures
- Prognosis and Outcome
- IGG4-Related Diseases
- 30. Raynaud Phenomenon and Vasomotor Syndromes
- Introduction
- Clinical Presentation
- Diagnosis
- Differential Diagnosis
- Treatment of Raynaud Phenomenon
- Management of Digital Ischemia
- Erythromelalgia
- Summary and Future Directions
- Section IV. Vasculitis
- 31. Inflammatory Central Nervous System Disorders
- Approach to Inflammatory Brain Disorders
- Diagnostic Approach to Inflammatory CNS Disorders
- General Approach to Inflammatory Brain Disorders
- Specific Inflammatory Brain Conditions
- Summary
- 32. Vasculitis and Its Classification
- Vessel Structure and Function
- Classification
- Evaluation of Vasculitis
- Epidemiology
- General Clinical Aspects of Vasculitis
- 33. Immune Complex Small-Vessel Vasculitis: IgA Vasculitis (Henoch–Schönlein) and Hypersensitivity Vasculitis
- IgA Vasculitis (Henoch–SchÖnlein Purpura)
- Hypersensitivity Vasculitis
- 34. Polyarteritis Nodosa
- Introduction
- Polyarteritis Nodosa (Systemic)
- Cutaneous Polyarteritis Nodosa
- Monogenic Autoinflammatory Conditions Mimicking Pan
- Summary
- 35. Kawasaki Disease
- Historical Background
- Definition and Diagnostic Criteria
- Epidemiology
- Etiology and Pathogenesis
- Genetic Background
- Clinical Manifestations
- Differential Diagnosis
- Pathology
- Laboratory Evaluation
- Treatment
- Treatment of IVIG Resistance
- Monitoring Cardiac Status
- Disease Course and Prognosis
- 36. Antineutrophil Cytoplasmic Antibody Associated Vasculitis
- Antineutrophil Cytoplasmic Antibodies
- Granulomatosis With Polyangiitis
- Microscopic Polyangiitis
- Eosinophilic Granulomatosis With Polyangiitis
- 37. Takayasu Arteritis and Other Vasculitides
- Takayasu Arteritis
- Cogan Syndrome
- Immune Complex Small-Vessel Vasculitis
- Vasculitis Associated With Systemic Disease
- Vasculitis Associated With Probable Etiology
- Other Vasculitides, Vasculopathies
- Mimics of Vasculitis
- 38. Behçet Disease
- Introduction and Historical Review
- Definitions and Classifications
- Epidemiology
- Genetic Background
- Etiology and Pathogenesis
- Clinical Manifestations
- Pathology
- Laboratory Investigations
- Radiological Examinations
- Differential Diagnosis
- Treatment
- Course of Disease and Prognosis
- Section V. Immune System Dysfunction: Autoinflammation and Immunodeficiency
- 39. Periodic Fever Syndromes and Other Inherited Autoinflammatory Diseases
- Hereditary Autoinflammatory Syndromes
- 40. Autoinflammatory Bone Diseases
- Autoinflammatory Bone Diseases
- Chronic Recurrent Multifocal Osteomyelitis
- Genetic Autoinflammatory Syndromes With Bone Inflamation
- 41. Pediatric Sarcoidosis
- Epidemiology
- Etiopathogenesis
- Pathology
- Clinical Features
- Diagnosis
- Pathology
- Genetic Testing
- Differential Diagnosis
- Prognosis
- Treatment
- 42. Macrophage Activation Syndrome
- Definition
- Epidemiology
- Triggers
- Genetic Background
- Pathophysiology
- Clinical Features
- Tissue Histology
- Diagnosis
- Differential Diagnosis
- Treatment
- Prognosis
- 43. Primary Immunodeficiencies and Rheumatic Diseases
- Introduction
- Overview of the Inborn Errors of Immunity
- Infection-Driven Approach
- Autoimmunity and Inflammation-Driven Approach
- Conclusion
- Section VI. Infection Related Rheumatic Disorders
- 44. Infectious Arthritis and Osteomyelitis
- Septic Arthritis
- Arthritis Caused by Viruses
- Arthritis Associated With Other Organisms
- Arthritis and Systemic Bacterial Infections
- Course and Prognosis of Septic Arthritis
- Osteomyelitis
- Pyogenic Diskitis and Spondylodiskitis
- 45. Lyme Disease
- Epidemiology
- Genetic Background
- Etiology and Pathogenesis
- Clinical Manifestations
- Laboratory Examination
- Diagnosis
- Treatment
- 46. Reactive Arthritis
- Reactive Arthritis After Enteric and Genitourinary Infections
- Classification and Diagnostic Criteria
- Epidemiology
- Genetic Background
- Pathogenesis
- Clinical Manifestation
- Musculoskeletal Manifestations
- Mucocutaneous and Ocular Disease
- Laboratory Examination
- Imaging Studies
- Differential Diagnosis
- Treatment
- Treatment of the Precipitating Infection
- Treatment of Reactive Arthritis
- Course of the Disease and Prognosis
- Reactive Arthritis After Streptococcal Infection
- Poststreptococcal Reactive Arthritis
- Section VII. Rheumatic Manifestations of Non-Rheumatic Disorders
- 47. Skeletal Malignancies and Related Disorders
- Introduction
- Primary Malignant Disease of Bone Marrow
- Tumors of Bone
- Tumors of Cartilaginous Origin
- Tumors of Fibrous Tissue
- Tumors of Musculoskeletal Soft Tissues
- Benign Tumors of Miscellaneous Origin
- Summary
- 48. The Impact of Rheumatic Diseases and Their Treatment on Bone Strength Development in Childhood
- Normal Skeletal Composition
- Physiology of the Developing Skeleton
- Osteoporosis in Pediatric Rheumatic Disorders: Clinical Manifestations and Risk Factors
- Diagnosis and Monitoring of Osteoporosis in Pediatric Rheumatic Disorders
- Impact of Medical Therapies on Skeletal Health in Childhood
- Future Directions
- 49. Skeletal Dysplasias
- Introduction
- Background
- History and Physical Examination
- Diagnostic Imaging
- Biochemical Investigations
- Prenatal Detection of Suspected Skeletal Dysplasia
- Cartilage Histology
