Sulfur in Proteins

1st Edition - January 1, 1959
Imprint: Academic Press
Editor: Reinhold Benesch
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 4 1 4 5 4 9 - 8
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 1 4 8 6 8 - 9

Sulfur in Proteins is a collection of papers presented at the 1958 Symposium on Sulfur in Proteins, held in Falmouth, Massachusetts. The symposium primary aims to explore the… Read more

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Sulfur in Proteins is a collection of papers presented at the 1958 Symposium on Sulfur in Proteins, held in Falmouth, Massachusetts. The symposium primary aims to explore the varied and unusual roles of –S–S– and –SH groups in proteins. This book is organized into eight chapters that cover a wide variety of proteins, including serum, iron, copper, and muscle proteins, as well as enzymes and viruses. The opening chapter describes the various protein reactions involving sulfur, emphasizing the chemical modification of thiol and disulfide groups. Considerable chapters are devoted to the chemical properties, biogenesis, reactivity, and oxygenation of specific proteins. A chapter highlights some aspects of protein structure in relation to the role of –S–S– and –SH groups in enzymic catalysis. This chapter also describes the properties of sulfhydryl groups in yeast alcohol dehydrogenase. The final chapters examine the role of sulfur groups in several virus proteins and in cell division. This work will be of great value to protein scientists and researchers.

Participants

Introduction

I. Protein Reactions Involving Sulfur

I.1. Chemical Modification of Thiol and Disulfide Groups in Proteins and Peptides

I.2. The Introduction of New Sulfhydryl Groups and Disulfide Bonds into Proteins

I.3. Disulfide Bonds in Proteins

I.4. The Varying Reactivity of the Cystine of Wool

I.5. A High-Sulfur Protein from Wool

I.6. The Decomposition of Keratin by Microorganisms

I.7. The Supercontraction of Keratin Fibers by Lithium Bromide

II. Serum Proteins

II.1. Some Chemical Properties of the Sulfhydryl Group in Bovine Plasma Albumin

II.2. Relative Probabilities of Isomers in Cystine-Containing Randomly Coiled Polypeptides

II.3. Biogenesis of Protein Fibers: The Clotting of Blood Plasma

III. Iron and Copper Proteins

III.1. The Role of Sulfur in Some Metal-Proteins

III.2. The Role of Sulfur in Cytochrome c

III.3. The Cystine/Cysteine Content of Hemoglobins

III.4. Sulfhydryl Groups and the Oxygenation of Hemoglobin

III.5. Relation of Iron to Sulfhydryl Groups in Ferritin

IV. Enzymes

IV.1. Some Aspects of Protein Structure in Relation to the Role of —SH and —S—S— Groups in Enzymic Catalysis

IV.2. Mechanism of Action of Alcohol Dehydrogenases from Yeast and Liver and β-Galactosidase of E. coli

IV.3. Determination and Properties of Sulfhydryl Groups in Yeast Alcohol Dehydrogenase

IV.4. Fluorometric Analysis of Coenzyme Binding and Thiol Interactions on Glyceraldehyde-3-phosphate and Lactic Dehydrogenases

IV.5. On the Order of Disulfide Bond Reduction in Ribonuclease

V. Muscle Proteins

V.l. Cysteine and Cystine Content of Muscle Protein Fractions

V.2. The Role of SH Groups in the Interaction of Myosin with Phosphate Compounds and with Actin

V.3. Studies on the Functional Sulfhydryl Groups of Myosin and Actin

VI. Viruses

VI.l. The Masked —SH Group in Tobacco Mosaic Virus Protein

VI.2. Structure and Function in T2 Bacteriophage

VII. Cell Division

VII.1. The Role of Thiol Groups in the Structure and Function of the Mitotic Apparatus

VII.2. Multiple Functions of Sulfur in Mitosis

VII.3. Function of Protein Disulfide Reductase in Cellular Division of Yeasts

VIII.Summary

Author Index

Subject Index

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health

Sulfur in Proteins

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