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Books in Life sciences

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    • Personalized Immunosuppression in Transplantation

      • 1st Edition
      • August 8, 2015
      • Michael Oellerich + 1 more
      • English
      • Hardback
        9 7 8 0 1 2 8 0 0 8 8 5 0
      • eBook
        9 7 8 0 1 2 8 0 1 1 3 3 1
      Personalized Immunosuppression in Transplantation: Role of Biomarker Monitoring and Therapeutic Drug Monitoring provides coverage of the various approaches to monitoring immunosuppressants in transplant patients, including the most recently developed biomarker monitoring methods, pharmacogenomics approaches, and traditional therapeutic drug monitoring. The book is written for pathologists, toxicologists, and transplant surgeons who are involved in the management of transplant patients, offering them in-depth coverage of the management of immunosuppressant therapy in transplant patients with the goal of maximum benefit from drug therapy and minimal risk of drug toxicity. This book also provides practical guidelines for managing immunosuppressant therapy, including the therapeutic ranges of various immunosuppressants, the pitfalls of methodologies used for determination of these immunosuppressants in whole blood or plasma, appropriate pharmacogenomics testing for organ transplant recipients, and when biomarker monitoring could be helpful.

    • Platelet-Activating Factor Acetylhydrolases (PAF-AH)

      • 1st Edition
      • Volume 38
      • November 24, 2015
      • English
      • Hardback
        9 7 8 0 1 2 8 0 3 9 0 8 3
      • eBook
        9 7 8 0 1 2 8 0 3 9 4 6 5
      This volume of The Enzymes summarizes the most important discoveries associated with a group of enzymes that play an important role in normal biological processes as presented and discussed by leaders authorities in the field.

    • Personalized Epigenetics

      • 1st Edition
      • April 28, 2015
      • Trygve O. Tollefsbol
      • English
      • Hardback
        9 7 8 0 1 2 4 2 0 1 3 5 4
      • eBook
        9 7 8 0 1 2 8 0 0 4 3 6 4
      Personalized Epigenetics discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy. The book details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the diagnostic, prognostic, and therapeutic potential of the field, it also reviews the impact of the environment on epigenetic variations among individuals and the role of pharmacology and drug development in personalized epigenetics. Most importantly, the text covers personalized epigenetics from a disease-oriented perspective, presenting chapters that provide advances in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management.

    • Hair Analysis in Clinical and Forensic Toxicology

      • 1st Edition
      • June 25, 2015
      • Pascal Kintz + 2 more
      • English
      • Paperback
        9 7 8 0 1 2 8 0 1 7 0 0 5
      • eBook
        9 7 8 0 1 2 8 0 1 7 1 0 4
      Hair Analysis in Clinical and Forensic Toxicology is an essential reference for toxicologists working with, and researching, hair analysis. The text presents a review of the most up-to-date analytical methods in toxicological hair analysis, along with state-of-the-art developments in the areas of hair physiology, sampling, and pre-treatments, as well as discussions of fundamental issues, applications, and results interpretation. Topics addressed include the diagnosis of chronic excessive alcohol drinking by means of ethyl glucuronide (EtG) and fatty acid ethyl esters (FAEE), the early detection of new psychoactive substances, including designer drugs, the development of novel approaches to screening tests based on mass spectrometry, and the detection of prenatal exposure to psychoactive substances from the analysis of newborn hair.

    • Nerves and Nerve Injuries

      • 1st Edition
      • April 15, 2015
      • R. Shane Tubbs + 5 more
      • English
      • Hardback
        9 7 8 0 1 2 8 0 2 6 5 3 3
      • eBook
        9 7 8 0 1 2 8 0 2 6 9 5 3
      Nerves and Nerve Injuries is a must-have for clinicians and researchers dealing with the Peripheral Nervous System and neuropathy. An indispensable work for anyone studying the nerves or treating patients with nerve injuries, these books will become the ‘go to’ resource in the field. The nerves are treated in a systematic manner, discussing details such as their anatomy (both macro- and microscopic), physiology, examination (physical and imaging), pathology, and clinical and surgical interventions. The authors contributing their expertise are international experts on the subject. The books cover topics from detailed nerve anatomy and embryology to cutting-edge knowledge related to treatment, disease and mathematical modeling of the nerves. Nerves and Nerve Injuries Volume 2 focuses on pain, treatment, injury, disease and future directions in the field. This volume also addresses new information regarding neural interfaces, stem cells, medical and surgical treatments, and medical legal issues following nerve injury.

