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Books in Life sciences

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    • The Cellular Secretome and Organ Crosstalk

      • 1st Edition
      • June 12, 2018
      • Juergen Eckel
      • English
      • Paperback
        9 7 8 0 1 2 8 0 9 5 1 8 8
      • eBook
        9 7 8 0 1 2 8 0 9 7 1 9 9
      The Cellular Secretome and Organ Crosstalk focuses on the release of peptides and proteins from different organs and their specific functions in metabolic regulation and cell- and organ crosstalk. The book is written for experts in the field, however, for each topic, helpful references are included. The book also includes technical sections that summarize the state-of-the-art of secretome and crosstalk analysis. This book fulfills the need for a resource that comprehensively describes the current knowledge of secretome biology in health and disease. Communication between different organs involves lipids and other small molecules and a host of proteins and peptides comprising the secretome of different organs (organokinome). More than 600 adipokines have been identified, and an increasing number of hepatokines and myokines have recently been discovered with mostly unknown physiological impact. Importantly, an aberrant signature of the organokinome may be critically underlying a variety of metabolic diseases and may determine the individual susceptibility to disease development.

    • Antimicrobial Peptides in Gastrointestinal Diseases

      • 1st Edition
      • June 6, 2018
      • Chi Hin Cho
      • English
      • Paperback
        9 7 8 0 1 2 8 1 4 3 1 9 3
      • eBook
        9 7 8 0 1 2 8 1 4 3 2 0 9
      Antimicrobial peptides (AMPs), including cathelicidins and defensins are host defence peptides that carry out multiple roles in the gastrointestinal (GI) tract. Antimicrobial Peptides in Gastrointestinal Diseases presents knowledge about the physiological functions and pharmacological actions of AMPs in inflammation, cancer, and further infection of the GI tract. The book provides coverage from the basic research to clinical application for GI diseases. Current research and development of AMPs is presented, opening the way for further work on these peptides, not only in the context of GI diseases, but also for similar pathologies in other organs. AMPs are key to the regulation of human microbiome and second line defence in the GI mucosa, prevent colonization of pathogens and modulation of innate response to invading pathogens, and modify immunological reactions during inflammatory processes and oncogenic development in the GI mucosa. More importantly, AMPs possess diversified anti-microbial actions against various infectious diseases in the GI tract. With these physiological functions and pharmacological actions, AMPs have significant potential as therapeutic agents for the treatment of inflammation, cancer and further infection in the GI tract.

    • Transfusion Medicine for Pathologists

      • 1st Edition
      • June 21, 2018
      • Brian Castillo + 4 more
      • English
      • Paperback
        9 7 8 0 1 2 8 1 4 3 1 3 1
      • eBook
        9 7 8 0 1 2 8 1 4 3 1 4 8
      Transfusion Medicine for Pathologists: A Comprehensive Review for Board Preparation, Certification, and Clinical Practice is a concise study guide designed to complement standard textbooks in the field of clinical pathology. Pathology residents and fellows of transfusion medicine will find this book useful as a preparation tool for their exams. In addition, the book is a valuable timesaver for busy residents looking for a focused and compact study guide on transfusion medicine that will also be ideal for practicing pathologists who cross-cover transfusion medicine in their clinical practice.

    • Whey Proteins

      • 1st Edition
      • September 3, 2018
      • Hilton C Deeth + 1 more
      • English
      • Paperback
        9 7 8 0 1 2 8 1 2 1 2 4 5
      • eBook
        9 7 8 0 1 2 8 1 2 1 2 5 2
      Whey Proteins: From Milk to Medicine addresses the basic properties of whey proteins including chemistry, analysis, heat sensitivity, interactions with other proteins and carbohydrates, modifications (hydrolysis, aggregation, conjugation), their industrial preparation, processing and applications, quality aspects including flavour and effects of storage, as well as their role in nutrition, sports and exercise, and health and wellness. Readers of Whey Proteins will gain a better understanding of the chemical nature of the various whey proteins in cow’s milk and the milk of other species. This includes their unique physical and functional properties; the industrial processes used to extract them from milk, to process them into various forms, and to modify them to enhance their functionality; and their nutritive value and application in the fields of sports and exercise science, infant nutrition and medicine. This book is an essential resource for food and nutrition researchers, dairy and food companies, pharmaceutical organizations, and graduate students.

    • Phosphatases

      • 1st Edition
      • Volume 607
      • August 23, 2018
      • English
      Methods in Enzymology, Volume 607: Phosphatases, the latest release in this ongoing series, highlights new advances in the field as detailed by an international board of authors. This latest release includes chapters on Empirical Valence Bond Simulations of the Evolution of Enzyme Function, QM/MM Free Energy and Kinetic Isotope Analysis of Phosphoryl Transfer in Enzymes, the Structural, Mechanism and Evolution of Phosphatases, How to Define Rapid Motions in Pumping Pyrophosphatases, The Evolution of K+-Independence in Pyrophosphatases, the Crystallization of Michaelis, Intermediate and Inhibited Complexes in Phosphatases, and an Investigation of Nucleotide Loading and Effector Binding of K-Ras.

