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Studies in Natural Products Chemistry
- 1st Edition, Volume 52 - February 17, 2017
- Editor: Atta-ur Rahman
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 4 - 6 3 9 3 1 - 8
- eBook ISBN:9 7 8 - 0 - 4 4 4 - 6 3 9 3 7 - 0
Studies in Natural Products Chemistry covers the synthesis, testing, and recording of the medicinal properties of natural products, providing cutting-edge accounts of the fascinati… Read more
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Request a sales quoteStudies in Natural Products Chemistry covers the synthesis, testing, and recording of the medicinal properties of natural products, providing cutting-edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis, and pharmacology of a diverse array of bioactive natural products.
Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then rapidly determine the structures and biological activity of natural products, thus opening up exciting opportunities in the field of new drug development in the pharmaceutical industry.
- Focuses on the chemistry of bioactive natural products
- Contains contributions by leading authorities in the field
- Presents sources of new pharmacophores
Natural product chemists, medicinal chemists, pharmacologists as well as academic and industry researchers
Chapter 1. Natural Environments for Nanoparticles Synthesis of Metal, Metal Oxides, Core–Shell and Bimetallic Systems
Introduction
Key Concepts of Biological Nanosynthesis, State of the Art
Biosynthesis of NPs by Bacteria
Biosynthesis of NPs by Fungi
Biosynthesis of NPs in Plant Extracts
Core@Shell and Mixed NPs
Mechanistic Concepts
Summary
Terms, Abbreviations, and Acronyms
Chapter 2. 2-Aminoimidazoles: Synthesis by Ring Transformation Reactions
Introduction
Synthesis of Aminoimidazoles From Aminooxazoles
Synthesis of Fused Aminoimidazoles From Aminooxazoles
Synthesis of Aminoimidazoles From Other Azoles
Synthesis of Aminoimidazoles From Imidazopyrimidines
Synthesis of Aminoimidazoles From Other Heterocycles
Conclusion
Chapter 3. Strategies for Total Synthesis of Furanocembranolides and Related Natural Products From Marine Organisms
Introduction
Synthesis of Acerosolide
Synthesis of Bipinnatin J
Synthesis of Rubifolide
Synthesis of Deoxypukalide
Further Synthetic Studies Toward Furanocembranolides
Furanocembranolid Derivatives and Related Compounds
Concluding Remarks
Chapter 4. Phyllobilins: A New Group of Bioactive Compounds
Introduction
Catabolism of Chlorophyll Pigments
The PaO/Phyllobilin Pathway
Regulation of the PaO/Phyllobilin Route
Structural Characteristics of the FCCs and DFCCs
Transport Into Vacuole and Isomerization to NCCs and DNCCs
Further Linear Chlorophyll Catabolites
Methods of Analysis of Phyllobilins
Extraction Procedures From Vegetal Tissues
Analytical and Semipreparative HPLC Methodologies
Structural Elucidation and Identification: Nuclear Magnetic Resonance
Structural Elucidation and Identification: Mass Spectrometry
Biological Properties of Phyllobilins
Chlorophyll Metabolism in Animals
Concluding Remarks
Abbreviations
Chapter 5. Artemisinin the Nobel Molecule: From Plant to Patient
Introduction
From the Plant: ART Biosynthesis
To the Patient
Conclusion
Abbreviations
Chapter 6. Bioactive Polyphenols for Diabetes and Inflammation in Psoriasis Disease
Introduction
Polyphenols From Forest Resources
Physiopathology of Diabetes Mellitus
Impact of Forest Biomass Polyphenols on Type 2 Diabetes Mellitus
Current Concepts of Psoriasis Pathogenesis
Natural Treatments for Psoriasis: Role of Forest Biomass Polyphenols
Research Perspective
Concluding Remarks
Abbreviation
Chapter 7. Nonhalogenated Heterotricyclic Sesquiterpenes From Marine Origin I: Fused Systems
Introduction
Fused Heterocyclic Sesquiterpenes
Conclusion
Abbreviations
Chapter 8. Phytochemicals With Antileishmanial Activity: Prospective Drug Targets
Introduction
Inhibition of Parasite Proteins as Prospective Drug Targets
Inhibition of Metabolic Pathway of Parasite as Prospective Drug Targets
Conclusion
Abbreviations
Chapter 9. Parthenolide and Parthenolide-Like Sesquiterpene Lactones as Multiple Targets Drugs: Current Knowledge and New Developments
Introduction
New Sources of Parthenolide
Pharmacology of Parthenolide
Synergistic Effects to Improving the Chemosensitivity to Parthenolide
Parthenolide Delivery
Pharmacology of Parthenolide-Like Sesquiterpene Lactones
Concluding Remarks
Abbreviations
Chapter 10. Alkaloids From Apocynaceae: Origin, Pharmacotherapeutic Properties, and Structure-Activity Studies
Introduction
Anticancer Activities of Apocynaceaeous Alkaloids
Neuroprotective and Psychoactive Activities of Apocynaceaeous Alkaloids
Biocidal Activities of Apocynaceaeous Alkaloids
Other Pharmacological Properties of Apocynaceaeous Alkaloids
Structure Activity Relationships
Derivatives and Synthetic Analogues
Concluding Remarks
Abbreviations
- No. of pages: 514
- Language: English
- Edition: 1
- Volume: 52
- Published: February 17, 2017
- Imprint: Elsevier
- Hardback ISBN: 9780444639318
- eBook ISBN: 9780444639370
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Atta-ur Rahman
Atta-ur-Rahman, Professor Emeritus, International Center for Chemical and Biological Sciences (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, Pakistan, was the Pakistan Federal Minister for Science and Technology (2000-2002), Federal Minister of Education (2002), and Chairman of the Higher Education Commission with the status of a Federal Minister from 2002-2008. He is a Fellow of the Royal Society of London (FRS) and an UNESCO Science Laureate. He is a leading scientist with more than 1283 publications in several fields of organic chemistry.
Affiliations and expertise
Professor Emeritus, International Center for Chemical and Biological Sciences (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, PakistanRead Studies in Natural Products Chemistry on ScienceDirect