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Books in Life sciences

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    • Enzymes of the Arterial Wall

      • 1st Edition
      • June 28, 2014
      • John Esben Kirk
      • English
      • Paperback
        9 7 8 1 4 8 3 2 5 5 0 2 6
      • eBook
        9 7 8 1 4 8 3 2 6 1 4 6 1
      Enzymes of the Arterial Wall is a comprehensive up-to-date monograph, and is the first publication dealing specifically with quantitative determinations of enzyme activities in human and animal vascular tissue. All available information concerning this subject is included. This summary of all current knowledge will be very useful to scientists who lack extensive library facilities and knowledge of foreign languages necessary for a thorough and time-consuming personal search of the original literature. A systematic description is made of 98 different enzymes; nearly all enzymes in the carbohydrate metabolic pathways are included. Brevity of discussion has made it possible to incorporate all available data. The results represent 27,200 quantitative biochemical assays performed with reliable analytical techniques on both normal and arteriosclerotic tissue; 70 enzymic procedures are described. The framework for the arrangement of facts throughout the book was designed to make information easily accessible. Each enzyme is described separately, using the sequence of The Commission on Enzymes of The International Union of Biochemistry, and is followed by literature references with full titles.

    • A Text-Book of Medical Bacteriology

      • 1st Edition
      • May 12, 2014
      • R. W. Fairbrother
      • English
      • Paperback
        9 7 8 1 4 8 3 2 1 1 9 2 3
      • eBook
        9 7 8 1 4 8 3 2 2 5 3 5 7
      A Text-Book of Medical Bacteriology provides information pertinent to the medical aspects of bacteriology. This book presents the biological relationship of allied organisms. Organized into three parts encompassing 37 chapters, this book begins with an overview of the salient features of the development of bacteriology. This text then explores the food requirements of the bacteria as well as the elements necessary for the synthesis of the bacterial protoplasm. Other chapters consider the numerous and complex factors involved in the reproduction of bacteria. This book discusses as well the presence of antitoxins in the serum of an individual, which is an indication of increased resistance to infection with the homologous organism. The final chapter deals with serological reactions that are most widely used, including agglutination, precipitation, and complement-fixation. This book is a valuable resource for medical students, physicists, bacteriologists, chemists, biochemists, and research workers.

    • The Mollusca

      • 1st Edition
      • Volume 2
      • June 28, 2014
      • Karl M. Wilbur + 1 more
      • English
      • Paperback
        9 7 8 1 4 9 3 3 0 4 6 2 2
      • eBook
        9 7 8 1 4 8 3 2 9 6 3 4 0
      The Mollusca, Volume 2: Environmental Biochemistry and Physiology provides information pertinent to the advances in the traditional areas of biochemistry and in other developed areas that have become a part of molluskan biochemistry. This book discusses the developments in the various aspects of molecular biomechanics and environmental biochemistry. Organized into 10 chapters, this volume begins with an overview of the comparative studies of the structure–function relationships in molluskan oxygen carriers. This text then describes the specific types and classes of molluskan respiratory proteins. Other chapters consider the nature and distribution of respiratory proteins in mollusks. This book discusses as well the oxygen equilibrium properties of gastropod hemocyanins. The final chapter deals with host–symbiont interactions in mollusks. This book is a valuable resource for researchers of the Mollusca and other phyla, as well as to teachers and qualified graduate students. Biochemists and physiologists will also find this book useful.

    • Drugs, Addiction, and the Brain

      • 1st Edition
      • July 12, 2014
      • George F. Koob + 2 more
      • English
      • Hardback
        9 7 8 0 1 2 3 8 6 9 3 7 1
      • eBook
        9 7 8 0 1 2 3 8 6 9 5 9 3
      Drugs, Addiction, and the Brain explores the molecular, cellular, and neurocircuitry systems in the brain that are responsible for drug addiction. Common neurobiological elements are emphasized that provide novel insights into how the brain mediates the acute rewarding effects of drugs of abuse and how it changes during the transition from initial drug use to compulsive drug use and addiction. The book provides a detailed overview of the pathophysiology of the disease. The information provided will be useful for neuroscientists in the field of addiction, drug abuse treatment providers, and undergraduate and postgraduate students who are interested in learning the diverse effects of drugs of abuse on the brain.

