Books in Life sciences

Calcium Disorders

1st Edition
October 22, 2013
David Heath + 1 more
English
eBook
9 7 8 1 4 8 3 1 9 2 1 0 9

Clinical Endocrinology 2: Calcium Disorders presents an extensive examination of the treatment of postmenopausal and senile osteoporosis. It discusses the acquired disorders of vitamin D metabolism. It addresses the prevention of osteoporosis. Some of the topics covered in the book are the classification of rickets; mechanisms of homeostasis; transepithelial transport of phosphate anion; definition of mendelian rickets; treatment of; classification of androgens and synthetic anabolic agents; and assessment of parathyroid function. The measurement of parathyroid hormone is fully covered. An in-depth account of the indirect assessment of parathyroid activity is provided. The acquired disorders of Vitamin D metabolism are completely presented. A chapter is devoted to the aetiological views of rickets and osteomalacia. Another section focuses on the treatment and prevention of rickets and osteomalacia. The analysis of renal osteodystrophy, hypercalcemia, and familial hypocalciuric hypercalcemia are briefly covered. The book can provide useful information to doctors, endocrinologists, students, and researchers.

Infections of the Nervous System

1st Edition
October 22, 2013
Peter G. E. Kennedy + 1 more
English
eBook
9 7 8 1 4 8 3 1 9 2 1 2 3

Infections of the Nervous System aims to continue the legacy of its predecessor, Modern Trends in Neurology. Its goal is to produce annually a monograph on a topic in clinical neurology in which progress through research has brought about new concepts of patient management. This book is organized into 13 chapters. It highlights the areas or subjects in which significant advances have been made which also have relevance to the treatment of patients. It covers a number of important aspects of different infectious diseases of the nervous system including acute bacterial meningitis, tuberculosis of the nervous system, spirochaetal infections of the nervous system, and fungal diseases of the central nervous system. This book is intended for use by physicians who deal with the problems of neurological disorder on a daily basis, whether they are neurologists, neurologists in training, or those in related fields such as neurosurgery, internal medicine, psychiatry, and rehabilitation medicine.

Movement Disorders

1st Edition
October 22, 2013
C. David Marsden + 1 more
English
eBook
9 7 8 1 4 8 3 1 6 3 1 4 7

Neurology, Volume 2: Movement Disorders is a part of an international series of critical reviews of topics in neurology. This volume focuses on Parkinsonism and dyskinesia, a condition characterized by abnormal involuntary movements. Organized into 18 chapters, this book first elucidates the problems, causes, pathology, brain neurotransmitter changes and receptors, depression, dementia, fluctuations of disability, and treatment of Parkinson's disease. Subsequent chapters then explore the problems, controversies, and surgical approaches involved in certain dyskinesias. The role of dopamine receptors in movement disorders is also explored. This book will be valuable to neurologists-in-trai... as well as to those in research field or in practice in this field of interest. The book's clinical content will help in the management of patients with movement disorders.

Drug Therapy During Pregnancy

1st Edition
October 22, 2013
Tom K. A. B. Eskes + 1 more
English
eBook
9 7 8 1 4 8 3 1 6 2 9 8 0

Drug Therapy During Pregnancy is a collection of papers dealing with the risks and benefits of drug treatment for both mother and fetus. One paper notes that the total use of medication during pregnancy in the Netherlands has decreased from 82.7 % to 71.7 %. The paper also points out the lack of a relationship between the number or type of congenital anomalies and the use of medication. Another paper assesses fetal drug exposure in two ways: firstly, through the physicochemical characteristics of the drug and the way it is handled by the mother in order to estimate placental passage and fetal exposure. Secondly, through the utilization of pharmacokinetic models estimating the probable time course of drug concentrations in the feto-maternal unit. One paper investigates the effects of hypertension during pregnancy, in which the etiology of hypertension, a group of disorders with one common abnormality, remains unsolved with a clinical diagnosis that is not always accurate. Treatment differs widely depending on the type: chronic hypertension, albuminuric hypertension, and hypertensive crises during pregnancy. One paper suggests that to prove any environmental exposure to a particular substance affecting pregnancy, the exact timing of exposure must be established, large samples are necessary, possibly on a national or international scale. The paper cites as example the four-year documentation period of the 50% to 80% incidence of malformations due to thalidomide. General medicine practitioners, obstetricians, gynecologists, and researchers dealing with pharmacology, pharmocokinetics, toxicology, or embryology will find the collection valuable.

Presystemic Drug Elimination

1st Edition
October 22, 2013
Charles F. George + 1 more
English
eBook
9 7 8 1 4 8 3 1 6 3 6 0 4

Butterworths International Medical Reviews, Clinical Pharmacology and Therapeutics 1: Presystemic Drug Elimination explores the principles of presystemic drug metabolism in human based on animal studies. This book is divided into four sections encompassing 10 chapters that specifically describe the extent of metabolism occurring in the gastrointestinal tract, liver, and lung. Section 1 focuses on presystemic elimination by the gastrointestinal tract. This section discusses the enzymatic biotransformation in the gastrointestinal mucosa and the ability of the microflora to metabolize drugs. Section 2 considers the contribution of the liver to presystemic drug elimination, with a particular emphasis on the physiological factors, which determine the rate of breakdown of drugs in vivo. This section also deals with the effects of hepatic cirrhosis on presystemic drug elimination. Section 3 presents first a brief outline of the knowledge of pulmonary structure and relevant physiology, followed by a discussion on “first-pass” metabolism of endogenous substrates and drugs across the pulmonary circulation and of environmental chemicals after inhalation. This section also provides the methods for distinguishing between the contribution of the various sites to presystemic drug elimination and the problems associated with attempts to analyze available pharmacokinetic data. This work is an ideal source for clinical pharmacologists and researchers.