- Molecular Basis
- Conclusion
- 50. Noninflammatory Musculoskeletal Pain
- Pain Associated With Hypermobility
- Pain Associated with Hypomobility
- Common Overuse Injuries
- Developmental Conditions
- Miscellaneous
- 51. Musculoskeletal Manifestations of Inflammatory Bowel Disease
- Definition and Classification
- Epidemiology
- Etiology and Pathogenesis
- Clinical Manifestations
- Ibd Diagnostic Clues
- Treatment and Disease Course
- Concluding Remarks
- 52. Musculoskeletal Manifestations of Systemic Disease
- Disorders Related to Vitamin Deficiency or Excess
- Disorders Related to Environmental Factors
- Metabolic Diseases
- Hematological Disorders
- Endocrine and Exocrine Glands
- Cystic Fibrosis
- Celiac Disease
- Hyperostosis
- 53. Pain Amplification Syndromes
- Evaluation of Musculoskeletal Pain
- Laboratory Examination
- Amplified Musculoskeletal Pain
- Historical Review
- Definition and Classification
- Epidemiology
- Etiology and Pathogenesis
- Genetic Background
- Clinical Manifestations
- Diffuse Amplified Pain Syndromes (Juvenile Fibromyalgia/Chronic Widespread Pain)
- The Impact of Chronic Musculoskeletal Pain on the Child and Family
- General Assessment of Pain in Children With Amplified Musculoskeletal Pain
- Pathology
- Laboratory Examination in Amplified Pain
- Radiographic Examination in Amplified Pain
- Treatment
- Natural History and Long-Term Outcomes
- Conclusion
- 54. Primary Disorders of Connective Tissue
- Introduction
- Index
- Edition: 8
- Published: December 3, 2020
- Imprint: Elsevier
- No. of pages: 768
- Language: English
- Hardback ISBN: 9780323636520
- eBook ISBN: 9780443352065
RP
Ross E. Petty
Ross E. Petty is a Canadian pediatric rheumatologist. He is a professor emeritus in the Department of Pediatrics at the University of British Columbia and a pediatric rheumatologist at BC Children’s Hospital in Vancouver, Canada. He established Canada’s first formal pediatric rheumatology program at the University of Manitoba in 1976, and three years later, he founded a similar program at the University of British Columbia.
In 2006, he was appointed a member of the Order of Canada for his contribution within Canada and around the world to improving the lives of children and youth with rheumatic diseases. In 2012, he was awarded a Queen Elizabeth II Diamond Jubilee medal. Petty has contributed more than 225 original research papers and book chapters in medical and scientific journals.
Affiliations and expertise
Professor Emeritus, Pediatric Rheumatology, Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, CanadaRL
Ronald M. Laxer
Dr. Ronald Laxer is an active staff physician in the Division of Rheumatology, and was an inaugural Division Head at the Hospital for Sick Children in Toronto. He is internationally recognized in the field of autoinflammatory disease and has been a part of genetic discoveries of several new autoinflammatory diseases. In addition to co-editing the Textbook of Pediatric Rheumatology, he is a co-editor of the Textbook of Autoinflammation. His recent achievements include receiving the American College of Rheumatology Master Designation Award from the American College of Rheumatology and the CRA Master Award from the Canadian Rheumatology Association. In 2020, he was appointed to the Covid-19 Government of Canada Task Force addressing gaps related to care for children.
Affiliations and expertise
Professor, Departments of Pediatrics and Medicine, University of Toronto; Division of Rheumatology, The Hospital for Sick Children, Toronto, Ontario, CanadaCL
Carol B Lindsley
Affiliations and expertise
Professor, Department of Pediatrics, University of Kansas School of Medicine; Chief of Pediatric Rheumatology, Department of Pediatrics, University of Kansas Medical Center, Kansas City, KansasLW
Lucy Wedderburn
Lucy Wedderburn is Professor in Paediatric Rheumatology at UCL (Institute of Child Health), Director of Arthritis Research UK Centre for Adolescent Rheumatology at UCL, and UCL Hospitals/GOSH consultant. Her research interests are T cell immunology, immune regulation and muscle biology, with a major focus upon human T cell responses and immune regulation. In particular, the autoimmune conditions of childhood, including Juvenile Idiopathic Arthritis (JIA) and Juvenile Dermatomyositis (JDM); the mechanisms which allow survival and expansion of inflammatory T cells within the joint, the control of their production of cytokines and chemokines, and their contribution to disease. She trained in Cambridge and then London in Immunology and Rheumatology and then spent time training in science at the University of Stanford, USA, before returning to the University College London and Great Ormond Street Hospital on a Wellcome Trust Fellowship.
Affiliations and expertise
Professor in Paediatric Rheumatology, Institute of Child Health, University College London; Consultant in Paediatric Rheumatology, Department of Rheumatology
Great Ormond Street Hospital National Health Service Trust, London, Great BritainRF
Robert C Fuhlbrigge
Affiliations and expertise
Children's Hospital Colorado
University of Colorado- DenverEM
Elizabeth D. Mellins
Affiliations and expertise
Department of Pediatrics
Stanford University School of Medicine