    • Stem Cells and Biomaterials for Regenerative Medicine

      • 1st Edition
      • November 7, 2018
      • Marek J. Los + 2 more
      • English
      • Paperback
        9 7 8 0 1 2 8 1 2 2 5 8 7
      • eBook
        9 7 8 0 1 2 8 1 2 2 7 8 5
      Stem Cells and Biomaterials for Regenerative Medicine addresses the urgent need for a compact source of information on both the cellular and biomaterial aspects of regenerative medicine. By developing a mutual understanding between three separately functioning areas of science—medicine, the latest technology, and clinical economics—the volume encourages interdisciplinary relationships that will lead to solutions for the significant challenges faced by today's regenerative medicine. Users will find sections on the homeostatic balance created by apoptosis and proliferating tissue stem cells, the naturally regenerative capacities of various tissue types, the potential regenerative benefits of iPS-generation, various differentiation protocols, and more. Written in easily accessbile language, this volume is appropriate for any professional or medical staff looking to expand their knowledge with regard to stem cells and regenerative medicine.

    • Analytical Methods for Agricultural Contaminants

      • 1st Edition
      • September 18, 2018
      • Britt Maestroni + 2 more
      • English
      • Paperback
        9 7 8 0 1 2 8 1 5 9 4 0 8
      • eBook
        9 7 8 0 1 2 8 1 5 9 4 1 5
      Analytical Methods for Agricultural Contaminants provides proven laboratory practices and methods necessary to control contaminants and residues in food and water. This reference provides insight into good laboratory practices and examples of methods used in individual specialist laboratories, thus enabling stakeholders in the agri-food industry to appreciate the importance of proven, reliable data and the associated quality assurance approaches for end product testing for toxic levels of contaminants and contaminant residues in food. The book offers standard operating procedures and tools for researchers, practitioners and students to confidently engage in using research methods with the aim to control contaminants. Users in a laboratory setting will find this to be a practical and useful reference on how to detect and control agricultural contaminants for a safe food supply.

    • The Opioid System as the Interface between the Brain’s Cognitive and Motivational Systems

      • 1st Edition
      • Volume 239
      • October 9, 2018
      • English
      • Hardback
        9 7 8 0 4 4 4 6 4 1 6 7 0
      • eBook
        9 7 8 0 4 4 4 6 4 1 6 8 7
      The Opioid System as the Brain’s Interface between Cognition and Motivation, Volume 239, focuses on the opioid system as the interface between the brain’s cognitive and motivational systems. As the opioid system is widely distributed through the brain, particularly in areas implicated in cognition (hippocampus, prefrontal cortex, claustrum, thalamus) and motivation (hypothalamus, amygdala, pontine nuclei, periaqueductal gray and medulla), this book provides chapters that address ongoing research on topics such as the Brain’s cognitive system, the Brain’s motivational system, Antidepressant prescription patterns, Antidepressant-like effects of opioid receptor modulators, the Behavioral effects of antidepressant and anxiolytic drugs, and more.

    • Epigenetics of Chronic Pain

      • 1st Edition
      • Volume 7
      • October 29, 2018
      • English
      • Hardback
        9 7 8 0 1 2 8 1 4 0 7 0 3
      • eBook
        9 7 8 0 1 2 8 1 4 0 7 1 0
      Epigenetics of Chronic Pain, Volume Nine, presents comprehensive information on the role of epigenetics in chronic pain sensitivity, providing a detailed, but accessible, view of the field from basic principles, to clinical application. Leading international researchers discuss essential mechanisms of chronic pain epigenetics, including the molecular processes of chromatin remodeling, histone modifications, and the microRNAs and noncoding RNAs involved in regulating genes tied to pain sensitivity. The influence of epigenetics in inflammatory, neuropathic, visceral and other pain models is examined, with data derived from epigenetic studies on peripheral and central mechanisms of pain sensitivity in animal models and clinical cases studies. The studies and case examples cited highlight therapeutic pathways of significance and next steps for researchers to develop epigenetic-based treatments for chronic pain. In recent years, epigenetic regulation of gene expression has been shown to play a central role in managing human pain sensitivity. Findings show that expression of many genes critical to increases or decreases in pain sensitivity are indeed regulated by DNA methylation and its enzymes, histone-involved chromatin remodeling, and noncoding RNAs, mainly microRNAs.

    • Imagining the Brain: Episodes in the History of Brain Research

      • 1st Edition
      • Volume 243
      • December 1, 2018
      • Chiara Ambrosio + 1 more
      • English
      • Hardback
        9 7 8 0 1 2 8 1 4 2 5 7 8
      • eBook
        9 7 8 0 1 2 8 1 4 2 5 8 5
      Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

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