Books in Life sciences

Retinoids as Anti-cancer Agents in Breast Cancer

1st Edition
July 25, 2025
Manzoor Ahmad Mir
English
Paperback
9 7 8 0 4 4 3 3 6 5 1 6 4
eBook
9 7 8 0 4 4 3 3 6 5 1 7 1

Retinoids as Anti-cancer Agents in Breast Cancer: A New Hope for Breast Cancer Treatment offers a comprehensive overview of the latest research and advancements in using retinoids to treat breast cancer. The book delves into novel approaches, including drug combinations and the development of new pharmaceuticals. It provides an in-depth analysis of current treatment methods, highlighting both challenges and opportunities in the field. Topics covered include the principles and mechanisms of retinoids as anti-cancer agents, preclinical and clinical studies, and advancements in drug delivery systems and nano-formulations.Fu... research directions are also explored, emphasizing new drug combinations, biomarkers for patient selection, and personalized treatment strategies. This book will serve as a platform for students, researchers, oncologists, pharmacologists, and healthcare professionals who want to understand the potential of retinoids in clinical practice.

100 Rare Tumors of the Digestive System

1st Edition
July 23, 2025
Xiaoyan Liao
English
Hardback
9 7 8 0 4 4 3 2 2 0 6 1 6
eBook
9 7 8 0 4 4 3 2 2 0 6 2 3

100 Rare Tumors of the Digestive System: A Case-Based Reference for Surgical Pathologists provides practicing surgical pathologists, gastroenterologists, oncologists, and surgeons with a comprehensive review on the clinical and pathologic features of rarely encountered neoplasms in the digestive system. The book uses a case-based format to cover typical clinical settings, including clinical history, symptoms, laboratory and radiographic findings, and representative histologic and immunologic pictures. This is the perfect reference for clinicians that would like to know more about updated terminology, histopathologic presentation, potential pathogenesis mechanisms, and treatment strategies for digestive disease entities.Scientists and researchers can also reference this book to find disease entities of interest, including pathogenesis, immunophenotype, and molecular findings. Multiple choice questioning is provided for readers to decide on the best diagnosis from a list of mimickers.

Pharmacoepigenetics

2nd Edition
Volume 10
July 18, 2025
Ramón Cacabelos
English
Hardback
9 7 8 0 4 4 3 1 8 7 2 2 3
eBook
9 7 8 0 4 4 3 1 8 7 2 3 0

Pharmacoepigenetics, Second Edition, Volume Ten in the Translational Epigenetics series, is a comprehensive reference on the role of epigenetics and epigenomics in drug discovery and development. Here, leading international researchers from across academia, clinical settings, and the pharmaceutical industry discuss the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, and treatment, current epigenetic drugs, and the application of epigenetic procedures in drug development. Throughout the book, chapter authors offer a balanced and objective discussion of the future of pharmacoepigenetics and its crucial contribution to the growth of precision and personalized medicine.This new edition has been fully revised to address recent advances in epigenetics, from new natural and synthetic compounds with epigenetic effects to the role of epigenetics in the pathogenesis of a growing number of complex diseases, including further cancers, cardiovascular disorders, and brain disorders. Newly identified molecular components in the functional architecture of the epigenetic machinery, as well as practical and relevant pharmacoepigenetics topics related to COVID-19 and other world health challenges are also discussed.

Essentials of Neuroanesthesia

2nd Edition
July 18, 2025
Hemanshu Prabhakar
English
Hardback
9 7 8 0 4 4 3 2 2 2 7 3 3
eBook
9 7 8 0 4 4 3 2 2 2 7 2 6

Essentials of Neuroanesthesia, Second Edition continues to offer valuable insights into the anesthetic management of neurosurgical and neurologic patients, covering all topics related to neuroanesthesia and providing essential knowledge on the brain and spinal cord. The book includes chapters on anatomy, physiology, and pharmacology, along with specific chapters addressing various neurosurgical and neurological problems and their anesthetic management. This updated edition introduces new chapters on artificial intelligence in neurosciences, the role of simulation in clinical neurosciences, robotic neurosurgery, trigeminal neuralgia, coexisting transplanted organs, brain resuscitation after cardiac arrest, and more.In addition to the foundational knowledge, the book addresses related issues such as the evidence-based practice of neuroanesthesia, sterilization techniques, biostatistics, and ethical issues. It is a valuable resource for trainees, clinicians, and researchers in the fields of neuroanesthesia, neurocritical care, critical care, neurosurgery, and neurology. The comprehensive coverage and updated content make it an indispensable guide for understanding and managing the complexities of neuroanesthesia.

Immuno-oncology and Immunotherapy Part D

1st Edition
Volume 196
July 18, 2025
Lorenzo Galluzzi + 2 more
English
Hardback
9 7 8 0 4 4 3 2 9 6 1 8 5
eBook
9 7 8 0 4 4 3 2 9 6 1 9 2

Immuno-oncology and immunotherapy, Part D, Volume 196 in the Methods in Cell Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Investigating the endothelial-immune axis in cancer, Establishing Tyro3, Axl, and Mertk Chinese Hamster Ovary (CHO) Reporter Cell Lines for Cancer Immunology and Therapeutic Applications, Amino acid analog-based labelling of the immunomodulatory cancer secretome, Human and mouse iNKT cell expansion and engineering with viral vectors, Next-generation deconvolution of the tumor microenvironment with omnideconv, and much more.Additional sections cover Comprehensive prediction of tumor neoantigens with NextNEOpi, Ex vivo profiling of organotypic tumor spheroids in 3D microfluidic culture, A flow cytometry-based assay for evaluation of T cell activation and degranulation in coculture systems, An adenosine production assay suitable for 2D and 3D cancer cell culture, Determination of lactate in the tumor interstitial fluid, Combined in vitro differentiation and cell sorting-based isolation of highly pure mouse bone marrow-derived basophils, Organ-on-Chip immunostaining method for three-dimensional identification and study of immune cells responding to drug-treated tumor cells, and much more.