    • Microbiology for Surgical Infections

      • 1st Edition
      • March 18, 2014
      • Kateryna Kon + 1 more
      • English
      • Paperback
        9 7 8 0 1 2 8 1 0 3 2 1 0
      • Hardback
        9 7 8 0 1 2 4 1 1 6 2 9 0
      • eBook
        9 7 8 0 1 2 4 1 1 6 4 2 9
      Microbiology for Surgical Infections: Diagnosis, Prognosis and Treatment explores current trends in etiology and antibiotic resistance of pathogens responsible for devastating and complex surgical infections. Clinicians and researchers report the most recent advances in diagnostic approaches to bacterial and non-bacterial surgical infections, including invasive fungal infections. Current guidelines for prophylaxis of community-acquired and nosocomial infections, complications in surgery, and improvement of diagnosis and treatment of these devastating surgical infections are also discussed. The work gives specific attention to intra-abdominal and wound infections, as well as infections in cardiac surgery and neurosurgery. Taken together, these explorations inform the work of specialists in different surgical arenas, as well as those working in microbiology. Microbiology for Surgical Infections provides a resource to those working to improve outcomes in this complicated arena by discussing prospects for future study and identifying targets for future research.

    • Personalized Cancer Chemotherapy

      • 1st Edition
      • December 5, 2014
      • Da Yong Lu
      • English
      • Hardback
        9 7 8 0 0 8 1 0 0 3 4 6 6
      • Paperback
        9 7 8 0 0 8 1 0 1 6 2 2 0
      • eBook
        9 7 8 0 0 8 1 0 0 3 4 7 3
      Personalized Cancer Chemotherapy separately describes and addresses "individualized cancer chemotherapy" (ICC) strategies new and old, to provide readers with new insights into their characteristics and techniques, as well as key debates and future trends in this area. The book devotes chapters to drug sensitivity testing, cancer biomarkers and bioinformatics detection, pharmacogenetics, individualized antimetastatic therapy, drug combinations, assistant chemotherapy, and cost-effectiveness considerations. A major obstacle to controlling cancer growth and metastases in patients is the inappropriate use of anticancer and antimetastatic drugs. Researchers and clinicians are now beginning to focus on ICC also called "personalized cancer chemotherapy" (PCC), to improve therapeutic quality and outcomes by selecting and prescribing the most appropriate and effective drugs. Using genetic, molecular, and bioinformatics data and modern experimental techniques, known tumor genes can be detected more easily than ever before; the average speed of genetic sequencing has increased 15,000 to 50,000 times since the Human Geonme Project was completed. This book will help readers understand the pros and cons of each individualized cancer chemotherapy strategy from different angles so as to make good judgments and predictions of drug responses and clinical outcomes.

    • Recombinant DNA Methodology

      • 1st Edition
      • May 19, 2014
      • English
      • eBook
        9 7 8 1 4 8 3 2 9 5 9 7 8
      Recombinant DNA methods are powerful, revolutionary techniques that allow the isolation of single genes in large amounts from a pool of thousands or millions of genes and the modification of these isolated genes or their regulatory regions for reintroduction into cells for expression at the RNA or protein levels. These attributes lead to the solution of complex biological problems and the production of new and better products in the areas of medicine, agriculture, and industry.Recombinant DNA Methodology, a volume in the Selected Methods in Enzymology series produced in benchtop format, contains a selection of key articles from Volumes 68, 100, 101, 153, 154, and 155 of Methods in Enzymology. The essential and widely used procedures provided at an affordable price will be an invaluable aid to the graduate student and the researcher.

