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    • The Biosynthesis of Mycotoxins

      • 1st Edition
      • December 2, 2012
      • Pieter Steyn
      • English
      • Paperback
        9 7 8 0 1 2 4 3 1 1 9 5 4
      • eBook
        9 7 8 0 3 2 3 1 4 9 9 3 8
      The Biosynthesis of Mycotoxins: A Study in Secondary Metabolism focuses on the biosynthetic analysis of mycotoxins, which are inherently a heterogeneous group of metabolites that are formed along the terpene route and the route polyketide, as well as from amino acids. This book discusses the unique biological properties and structural complexity of the highly specialized secondary microbial metabolites. Organized into 12 chapters, this book starts with an overview of the characteristics of secondary metabolites, including their problematic function and the combination of their structural diversity with their restricted biological occurrence. This text then explains the sporadic occurrence of the mycotoxins as fungal metabolites. Other chapters explore ergochromes, which are a group of light yellow mycotoxins that are isolated from ergot, mold fungi, and lichens. The final chapter discusses the biosynthesis of several unrelated fungal metabolites for which toxicological data are reported. Biochemists, organic chemists, mycologists, enzymologists, plant pathologists, toxicologists, and graduate students will find this book useful.

    • The Hormones V1

      • 1st Edition
      • December 2, 2012
      • Mohhamad Reza Kiani
      • English
      • eBook
        9 7 8 0 3 2 3 1 4 2 0 6 9
      The Hormones: Physiology, Chemistry and Applications, Volume I covers roles of hormones in a wide diversity of vital processes. This volume consists of 16 chapters that discuss the chemistry of hormones, their role in organisms other than mammals, and some aspects of the animal physiology. After a brief history of hormone research studies, this book goes on exploring the chemistry, physiology, assay, and mechanism of action of plant, insect, and crustacean hormones. The subsequent chapters examine the biochemistry, physiology, and assay methods of hormones of the gastrointestinal tract, parathyroid gland, pancreas, and ovary. These topics are followed by discussions on the chemistry and metabolism of other hormones, such as progesterone, androgens, and adrenal cortical and anterior pituitary hormones. The final chapters consider the role of ovarian, pituitary, and thyroid hormones in mammary growth, as well as the mechanism of hormonal control of lactation. Endocrinologists, applied biologists, physiologists, biochemists, and researchers in various fields of medicine will find this book of great value.

    • Wood Microbiology

      • 1st Edition
      • December 2, 2012
      • Robert A. Zabel + 1 more
      • English
      • Paperback
        9 7 8 0 1 2 3 9 6 0 9 2 4
      • eBook
        9 7 8 0 3 2 3 1 3 9 4 6 5
      An in-depth examination of deterioration caused by fungi and other microorganisms, Wood Microbiology explores the major damages to wood and wood products during growth, harvesting, storage, and conversion to finished lumber. The characteristics, causes, detection, effects, and control measures for wood damage are stressed.

    • Receptors and Hormone Action

      • 1st Edition
      • December 2, 2012
      • Bert O'Malley + 1 more
      • English
      • Paperback
        9 7 8 0 1 2 4 1 4 1 7 9 7
      • Hardback
        9 7 8 0 1 2 5 2 6 3 0 1 6
      • eBook
        9 7 8 0 3 2 3 1 4 4 9 4 0
      Receptors and Hormone Action, Volume 1, provides an overview of the state of knowledge in hormone action. This book describes basic methodologies and model systems used in the exploration of the molecular bases of hormone action. The chapters present not only a rather extensive description of hormone receptors and their properties, but also basic aspects of structure and function of chromatin and membranes, the sites at which hormones and their receptors exert their action. The receptors discussed include soluble cytoplasmic and nuclear receptors for steroid hormones and vitamins, membrane-bound receptors for protein hormones and biogenic amines, and nuclear receptors for thyroid hormones. Receptor types are also covered in view of the large body of literature accumulated on the various functions of these fascinating but elusive molecules. This book is intended for a broad spectrum of readers, including those who have not yet worked in the field as well as those who have considerable expertise in one or another aspect of hormone action.

    • Molecular Epidemiology

      • 1st Edition
      • December 2, 2012
      • Paul A. Schulte + 1 more
      • English
      • Paperback
        9 7 8 0 1 2 3 9 5 9 7 9 9
      • eBook
        9 7 8 0 3 2 3 1 3 8 5 7 4
      This book will serve as a primer for both laboratory and field scientists who are shaping the emerging field of molecular epidemiology. Molecular epidemiology utilizes the same paradigm as traditional epidemiology but uses biological markers to identify exposure, disease or susceptibility. Schulte and Perera present the epidemiologic methods pertinent to biological markers. The book is also designed to enumerate the considerations necessary for valid field research and provide a resource on the salient and subtle features of biological indicators.

    • Enzymes as Targets for Drug Design

      • 1st Edition
      • December 2, 2012
      • Michael Palfreyman
      • English
      • Paperback
        9 7 8 0 1 2 4 1 2 0 7 9 2
      • eBook
        9 7 8 0 3 2 3 1 4 0 4 8 5
      Enzymes as Targets for Drug Design is a collection of scientific discussions related to enzyme inhibitors that show the many facets of the drug discovery process from the basic sciences through clinical applications. Topics include the biogenesis of phosphatidylinositol glycosyl membrane proteins, structure and catalytic function of ADP-ribose polymerase (ADPRT), and modulation of the dopaminergic system in cardiovascular therapeutics. The therapeutic utility of selected enzyme-activated irreversible inhibitors, the role of proteinases in the fibrosis of systemic sclerosis, and therapeutic opportunities in eicosanoid biosynthesis are also discussed. This book consists of 18 chapters and begins with examples of enzymes whose activities have recently been elucidated, or for which newer insights have been gleaned, but which do not yet have selective or potent inhibitors. The second part provides examples of enzymes where inhibitors have been identified but it is still not clear whether or not such an enzymatic blockade will be therapeutically beneficial. The final section describes clinical studies of newer, and not so new, enzyme inhibitors that are clearly of therapeutic importance. The therapeutic activity of monoamine oxidase inhibitors and the associated clinical issues are considered. This book is intended for clinicians as well as basic scientists in biochemistry, chemistry, pharmacology, and cell biology.

