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Books in Pharmaceutical sciences

Elsevier's Pharmaceutical Science collection helps pharmaceutical scientists striving to optimize drug design and improve healthcare outcomes by offering comprehensive coverage of every aspect of drug development, integrating disciplines like organic chemistry, biology, and biotechnology. Focused on safety, efficacy, and formulation design, it includes specialized fields such as Clinical Pharmacology and Translational Research, providing valuable insights into the latest advancements in drug discovery.

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341-350 of 360 results in All results

Analytical Profiles of Drug Substances and Excipients

  • 1st Edition
  • Volume 26
  • October 5, 1999
  • Harry G. Brittain
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 8 6 1 2 1 - 0
Although the official compendia define a drug substance as to identity, purity, strength, and quality, they normally do not provide other physical or chemical data, nor do they list methods of synthesis or pathways of physical or biological degradation and metabolism. Such information is scattered throughout the scientific literature and the files of pharmaceutical laboratories. Edited by the Associate Director of Analytical Research and Development for the American Association of Pharmaceutical Scientists, Analytical Profiles of Drug Substances and Excipients brings this information together into one source. The scope of the series has recently been expanded to include profiles of excipient materials.

Advances in Pharmacology

  • 1st Edition
  • Volume 46
  • May 5, 1999
  • J. Thomas August + 3 more
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 5 8 1 3 8 - 5
Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental.

Medical Applications of Liposomes

  • 1st Edition
  • July 22, 1998
  • D.D. Lasic + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 4 4 4 - 8 2 9 1 7 - 7
  • eBook
    9 7 8 - 0 - 0 8 - 0 5 3 6 0 8 - 8
The development of liposomes as a drug delivery system has fluctuated since its introduction in the late 1960's by A.D. Bangham. While academic research of liposomes as a model membrane system has always flourished, as the exponential growth of papers can testify, the application of these findings to medically useful products has gone through several crises. Following the original optimism in the 70's and early 80's, a period of severe skepticism ensued at the end of the 80's and beginning of the 90's, culminating in a moderate but real optimism in the mid 90's, as a result of a successful launch of the first products in the US and Europe.In this collection of papers, the editors have gathered the most promising ideas, approaches, applications and commercial developments, thereby presenting an up-to-date compilation of the present status of the field. This includes such broad areas as anti-cancer chemotherapy immune stimulation and infectious diseases. Currently, the major areas of progress are in delivery of anti-fungal agents by conventional liposomes or lipid-based carriers and systemic anticancer therapy using long-circulating liposomes. The future applications as characterized by the direction of present day research is in specific targeting and delivery of informational molecules such as DNA plasmids (genes), antisense oligonucleotides or ribozymes. Other future developments may be in topical delivery, vaccination and in diagnostics.Features of this book:• Contributions from almost all the leading labs in the field• Up-to-date, critical reviews bridged by editors' introductions• Organized into a logical framework.

Analytical Profiles of Drug Substances and Excipients

  • 1st Edition
  • Volume 25
  • March 2, 1998
  • Harry G. Brittain
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 8 6 1 2 0 - 3
Although the official compendia define a drug substance as to identity, purity, strength, and quality, they normally do not provide other physical or chemical data, nor do they list methods of synthesis or pathways of physical or biological degradation and metabolism. Such information is scattered throughout the scientific literature and the files of pharmaceutical laboratories. Edited by the Associate Director of Analytical Research and Development for the American Association of Pharmaceutical Scientists, Analytical Profiles of Drug Substances and Excipients brings this information together into one source. The scope of the series has recently been expanded to include profiles of excipient materials.

Approaches to Design and Synthesis of Antiparasitic Drugs

  • 1st Edition
  • Volume 25
  • July 10, 1997
  • N. Anand + 1 more
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 5 2 7 5 2 - 9
This book presents a comprehensive and up to date account of the chemotherapy of parasitic diseases, both human and veterinary. The book starts with an overview of parasitic diseases. The body of the book is divided into two parts: antihelminthic drugs, and antiprotozoal drugs. Both parts start with chapters highlighting the 'biochemical targets' available for chemotherapeutic interference. Individual chapters deal with one chemical class of compounds and describe their origin, structure-activity relationship, mode of action, and methods of synthesis and their status both in clinical and veterinary practice. The book will be useful to a wide spectrum of readers: students embarking on a research career in parasitic chemotherapy, clinicians (and veterinarians) and clinical pharmacologists desiring detailed information about the drugs currently in use, and pharmaceutical technologists wanting to update their knowledge of the methods of manufacture.