    • Cholinergic Ligand Interactions

      • 1st Edition
      • June 28, 2014
      • D. J. Triggle + 2 more
      • English
      • Paperback
        9 7 8 1 4 8 3 2 4 7 6 9 4
      • eBook
        9 7 8 1 4 8 3 2 7 6 5 6 4
      Cholinergic Ligand Interactions presents the papers read at a symposium held at the State University of New York at Buffalo, 25-26 May 1970. The recent purification and crystallization of acetylcholinesterase together with real progress in the purification of receptor components indicated the desirability of organizing a symposium to discuss not only these aspects but also the structural bases for cholinergic ligand interaction with these macromolecules, the conformational changes involved with ligand binding, the quantitation of cholinergic ligand binding sites, and the roles of acetylcholinesterase and its isozymes in muscle disease. The volume contains nine chapters and begins with a study on possible conformational changes in acetylcholinesterase... This is followed by separate chapters on the subunits of acetylcholinesterase... in vitro studies with the cholinergic receptor of the eel electroplax; identification and isolation of acetylcholine receptors; assay and properties of essential (junctional) cholinesterases of the rat diaphragm; and structural variations in cholinergic ligands. Subsequent chapters deal with ligand interactions at the muscarinic receptors and changes in cholinesterases isozymes during normal and dystrophic muscle development.

    • Fed-Batch Fermentation

      • 1st Edition
      • September 29, 2014
      • G G Moulton
      • English
      • Paperback
        9 7 8 0 0 8 1 0 1 3 6 7 0
      • Hardback
        9 7 8 1 9 0 7 5 6 8 9 2 3
      • eBook
        9 7 8 1 9 0 8 8 1 8 3 3 1
      Fed-batch Fermentation is primarily a practical guide for recombinant protein production in E. coli using a Fed-batch Fermentation process. Ideal users of this guide are teaching labs and R&D labs that need a quick and reproducible process for recombinant protein production. It may also be used as a template for the production of recombinant protein product for use in clinical trials. The guide highlights a method whereby a medium cell density - final Ods = 30-40 (A600) - Fed-batch Fermentation process can be accomplished within a single day with minimal supervision. This process can also be done on a small (2L) scale that is scalable to 30L or more. All reagents (media, carbon source, plasmid vector and host cell) used are widely available and are relatively inexpensive. This method has been used to produce three different protein products following cGMP guidelines for Phase I clinical studies.

    • Switchable and Responsive Surfaces and Materials for Biomedical Applications

      • 1st Edition
      • December 11, 2014
      • Johnathan Zhang
      • English
      • Hardback
        9 7 8 0 8 5 7 0 9 7 1 3 2
      • eBook
        9 7 8 0 8 5 7 0 9 7 1 7 0
      Surface modification of biomaterials can ultimately determine whether a material is accepted or rejected from the human body, and a responsive surface can further make the material "smart" and "intelligent". Switchable and Responsive Surfaces and Materials for Biomedical Applications outlines synthetic and biological materials that are responsive under different stimuli, their surface design and modification techniques, and applicability in regenerative medicine/tissue engineering, drug delivery, medical devices, and biomedical diagnostics. Part one provides a detailed overview of switchable and responsive materials and surfaces, exploring thermo-responsive polymers, environmentally responsive polyelectrolytes and zwitterionic polymers, as well as peptide-based and photonic sensitive switchable materials. Further chapters include a detailed overview of the preparation and analysis of switchable polymer brushes and copolymers for biomedical application. Part two explores the biological interactions and biomedical applications of switchable surfaces, where expert analysis is provided on the interaction of switchable surfaces with proteins and cells. The interaction of stimuli-sensitive polymers for tissue engineering and drug delivery with biosurfaces is critiqued, whilst the editor provides a skillful study into the application of responsive polymers in implantable medical devices and biosensors.

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