Regulated Cell Death in Neurodegenerative Disorders

1st Edition
July 18, 2025
Heba Mohamed Mansour + 1 more
English
Paperback
9 7 8 0 4 4 3 3 2 8 5 2 7
eBook
9 7 8 0 4 4 3 3 2 8 5 3 4

Regulated Cell Death in Neurodegenerative Disorders is a comprehensive exploration of the mechanisms and implications of RCD within the realm of neurodegenerative diseases. The book delves into various forms of RCD such as apoptosis, necroptosis, ferroptosis, pyroptosis, and autophagy-mediated cell death, shedding light on their specific roles in disorders like Alzheimer’s, Parkinson’s, Multiple sclerosis, Amyotrophic lateral sclerosis, and Huntington’s. Written by leading experts, each chapter offers unique insights into cellular demise, providing valuable information on treatment options and therapeutic targets. The book features 14 chapters that cover molecular, cellular, and pharmacological mechanisms from an applied science perspective.Topics include the importance of chaperones, kinases, growth factors, inflammaging, mitochondrial dynamics, and oxidative stress. It presents targeted strategies to prevent cell death, reflecting ongoing pursuits in understanding and innovating treatments for neurodegenerative diseases. By offering therapeutic strategies to modulate RCD, this book not only shares knowledge but also provides hope for future advancements in combating these debilitating conditions.

Myasthenia Gravis, Part A

1st Edition
Volume 182
July 18, 2025
Anna Rostedt Punga + 1 more
English
Hardback
9 7 8 0 4 4 3 4 2 9 8 3 5
eBook
9 7 8 0 4 4 3 4 2 9 8 4 2

Myasthenia Gravis, Part A, Volume 182 in the International Review of Neurobiology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as the Structure of the NMJ and Neuromuscular Transmission, Neuromuscular Junction and the Complement System, Regulation of the Autoimmune Response, The Thymus, Antibodies/Subclasse... (IgG) and Antigens, Cell Models of MG, Mouse Models of EAMG and Passive Immunization, Epidemiology of Myasthenia Gravis, Special Populations: Juvenile, Early, Late, and Very Late-Onset, Blood and Digital Biomarkers in MG, Lambert-Eaton Myasthenic Syndrome, and Congenital Myasthenic Syndromes.

Environmental Pollution and Cardiovascular Diseases

1st Edition
July 17, 2025
Sultan Ayoub Meo
English
Paperback
9 7 8 0 4 4 3 2 6 7 6 9 7
eBook
9 7 8 0 4 4 3 2 6 7 7 0 3

Environmental Pollution and Cardiovascular Diseases helps stakeholders enhance their knowledge about environmental pollution, weather conditions, climate change, and impacts on the cardiovascular system. The book further aims to ameliorate the global burden of cardiovascular deaths attributable to pollution by identifying trends in pollution-linked cardiovascular disease from the 1990s to present day. Overall, air pollution is estimated to cause about 34% of ischemic heart disease deaths. As these figures show no sign of declining, this book is a must-have for researchers, cardiologists, and others seeking to understand such an important etiological factor in so many cardiovascular illnesses.

Evapotranspiration in Agro-Ecosystems and Forestry

1st Edition
July 15, 2025
Suat Irmak
English
Paperback
9 7 8 0 4 4 3 2 1 6 4 9 7
eBook
9 7 8 0 4 4 3 2 1 6 4 8 0

Evapotranspiration in Agro-Ecosystems and Forestry: Spatio-temporal Applications presents the progress and advances made in terms of science and application of evaporation, transpiration, and evapotranspiration for various vegetation surfaces, water bodies, and bare soil under different soil and crop management (including different irrigation and tillage management) conditions. Sections on forest and wetlands evapotranspiration and grassland evaporative losses are included, as are the fundamentals of original Penman, Penman-Monteith, Shuttleworth-Wallace and ASCE-EWRI and FAO56 Penman-Monteith equations and their derivatives.The book is an excellent resource to better understand the progression and applications and dynamics of most recent evapotranspiration, evaporation and transpiration measurement and modeling technologies. Case studies will be provided in terms of how different technologies are currently deployed, how data are used for providing information and management decisions to the users.

Narcolepsy

1st Edition
July 15, 2025
Ahmed S. BaHammam + 2 more
English
Paperback
9 7 8 0 4 4 3 3 0 0 0 4 2
eBook
9 7 8 0 4 4 3 3 0 0 0 5 9

Narcolepsy: Integrating Basic and Clinical Knowledge provides comprehensive coverage of narcolepsy-related topics. The book offers updated, deep coverage of its diagnosis, treatment, and impact on mental health based on the latest research findings and clinical practices. Its interdisciplinary approach brings together experts from different specialties, such as sleep medicine, psychology, and neurology to offer a more holistic understanding. This allows for a more nuanced discussion of how narcolepsy interacts with various aspects of health and well-being. Researchers and clinicians will find within this book novel information on pathophysiology and neurobiology, as well as behavioral and psychosocial considerations.Users will find this to be a resource that takes a deep dive into narcolepsy, introducing topics never before discussed in books on the topic, including COVID-19 and sleep, as well as immunotherapy and gene therapy. It’s the cutting-edge medical volume professionals need, whether narcolepsy specialists or more casual readers.

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