    • Medicinal Plants

      • 1st Edition
      • June 25, 2015
      • Da-Cheng Hao + 2 more
      • English
      • Hardback
        9 7 8 0 0 8 1 0 0 0 8 5 4
      • eBook
        9 7 8 0 0 8 1 0 0 1 0 3 5
      Medicinal Plants: Chemistry, Biology and Omics reviews the phytochemistry, chemotaxonomy, molecular biology, and phylogeny of selected medicinal plant tribes and genera, and their relevance to drug efficacy. Medicinal plants provide a myriad of pharmaceutically active components, which have been commonly used in traditional Chinese medicine and worldwide for thousands of years. Increasing interest in plant-based medicinal resources has led to additional discoveries of many novel compounds, in various angiosperm and gymnosperm species, and investigations on their chemotaxonomy, molecular phylogeny and pharmacology. Chapters in this book explore the interrelationship within traditional Chinese medicinal plant groups and between Chinese species and species outside of China. Chapters also discuss the incongruence between chemotaxonomy and molecular phylogeny, concluding with chapters on systems biology and “-omics” technologies (genomics, transcriptomics, proteomics, and metabolomics), and how they will play an increasingly important role in future pharmaceutical research.

    • Handbook of the Biology of Aging

      • 8th Edition
      • August 20, 2015
      • Nicolas Musi + 1 more
      • English
      • Paperback
        9 7 8 0 1 2 4 1 1 5 9 6 5
      • eBook
        9 7 8 0 1 2 4 1 1 6 2 0 7
      Handbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of ‘big data’ approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems. The book includes discussions on longevity pathways and interventions that modulate aging, innovative new tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, new strategies to pharmacologically modulate the mTOR pathway to delay aging, the importance of sirtuins and the hypoxic response in aging, and how various pathways interact within the context of aging as a complex genetic trait, amongst others.

    • The Neuronal Codes of the Cerebellum

      • 1st Edition
      • October 7, 2015
      • Detlef Heck
      • English
      • Paperback
        9 7 8 0 1 2 8 0 1 3 8 6 1
      • eBook
        9 7 8 0 1 2 8 0 1 6 7 5 6
      The Neuronal Codes of the Cerebellum provides the most updated information on what is known on the topics of the cerebellum’s anatomy and single cell physiology, two areas where there has been a gap in knowledge regarding the specific codes it uses to process information internally and convey commands to other brain regions. This has created difficulties for researchers and clinicians looking to develop an understanding of the mechanisms by which it contributes to behavior and how its dysfunction causes neurological symptoms. Focused on findings related to the neuronal code used by cerebellar neurons for the representation of behavioral and sensory processes, this edited volume will aid scientists in overcoming that knowledge gap, also serving as the first resource to broadly address the different aspects of spike coding in the cerebellum that focuses on spike train analysis.

    • Basic Principles of Drug Discovery and Development

      • 1st Edition
      • April 24, 2015
      • Benjamin E. Blass
      • English
      • Paperback
        9 7 8 0 1 2 4 1 1 5 0 8 8
      • eBook
        9 7 8 0 1 2 4 1 1 5 2 5 5
      Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, providing comprehensive explanations of enabling technologies such as high throughput screening, structure based drug design, molecular modeling, pharmaceutical profiling, and translational medicine, all areas that have become critical steps in the successful development of marketable therapeutics. The text introduces the fundamental principles of drug discovery and development, also discussing important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles in pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. It is designed to enable new scientists to rapidly understand the key fundamentals of drug discovery, including pharmacokinetics, toxicology, and intellectual property."

    • Genomics and Society

      • 1st Edition
      • October 29, 2015
      • Dhavendra Kumar + 1 more
      • English
      • Hardback
        9 7 8 0 1 2 4 2 0 1 9 5 8
      • eBook
        9 7 8 0 1 2 7 9 9 9 2 1 0
      Genomics and Society; Ethical, Legal-Cultural, and Socioeconomic Implications is the first book to address the vast and thorny web of ELSI topics identified as core priorities of the NHGRI in 2011. The work addresses fundamental issues of biosociety and bioeconomy as the revolution in biology moves from research lab to healthcare system. Of particular interest to healthcare practitioners, bioethicists, and health economists, and of tangential interest to the gamut of applied social scientists investigating the societal impact of new medical paradigms, the work describes a myriad of issues around consent, confidentiality, rights, patenting, regulation, and legality in the new era of genomic medicine.

Related subjects

Agricultural and biological sciences

Drug discovery

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Neuroscience

Pharmaceutical sciences

Pharmacology

Toxicology