    • Molecular Basis of Lysosomal Storage Disorders

      • 1st Edition
      • December 2, 2012
      • John Barranger
      • English
      • Paperback
        9 7 8 0 1 2 4 1 4 4 1 0 1
      • eBook
        9 7 8 0 3 2 3 1 4 7 2 8 6
      Molecular Basis of Lysosomal Storage Disorders contains the proceedings of the 1983 Conference on the Molecular Basis of Lysosomal Storage Disorders, held at the National Institutes of Health in Bethesda, Maryland. The papers focus on the molecular biology of, and therapeutic approaches to, lysosomal storage disorders, such as mucopolysaccharidose... sphingolipidoses, and Gaucher disease. Organized into six sections comprised of 29 chapters, this book begins with an overview of enzymes, activator proteins, and stabilizers that underlie lysosomal storage disorders. It then discusses some developments in enzyme purification, receptors for glycoprotein enzymes, factors that control endocytosis, and the intracellular fate of lysosomal hydrolases. Some chapters explain the enzyme biosynthesis, bone marrow transplantation, and enzyme replacement, along with cell hybridization, chromosome localization, phenotype discrimination, and cloning of genes for human lysosomal enzymes. This book is helpful to biochemists, physiologists, pathologists, geneticists, clinical investigators, and practicing physicians concerned with the study, care, and treatment of patients with hereditary metabolic disorders, as well as undergraduate and graduate level students involved in research in this discipline.

    • Fish As Food V1

      • 1st Edition
      • December 2, 2012
      • Georg Borgstrom
      • English
      • Paperback
        9 7 8 0 1 2 4 1 2 3 6 5 6
      • eBook
        9 7 8 0 3 2 3 1 4 2 8 0 9
      Fish as Food, Volume I: Production, Biochemistry, and Microbiology discusses progress in the field of fish research. This volume is composed of 17 chapters that cover the biology, biochemistry, world production, cultivation, nutritional composition, and microbiology of fish. The introductory chapters present some examples of the biological basis for the relationships between yield in fishery and economics. The book goes on discussing fish cultivation in Europe, Japan, and South East Asia and the factors to consider in various cultivation methods. The subsequent chapters are devoted to the nutritional value of fish, including its lipid, mineral, water, fatty acid, and protein content. A chapter considers the oxidation properties and rancidity of fish. The book also covers some problems related to fishery business, such as the production of histamine, the occurrence of non-protein nitrogenous compounds, and the rigor mortis. The concluding chapters focus on microbiological aspects of fish production. Discussions on the microbial spoilage of marine fish, crustaceans, and mollusks; the microbiology of shellfish deterioration; and the use of chemical preservatives to control microbiological fish deterioration are also included. The book is an invaluable source primarily to food scientists and also to a wide range of research workers, including biologists, chemists, bacteriologists, parasitologists, oceanographers, nutritionists, and technologists.

    • Proteolysis and Physiological Regulation

      • 1st Edition
      • December 2, 2012
      • D.W. Ribbons
      • English
      • Paperback
        9 7 8 0 1 2 4 3 1 2 7 9 1
      • Hardback
        9 7 8 0 1 2 5 8 8 2 5 0 7
      • eBook
        9 7 8 0 3 2 3 1 5 0 7 9 8
      Miami Winter Symposia, Volume 11: Proteolysis and Physiological Regulation contains the proceedings of the University of Miami's Biochemistry Department Symposium on "Proteolysis and Physiological Regulation", which is published simultaneously with the proceedings of the Papanicolaou Cancer Research Institute's Symposium on "Cancer Enzymology" (Volume 12). This volume is composed of 35 chapters and begins with surveys of the structural properties and role of various enzymes in biological regulation. The subsequent chapters describe the structure-activity relationship, cellular production, selectivity, mechanisms, and substrate specificity of the enzymes. Other chapters explore the activation, regulation, biosynthesis, and other biological activities of other enzymes. The remaining chapters discuss property modification, metabolism, binding, and other biological aspects of enzymes. This book will prove useful to enzyme scientists, cell biologists, biochemists, and researchers.

    • Foundations of Modern Auditory Theory

      • 1st Edition
      • December 2, 2012
      • Jerry Tobias
      • English
      Foundations of Modern Auditory Theory, Volume I is an 11-chapter text that covers the basic auditory processes. This volume deals first with the electrophysiological and conditioning data that reflect periodicity perception, the analysis of high-frequency tones, and the mechanisms and effects of auditory masking. These topics are followed by discussions on the poststimulatory auditory fatigue and adaptation; the theoretical bases necessary for an understanding of the critical band’s ubiquity; and the mechanical events in transformation process occurring in cochlea. This volume describes the anatomical structure and electrophysiological action of the cochlea and further explores ear models to study the mechanical properties of the auditory system and the basic neural transmission processes and their properties. The concluding chapters look into the distinct patterns of disorder in psychoacoustic function and the perception of musical stimuli. This book is an ideal source for teachers and students who wish to understand the mechanisms of the auditory system.

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