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Testosterone, An Issue of Urologic Clinics
- 1st Edition, Volume 49-4 - October 29, 2022
- Editor: Kevin R. Loughlin
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 9 2 0 0 6 - 3
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 2 0 0 7 - 0
In this issue of Urologic Clinics of North America, guest editor Dr. Kevin R. Loughlin brings his considerable expertise to the topic of Testosterone. With about 2 out of 10 men… Read more
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Request a sales quoteIn this issue of Urologic Clinics of North America, guest editor Dr. Kevin R. Loughlin brings his considerable expertise to the topic of Testosterone. With about 2 out of 10 men older than 60 years having low testosterone (American Urological Association), coupled with an aging population, this issue is an important resource for all urologists for effectively treating men and improving outcomes. It provides a current update on testosterone in men from top experts in the field, covering prostate cancer treatment, the use of anabolic steroids, hypogonadism, testosterone replacement, and more.
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Contains 15 practice-oriented topics including current management and controversies surrounding andropause; testosterone and male sexual function; the interplay of testosterone and dihydrotestosterone in prostate cancer; and more.
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Provides in-depth clinical reviews on testosterone, offering actionable insights for clinical practice.
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Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Urology
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Forthcoming Issues
- Preface
- The Inexorable March of Prostate Cancer Research: Testosterone and Beyond
- Key points
- Introduction
- The surgical foundation: hugh hampton young,1904
- The british empire cancer campaign: 1923
- Charles huggins: the testosterone-prostate cancer link: 1941
- The Veterans Administration cooperative urological research group studies 1960-1975
- Donald gleason: pathologic scoring of prostate cancer: 1962
- The identification of prostate-specific antigen: 1970
- Andrew schally: gonadotropin-releasing hormone agonist analogues, 1972-1978
- Patrick C. Walsh: nerve-sparing radical prostatectomy, 1982
- Malcolm bagshaw and radiation therapy for prostate cancer
- Willet F. whitmore and interstitial implantation of iodine-125
- Laurence klotz and active surveillance of prostate cancer
- Laparoscopic and robotic prostatectomy
- The antiandrogens
- Prostate biopsy techniques
- Genetic testing and prostate cancer risk
- Biomarkers
- Immunotherapy and prostate cancer
- Poly(adenosine diphosphate-ribose) polymerase inhibitors and prostate cancer
- Prostate cancer research: the modern era
- Clinics care points
- Testosterone Therapy and Prostate Cancer: Incorporating Low-Level Evidence into Practical Recommendations
- Key points
- Introduction
- The controversy
- Androgens and prostate cancer
- The androgen receptor and the prostate
- Androgens homeostasis and prostate cancer risk
- Relevant clinical situations
- Dissecting the controversy: past, present, and future
- Summary
- Illustrative cases
- Clinics care points
- Disclosure
- Current Management and Controversies Surrounding Andropause
- Key points
- Introduction
- Discussion
- Summary
- Clinics care points
- Benefits and Risks of Testosterone Treatment of Older Men with Hypogonadism
- Key points
- Introduction
- Epidemiology
- Pathophysiology of age-related decline in serum testosterone levels
- Potential benefits of testosterone treatment in older men: randomized clinical trials data
- Potential risks of testosterone treatment
- A patient-centric approach based on consideration of individualized benefits and risks and values
- Clinics care points
- Disclosure
- Testosterone and the Androgen Receptor
- Key points
- Introduction
- Historical effects of testosterone
- Androgen steroidogenesis from cholesterol
- Testosterone regulation, production, and transport
- Testosterone variation and function
- Testosterone replacement therapy
- Androgen deprivation therapy
- The androgen receptor
- Metabolism of testosterone (aromatase, 5α-reductase)
- Summary
- Funding
- Clinics care points
- Molecular Mechanisms of Castrate-Resistant Prostate Cancer
- Key points
- Introduction
- Androgen receptor-related mechanisms
- Androgen receptor-unrelated mechanisms
- Discussion
- Summary
- Clinics care points
- Testosterone and Male Sexual Function
- Key points
- Introduction
- Male sexual function physiology: role of testosterone
- Male sexual dysfunction pathophysiology: role of testosterone
- Clinical evaluation of low testosterone
- Treatment options for male sexual dysfunction
- Considerations for special populations
- Clinics care points
- What We Have Learned from The Testosterone Trials
- Key points
- Testosterone decreases with increasing age
- The Testosterone Trials
- Funding
- Clinics care point
- Androgenic Steroids Use and Abuse: Past, Present, and Future
- Key points
- Introduction
- Epidemiology of anabolic androgenic steroid abuse
- Behaviors among anabolic androgenic steroid abusers
- Detection of anabolic androgenic steroid use
- Adverse effects of anabolic androgenic steroid abuse
- Management of anabolic androgenic steroid use among the general population
- Potential clinical uses of prescription androgens
- Summary
- Clinics care points
- Testosterone Assays
- Key points
- Introduction
- The availability of testosterone in the serum and the free hormone hypothesis
- Testosterone measurements
- Total testosterone
- Free testosterone
- Bioavailable testosterone
- Reference ranges
- Other factors affecting accuracy of total testosterone measurement
- Summary
- Clinics care point
- Disclosure
- Testosterone Replacement Options
- Key points
- Introduction
- Physiology
- Testosterone preparations
- Summary
- The Prostate as an Endocrine Organ: Its Modulation of Serum Testosterone
- Key points
- Introduction
- Summary
- No. of pages: 240
- Language: English
- Edition: 1
- Volume: 49-4
- Published: October 29, 2022
- Imprint: Elsevier
- Hardback ISBN: 9780323920063
- eBook ISBN: 9780323920070
KL
Kevin R. Loughlin
Affiliations and expertise
Emeritus Professor of Surgery (Urology), Harvard Medical School, Visiting Scientist, Vascular Biology Research Program at Boston Children’s Hospita