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Books in Drug discovery

Elsevier's Drug Delivery collection is an indispensable resource for scientists and researchers in the pharmaceutical field, exploring the administration of pharmaceutical compounds for therapeutic effects from molecule identification to medication development. It provides comprehensive coverage, including crucial aspects such as drug screening, medicinal chemistry, and preclinical safety assessments. Highlighting emerging trends like precision medicine, AI applications, immunotherapy, and innovative delivery systems, the collection offers insights into the latest advancements and their impact on healthcare.

21-30 of 44 results in All results

Basic Principles of Drug Discovery and Development

  • 1st Edition
  • April 24, 2015
  • Benjamin E. Blass
  • English
  • eBook
    9 7 8 - 0 - 1 2 - 4 1 1 5 2 5 - 5
Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, providing comprehensive explanations of enabling technologies such as high throughput screening, structure based drug design, molecular modeling, pharmaceutical profiling, and translational medicine, all areas that have become critical steps in the successful development of marketable therapeutics. The text introduces the fundamental principles of drug discovery and development, also discussing important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles in pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. It is designed to enable new scientists to rapidly understand the key fundamentals of drug discovery, including pharmacokinetics, toxicology, and intellectual property."

Understanding the Basics of QSAR for Applications in Pharmaceutical Sciences and Risk Assessment

  • 1st Edition
  • March 3, 2015
  • Kunal Roy + 2 more
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 0 1 5 0 5 - 6
  • eBook
    9 7 8 - 0 - 1 2 - 8 0 1 6 3 3 - 6
Understanding the Basics of QSAR for Applications in Pharmaceutical Sciences and Risk Assessment describes the historical evolution of quantitative structure-activity relationship (QSAR) approaches and their fundamental principles. This book includes clear, introductory coverage of the statistical methods applied in QSAR and new QSAR techniques, such as HQSAR and G-QSAR. Containing real-world examples that illustrate important methodologies, this book identifies QSAR as a valuable tool for many different applications, including drug discovery, predictive toxicology and risk assessment. Written in a straightforward and engaging manner, this is the ideal resource for all those looking for general and practical knowledge of QSAR methods.

A Pharmacology Primer

  • 4th Edition
  • March 26, 2014
  • Terry P. Kenakin
  • English
  • Hardback
    9 7 8 - 0 - 1 2 - 4 0 7 6 6 3 - 1
  • eBook
    9 7 8 - 0 - 1 2 - 4 0 7 6 8 9 - 1
A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, 4th Edition features the latest ideas and research about the application of pharmacology to the process of drug discovery to equip readers with a deeper understanding of the complex and rapid changes in this field. Written by well-respected pharmacologist, Terry P. Kenakin, this primer is an indispensable resource for all those involved in drug discovery. This edition has been thoroughly revised to include material on data-driven drug discovery, biased signaling, structure-based drug design, drug activity screening, drug development (including pharmacokinetics and safety Pharmacology), and much more. With more color illustrations, examples, and exercises throughout, this book remains a top reference for all industry and academic scientists and students directly involved in drug discovery, or pharmacologic research.

Transporters in Drug Discovery and Development

  • 1st Edition
  • October 31, 2013
  • Yurong Lai
  • English
  • Hardback
    9 7 8 - 1 - 9 0 7 5 6 8 - 2 1 - 3
  • eBook
    9 7 8 - 1 - 9 0 8 8 1 8 - 2 8 - 7
Written by a leading researcher in the field, Transporters in Drug Discovery and Development provides a comprehensive and practical guide to drug transporter families that are the most important for drug discovery and development. It covers: an overview of transporter families and organ distribution; clinical relevant drug-drug interaction; clinical relevant polymorphism; drug transporter related pharmacokinetic, pharmacodynamics and toxicity; in vitro/in vivo probes of drug transport studies; the practical methodologies of industrial transporter screening and translational aspect in drug discovery and developments.

The Future of Drug Discovery

  • 1st Edition
  • May 18, 2013
  • Tamas Bartfai + 1 more
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 4 0 7 1 8 0 - 3
  • eBook
    9 7 8 - 0 - 1 2 - 4 0 9 5 1 9 - 9
The Future of Drug Discovery: Who decides which diseases to treat? provides a timely and detailed look at the efforts of the pharmaceutical industry and how they relate, or should relate, to societal needs. The authors posit that as a result of increasing risk aversion and accelerated savings in research and development, the industry is not developing drugs for increasingly prevalent diseases, such as Alzheimer’s disease, untreatable pain, antibiotics and more. This book carefully exposes the gap between the medicines and therapies we need and the current business path. By analyzing the situation and discussing prospects for the next decade, the The Future of Drug Discovery is a timely book for all those who care about the development needs for drugs for disease.