New Cosmetic Science

  • 1st Edition
  • June 19, 1997
  • T. Mitsui
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 5 3 7 4 9 - 8
Cosmetic science covers the fields from natural sciences to human and social sciences, and is an important interdisciplinary element in various scientific disciples. New Cosmetic Science is a completely updated comprehensive review of its 35 year old counterpart Cosmetic Science. New Cosmetic Science has been written to give as many people as possible a better understanding of the subject, from scientists and technologists specializing in cosmetic research and manufacturing, to students of cosmetic science, and people with a wide range of interests concerning cosmetics.The relationship between the various disciplines comprising cosmetic science, and cosmetics, is described in Part I. In addition to discussing the safety of cosmetics, the "Usefulness of Cosmetics", rapidly becoming an important theme, is described using research examples. The latest findings on cosmetic stability are presented, as are databases, books and magazines, increasingly used by cosmetic scientists. Part II deals with cosmetics from a usage viewpoint, including skin care cosmetics, makeup cosmetics, hair care cosmetics, fragrances, body cosmetics, and oral care cosmetics. Oral care cosmetics and body cosmetics are presented with product performance, types, main components, prescriptions and manufacturing methods described for each item.This excellent volume enlightens the reader not only on current cosmetics and usage, but indicates future progress enlarging the beneficial effects of cosmetics. Products with better pharmaceutical properties (cosmeceuticals), working both physically and psychologically, are also highlighted.

Robustness of Analytical Chemical Methods and Pharmaceutical Technological Products

  • 1st Edition
  • Volume 19
  • December 11, 1996
  • M.M.W.B. Hendriks + 2 more
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 5 4 0 6 3 - 4
In analytical chemistry and pharmaceutical technology attention is increasingly focussed on improving the quality of methods and products. This book aims at fostering the awareness of the potential of existing mathematical and statistical methods to improve this quality. It provides procedures and ideas on how to make a product or a method less sensitive to small variations in influencing factors. Major issues covered are robustness and stability improvement and ruggedness testing. General strategies and a theoretical introduction to these methods are described, and thorough overviews of methods used in both application areas and descriptions of practical applications are given.Features of this book:• Gives a good overview of mathematical and statistical methods used in two application areas, i.e. pharmaceutical technology and analytical chemistry• Illustrates the different approaches available to attain robustness• Gives ideas on how to use methods in practical situations.The book is intended for those who develop and optimize, and are responsible for the overall quality of, analytical methods and pharmaceutical technological products and procedures.

Advances in Pharmacology

  • 1st Edition
  • Volume 37
  • September 30, 1996
  • J. Thomas August + 3 more
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 5 8 1 2 9 - 3
Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental.

Advances in Drug Research

  • 1st Edition
  • Volume 28
  • July 2, 1996
  • Bernard Testa + 1 more
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 5 2 6 7 1 - 3
This volume continues the trend for Advances in Drug Research of shorter, but more frequent volumes. In line with the tradition of the series, chapters on general themes are interspersed with chapters on specific drug classes and targets.

Advances in Antiviral Drug Design

  • 1st Edition
  • Volume 2
  • April 23, 1996
  • E. De Clercq
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 5 2 6 0 3 - 4
The purpose of the series on Advances in Antiviral Drug Design is to regularly review the "state of the art" on emerging new developments in the antiviral drug research field, thereby spanning the conceptual design and chemical synthesis of new antiviral compounds, their structure-activity relationship, mechanism and target(s) of action, pharmacological behavior, antiviral activity spectrum, and therapeutic potential for clinical use. Volume 2 begins with a description of the antiviral potential of antisense oligonucleotides by J. Temsamani and S. Agrawal. According to the aims of the anitsense technology, these oligonucleotides should be targeted at specific viral antisense technology, these oligonucleotides should be targeted at specific viral mRNA sequences so that translation to the virus-specified proteins is blocked; this has been achieved for a number of oligomers, some of which are now in clinical trials for the treatment of HIV, HCMV, and human papilloma virus (HPV) infections. Then C.-S. Yuan, S. Liu, S.F. Wnuk, M.J. Robins and R.T. Borchardt assess the role of S-adenosylhornocysteine (AdoHcy) hydrolase as target for the design of antiviral agents with broad-spectrum antiviral activity. This is followed by an in-depth account on the design and synthesis of a number of first-, second- and third-generation AdoHcy hydrolase inhibitors and their mode of action at the enzyme level.V.E. Marquez provides a comprehensive description of the various carbocyclic (carba) nucleosides that have been synthesized and evaluated for antiviral activity. Although the number and diversity of the carba-nucleosides that have been found to be antivirally active (or inactive) is astonishingly high, there is no limit to further expansion of this fascinating class of molecules. For the various nucleoside analogues that have to be intracellularly phosphorylated to the 5'-triphosphate stage, to interact with their target enzyme (i.e., herpesviral DNA polymerase or retroviral revers transcriptase) the first phosphorylation step is often the rate-limiting step, and thus various strategies are envisaged by C. Perigoud, J.-L. Girardet, G. Gosselin and J.-L. Bach on how to bypass this initial phosphorylation and to deliver the nucleoside 5'-monophophate directly inside the cells.The HIV protease has been considered as a paradigm for rational drug design. The enzyme is among the best understood in terms of both structure and action, and because of its crucial role in the maturation of HIV, it has been vigorously pursued as a target for anti-HIV chemotherapy. In their comprehensive review of the multidisciplinary approach towards the development of HIV protease inhibitors A.G. Tomasselli, S. Thaisrivongs and R.L. Heinrikson highlight those protease inhibitors which have been brought forward to clinical trials.

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