Skip to main content
Elsevier
View Cart

Books in Drug discovery

Elsevier's Drug Delivery collection is an indispensable resource for scientists and researchers in the pharmaceutical field, exploring the administration of pharmaceutical compounds for therapeutic effects from molecule identification to medication development. It provides comprehensive coverage, including crucial aspects such as drug screening, medicinal chemistry, and preclinical safety assessments. Highlighting emerging trends like precision medicine, AI applications, immunotherapy, and innovative delivery systems, the collection offers insights into the latest advancements and their impact on healthcare.

  • Antimicrobial Therapeutics and Drug Discovery

    • 1st Edition
    • Chengyuan Liang + 1 more
    • English
    Antimicrobial Therapeutics and Drug Discovery is a comprehensive resource that provides an overview of antimicrobial drug discovery. It covers a wide spectrum of pathogenic organisms causing human infections, exploring alternative therapeutic strategies beyond traditional small molecule drugs. The contents in the book are structured into four parts, each focusing on a different aspect of antimicrobial drug discovery. From exploring viral and host targets, understanding antibiotic resistance mechanisms, to the potential of nanomedicine and computational approaches, the book offers a comprehensive view of the field. Employing a multidisciplinary approach, chapters discuss the importance of drug discovery for fungi, Mycobacteria, Mycoplasma, and parasites, and offers insights into innovative biomedical approaches and combination therapies. By bridging the gap between experimental research and practical application, Antimicrobial Therapeutics and Drug Discovery is a key reference for pharmacologists and pharmaceutical scientists working in academic and corporate research. Medicinal chemists and microbiologists will also benefit from the multidisciplinary coverage of the book.

  • Natural Product Drug Discovery

    Highly Anticipated Natural Molecules
    • 1st Edition
    • Ning Li + 1 more
    • English
    Natural Product Drug Discovery: Highly Anticipated Natural Molecules, a new volume in the Drug Discovery Opinion series, provides a comprehensive examination of the role of natural products in innovative drug development. The book addresses the significant challenges that highly active natural molecules face in the drug development process, including issues related to bioavailability and potency. Sections present analyses of various classes of natural products, including polysaccharides, volatile oils, and diterpenoids, exploring their chemical properties, biological activities, and potential clinical applications. Each chapter, written by leading experts, offers insights into structural modification techniques, naturally sourced inhibitors, and the application of green biomanufacturing strategies.It will serve as an essential resource for researchers, pharmacologists, and industry professionals involved in natural product drug discovery. Readers will find the necessary information to navigate the complexities of the field, emphasizing the integration of traditional knowledge with modern scientific approaches. Through a thorough understanding of these natural compounds, this book aims to contribute to the advancement of therapeutic innovations in pharmacotherapy.

  • Medicinal Plants

    Chemistry, Biology and Omics
    • 2nd Edition
    • Da-Cheng Hao + 1 more
    • English
    Medicinal Plants: Chemistry, Biology, and Omics, Second Edition is a reference to help researchers identify and master the patterns in the distribution of medicinal compounds on the phylogenetic tree to explore new drug resources and develop novel therapies against different diseases. The book provides a deeper understanding of how the interrelationship between phytometabolites, bioactivities and omics techniques facilitates sustainable conservation and application of phytomedicine resources. Now in 2nd edition, the contents have been updated to include topics as machine learning applications, geographic distribution of phytometabolites, comparative analysis of alkaloids, expanded coverage of selected taxa, and conditions like cardiovascular disease and cancer. The book is structured around chemotaxonomy. After an introduction and review of taxonomy, chemistry, biology and omics, the authors dive into a taxon-guided exploration of medicinal resources for Fritillaria, Chelidoniae, Dichocarpum, Aconitum, Cimicifugeae, Clematis, Potentilla, Rubus, Cannabis, and other taxa. All chapters follow a similar and consistent structure, offering detailed information on each of them. Researchers in phytopharmacology can acquire in-depth understanding of the interrelationships between chemistry, biology and omics, as well as the implications of the link between phylogeny, phytometabolites and bioactivities in medical biotechnology and sustainability. Clinicians can better understand the principles of mutual interactions between phytometabolites and drug efficacy.

  • Emerging Trends in Phytotherapy of Cancer

    • 1st Edition
    • Mahendra Rai + 1 more
    • English
    Emerging Trends in Phytotherapy of Cancer is an essential reference that explores the multifaceted role of medicinal plants in combating cancer. The book covers a broad range of interconnected topics including ethnomedicinal plants used in cancer by tribes and aboriginals, herbs used in Ayurvedic medicine for cancer, integrated approaches of modern and conventional drugs, anti-cancerous secondary metabolites, plant-based anticancer drugs approved by FDA and WHO, toxicity to humans, and the role of emerging technologies such as the applications of nanotechnology and artificial intelligence. The contents are divided into six parts. Part one opens with an introductory chapter, followed by the different combinations of plant-based drugs and modern medicine for cancer treatment, and recent developments in cancer research. Part two discusses the ethnomedicinal uses of plants in cancer and the role of Ayurvedic herbal medicines in cancer. Part three incorporates the role of secondary metabolites in cancer treatment. Part four elaborates on the plant-based drugs recommended by FDA/WHO. Part five concerns the human phytotoxicity of secondary metabolites, and part six describes the role of emerging nanotechnologies and artificial intelligence in phytotherapy drug delivery and treatment. Targeted at researchers, healthcare professionals, and advanced students in related fields, this book provides technical and in-depth knowledge, contributing to ongoing advancements in cancer treatment. It uniquely integrates ethnomedicinal therapies with modern technologies, offering a comprehensive overview of the research into phytomedicinal cancer therapies.