Ligand Efficiency Indices for Drug Discovery

  • 1st Edition
  • January 22, 2013
  • Celerino Abad-Zapatero
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 4 0 4 6 3 5 - 1
  • eBook
    9 7 8 - 0 - 1 2 - 4 0 4 6 8 2 - 5
The purpose of Ligand Efficiency Indices for Drug Discovery: Towards an Atlas-Guided Paradigm is to introduce in a concise and self-contained form the concepts, ideas, applications and examples of efficiency-driven drug discovery to the biomedical community at large. The book emphasizes the use of 'new variables' and more objective numerical methods to drive drug discovery in an encompassing way. These 'new variables' are based on Ligand Efficiency Indices (LEIs) formulated in a way that permits mapping Chemico-Biological Space (CBS) in an Atlas-like representation. It provides a practical and timely discussion of the concepts, ideas, applications and examples of efficiency-driven drug discovery. This book emphasizes the use of a graphical representation and objective numerical methods to drive drug discovery more effectively. It presents the definition of LEIs and the corresponding efficiency planes within an atlas-like environment to provide a robust graphical and numerical framework for medicinal chemists and drug-discoverers.

Pharmacology in Drug Discovery

  • 1st Edition
  • September 1, 2011
  • Terry P. Kenakin
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 3 8 4 8 5 6 - 7
  • eBook
    9 7 8 - 0 - 1 2 - 3 8 4 8 5 7 - 4
Pharmacology in Drug Discovery: Understanding Drug Response is designed for all students, recent graduates, and new researchers in the pharmaceutical and biotechnology industries who need to interpret change in physiology induced by a chemical substance. Physiological systems customize chemical signal input to their own needs; therefore the same drug can have different effects in different physiological systems. The field of pharmacology is unique in that it furnishes the tools to analyze these different behaviors and traces them to their root cause. This enables predictions of drug behavior to be made in all systems, an invaluable tool for drug discovery because almost all drugs are developed in test systems far removed from the therapeutic one. This valuable resource provides simple explanations of the ways in which biological systems use basic biochemical mechanisms to produce fine chemical control of physiology, allowing for more informed predictions of drug effects in all systems and forming the basis of the drug-discovery process. Chapters follow a logical progression on how to characterize the pharmacology of any given molecule, and include important terminology, chapter summaries, references, and review questions to aid the reader in understanding and retention of the material.

Progress in Medicinal Chemistry

  • 1st Edition
  • Volume 50
  • February 9, 2011
  • G. Lawton + 1 more
  • English
  • eBook
    9 7 8 - 0 - 1 2 - 3 8 1 2 9 1 - 9
Progress in Medicinal Chemistry provides a review of eclectic developments in medicinal chemistry. This volume continues in the serial's tradition of providing an insight into the skills required of the modern medicinal chemist; in particular, the use of an appropriate selection of the wide range of tools now available to solve key scientific problems.

Membrane Proteins as Drug Targets

  • 1st Edition
  • Volume 91
  • August 24, 2010
  • Charles.A Lunn
  • English
  • eBook
    9 7 8 - 0 - 1 2 - 3 8 1 2 8 9 - 6
Membrane proteins continue to be prime drug targets because they perform essential processes in the cell including controlling the flow of information and materials between cells and mediating activities like hormone action and nerve impulses. The study of membrane proteins could lead to new and improved pharmaceutical treatments for a wide range of illnesses such as heart disease, cystic fibrosis and depression. Membrane Proteins as Drug Targets reviews the latest developments in the field.

Real World Drug Discovery

  • 1st Edition
  • July 7, 2010
  • Robert M. Rydzewski
  • English
  • eBook
    9 7 8 - 0 - 0 8 - 0 9 1 4 8 8 - 6
Drug discovery increasingly requires a common understanding by researchers of the many and diverse factors that go into the making of new medicines. The scientist entering the field will immediately face important issues for which his education may not have prepared him: project teams, patent law, consultants, target product profiles, industry trends, Gantt charts, target validation, pharmacokinetics, proteomics, phenotype assays, biomarkers, and many other unfamiliar topics for which a basic understanding must somehow be obtained. Even the more experienced scientist can find it frustratingly difficult to get an overview of the many factors involved in modern drug discovery and often only after years of exploring does a whole and integrated picture emerge in the mind of the researcher.Real World Drug Discovery: A Chemist’s Guide to Biotech and Pharmaceutical Research presents this kind of map of the landscape of drug discovery. In a single, readable volume it outlines processes and explains essential concepts and terms for the recent science graduate wondering what to expect in pharma or biotech, the medicinal chemist seeking a broader and more timely understanding of the industry, or the contractor or collaborator whose understanding of the commercial drug discovery process could increase the value of his contribution to it.