The Molecular Biology of Neurological Disease

1st Edition
October 22, 2013
Roger N. Rosenberg + 1 more
English
eBook
9 7 8 1 4 8 3 1 6 3 3 0 7

The Molecular Biology of Neurological Disease reviews advances that have been made in understanding the molecular mechanisms of neurological disorders as well as immediate and future applications of molecular biological techniques to clinical practice. This book explores the molecular genetics of neurological disease such as muscular dystrophy, Joseph disease, and Huntington's disease, along with the mitochondrial genes implicated in such conditions. This text is comprised of 18 chapters and begins by introducing the reader to the basic principles and methods of molecular genetic techniques used in the diagnosis of neurological disease. Attention then turns to several aspects of genetic expression in the brain, including the extent to which the genome is expressed in the brain. The next chapter focuses on the visualization of polyadenylated messenger RNAs in individual cells in mammalian brain using in situ hybridization techniques, combined with immunohistochemical localization of specific proteins and neuropeptides implicated in diseases such as Alzheimer dementia. This book also discusses the molecular biology of chemical synaptic neurotransmission; proteins involved in the regulation of nervous system development; and gene expression in skeletal muscle. This text then concludes with a summary of the ""neurological gene map"" as it stands in the latter part of 1987. This book is intended for physicians who grapple with the problems of neurological disorders on a daily basis, including neurologists, neurologists in training, and those in related fields such as neurosurgery, internal medicine, psychiatry, and rehabilitation medicine.

Theory and Practice of Blood Flow Measurement

1st Edition
October 22, 2013
John P. Woodcock
English
eBook
9 7 8 1 4 8 3 1 8 2 7 3 5

Theory and Practice of Blood Flow Measurement presents the methods for determining the metrics of blood flow in the major vessels. This book is organized into two sections encompassing 16 chapters that discuss the theories behind the different techniques of flow measurement and the performance of flowmeters and their practical application to determining blood flow volume in the tissues and organs. Considerable chapters are devoted to various methods of blood measurement, including dilution, transport, and thermal techniques, as well as the effect of catheter sampling on the shape of indicator dilution curves. Other chapters are concerned with the possible errors in the application of indicator dilution techniques and the types of dilution indicator, and measurement of indicator concentration. A chapter is devoted to the advantages and disadvantages of thermistor flowmeter. The last chapter focuses on the design of a thermal dilution catheter. The book can provide useful information to physicists, bioengineers, surgeons, students, and researchers.

Vertebral Manipulation

4th Edition
October 22, 2013
G. D. Maitland
English
eBook
9 7 8 1 4 8 3 1 9 2 1 8 5

Vertebral Manipulation: Fourth Edition presents a comprehensive examination of the methods of passive movement treatment. It discusses the effectiveness of gentler manipulation of conscious patients. It addresses the relationship between the treatment and the patient’s symptoms and signs. Some of the topics covered in the book are the organic disorders not involving the vertebrae; disease of the spinal cord; passive physiological intervertebral movement; techniques of mobilization; method of oscillatory movement; postero-anterior central vertebral pressure; and method of progression of the lumbar region. The methods in the application of mobilization are fully covered. An in-depth account of the manipulative techniques is provided. The manipulations are progressions from mobilizations which have increased in strength. Application of such manipulations is completely presented. A chapter is devoted to the movements of the faulty intervertebral joint. Another section focuses on the assessment related to abnormal movements at the initial examination. The book can provide useful information to therapists, doctors, students, and researchers.

The Peripheral Blood Film

2nd Edition
October 22, 2013
Trevor A. Harper
English
eBook
9 7 8 1 4 8 3 1 8 2 7 5 9

The Peripheral Blood Film, Second Edition presents the various concepts of the origin, development, and functions of blood cells. This book serves as a practical guide to the different types of film appearances that may be encountered in the routine examination of peripheral blood films. Organized into 14 chapters, this edition begins with an overview of the composition of plasma, which consists mainly of water and many organic and inorganic compounds. This text then discusses the process of obtaining capillary blood and explains how the thin blood film is prepared in the laboratory. Other chapters present the alphabetical listing of diseases, disorders, and abnormal film appearances for easier reference. This book discusses as well the characteristics of normal peripheral blood cells. The final chapter deals with the characteristics of blood film in various types of diseases, including Cushing's disease, Addison's disease, cirrhosis of the liver, and collagen disorders. This book is a valuable resource for hematologists and pathologists.

The Actions and Uses of Ophthalmic Drugs

2nd Edition
October 22, 2013
P. H. O'Connor Davies
English
eBook
9 7 8 1 4 8 3 1 9 2 2 0 8

The Actions and Uses of Ophthalmic Drugs: A Textbook for Students and Practitioners, Second Edition provides pertinent information in relation to concepts in pharmacology, the formulation and application of ophthalmic drugs, and adverse ocular effects of systemic medication. This book discusses the preparations used in contact lens practice. Organized into 17 chapters, this edition begins with an overview of the primary systems of drug classification according to their actions or effects, or on the basis of their chemistry. This text then presents a detailed discussion on the actions and uses of ophthalmic autonomic drugs. Other chapters consider the structure and function of the involuntary nervous system in the orbital region. This book discusses as well the two main classifications of ophthalmic drugs, namely, therapeutic and diagnostic. The final chapter deals with the clinical significance of medication-induced ocular adverse effects. This book is a valuable resource for ophthalmologists, students, and practitioners.

Related subjects

Agricultural and biological sciences

Drug discovery

Immunology

Microbiology and virology

Neuroscience

Pharmaceutical sciences

Pharmacology

Toxicology

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health