Studies in Natural Products Chemistry

Chapter 1. Natural Environments for Nanoparticles Synthesis of Metal, Metal Oxides, Core–Shell and Bimetallic Systems

Introduction

Key Concepts of Biological Nanosynthesis, State of the Art

Biosynthesis of NPs by Bacteria

Biosynthesis of NPs by Fungi

Biosynthesis of NPs in Plant Extracts

Core@Shell and Mixed NPs

Mechanistic Concepts

Summary

Terms, Abbreviations, and Acronyms

Chapter 2. 2-Aminoimidazoles: Synthesis by Ring Transformation Reactions

Introduction

Synthesis of Aminoimidazoles From Aminooxazoles

Synthesis of Fused Aminoimidazoles From Aminooxazoles

Synthesis of Aminoimidazoles From Other Azoles

Synthesis of Aminoimidazoles From Imidazopyrimidines

Synthesis of Aminoimidazoles From Other Heterocycles

Conclusion

Chapter 3. Strategies for Total Synthesis of Furanocembranolides and Related Natural Products From Marine Organisms

Introduction

Synthesis of Acerosolide

Synthesis of Bipinnatin J

Synthesis of Rubifolide

Synthesis of Deoxypukalide

Further Synthetic Studies Toward Furanocembranolides

Furanocembranolid Derivatives and Related Compounds

Concluding Remarks

Chapter 4. Phyllobilins: A New Group of Bioactive Compounds

Introduction

Catabolism of Chlorophyll Pigments

The PaO/Phyllobilin Pathway

Regulation of the PaO/Phyllobilin Route

Structural Characteristics of the FCCs and DFCCs

Transport Into Vacuole and Isomerization to NCCs and DNCCs

Further Linear Chlorophyll Catabolites

Methods of Analysis of Phyllobilins

Extraction Procedures From Vegetal Tissues

Analytical and Semipreparative HPLC Methodologies

Structural Elucidation and Identification: Nuclear Magnetic Resonance

Structural Elucidation and Identification: Mass Spectrometry

Biological Properties of Phyllobilins

Chlorophyll Metabolism in Animals

Concluding Remarks

Abbreviations

Chapter 5. Artemisinin the Nobel Molecule: From Plant to Patient

Introduction

From the Plant: ART Biosynthesis

To the Patient

Conclusion

Abbreviations

Chapter 6. Bioactive Polyphenols for Diabetes and Inflammation in Psoriasis Disease

Introduction

Polyphenols From Forest Resources

Physiopathology of Diabetes Mellitus

Impact of Forest Biomass Polyphenols on Type 2 Diabetes Mellitus

Current Concepts of Psoriasis Pathogenesis

Natural Treatments for Psoriasis: Role of Forest Biomass Polyphenols

Research Perspective

Concluding Remarks

Abbreviation

Chapter 7. Nonhalogenated Heterotricyclic Sesquiterpenes From Marine Origin I: Fused Systems

Introduction

Fused Heterocyclic Sesquiterpenes

Conclusion

Abbreviations

Chapter 8. Phytochemicals With Antileishmanial Activity: Prospective Drug Targets

Introduction

Inhibition of Parasite Proteins as Prospective Drug Targets

Inhibition of Metabolic Pathway of Parasite as Prospective Drug Targets

Conclusion

Abbreviations

Chapter 9. Parthenolide and Parthenolide-Like Sesquiterpene Lactones as Multiple Targets Drugs: Current Knowledge and New Developments

Introduction

New Sources of Parthenolide

Pharmacology of Parthenolide

Synergistic Effects to Improving the Chemosensitivity to Parthenolide

Parthenolide Delivery

Pharmacology of Parthenolide-Like Sesquiterpene Lactones

Concluding Remarks

Abbreviations

Chapter 10. Alkaloids From Apocynaceae: Origin, Pharmacotherapeutic Properties, and Structure-Activity Studies

Introduction

Anticancer Activities of Apocynaceaeous Alkaloids

Neuroprotective and Psychoactive Activities of Apocynaceaeous Alkaloids

Biocidal Activities of Apocynaceaeous Alkaloids

Other Pharmacological Properties of Apocynaceaeous Alkaloids

Structure Activity Relationships

Derivatives and Synthetic Analogues

Concluding Remarks

Abbreviations