  • Synthesis of Best-Seller Drugs

    • 2nd Edition
    • Ruben Vardanyan + 1 more
    • English
    Synthesis of Best-Seller Drugs, Second Edition provides detailed information on the most popular drugs, using a practical layout arranged according to drug type. Each chapter reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and synthesis. Of high interest to all those who work in the captivating areas of biologically active compounds and medicinal drug synthesis, in particular medicinal chemists, biochemists, and pharmacologists, the book aims to support current research efforts, while also encouraging future developments in this important field.

  • Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders

    Alzheimer's Disease
    • 2nd Edition
    • Adeboye Adejare
    • English
    Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders: Alzheimer’s Disease, Second Edition delves into the complexities of drug discovery, specifically for Alzheimer's Disease, presenting the necessary paradigm for future success in research and treatment. This edition is thoroughly updated with recent developments in therapeutic strategies, including amyloid hypothesis, tau, apo E, insulin, and others, and introduces a new chapter on drug delivery to the brain. Additionally, the book encompasses diagnosis, epidemiology, drug discovery strategies, current therapeutics, and more, offering a comprehensive approach to Alzheimer's Disease.It covers the latest in targeted drug design, preclinical studies, and animal models, making it an essential resource for pharmaceutical scientists, pharmacologists, neuroscientists, and clinical researchers. Patients and advocacy groups can also gain valuable insights from the overview of current treatments and scientific advancements in the field.

  • Deep Learning in Drug Design

    Methods and Applications
    • 1st Edition
    • Qifeng Bai + 2 more
    • English
    Deep Learning in Drug Design: Methods and Applications summarizes the most recent methods, and technological advances of deep learning for drug design, which mainly consists of molecular representations, the architectures of deep learning, geometric deep learning, large models, etc., as well as deep learning applications in various aspects of drug design. This book offers a comprehensive academic overview of deep learning in drug design. It begins with molecular representations, CNNs, GNNs, Transformers, generative models, explainable AI, large models, etc. Next, it covers deep learning applications like protein structure prediction, molecular interactions, ADMET prediction, antibody design, and so on. Finally, a separate chapter is dedicated to the introduction of the ethics and regulation of artificial intelligence in drug design. This book is ideal for readers aiming to learn and implement deep learning methods and applications in drug design and related fields.Deep Learning in Drug Design: Methods and Applications is particularly helpful to undergraduate, graduate, and doctoral students in need of a practical guide to the principles of the discipline. Established researchers in the area will benefit from the detailed case studies and algorithms presented.

  • Medicinal Chemistry and Drug Development

    • 1st Edition
    • Gang Liu
    • English
    Medicinal Chemistry and Drug Development describes the key events and roles of medicinal chemistry in the discovery and development of lead compounds into drugs, including target identification, which is accomplished by using 30 case studies. This book outlines all the stages of drug development, including the discovery of active compounds, research on the pharmacologicalprope... of molecules, and confirmation of drug targets. The role of the case studies is to show the common factors in the successful development of drugs, thereby showing medicinal chemists how best to explore the scientific pathways when developing new drugs. This makes the book especially relevant for senior university students majoring in pharmaceutical sciences as well as graduate students and researchers.

  • Privileged Scaffolds in Drug Discovery

    • 1st Edition
    • Bin Yu + 2 more
    • English
    Privileged Scaffolds in Drug Discovery is the most complete and up-to-date work in the area. Covering a wide range of privileged structures, it is a perfect reference for scientists involved in targeted drug development.The editors recruited experts from several prestigious Chinese institutions to cover the areas of antiviral drugs, chalcone, pyrimidine, (benz)imidazoles, natural product-derived privileged scaffolds, N-Sulfonyl carboxamides, kinase inhibitors, antitumor molecules, antineurodegenerativ... drugs, triazoles, oxazolidinone, indole and indoline scaffolds, tigliane diterpenoids, peptide and peptide-based drugs, quassinoids, and others including pseudonatural products, macrocycles, stable peptides and peptidomimetics. The book also explores scaffolds in drug molecules approved in recent years.Privileged Scaffolds in Drug Discovery is a complete reference for researchers in drug discovery and organic synthesis, in academic and corporate settings, who are investigating privileged structures upon which to base new drugs. Researchers in medicinal chemistry and chemical biology will also find the contents of this book valuable.

  • Antioxidants Effects in Health

    The Bright and the Dark Side
    • 1st Edition
    • Seyed Mohammad Nabavi + 1 more
    • English
    Antioxidants Effects in Health: The Bright and the Dark Side examines the role that antioxidants play in a variety of health and disease situations. The book discusses antioxidants’ historical evolution, their oxidative stress, and contains a detailed approach of 1) endogenous antioxidants, including endogenous sources, mechanisms of action, beneficial and detrimental effects on health, in vitro evidence, animal studies and clinical studies; 2) synthetic antioxidants, including sources, chemistry, bioavailability, legal status, mechanisms of action, beneficial and detrimental effects on health, in vitro evidence, animal studies and clinical studies; and 3) natural antioxidants, including sources, chemistry, bioavailability, mechanisms of action, possible prooxidant activity; beneficial and detrimental effects on health, in vitro evidence, animal studies and clinical studies. Throughout the boo, the relationship of antioxidants with different beneficial and detrimental effects are examined, and the current controversies and future perspectives are addressed and explored. Antioxidants Effects in Health: The Bright and the Dark Side evaluates the current scientific evidence on antioxidant topics, focusing on endogenous antioxidants, naturally occurring antioxidants and synthetic antioxidants. It will be a helpful resource for pharmaceutical scientists, health professionals, those studying natural chemistry, phytochemistry, pharmacognosy, natural product synthesis, and experts in formulation of herbal and natural pharmaceuticals.